Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Fam50aP1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr17:30864261-30864822  UCSC
Strand -
Parental Sequence NM_001170573.1
Parental seq. overlap 445 bp
Parental seq. overlap (%) 33.9%
Genomic Region Intergenic
Retrocopy Summary Fam50aP1, located on chr17:30864261-30864822, is a retrocopy of the parental gene Fam50a. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Fam50a
Full Name family with sequence similarity 50, member A
Also known as RGD1560964
Coordinate chrX:156392646-156399763
Strand -
Gene summary Predicted to be involved in chromatin organization and regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Armfield syndrome. Orthologous to human FAM50A (family with sequence similarity 50 member A). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Mouse Mus musculus Fam50aP1
Horse Equus caballus FAM50AP1
Cat Felis catus FAM50AP1
Egyptian rousette Rousettus aegyptiacus FAM50AP2
Sloth Choloepus didactylus FAM50AP1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Fam50aP1
AAGAACTTGGGCAAGAACCCCGATGTGGACACGAGCTTCCTGCCCGATCGCGAACGCGAGGAGGAGGAGAACCGGCTGCGGGAGGAACTGCGGCAGGAGTGGGAGGCGAAGCGCGAGAAGGTGAAGGGCGAGGAGGTGGAGATCACCTTCAGCTACTGGGATGGCTCTGGCCACCGGCGCACAGTACGCATGCGCAAGGGCAGCACTGTGCAGCAGTTCCTGAAGCGGGCGCTGCAGGGGCTGCGCAGGGACTTCCGGGAGCTGCGGGCGGCGGGCGTGGAGCAGCTCATGTACGTCAAGGAGGATCTCATCCTGCCGCACTACCACACCTTTTACGACTTCATCGTGGCCAAAGCGCGGGGCAAGAGTGGGCCGCTCTTCAGCTTCGACGTGCACGATGATGTGCGGCTGCTGAGCGATGCCACGATGGAGAAAGACGAGTCACACGCGGGAAAGGTGGTGCTGCGCAGCTGGTATGAGAAGAACAAGCACATCTTCCCCGCCAGCCGCTGGGAGCCCTACGACCCCGAGAAGAAGTGGGACAAGTACACCATCCGGTGAT
>NM_001170573.1
CGTCACGTATCAGCTGACTAAATTGCTGCCGCCACGGACGTCGCCTTCACTGCCAGGACTTCTTCAGGCGAAAGTCACTGTTGCCGCTGTTGCTGCCGCCGCCGCCACTGAAACCACCGCTGCCACCATGGCTCAGTACAAGGGCGCTGCAAGTGAGGCGGGACGTGCCATGCACCTAATGAAGAAGAGAGAGAAGCAGCGTGAGCAAATGGAGCAGATGAAGCAGAGGATTGCAGAGGAGAACATAATGAAATCTAACATTGACAAGAAGTTCTCTGCACACTATGATGCTGTGGAAGCAGAGCTCAAGTCCAGTACTGTGGGTCTTGTGACCCTGAATGACATGAAGGCCAAACAGGAGGCACTGGTGAAGGAGCGAGAAAAGCAGTTGGCAAAAAAGGAACAGTCAAAGGAGCTACAGCTGAAGCTAGAGAAGCTTCGAGAGAAGGAGCGCAAGAAGGAGGCCAAACGGAAGATCTCTAGCCTGTCCTTCACCTTGGAGGAAGAAGAGGAGGGAGGTGAAGAGGAAGAAGAGATGGCCATGTATGAGGAAGAACTGGAGAGGGAAGAGATCACCACAAAGAAAAAGAAATTGGGGAAGAACCCTGATGTGGATACAAGCTTCTTGCCTGACCGGGATCGGGAGGAGGAGGAGAATCGGCTTCGGGAAGAGCTGCGCCAGGAATGGGAAGCCAAGCAAGAAAAAATCAAGAgtgaagagattgaaatcaCCTTTAGTTACTGGGATGGCTCTGGGCACCGGCGCACTGTTAAGATGAAGAAGGGCAACACCATGCAGCAGTTCCTGCAGAAAGCACTAGAGATCTTGCGGAAAGACTTCAGTGAGCTCAGGTCAGCAGGAGTGGAACAGCTCATGTACATCAAGGAGGATTTAATCATCCCCCATCATCACAGCTTCTATGACTTCATTGTTACCAAGGCGCGAGGAAAAAGTGGGCCACTCTTCAACTTTGATGTTCATGATGATGTTCGACTGCTCAGTGATGCCACTGTGGAAAAGGATGAGTCACATGCAGGCAAAGTGGTGCTGAGGAGCTGGTATGAGAAGAACAAACACATTTTTCCTGCTAGTCGCTGGGAGCCCTATGACCCAGAGAAGAAATGGGACAAGTACACGATCCGGTGAGCATCCAAAAGTGGGCATGACCTTGGCTCTCTCCAGCGTGTCCCCATGTCTCCAGGGCTCCAGGTGACCATGGCAGAGCACTCTGGGAGTATGGTAGTTGCTATTCCCTGACTTGATGTTGTCATTACTGCTTTTCCCTTTTACAATAAAAAAGTTCACATGTT

Publications

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