Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Hmgb1P74
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr17:30736067-30736592  UCSC
Strand +
Parental Sequence NM_012963.2
Parental seq. overlap 490 bp
Parental seq. overlap (%) 27.2%
Genomic Region Intergenic
Retrocopy Summary Hmgb1P74, located on chr17:30736067-30736592, is a retrocopy of the parental gene Hmgb1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Hmgb1
Full Name high mobility group box 1
Also known as Ac2-008|Hmg1
Coordinate chr12:7082529-7090246
Strand +
Gene summary Enables several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of DNA ligation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including DNA geometric change; induction of positive chemotaxis; and positive regulation of mesenchymal cell proliferation. Located in several cellular components, including cytosol; extracellular space; and membrane raft. Used to study congestive heart failure; high grade glioma; myocardial infarction; pulmonary hypertension; and sciatic neuropathy. Biomarker of several diseases, including atherosclerosis; colon adenocarcinoma; hydrocephalus; middle cerebral artery infarction; and obstructive jaundice. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Hmgb1P74
CGGCACTGGGCGACTCTGTGCCTCGCGGACTCGCTGAGGAAAATCCAGTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCCTCATATGCATTCTTTGTGCAAACCTGCTGGGAGGAGCACAAGAAGAATCACGTGGATGCTTCTGTCATCTTCTCAGAGTTCTCCAAGAAGTGCTCAGGGAGGTGGAAGACCATGTCTGCTAAAAAAAAGGGGGAAATTTGAAGATAAGGCAAAGACTGACAAGGCTCGTTATGAAAGAGAAATGGAAGCCTACATCCCTCCCAAAGGGGAGACCAAAGAGAAGTTCAAGGACCCCAATGACCCCAAGAGGCCTCCGTCGGCCTTCTTCTTGTTCTGTTCTGAGTAGCGCCCAAAAATCAAAGGCGAGCATCCTGGCTTATCCATTGGTGATGTTGCAAAGAAACGAGGAGAGATGTGGAACAACGCTGCCGCGGATGACAAGCAGCCCTATGGGAAGATGGCCGCCAAGCTGAAGGAGAAGTACGAGAAGG
>NM_012963.2
CGAGAGCCGGACGGGCACTGGGCGACTCTGTGCCTCGCGGAGGAAAATCAACTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCCTCATATGCATTCTTTGTGCAAACCTGCCGGGAGGAGCACAAGAAGAAGCACCCGGATGCTTCTGTCAACTTCTCAGAGTTCTCCAAGAAGTGCTCAGAGAGGTGGAAGACCATGTCTGCTAAAGAAAAGGGGAAATTTGAAGATATGGCAAAGGCTGACAAGGCTCGTTATGAAAGAGAAATGAAAACCTACATCCCCCCCAAAGGGGAGACCAAAAAGAAGTTCAAGGACCCCAATGCCCCCAAGAGGCCTCCTTCGGCCTTCTTCTTGTTCTGTTCTGAGTACCGCCCAAAAATCAAAGGCGAGCATCCTGGCTTATCCATTGGTGATGTTGCGAAGAAACTAGGAGAGATGTGGAACAACACTGCTGCGGATGACAAGCAGCCCTATGAAAAGAAGGCCGCCAAGCTGAAGGAGAAGTATGAGAAGGGTGCACAGCACAAATTAGTTATATATGGGGACAGTAGTTTGGtttttggtttcttttttttttttttttttggttttggtttttttccttttgttttttttttCCATCTTCAGTTGTCTCTGATGCAGCTTATACGAAGGTAATTGTTGTTCTGTTAACTGAATACCACTCTGTAATTGCAAAAAAATGGCGGCTGTTTTGTTGACATTCTGAATGCTTCTAAGTAAATACAATTTTTTTTATTAGTACTGTTGTCCTTTTCATAGGTCTGAAAGTTTTCTTCTCAAGGGGAAGCTAGTCTTTTGCTTTTGCCCATTTTGGGTCACATGGATTATTAGTGTGTATCTTCATATAGTTGGAAAAATCTTTTGTCCACACACCCTGCATATTGTGGTAGGGGTAACATTTTCATCTACAGTTGAAGAATTCTCCAAAATTGTGATCAGTTGGATAAGAGATACTCTACTTAGCAAAGCAAGGAGTGATCAATTCTGTCACACCATGGGATTATTAGATCAAACAGTCTGAAAGTCTGTCCTTGAAGGACTAATAGAAAAGTATGTTCTGCTCCTTACCTGAGGACTCCTTTAACTGCCATTACTGTGTAATGACAGTTATATTTTGCAGTTTCCCCTACTAAAGACCTGAGAATGTATCCCCAAAAGCGTGAGCTTAAAATACAAGATTGCTGTACTATTTGTTGACCTTAGTCCCAGCGAAGGCTATCATGAGAAGCTGGCTGTAATGCCTTTGCCCTTCTATCTAAATACGGATTGCTCAGGAAACTTGACTGTTTAAAGGTATATTTAATTAGTTGAGCCAGCTTTTAAAATTATGCCACATTTAAAATGAAGGGTATATTTTCCTATATTGTGGTTTGTCCCTTTATAAATCAGATACAAGGAAAGCGGATAAACTTTGCATATTAGTACCAGTTGTCCAAGCCATTTGCTTTTTCTTTATAAAGCCCGAACTCATTCATTAATCATGTTTAATCTGCTTAGTTTAGGGAACAATTTGGCAATTTTGTGGGttttctttttttctttttctttttttttttttttttGAGATTATCATTCTCTTAAAGTGCCAGTGTTTTAAAATAGCGTTCTTGTAATTTTCCGCGCTTTTGTGATGGAGTGCTGTTATATCATTTTGACTTGGGTTCTTTACAGTTGCCTTTGTTCTGTAATTTGAGGAGGAATACTGAACATGAGTCCTGGATGATACTAATAAACTAATAATTGCAGAGGTTTTAAA

Publications

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