RCPedia: Rtcs

Summary

Retrocopy Name	Mcts1P1	Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species	Rattus norvegicus
Coordinates	chr3:148168346-148168898 UCSC
Strand	+
Parental Sequence	XM_006257488.3
Parental seq. overlap	478 bp
Parental seq. overlap (%)	46.1%
Genomic Region	Intergenic
Retrocopy Summary	Mcts1P1, located on chr3:148168346-148168898, is a retrocopy of the parental gene Mcts1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	Mcts1
Full Name	MCTS1, re-initiation and release factor
Also known as	-
Coordinate	chrX:124894269-124906129
Strand	+
Gene summary	Predicted to enable RNA binding activity. Predicted to be involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Predicted to be located in cytosol and plasma membrane. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Human	Homo sapiens	MCTS2P
Chimpanzee	Pan troglodytes	MCTS1P1
Bonobo	Pan paniscus	MCTS1P1
Gorilla	Gorilla gorilla	MCTS1P1
Orangutan	Pongo abelii	MCTS1P1
Gibbon	Nomascus leucogenys	MCTS1P1
Green monkey	Chlorocebus sabaeus	MCTS1P1
Crab-eating macaque	Macaca fascicularis	MCTS1P1
Rhesus	Macaca mulatta	MCTS1P1
Baboon	Papio anubis	MCTS1P1
Golden snub-nosed monkey	Rhinopithecus roxellana	MCTS1P1
Marmoset	Callithrix jacchus	MCTS1P2
Mouse lemur	Microcebus murinus	MCTS1P3
Mouse	Mus musculus	Mcts1P1
Chinese hamster	Cricetulus griseus	Mcts1_1P1
Rabbit	Oryctolagus cuniculus	MCTS1P1
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>Mcts1P1
AGATCATGTTCAAGAAATTTGACGAGAAAGAAAGTGTGTCCAACTGCATCCAACTGAAAACTTCCGTTATTAAGGGTATTAAGAGCCAACTGACTGAGCAGTTTCCAGGTATCGAGCCGTGGCTTAATCAAATCATGCCTAAGAAAGATCCCGTCAAAATAGTGAGATGCCATGAACACATGGAAATCCTTACAGTCAACGGAGAATTACTGTTTTTCAGGCAGAGAAAAGGACCTTTTTATCCAACGCTAAGATTACTTCACAAATACCCGTTTATCCTGCCACACCAGCAGGTCGACAAAGGAGCCATCAAATTTGTGCTCAGTGGTGCAAATATCATGTGTCCGGGTTTAACATCTCCTGGAGCGAAGCTCTACACTGCTGCAGTAGATACCATCGTGGCGGTCATGGCAGAAGGGAAAGAGCATGCCCTGTGTGTCGGAGTCATGAAGATGGCAGCAGCAGACATTGAGAAGATCAACAAGGGGATCGGCATTGAGAATATCCATTATCTAAATGACGGGCTGTGGCACATGAAGACATATAAGTGAGC

>XM_006257488.3
CCGGTAACTGATTGCCACAATTTCTGCTTTGATTGATTTCCTCCCTCCTCCATTCTTCTCTTCCAGCCACCAGAAAGAATTGTTTGATCACTTCTTCCTTCTGAAGTCCCGCCCTTTCGGCTACCCCCAATGGAGAATAAGCTGTTACTGAAAAGGAGCGGACAAAAGCGTCAACGTGGAGGCGAGAGGAGCGGAAGTAGTCAGATTTCGCATAGGGCCGTAAAGCGGATAGTGTTTTCGCCTTCCGGATTAACGACAGCAGCTCAGACTGTCAGTGCCGGCCTTCCTTGTGCCGGACCCTTCCTAATTCAATTTCCTTCCCATTCCGGGCCCTTCCCTATCGTCGCCCCTTTCACCTTGGATCATGTTCAAGAAATTTGATGAAAAAGAAAATGTGTCCAACTGCATCCAGTTGAAAACCTCGGTTATTAAGGGTATTAAAAATCAATTGCTAGAGCAATTTCCAGGTATTGAACCATGGCTTAATCAAATCATGCCTAAGAAAGATCCTGTGAAAATTGTCCGATGCCATGAACACATAGAAATCCTTACAGTAAATGGAGAGTTACTGTTTTTTAGACAAAGAGAAGGGCCTTTTTATCCAACCTTAAGATTACTTCATAAATATCCTTTTATCTTGCCACATCAGCAGGTTGATAAAGGAGCCATCAAATTTGTACTCAGTGGAGCAAATATCATGTGTCCCGGCTTAACGTCTCCTGGAGCTAAGCTTTATCCTGCTGCAGTAGATACTATTGTTGCAATCATGGCAGAAGGAAAACAACATGCTTTATGTGTGGGCGTCATGAAGATGTCTGCAGAAGATATTGAGAAAGTCAACAAAGGAATTGGCATTGAAAATATCCATTATCTAAATGATGGGCTGTGGCATATGAAGACATATAAATGAGCTTCCAAAGGAATGTGCTTGGGCTAACTATAGATACTGTGCTGTATCTGTCTCTGTGTCTGTATGACAGCATGAAGACAATGCCTCTATGGTTATGCTGAATAAAAATTCTGTGAATGCTAAAA

>XM_006257488.3 

CCGGTAACTGATTGCCACAATTTCTGCTTTGATTGATTTCCTCCCTCCTCCATTCTTCTCTTCCAGCCACCAGAAAGAATTGTTTGATCACTTCTTCCTTCTGAAGTCCCGCCCTTTCGGCTACCCCCAATGGAGAATAAGCTGTTACTGAAAAGGAGCGGACAAAAGCGTCAACGTGGAGGCGAGAGGAGCGGAAGTAGTCAGATTTCGCATAGGGCCGTAAAGCGGATAGTGTTTTCGCCTTCCGGATTAACGACAGCAGCTCAGACTGTCAGTGCCGGCCTTCCTTGTGCCGGACCCTTCCTAATTCAATTTCCTTCCCATTCCGGGCCCTTCCCTATCGTCGCCCCTTTCACCTTGGATCATGTTCAAGAAATTTGATGAAAAAGAAAATGTGTCCAACTGCATCCAGTTGAAAACCTCGGTTATTAAGGGTATTAAAAATCAATTGCTAGAGCAATTTCCAGGTATTGAACCATGGCTTAATCAAATCATGCCTAAGAAAGATCCTGTGAAAATTGTCCGATGCCATGAACACATAGAAATCCTTACAGTAAATGGAGAGTTACTGTTTTTTAGACAAAGAGAAGGGCCTTTTTATCCAACCTTAAGATTACTTCATAAATATCCTTTTATCTTGCCACATCAGCAGGTTGATAAAGGAGCCATCAAATTTGTACTCAGTGGAGCAAATATCATGTGTCCCGGCTTAACGTCTCCTGGAGCTAAGCTTTATCCTGCTGCAGTAGATACTATTGTTGCAATCATGGCAGAAGGAAAACAACATGCTTTATGTGTGGGCGTCATGAAGATGTCTGCAGAAGATATTGAGAAAGTCAACAAAGGAATTGGCATTGAAAATATCCATTATCTAAATGATGGGCTGTGGCATATGAAGACATATAAATGAGCTTCCAAAGGAATGTGCTTGGGCTAACTATAGATACTGTGCTGTATCTGTCTCTGTGTCTGTATGACAGCATGAAGACAATGCCTCTATGGTTATGCTGAATAAAAATTCTGTGAATGCTAAAA

Publications

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