Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Nlgn2P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chrX:71219454-71219832  UCSC
Strand +
Parental Sequence NM_053992.1
Parental seq. overlap 301 bp
Parental seq. overlap (%) 7.6%
Genomic Region Intragenic (Nlgn3)
Retrocopy Summary Nlgn2P1, located on chrX:71219454-71219832, is a retrocopy of the parental gene Nlgn2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Nlgn2
Full Name neuroligin 2
Also known as -
Coordinate chr10:56431586-56444847
Strand -
Gene summary Predicted to enable several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including positive regulation of protein localization; presynapse organization; and regulation of synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including dendritic shaft; inhibitory synapse; and ribbon synapse. Is integral component of postsynaptic membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens NLGN2P1
Chimpanzee Pan troglodytes NLGN2P1
Bonobo Pan paniscus NLGN2P1
Gorilla Gorilla gorilla NLGN2P1
Orangutan Pongo abelii NLGN2P1
Gibbon Nomascus leucogenys NLGN2P1
Green monkey Chlorocebus sabaeus NLGN2P1
Rhesus Macaca mulatta NLGN2P1
Dog Canis familiaris NLGN2P1
Panda Ailuropoda melanoleuca NLGN2P1
Greater mouse-eared bat Myotis myotis NLGN2P1
Greater horseshoe bat Rhinolophus ferrumequinum NLGN2P1
Egyptian rousette Rousettus aegyptiacus NLGN2P1
Sloth Choloepus didactylus NLGN2P1
Opossum Monodelphis domestica NLGN2P1
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Nlgn2P1
AGGAGCTGGTAGAACAGGACATTCAGCCAGCCCGCTACCATGTGGCTTTTGGCCCTGTGATTGATGGTGATGTCATTCCTGATGACCCTGAGATCCTTATGGAACAGGGAGAGTTCCTCAACTATGATATCATGCTAGGCGTCAACCAGGGTGAGGGTCTCAAGTTTGTGGAAGGGGTGGTGGACCCCGAGGATGGTGTCTCTGGCACTGACTTTGACTACTCTGTCTCCAATTTTGTGGACAATCTATATGGCTATCCCGAGGGTAAGGACACCCTGCGGGAGACTATCAAGTTCATGTATACAGACTGGGCAGACCGAGACAACCCTGAGACCCGCCGTAAAACACTGGTGGCACTCTTCACTGACCACCAGTGGGT
>NM_053992.1
AGCCAGTGGATCTCCAGTCCAGTCCTGTCCCATTGCTTCCTCCTGGCTCAGCCTTCCCCACTGCGGGGTTCCCTGTTCTTGAGCTTCCTCTGACCCTATACCCTAGCTTTCCTTTTCCTGGGGATCGACTGGATCCCGGCCCCGCCCCCCGGGGCTGGGGCGATCCCCCTCCCCCGCCGGGTGAGGCGCTGCAGGCGGGGGCTGGGCCTGCGGGGCCGCGGGGGCTCAGAGGCCGCCGCCCCCCTTCTGAAGCCCGTCCGCCCCCCACTCGTAGCCCTGGATGGAGGCACCACGGCCCCAGGGCTGATCCAGGTCGGGCCTCCCAGCATCTTCTTCTACCTTCTTCCCCTTCCCCACCCCTTACCCCCTCCATGGAGAGAAATAGACTCCTCTTCTGTCCCTTCTAACCCAGGtccctacccgtacccctcctccttcctttccccgccccctcctccctcctGGGGCGAGGGGGGcctccctccctctcccccccttctctctctccGAGGGGGGGGTCAGGGGAGGGAGGGGGGGTCCCCCAATCAGCATGTGGCTCCTGGCGTTGTGTCTGGTGGGGCTGGCTGGGGCTCAACGGGGAGGAGGGGGTCCCGGCGGCGGCGCCCCGGGCGGCCCAGGCCTGGGCCTCGGCAGCCTCGGGGAGGAGCGCTTCCCGGTGGTGAACACAGCCTACGGGCGAGTGCGCGGTGTGCGGCGCGAGCTCAACAACGAGATCCTGGGCCCGGTCGTGCAGTTCTTGGGCGTGCCCTACGCCACGCCGCCCTTGGGCGCCCGCCGCTTCCAGCCGCCTGAGGCACCTGCCTCGTGGCCCGGCGTGCGCAACGCCACCACCCTGCCGCCCGCCTGCCCGCAGAACCTGCACGGGGCCCTGCCGGCCATCATGCTGCCTGTGTGGTTCACCGACAACTTGGAGGCGGCCGCCACCTACGTGCAGAACCAGAGCGAGGACTGCCTGTACCTCAACCTCTACGTGCCCACTGAGGACGGTCCGCTCACAAAAAAACGTGACGAGGCGACGCTCAATCCGCCAGACACAGATATCCGGGACTCTGGGAAGAAACCAGTCATGCTGTTTCTACACGGCGGCTCCTACATGGAGGGCACCGGGAACATGTTCGACGGCTCAGTCCTGGCTGCCTATGGCAATGTCATCGTAGCCACACTCAACTACCGTCTTGGGGTGCTCGGCTTTCTCAGCACTGGTGACCAGGCTGCAAAAGGCAACTACGGGCTCCTGGACCAGATCCAGGCCCTGCGCTGGCTCAGTGAAAACATTGCCCACTTTGGCGGTGACCCTGAACGCATCACCATCTTTGGGTCTGGTGCGGGGGCCTCCTGTGTCAACTTGCTGATCCTCTCCCACCATTCAGAAGGGCTGTTCCAGAAGGCCATTGCTCAGAGTGGCACTGCCATTTCCAGCTGGTCTGTCAACTACCAGCCGCTCAAGTACACGCGGCTGCTGGCAGCCAAAGTGGGCTGTGACCGAGAGGACAGCACGGAAGCTGTGGAATGTCTACGCCGGAAGTCTTCCCGGGAGCTAGTAGACCAGGATGTGCAGCCTGCCCGCTACCACATTGCCTTTGGGCCTGTGGTGGACGGCGATGTAGTCCCTGATGACCCTGAGATCCTCATGCAACAGGGAGAATTCCTCAACTACGACATGCTCATTGGCGTCAACCAGGGAGAGGGTCTCAAGTTCGTGGAGGACTCTGCAGAGAGTGAGGACGGGGTGTCTGCCAGCGCCTTTGACTTCACTGTCTCCAACTTTGTGGACAACTTGTATGGGTATCCAGAGGGCAAGGATGTGCTTCGAGAGACCATCAAGTTCATGTACACGGACTGGGCTGACCGGGACAATGGCGAGATGCGGCGTAAGACCCTGTTGGCACTCTTTACTGACCACCAGTGGGTAGCCCCAGCTGTGGCCACTGCCAAGCTACATGCTGACTACCAGTCCCCTGTCTACTTTTACACTTTTTACCACCACTGCCAGGCTGAGGGCCGGCCAGAGTGGGCAGATGCAGCGCATGGGGATGAGCTGCCCTACGTCTTTGGTGTGCCCATGGTGGGCGCCACCGACCTCTTCCCCTGCAACTTCTCCAAGAATGATGTCATGCTCAGCGCAGTAGTCATGACCTACTGGACCAACTTCGCCAAGACTGGTGACCCCAACCAGCCTGTGCCACAGGACACCAAGTTCATCCACACCAAGCCCAACCGCTTTGAAGAGGTGGTATGGAGCAAGTTCAACAGCAAGGAAAAGCAGTACCTGCACATAGGCTTGAAACCACGCGTGCGTGACAACTACCGTGCCAACAAGGTGGCCTTCTGGCTGGAGCTCGTGCCCCACCTGCACAACCTGCACACAGAGCTCTTCACCACCACCACTCGCCTGCCTCCCTACGCCACACGCTGGCCACCTCGCACACCGGGTCCTGGCACTTCCGGCACACGCCGTCCTCCCCCACCCGCCACTCTGCCACCTGAGTCTGATATTGACCTGGGCCCAAGGGCCTATGACCGCTTCCCCGGTGACTCGAGGGACTACTCCACGGAGCTAAGCGTGACTGTAGCAGTGGGTGCCTCCCTCCTCTTCCTCAACATCCTTGCCTTTGCCGCCCTCTACTACAAGCGGGACCGGCGCCAGGAGCTGCGGTGCAGGCGGCTTAGCCCACCAGGAGGCTCAGGCTCAGGTGTGCCTGGTGGGGGCCCCTTGCTTCCCACTGCTGGCCGTGAGCTACCCCCTGAGGAGGAGCTGGTATCGCTGCAGCTGAAGCGGGGTGGTGGCGTTGGGGCGGACCCTGCTGAGGCCCTGCNCCCTGCCTGTCCACCCGACTATACCCTGGCCTTGCGCCGGGCACCGGACGATGTGCCTCTCTTGGCCCCGGGGGCCCTGACCCTGCTGCCCAGTGGCCTGGGGCCCCCGCCCCCACCCCCACCTCCTTCTCTCCATCCCTTTGGGCcaccaccaccccctactgctaccagccacaacaacacgctaccccatccccactccaccacTCGGGTATAGGGGGCGGCTTGGGGAGGTCTGCCTCCCTAACCCTCCCCAGCCCAGGCCACTCGAAGGCAGGGAGGACGACTTGGCACCGGGCTTTACCCCTGTGGATTTGTCAAAACTTCGTGGAGCAGTGTTAAGGTGGACATGGGATTCCTCACTGGGAAGCGAGTTTTTTCCCATGCAGAGAGCCCCATTATCTCCTCTGGACCTGGGCCTTTGAATACCTGGGGGCATTTTTTGCCTTCCTTTGGGACACCAGTCTTCGGTGTGTGGAAATGTGGAAGTCTTTTTGCCCATGTGGAGACACGCTTTCCTCATGGGGGGAGGGGTGGGGGTGTTTCCCATGTGCAGGGTAAGgtttgtttgtttgtttttttgttgttgtttttgttttgatttgggttttttgCCGCCCTGGACATGTTGGCCTCCTCAAAGAATTTCTGCGGGGATTTGTACCCCATGCCTTCGCCTTCTCCCCATTCAACCCCCTGGAGACCCTGGAAGTGATGTGTGCACACAGGGTGACCCTTGGCCACCAGACTATGCAGGGTGGTACCTGGGGAGCAGCAAGGAAATCACAGGCCCCCTGGACCCCACTCCCCACCCACCCCTGAAAAGCATGTTTCTCCCCCATGGCACAGTCAGGTGAAGCACGTTCTCCCTGGAAGCCCTCACCTTCCACAGACAACTCAGATTTCCTACTAGAGGAAGGGGAGGATCTCTGTGCATCCCAGTACTGCCTGGAAACTTACCTTCCCATGGTCCAGGACACATCTCATCGAATGGAAACATGTTCTTGCATGTGGATGTGTGTTTCCCAGGCAGAGGGTCCTGCGTTCCTCAGCACTTCCCTGCATTCTCCCAGACCTCAGGTCCAGCACATGCTTCCTCCTTGCATAGCAGGTGGGAACCGACTT

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