RCPedia: Rtcs

Summary

Retrocopy Name	SELENOKP8	Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species	Macaca mulatta
Coordinates	chr19:36936734-36937278 UCSC
Strand	-
Parental Sequence	NM_001159381.2
Parental seq. overlap	506 bp
Parental seq. overlap (%)	71.7%
Genomic Region	Intergenic
Retrocopy Summary	SELENOKP8, located on chr19:36936734-36937278, is a retrocopy of the parental gene SELENOK. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	SELENOK
Full Name	N/A
Also known as	SELK
Coordinate	chr2:110076408-110083112
Strand	-
Gene summary	The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Sep 2017]

Homology

Species	Scientific Name	Retrocopy
Human	Homo sapiens	SELENOKP1
Chimpanzee	Pan troglodytes	SELENOKP5
Bonobo	Pan paniscus	SELENOKP4
Gorilla	Gorilla gorilla	SELENOKP4
Orangutan	Pongo abelii	SELENOKP4
Gibbon	Nomascus leucogenys	SELENOKP4
Green monkey	Chlorocebus sabaeus	LOC103227769P3
Baboon	Papio anubis	SELENOKP5
Golden snub-nosed monkey	Rhinopithecus roxellana	SELENOKP4
Crab-eating macaque	Macaca fascicularis	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>SELENOKP8
AAGATGGTTTACATCTCAAATGCACAAGTGTTGGACAGCCTGGAGTCAGTTTCCATGGAGATTATCTTTGATAACAGATTACTTCTGGGGAATAGCTGAGTTTGTGGTTTTGTTTTTCAAAACTGCTTCAGCAAGATTTGAAAAAAAGAAGCAGCTATGGAAACTCATGTGATTCCAGATATGATGGTAATGGAAGAGGGCCACTGGGAAACCCTCCCGGAAGAATGGGTCCAATCAATCATCTGGGTGGCCCCAGTCCTCCAATGGCTGGTGGATGAGGAAGGTAAACGTCTGCTCTAAGAAGCAACTGGACATGCGCATTCATAGCAGAAGGAAACCATCAAGAAGTGGAGTACTGACCATGCTGGAGCAGTAGATGAAACTGTCTGTCTAAACAAGGACTGCTCTGTGTCCTCACAGATGAATGAGGTCATGCTGGGAATTCCCTCTGCAGGGAACTGGCCTGACTGACGTGCAGTTCCACAAATGCACGTTTGTCTCATTATCTTTTTAGTATAGTTTATTAAAGTATTAATATAGTTTTG

>NM_001159381.2
CAGAGGCCGAGAGGGGCCAGGCGCCCGGTCGATCTGAAGCCGGGTAGTGGGAGAAGATGGTTTACATCTCGAACGGACAAGTGTTGGACAGCCGGAGTCAGTCTCCATGGAGATTATCTTTGATAACAGATTTCTTCTGGGGAATAGCTGAGTTTGTGGTTTTGTTTTTCAAAACTCTGCTTCAGCAAGATGTGAAAAAAAGAAGAAGCTATGGAAACTCATCTGATTCCAGATATGATGATGGAAGAGGGCCACCGGGAAACCCTCCCCGAAGAATGGGTAGAATCAATCATCTGCGTGGCCCTAGTCCTCCTCCAATGGCGGGTGGATGAGGAAGGTAAATGTCTGCTCTAAGAAGCAGACAACTGGACATGCACATTCACAGCAGAAGGAAACCATCAAGAAGTGGAAGGCCGACCATGCTGAGCCGTAGATGAATGTGTCTGTCTAAACAAGGACTGCTCTGTGTCCTCACAGATGAATGAGGTCATGCTAGGAATTCCCTCTACAGGGAACTGGCCTGACTGACATGCAGTTCCATAAATGCAGATGTTTGTCTCATGACCTTTTTGTATAGTTTATTAAAGTATTAATATAGTTTTAATAAGTAAATATTTTTAGGTTGCAGAGTGGACTCCTCATCTTTATATTCACGAAAAAACAATCTGAAGAAAATAAATAAAAGCCTGTGTATTTAGCA

>NM_001159381.2 

CAGAGGCCGAGAGGGGCCAGGCGCCCGGTCGATCTGAAGCCGGGTAGTGGGAGAAGATGGTTTACATCTCGAACGGACAAGTGTTGGACAGCCGGAGTCAGTCTCCATGGAGATTATCTTTGATAACAGATTTCTTCTGGGGAATAGCTGAGTTTGTGGTTTTGTTTTTCAAAACTCTGCTTCAGCAAGATGTGAAAAAAAGAAGAAGCTATGGAAACTCATCTGATTCCAGATATGATGATGGAAGAGGGCCACCGGGAAACCCTCCCCGAAGAATGGGTAGAATCAATCATCTGCGTGGCCCTAGTCCTCCTCCAATGGCGGGTGGATGAGGAAGGTAAATGTCTGCTCTAAGAAGCAGACAACTGGACATGCACATTCACAGCAGAAGGAAACCATCAAGAAGTGGAAGGCCGACCATGCTGAGCCGTAGATGAATGTGTCTGTCTAAACAAGGACTGCTCTGTGTCCTCACAGATGAATGAGGTCATGCTAGGAATTCCCTCTACAGGGAACTGGCCTGACTGACATGCAGTTCCATAAATGCAGATGTTTGTCTCATGACCTTTTTGTATAGTTTATTAAAGTATTAATATAGTTTTAATAAGTAAATATTTTTAGGTTGCAGAGTGGACTCCTCATCTTTATATTCACGAAAAAACAATCTGAAGAAAATAAATAAAAGCCTGTGTATTTAGCA

Publications

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