Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Eif4eP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr1:169419093-169419693  UCSC
Strand -
Parental Sequence NM_007917.4
Parental seq. overlap 445 bp
Parental seq. overlap (%) 8.9%
Genomic Region Intergenic
Retrocopy Summary Eif4eP1, located on chr1:169419093-169419693, is a retrocopy of the parental gene Eif4e. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Eif4e
Full Name eukaryotic translation initiation factor 4E
Also known as EG668879|Eif4e-ps|If4e|eIF-4E
Coordinate chr3:138231952-138265457
Strand +
Gene summary This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chinese hamster Cricetulus griseus Eif4e_1P6
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Eif4eP1
aaaaacagaatttaaCAGGAGGTTGCTAATGCAGAACACTGTGATAAACATTCTCTACTGAGCCACTGGGTACTCTGGTTTTTCAAGGATAATAAAATCAAAACTCAGCAAGCCAACCTTTGATGGTTCCCTAAGCTTAATACCATTGAAGACTTTTGGGCTCTGTACAAACTTATCCAGTTATTTAGTAATTTGATGTCTGGCTTTGACTACTATTGAGCCTTTGTGggaagatgaaaaataaaactggagGTTGATGGGCAATTACATTGAACAAATAGGAGAGACAAAGTGACCTTGACCACTTCTGGATAGAGACGCTGTGGTGCCTAAGTAGAAAATCTCTGAGCTTGAGGGGATGAGACAGTAACATGATCTACTGAATGTGAGATCagagacacagtcacacacatgacAGGACCGTATACAAATAAAAGGTAGGACTTCCTGCAAAGACAGTGAGTGGCTATCAGTCCCATGCACACTCAGCTACAAAGGGTGGCCTCACCACTAAAACCAGGTTTGTCATTAAGAAGACACCTTCTGAGTATTCTT
>NM_007917.4
GGAGGCGGAGGGAGCTGGTCCTTAAGGAAGGCACGCGCTTGCTTCTAGATTCCGAAGCGTTTTCAAAGCTGGTTACAGTCCTTACCACAGCACACCCTTGTGAGGAGCGGTTGTGCGATCAGATCGATCTAAGATGGCGACTGTGGAACCGGAAACCACCCCTACCACTAATCCCCCACCTGCAGAAGAGGAAAAAACAGAGTCTAATCAGGAGGTTGCTAACCCAGAGCACTATATTAAACACCCTCTACAGAACAGGTGGGCActctggttttttaaaaatgataaaagcaaaacTTGGCAAGCAAACCTTCGATTGATCTCTAAGTTTGATACTGTTGAAGACTTTTGGGCTCTATACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGACGGGATTGAGCCTATGTGGGAAGATGAGAAAAACAAACGAGGAGGACGGTGGCTGATCACACTGAACAAGCAGCAGAGACGGAGTGACCTCGATCGCTTCTGGCTAGAGACActgCTGTGCCTTATTGGAGAATCTTTCGATGACTACAGTGATGATGTGTGTGGAGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGATAGCAATATGGACTACTGAGTGTGAAAACAGAGATGCAGTCACACACATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCGAAGATAGTGATTGGTTATCAGTCCCACGCAGACACAGCTACAAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAAGAAGACACCTTCTGAGTATTCTCACAGGAGACTGCGTCACGCAATCGAGATTGGGAGCTGAACCAAAGCCTCATCAAAGCAGAGTGGACTGCACTGAAGTTGATTCCATCCAAGTGTTGCTAAGATATAAGAGAAGTCTCATTCGCCTTTGTCTTGTACTTCTGTGTTcattctcctcccccacccccaatttttgCTAGTGTGTCCACTATCCCAATCAAAGAATTACAGTATACGTCACCCCAGAACCCGCAGATGTGTTCCTGGCCCGCTCTGTAACAGCCGGTTAGAATTACCATGACACACACATTTGCCTTTCCACAGTATTCGAAAAAGAACTTGCATTTCTATTACCTTAGCAGGAAAGATCTGGTTTTGCTCCACTCCATGCAGGAGCGGACTTTGCTGGTGTGAGAGTCTGAGTACAGCTTTCTAGCAACCTTCTGTTTCCTTTCACAGCATTGTCCTTGCTGTCCTCTTGCTGATGGCTGCTAGATTTAATTTATTTGCTTCCCTCCTTGATAACATTAGTGATTCTGATttcagtttttcatttgttttgcttttgtttttttcctcgtGTAACATTGGTGAAGGATCCAGGAATATGACAGAAAGGTGGAATAAACATTAAATTTGTGCATTCTTtggtaatttttttgttttttgtaactaCAAAGCTTTGCTACAAATTTATGCATTTCATTCAAATCAGTGATCTATGTCTGTGTGATCCCTAAACATAATTGTGGACTATAAAAATGTAACACCATAATTACATTCCTAACTAGAATTAGTATGTCTGCCTTTGTATCTCTATGCTGTACTTTAACACTTTGTATTCTTAGGTTATTTTGCTTTGGTTACAATGGCTCAAGTAGAAAAGCGGTCCCATCCATATTAAGACAGTGTACAAAACTGTAAATAAAATGTGTACAGTGAATTGTCTTTTAGACAACTAGATTTGTCCTTTATTTCTCCATCTCTAGAAGGAATCTGTACTTCGTATTGCAAGGCAGTCTCTTGTGTCTTCTTAGAGTGTCTTCCCCATGCACAGCCTCAGTTTGGAGCACTAGTTTATTATGTTTATTACAATTTTTAATAAATTGACTAGGTAGTATCACATGTAATTACACTGATGTGGCTATCTTTTTAATAAAGTTAAGGCACAGTTGCTCAGTCCTAGGTTGAGTGATGGACTTTGACTATGTTACAGTTGATGAGGATTGGGGTTTTGGTGCATCACCATTCGGTAGGAACAGCGGCTAGAAACTGATTGTTGGGTTTAAGATGTTTTTACTTAATGGCCAGAAAATTAGCGTAAGGAAAGTATATAGAGAAACATGCGTTAGGGACATTAGTGTTACTATCTGaataaaacacaataaacaaGTATTAAGAACTACTTATATTGGTCAATTGTTGCAGTATGGTTTTCTGTAAACTTGAAACCTTGATCTATTCTTTGTATCATTTAAAGCAAACATGAAGACATTTTGTCTGCAGTACGTAATTGTATAGTTCAGATCCTGTGAGATGAGGTGTGGCTGTTAACGCCGAAGGGTAAGCTGAACTGTGGGTAGCAGAGTGGAAACCATTGGCTGAGAGAAAAATGCTCTTTAAGTGGTGGTTGTTATGAATTCACACTGATAACTTGATAAAGATCCTTATAAAATACATACGGAATTAATAGCATTGCTCTTATTATGTACGTCAAGAATGTATAACCGCCTGCTCTTGTTGTCACAGATAACTCCCTGTTCAGTGCTTTGGAAATAGCGATGCTCACGATCTCAGCATTCTGTACCCTACATCTACTGTGTGGATCATTGAGAGATCTTTTGACATTGCAACATGATATGGTCTATGTTGGGCTGCATTCCTGGCTGTCTTGTATGAGACCCCGGTTGGCTCCCTGAAGCTGATTGATACAGTGTACAGGCATGAAGGTGGCTGATGAGGCTTTCTTACCAACATGTGGGATTCTAGTAGTTGTATCTATTAGAGATTAATTCTCATATTCCTTTTCATTCATTTGTAAGAAGTATCAACTTTAGAAGTGAAAAAAGAATcataaaatacagtttttaaagttaaaaacttTGAGTAGGATGTATCTTTGTTATAGAAAGTTGAAATAATTTGTAATGGATGAATAATtataatggaaaaatgaaaaaactgGACAGAAAGATTTAGCATATACTATATAGGAATTAATAACTACAGCACTTACATAATAAGTTAGGCAGTGTTTTATTCTTGTCACGTGTTCATAATATATGTAGGTAtttctcccttttataaatgaatgAGAATTGGGATTTGGTGTATCACCATTTGATACATTAAGATTTAAATAATTTCATAGCTTCTGTCAGATACAGAGTATGAACTTGTGAATAATTCTTAATCACATAAATCACACACTCCCTGAAGATGTAATAAATAGGTTGTAGTACATTAGATTCTAAATTCCAGTTAGACTCAGCTACAAGCTAGGCATATAAACAGCCAGCAAAGCTAGTCACAAATAACCATGGAGACTAAGGTACAGGGTTAAAGTATGAATGTTTTTATTGGTGCTCTAAATCACCATCTAAGATAGATGGTAGTGTTCAACTTGACAGAAATAGACGTTCTTGAATGCTGCTGGAGTTGCATTTAAAAGGTTAAATTTAGTAAATGGCCTGTATGGTGGGTACATATCTGTAATCACAGTGCTGAGATGGAATGACCataaggccaacctgggttacgTAAACCctttatcaaaaagacaaggaccAGGAATGTGCTTCATTGAGAGTGCTTGCCAAGCATGTACTATGTTCTGTGTGTGATTGCCAGCACTGTCAGGAAGATGAGGTGTAGTGTTGGGTCTCTGTGTATCACGTTTCTCATGACACCCAGCTTTGTATTCTCAGTGTGGAGTATTATGGGGCAAGTGGATAGATATTCTCATTTGGCACCAGCCCTCTAAATACACATCAAATTGATGAGTAtaccttgaggccagcctggtccataatGCTAGTTCTAGGACAACTAAGGCtacacaaaccctgtctcgaaacattGAATCCAAATGAATCCCACTGTGGGAGGATGCCTGAAAGCCAGTGCATACAAATGCCACTTTGTAacatcccctcccctccagctGTGGTCATGCCAGTcgtgggtttggtttggtttggttttttaatgtgtatgcatgcatgttttgTATCGTGTGGTGCCTGAGGTGGTCAGCAGAGGGCATGAAATCCCTGCAACTGAAGTTAATTACTTagcacagttgtgagccaccatgtgagtgctgggagtcAACTGGATCTTACACAAAACCAACGACTCTGCTTACTGCAGAGCCATTACTCCAGCCCCATGGCTCTTGTTTATGTGATGGtatgttcatttgtttttcatgACAGGCTTTCTAtaagcccaggctgtcctggaactcactgtagactaggctgggcaCCAgaataagtgctgggattaaaggttgtgCCCCCAACACTGCCCGGTAgtactttgattttctttctttgggggagaggggagcttGGTGTagtggtgcctgcctttaatcccagcactcaggaggtagaaacaggcacagcctgatctacagaggctagcctgatctacagagctatatctaggacagccagggctatacacagattatataaattttgttattttgagacaggttttctctgtagccttggctgttctggaactcattctgtagaccaggctgagcaactgcctctgcctccagagtgctgggattaaaggtgttcaccaccactaCCCCTACCCAGTTTTGTATTCTCAGATTAAGACTCCATGGTCTAAATGTCTAGAtggcaataaatatttaaatcaatGTAAAAATCACTTGTAGAAAAAACGAAAAACACCGTCTTAAAACTCAAATGGGAGAACTTGCTTATTACCTgtattttttgtgggtttttctttttcttttgagcttAGGTTCTACACAGCCCAGAATGGCTttaaacctgcctcagcctcccaaatgttgggattacagctgtgtgccTGCTTGTTTGTTCCTTTTGAGACCTGGTGTCGTTTCATATCTCCGGCTGTAATGGAAGTCAGATCCATCTTATTGCAGAGGATTGGAATTAAATGCGTTCACTACCga

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