Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name Fkbp1aP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr10:21285051-21286410  UCSC
Strand -
Parental Sequence NM_008019.3
Parental seq. overlap 1220 bp
Parental seq. overlap (%) 72.9%
Genomic Region Intergenic
Retrocopy Summary Fkbp1aP1, located on chr10:21285051-21286410, is a retrocopy of the parental gene Fkbp1a. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Fkbp1a
Full Name FK506 binding protein 1a
Also known as FKBP12|Fkbp|Fkbp1
Coordinate chr2:151384403-151403611
Strand +
Gene summary This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Fkbp1aP1
GGTGCACTACATGGGGATActtgaagatggaaagaactttgACTCCTCTCGGGACAGAAGCAACCTTTTAAGTTTACACTAGGTAAGCAGGAGGTGATCTGAAGTGGAAGAAGGGGTAGCCAGATGAGTGTGGGTCAGAAAGCCAAACGGATAGTGTCCTCAGACTATGACAATGAAGCCACCGGGCCCCCAGGCATCATCCTACCACATGCCATTCTTGGTTTTGATGTGGAGCTTCTAAAACTGGAATGACCGAAGTAGCCTCCTCCCTTAGCTCTGCATGCGGATCTGCCATGGAGGAATCTGGTACCTCCAGATGGGTGCACATGAATCTGTTGGGAGCTTTGCCTGACGTCACCACCCTTTATAGACACCTACCCGACTGAATGTGTTCTGTCACTTAAGCTTTGCTTAAGATACCTCCAtgtcctcttcccccttctgtatgtgtgttgtccTAACCTATATGCCATAAACCTCAAGTTACTTTATTTGGGAGTGAAGACTCAGTTTCTGTCTTTCAGATCTAAGTTTCCAATGAAGTATATTGTCGTGTTAACAGCACAAGTGATGGGTTAATTTTAGAATATGAATTGGTGTTCTGGGGGggggtttgcaagaatttttattttattttaattttttggatGAAAATGTTATCTATTATATATTAAGACATTCTGTTACTGCGCTGCAAAGCCATAGCAGATTCAAGATGCTGTTGAGGGCTGGATTTTTCTCCCGTGAGGGAGGTCCTGTTAAACTGAAAGCCCTACCCAAACtcctttGCTTCTGACAGTCCTCCCATCTTCTGAGACTAGCTGCCTTTTAAAGCAGGTCCCTTCACTGCTGTGTTGGACACTACAATATCTGTCCCTGGGACAGCAGGGACCTCTGAAGCCTTCTTTGTGACCTGGGttactttgtttttcttccaaTGGTTTTTCTAATAGATTTTCTGGACTTTTGTAATCATGTATCTATCCACGCTCCACTCCCTAAATTTAAGAATTTTGGTGGACAGTTTGAATTGAACGTGCTGTTTGTAGACTTACCACCCAACAGATGCCCAGCCACCATGACAAATCCTTGAGTGTTCTCTAAGAAAATGATGCTGGTCATCACAGCTTCAGCATCTCCTGGGTTTTGATGCTTGGGTCTTTGTTGATCTTGGCTTCCTGGCTTttcctccttcagttccttctcatCCTCTGCTGTCCTTGTGTAGTGATTTGGTGAGAGAAAGCTTTTGTCCCCTGCCCTCTGTACTACATATGCGGTTCAAGTAATACTACATATTACAATAAAAGTGCTTTACGCTGGCTTTTCTCaa
>NM_008019.3
TTCCGGTCCCTCCGCCTAGCTGCCCCGCTTCAGGGATGTGAGCGCCTCGCGCAAATAGGGCGGGGCGTGCCGTGCGGTGCGGTGCGCGTGCGCAGGAGCCACGAGAGGGACGAAGCCGAACCTCTGAACCGCCGCCAGGTCCGCTCCGGCTCCACGCCGCCCGTCGCGCCGCCACCCGcgtccttttcctcctcctccgccaacgccgccgccgccgccgccgccatggGAGTGCAGGTGGAGACCATCTCTCCTGGAGACGGGCGCACCTTCCCAAAGCGCGGCCAGACCTGCGTGGTGCACTACACGGGGATGCTTGAAGATGGAAAGAAATTTGATTCCTCTCGGGACAGAAACAAGCCTTTTAAGTTTACACTAGGCAAGCAGGAGGTGATCCGAGGCTGGGAGGAAGGGGTAGCCCAGATGAGTGTGGGTCAGAGAGCCAAACTGATAATCTCCTCAGACTATGCCTATGGAGCCACCGGGCACCCAGGCATCATCCCACCACATGCCACTCTTGTTTTTGATGTGGAGCTTCTAAAACTGGAATGACAGAAGTGGCCTCCTCCCTTAGCTCTGCACGTGGATCTGCCATGGAGGAATCTGGTACCTCCAGATGGGTGCACATGAATCCATGGGGAGCTCTTCCTGACGTCCCACCACCCTTTGTATAGACACCTACCCGACTGAATGTGTTCCGTCACTCAGCTTTGCTTCGGACACCTCCATGTCCTCTTCccccctctgtatgtgtgttgacCTAAACTATATGCCATAAACCTCAAGTTACTTTATTTTGGGGTGAAGACTCAGTTTCTGTTTCAGATCTAAGTTTCCAATGAAGTATATTGTCAAGTGTTAACAGCACAAGCGATGGGTTAACTTAGAATAGAAATTGGTGTTGGGGGGGGATTtgcaagaatttttattttattttattttaattttttggatGAAAATTTTATCTATTATATATTAAGACATTCTGCTGCTGTGCTGCAAAGCCATAGCAGATTCGAGATGCTGTTGAGGGCTGGATTTTTCTCTAGTGAGGGAGGTCCTGTTAAACTGAAAGCCCTACCCAAACTGAGGTGGGAAGGAAGCGGGGGAGAGAGCCTTGGCTTCTGACAGTCCTTCCACCTTCTGAAACTAGCTGCCTTTTAAAGCAGATCCCTTCACTGCTATGTTGGACACTACAGTATCTGTCCCTGGGTTGGCAGAGACTTGAAAGCCTTTGTGACCTGGCTTAATTTGTTTTTCATCCTATGGTTTTTCTAATGGATTTTCTGGACTTTTGTAATCTTGTAACTATTCAAGCTCCACTTTCTAAATTTTAAGAACTTCAGTGGAAAGTTTAAATTGAAGGTGCTGTTTGTAGACTCACCACCCAACGGACGCCCAGCCACCACGGCAAATCCTTGAGTGTTCTCTAAGAATACGATGCTGGTCATCACAGCTTCAGCATCTCCTGGGTTTTGATGCTTGGCTCTTTGCTGATCTTGGCTTCCTGGCTTttcctccttcagttccttctcaccCTCTGCTGTCCTTGTGTAGTGATTTGGTGAGAGAAAGCTTTTGTCCCCTGCCCTCTGCACTACATATGCGGTTCAAGTTTTATTATTGCAATAAAAGTGCTTTATGCTGGCTTTTCTCA

Publications

PMID - Link Title