Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Rpl7P12
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr10:46956644-46957408  UCSC
Strand +
Parental Sequence NM_011291.5
Parental seq. overlap 617 bp
Parental seq. overlap (%) 66.1%
Genomic Region Intergenic
Retrocopy Summary Rpl7P12, located on chr10:46956644-46957408, is a retrocopy of the parental gene Rpl7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Rpl7
Full Name ribosomal protein L7
Also known as Rpl7a|Surf-3
Coordinate chr1:16171519-16174657
Strand -
Gene summary Predicted to enable identical protein binding activity and nucleic acid binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within translation. Located in synapse. Part of cytosolic large ribosomal subunit and polysome. Is expressed in several structures, including brain; early conceptus; female reproductive system; and liver. Orthologous to human RPL7 (ribosomal protein L7). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens RPL7P18
Chimpanzee Pan troglodytes RPL7P12
Bonobo Pan paniscus RPL7P12
Gorilla Gorilla gorilla RPL7P18
Orangutan Pongo abelii RPL7P13
Gibbon Nomascus leucogenys RPL7P2
Green monkey Chlorocebus sabaeus RPL7P4
Crab-eating macaque Macaca fascicularis RPL7P22
Rhesus Macaca mulatta RPL7P22
Golden snub-nosed monkey Rhinopithecus roxellana RPL7P4
Rat Rattus norvegicus Rpl7P56
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Rpl7P12
TGCTGTGCAAGAAATCCTTAAGAAATAGCAAGGGAATTTTGCAGAGTTGAAGGTGAAGCACCTGCTGAAGCACATTGCCTTGAAGACACTGAGAAAAGCAAGGAGAAAGCTCATCTATGAGAATGCAAAGCACTATCACAAGGAGTACTGTATTGCAATTTGGATGACAAGAACGGCAAGGAAAGCTGGAAAATTCTATGTGCCTGCAGAACCAAAATTGGCATTTGTCATCAAAATCCAAGTTATCACTGGTGTAACCACAAAACTCTGCAAGGTATTGCACCTTCTTTGTCTTCAACAGAACTTCAATGGTACCTTTGTTAGGCTCAACAAGCCTTCAGTTAACATGCTGAGGGTTGTAGAGCCATACATTGCATGGAGGCACTCTAAGCTGAAGTCAGTAAATGAGCTCATCTACTAGTGAGACTATGGCAAACACATTAAGAAATGAATTGCCTTGACAGTTAGTTTGTTGATCGCTCCATCTCTTGGTAAATTCAGCATCATCTGCATGGAGGATCTAATTTGTGAGATCTATACAGTTGAGAAGCTATTCAAGGAAGCAAATCAATTCCTGCAGTCCTTCAAATTATCTTTTCTATGATGTGGAATGAAGAAAAAGACAACTCACTTTTAGAAGGTAGAGATGATGACAACAGGGAAGACCAGATAAACAGGCTTATTAGATAGATGAATAAAAGTGTTACCCATGCTATTTTTGTAATCTGCTCAGTT
>NM_011291.5
TTTAAGGAGACAGTGCGCATGCGccacctttctctcttcttttccggCTGGAACCATGGAGGCTGTTCCagagaagaaaaagaaggttgCCACTGTGCCAGGAACCCTTAAGAAAAAGGTTCCTGCTGGGCCAAAAACTCTCAAGAAAAAGGTTCCCGCTGTGCCAGAAACCCTCAAGAAAAAGCGAAGGAATTTCGCAGAGTTGAAGGTGAAGCGCCTGAGGAAGAAGTTTGCCCTGAAGACACTTCGAAAGGCAAGGAGGAAGCTCATCTATGAGAAGGCAAAGCACTATCACAAGGAGTACAGGCAGATGTACCGCACTGAGATTCGGATGGCCAGGATGGCAAGGAAAGCTGGCAACTTCTATGTGCCCGCAGAACCAAAGCTGGCCTTTGTCATCAGAATTCGAGGTATCAATGGAGTAAGCCCAAAGGTTCGTAAGGTTCTGCAGCTCCTTCGTCTTCGACAGATCTTCAATGGCACCTTTGTTAAGCTCAACAAGGCTTCAATTAACATGCTGCGGATTGTGGAGCCATACATTGCATGGGGGtaccccaacctgaagtcagtaaACGAGCTCATCTACAAGCGAGGCTACGGCAAAATCAACAAGAAGCGGATTGCCTTGACAGATAATTCCTTGATTGCTCGGTCTCTTGgtaaGTTTGGCATCATCTGCATGGAGGATCTAATTCATGAGATCTATACAGTCGGGAAACGCTTCAAGGAAGCAAATAACTTCCTGTGGCCCTTCAAGTTATCTTCCCCACGAGGTGGGATGAAGAAAAagacaactcactttgtagaaggtGGAGATGCTGGCAACAGGGAAGACCAGATAAACAGGCTTATTAGACGGATGAACTAAGGTGTCACCCATTGTATTTTTGTAATCTGGTCAGTTAATAAACAGTCACAGCTTGGCAAATTGAAA

Publications

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