Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Hsp90ab1P8
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr11:6786098-6787107  UCSC
Strand -
Parental Sequence NM_008302.3
Parental seq. overlap 811 bp
Parental seq. overlap (%) 32.2%
Genomic Region Intergenic
Retrocopy Summary Hsp90ab1P8, located on chr11:6786098-6787107, is a retrocopy of the parental gene Hsp90ab1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Hsp90ab1
Full Name heat shock protein 90 alpha (cytosolic), class B member 1
Also known as 90kDa|Hsp84|Hsp84-1|Hsp90|Hspcb
Coordinate chr17:45878704-45884187
Strand -
Gene summary Enables protein folding chaperone; protein kinase binding activity; and tau protein binding activity. Contributes to protein kinase regulator activity. Involved in several processes, including axonogenesis; positive regulation of protein kinase B signaling; and regulation of cellular protein metabolic process. Acts upstream of or within cellular response to interleukin-4; negative regulation of apoptotic process; and placenta development. Located in growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of HSP90-CDC37 chaperone complex. Is expressed in several structures, including branchial arch; central nervous system; eye; limb; and placenta. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Hsp90ab1P21
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Hsp90ab1P8
TCACCTCAAACGAGACCAGACAGAATACTAATAGGAGATGGGGtcaaggaggaggtggagaaactCCTAGAGTTCATAGGCTATCCCATCACCCTCTACTTGGAGAAGGGACTAGGAAATGAGATCAGTgatgaggaggcagaggaagataaggtgagaaagaggaggaagataagAATGATAAGGAGAAGCCTAAGGTTGAAGATGTGGAGTCAGATGAGGAGGATGACAGtggcaaagttaaaaaaaatgacattGATCAGGAAGAGTTGAATAAGACTAAGCCTACTTGGACCAGAAACCCTGATGACATCACTCAGGAATATGGTGAATTCTATAAGAGCTTTACCCATGATTGGGAAGGCCACTGGGCAGTCAAGTATTTCTCTGTAGAAGGTCAGTTGGGATTCAGGGCATTGCTCTTCATTCTTCATAGGGCTCCCTTTGACCTTtctgtgacctGTACGTCCACCATGTGTTCATCATGGGCAGCTGTGATGAGTTGATTCCTGAGTACCTGACCTTCTCCGTGGTGTGATTGTCTCCAAGGTCCTGCCCCTGAACATCTTCCAAGAAATGTCCCAGCAGAACAAGATCCTGAAAGTCATCCACAAAAACACCGTGAAGAAGTATCTGGAATTGGCTGAAGACAGAGAGAACTACAAGAAATCTTATGAGACATTCTCCAAGAATTTAAAGCTTGAAATCCATGACGATTCCACTGAACACCGGCACCTCTCTGAGCTCTCGATATCACACCTCTCACTCTGGAGATGAGGTGACTTCCCTGTCAGCCTATGTATCTCACATGACTGCAACACAGAAGTCCATCTAGGATATCACTGCTGAGAGCAAAGAGCAGGTGGGCAACTCTGCCTCTGAGGAGTGTGCACAGAAGAAGCAGGGCTTTGAGGTGGTGTATAGGACTGAGCCTATCGATGGCTACTGCATACAGCAGCTCC
>NM_008302.3
GAGTCACCCCCGCGCAGCCTAGGCTTGCCGTGCGAGTCGGACTTGGTCCGGGCCCACCACCCTGCTCTGTACTACTACTCGGCTTTCCCGTCAAGATGCCTGAGGAAGTGCACCatggagaggaggaggtggagaccTTTGCCTTTCAGGCAGAAATTGCCCAGCTCATGTCCCTCATCATCAACACTTTCTATTCAAACAAGGAGATTTTCCTCCGCGAGTTGATCTCTAATGCTTCAGATGCCCTGGACAAGATTCGATATGAGAGCCTGACGGACCCTTCTAAGTTGGACAGTGGGAAAGAGCTGAAAATTGACATCATCCCCAACCCTCAGGAGCGCACGCTGACTTTGGTGGACACAGGCATTGGCATGACCAAGGCTGACCTCATTAATAACCTGGGAACCATTGCTAAGTCTGGCACGAAGGCGTTCATGGAGGCTCTCCAGGCTGGTGCAGACATCTCCATGATCGGGCAGTTTGGTGTCGGATTCTACTCGGCCTATCTAGTTGCAGAGAAAGTGGTTGTGATCACGAAGCACAATGATGATGAGCAGTATGCCTGGGAGTCGTCTGCGGGTGGCTCCTTCACCGTCCGGGCAGACCATGGTGAGCCCATTGGCCGGGGTACCAAAGTGATCCTTCACCTCAAAGAAGACCAGACAGAGtacttggaggagaggagggtcaAGGAAGTGGTGAAGAAACATTCGCAGTTCATAGGCTATCCCATCACCCTCTATTTGGAGAAGGAACGGGAGAAGGAGATCAGTGATgatgaggcagaggaagagaaaggtgagaaagaggaggaagataaggaggatgaggagaagcCTAAGATTGAAGATGTGGGATCCGATGAGGAAGATGACAGCGgcaaagacaagaaaaagaaaacaaagaagatcaAAGAGAAGTACATTGACCAGGAGGAGCTGAACAAGACAAAGCCTATCTGGACCAGAAACCCGGATGACATCACGCAGGAGGAGTATGGCGAATTCTATAAGAGCCTCACCAATGACTGGGAGGACCACTTGGCAGTCAAGCACTTCTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTCTTCATTCCCCGGCGGGCTCCCTTCGACCTTTttgagaacaagaagaagaagaacaacatcaaATTGTATGTCCGCCGTGTGTTCATCATGGACAGCTGTGACGAGCTGATACCTGAGTACCTCAACTTTATCCGCGGTGTGGTTGACTCCGAGGACCTGCCCCTGAACATCTCCCGGGAGATGCTGCAGCAGAGCAAGATCCTGAAGGTCATCCGCAAGAACATCGTCAAGAAGTGCCTGGAGCTCTTCTCCGAGCTGGCTGAGGACAAGGAGAACTACAAGAAGTTCTATGAGGCCTTCTCCAAAAATTTAAAGcttgGAATTCATGAAGATTCCACTAACCGACGCCGCCTCTCTGAGCTCCTTCGCTATCACACCTCTCAGTCTGGAGATGAGATGACCTCCTTGTCAGAGTATGTGTCTCGCATGAAGGAGACCCAGAAGTCCATCTACTATATCACTGGTGAGAGCAAAGAGCAAGTGGCCAACTCTGCCTTTGTGGAGCGAGTGCGGAAGCGGGGCTTCGAGGTGGTGTATATGACTGAGCCTATTGACGAGTACTGCGTGCAGCAGCTCAAGGAGTTTGATGGGAAGAGCCTGGTCTCAGTGACTAAGGAGGGCCTGGAGCTACCAGAGGacgaggaagagaagaagaaaatggaggagaGCAAGGCAAAGTTTGAGAATCTCTGCAAGCTCATGAAGGAGATCTTGGACAAGAAGGTTGAAAAGGTGACAATCTCCAATAGGCTTGTGTCTTCACCCTGCTGCATTGTGACAAGCACCTATGGCTGGACAGCCAACATGGAACGGATCATGAAGGCCCAGGCACTGCGAGACAACTCTACAATGGGCTACATGATGGCCAAAAAACACCTGGAGATCAACCCTGACCACCCCATCGTGGAGACCCTGcggcagaaggctgaggcagacaaAAACGACAAAGCTGTCAAGGACCTGGTGGTGCTGCTGTTTGAAactgctctgctctcctctggTTTCTCACTTGAGGATCCCCAAACCCACTCCAACCGCATCTACCGCATGATTAAACTAGGCCTGGGCATCGATGAAGATGAGGTCACTGCAGAGGAGCCCAGTGCTGCTGTTCCTGATGAGATCCCCCCTCTGGAAGGCGATGAGGATGCCTCGCGCATGGAAGAGGTGGATTAAAGCCTCCTGGAAGAAGCCCTGCCCTCTGTATAGTATCCCCGTGGCTCCCCCAGCAGCCCTGACCCACCTGGCTCTCTGCTCATGTCTACAAGAATCTTCTATCCTGTCCTGTGCCTTAAGGCAGGAAGATCCCCTCCCACAGAATAGCAGGGTTGGGTGTTAtgtattgtggtttttttgtttgttttattttgttctaaaatTAAAAGTATGCAAAATAAAGAAGATGCAGTTTTA

Publications

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