Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UbbP2
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr11:63131962-63132335  UCSC
Strand -
Parental Sequence NM_011664.4
Parental seq. overlap 324 bp
Parental seq. overlap (%) 21.6%
Genomic Region Intergenic
Retrocopy Summary UbbP2, located on chr11:63131962-63132335, is a retrocopy of the parental gene Ubb. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ubb
Full Name ubiquitin B
Also known as Rps27a|Uba52|Ubb2|Ubc
Coordinate chr11:62441997-62444039
Strand +
Gene summary This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Uba52P14
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UbbP2
TTTGTGGTTTCATCACAATCGATAACAGGTCAGAATGCAAATCTTCATAAAGACCCTGGCCAGAAAAGACCATCATCCTGGAGGCGGAGCCCAGTGACACCATCAAGAACGTGAAGGCCAAGATCCAGGATAAAGAGGACATCCCCTCTGACGTGCAGAGTTTCATCTCTGCTGGCAAGCAGCTGGAAGATGGTCACAACAACATCCACAAAGAGTTGGCCCTACACCTAGTCCTCCATCTGAGGGGTGACTATTCATTCTTCAGTCTGCATTCCCAGTGGGCAGTGATGACATTACTCTGCACTCTAGCCATTTGCCCCAATTTAAGTTTAGAAATTACAAGTTTCAGTAATAGCTGAACCTCTGTTTAAAAT
>NM_011664.4
CTTTGACTCCTCACCAATCAGCGCTGGCGCCGCAAGGAGGTTTCCAGAGCTTTCGAGGGAGGGCCCTTTAACTTGGATTCATCCGCGTGatgattttttcaattttttgcaCGAGAGGAGACGAGACGCCGGGAATACAGTGTCTCTCGTTTGGTAGTACTCTTTTCTTTGGTTCTGAAGAATCGGGAGCTCGGCAAAAACGCCTAATTGGTCTGGGGGAGGTGGGGGCCCGCGGAACTACTTTCGGTGGCGCAGGAAGACAACAGCTACGTAGGAGTGAGCAGTCACGCAACAGACGCTGCATAAATAGCGGCTCGCGCGGCCACTGAGCTCAGTGACGAGAGGCTTTGTCCGGTTCGGCGGTctttctgtgagggtgtttcgaCGCGCTGGGCGGTTTGTGCTTTCATCACATTTGTTAACAGGTCAAAATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACCCTAGAGGTGGAGCCCAGTGACACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAAGAGGGCATCCCCCCTGACCAGCAGAGGCTGATCTTTGCCGGCAAGCAGCTGGAAGATGGCCGCACCCTCTCTGATTACAACATCCAGAAGGAGTCAACCCTGCACCTGGTCCTTCGCCTGAGAGGTGGCATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACCCTGGAGGTGGAGCCCAGTGACACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAAGAGGGCATCCCCCCTGACCAGCAGAGGCTGATCTTTGCCGGCAAGCAGCTGGAAGATGGCCGCACCCTCTCTGATTACAACATCCAGAAAGAGTCAACCCTGCACCTGGTCCTCCGTCTGAGGGGTGGCATGCAGATCTTCGTGAAGACCCTGACTGGCAAGACCATCACCCTGGAGGTGGAGCCCAGTGACACCATCGAGAACGTGAAGGCCAAGATCCAGGATAAAGAGGGCATCCCCCCTGACCAGCAGAGGCTGATCTTTGCCGGCAAGCAGCTGGAAGATGGCCGCACCCTCTCTGATTACAACATCCAGAAGGAGTCAACCCTGCACCTGGTCCTTCGCCTGAGAGGTGGCATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACCTTGGAGGTGGAGCCCAGTGACACCATCGAGAATGTGAAGGCCAAGATCCAGGATAAAGAGGGCATCCCCCCTGACCAGCAGAGGCTGATCTTTGCCGGCAAGCAGCTAGAAGATGGCCGCACTCTCTCTGATTACAACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTCCGTCTGAGGGGTGGCTATTAATTATTCGGTCTGCATTCCCAGTGGGCAGTGATGGCATTACTCTGCACTCTAGCCACTTGCCCCAATTTAAGTTTAGAAATTACAAGTTTCAATAATAGCTGAACCTCTGttaaaaaatgttaataaagGTTTTGTTGCATGGTAAGCATA

Publications

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