Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Ap3s1P3
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr13:57424732-57424900  UCSC
Strand +
Parental Sequence NM_009681.5
Parental seq. overlap 144 bp
Parental seq. overlap (%) 9.4%
Genomic Region Intergenic
Retrocopy Summary Ap3s1P3, located on chr13:57424732-57424900, is a retrocopy of the parental gene Ap3s1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ap3s1
Full Name adaptor-related protein complex 3, sigma 1 subunit
Also known as -
Coordinate chr18:46874849-46923893
Strand +
Gene summary This gene encodes the sigma subunit of the heterotetrameric adaptor protein complex AP-3 which is involved in the formation of specialized lysosome-related compartments such as melanosomes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on chromosomes 1, 8, 16, 17 and X. [provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Ap3s1P4
Chinese hamster Cricetulus griseus Ap3s1_1P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Ap3s1P3
GACATTAGACAAATGTTATTTTTGAAAATGTCTGTGAACTGGGTTTATTATTTCGTATAGACAAGGTTCACAATATTCTTGCAGAAACGGTGACGAGGGAGAAAAGGTATTGGAGACCAGCATGAATAAGATTGTTGCAAAAATTGATGCACAAAATTAACTGGAGAAA
>NM_009681.5
CCCTCGGCGCGggagcgcgcgcgcgcgtgcgggAGGGGGCGGGTGGGGAAGCCGCGGCTCGAAGCTCCCGGAGGCGAGGCTCGCGCGCCCGCCCCCGCCCTGGCCCCAGCGCCCACCCGGTCGGCCCCGGCCCAGCCATGatcaaggccatcctcatctTCAACAACCACGGGAAGCCGCGGCTCTCCAAGTTCTACCAGCCCTATAGTGAAGACACGCAACAGCAAATCATCAGGGAGACTTTCCATTTGGTGTCTAAGCGCGATGAGAACGTTTGTAATTTCCTAGAAGGAGGATTATTAATTGGAGGCTCTGACAACAAGCTCATTTACAGACATTATGCAACACTATATTTTGTCTTCTGTGTGGACTCCTCAGAAAGTGAACTTGGCATTTTAGATCTAATTCAAGTATTTGTGGAAACATTAGAcaaatgttttgaaaatgtttGTGAACTGGATTTAATATTCCATGTAGacaaggttCATAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACCAACATGAATGAGATTGTCACACAAATTGATGCACAAAATAAACTGGAGAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAGTATTAAAAAGGCCACTCCCAGGTAAAATCCAGAGGGAACGTCATCTAAGTTTACCATGCAATTGTTTACCAAAAATAGTGAAGGAGACTCTTAACTTTGCTCTTGGAGTTAAGTCAAGGTACTGTATAGAAGCTGCATAAAATCAGTATGGAAGTTCAATGTTGCTTTTCTTGCTCAgtgattttaaagaaattgactAGCTCCcgtgtgattttgttttgttttgtttttcttttcttttctaaattgcaTTCCTATGCCCACATAAAGGCATGCctctatatattggctattacaGTATTTCGAAAAGTGAGATGTTTCTTTAATTATGTACAACCCAAAATGTTGATGTTTTGTATGGATCACAAGTGCAGCATTCTCTAATTCTTTCTGCTGTTTGTCACAATTGTTATTTAAAGAACCAAGTATGTATTGCATGAAAACATGACCTTTTCTTTAGTTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGTACCTTTCTGTTTTGCTTGGTATCTACTTtagcaataatttttttttacaatcttcTGACtcaacaaagtaaataaaagtatattttccCACTGTTAAGCAACTGTCAGTGTTGACTTTTTCAATTCATACTCACGTTTTTATTTCTCAGTGGCTCACTGAACCAGTCAGAAACTGCTCTGTCAAAGACCGAGTGTTGTATCTCAGGCTGTTTATTTTGTATGATGAGACTTACAGTGGGAGATGGTGGGTCTTTTTCAAAAGTGTTAAagatatgttttgtttttctataaataTCCTTGTCTT

Publications

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