Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Parp1P1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr14:86453051-86453872  UCSC
Strand -
Parental Sequence NM_007415.3
Parental seq. overlap 735 bp
Parental seq. overlap (%) 20%
Genomic Region Intergenic
Retrocopy Summary Parp1P1, located on chr14:86453051-86453872, is a retrocopy of the parental gene Parp1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Parp1
Full Name poly (ADP-ribose) polymerase family, member 1
Also known as 5830444G22Rik|ARTD1|Adprp|Adprt1|PARP|PPOL|msPARP|parp-1|sPARP-1
Coordinate chr1:180396456-180428564
Strand +
Gene summary Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Parp1P1
CTGTAGCAGGGTCTGCGGATAGCCTCACCTGAAGCTCTTGTGACAGGCTACATGTCTGGGAAAGGGTTCTACGTTGCCGATATGGTGTCTAAAAGTGCAAACTACTGCCACACATCTCAGGGAGACCCGATTGGATTAATACTGTTGGGACAAGTTGCCCTTCGAAACATGTACCAACTCAAGCATGCTTCACATATCAGCAAGTTAACCAAGGGCAAGCATAGTGTCAAAGGTTTGGAAAAAACCACCTCTGACCCTTCGGCCAGCATCACCCTGGAAGGTGTAGAGGTTCCACTGGGAACAGAGATCCCATCTGGTATTAATGGCACCTGCCTGCTTTATAACGAATACATGAATACATTGTCTACCACATTGCTCAGGTGAATCTGAAATTCCTGCTGACACTCAAGTTCAATTTTAAGACGTCCCTGTGATAAAGTGCAAGGGGTGGGCTATGACCAGCACCCAGGGCCTAGTGGGTAATTCCCCCTAGTGCCTCTCTACCAGACACCACAAAACCTCAGCCATGCTGCCTCCGAGGGAGGATGGTTGTTTGTGGTTTTATCCTACCAGCCACAGCCCCGATAGATGCAGCTGGCAGTAGAGCAAAAGTAGGggagacttttttgtttttgttgtttgcctAGATTAGTCCCGAGAGCAGAAACGTGCCACGTCACAGTCACAATGTCTGCCTTACTGGCTTCGCCAGCGAAGGAAAAATgtgcttcctcccttcttttaaGGGTTCATCTTTGGTTTCATTTTGGCAAAATGTTAAGCATTTATTTTGAGCTAAAGATAAAAACTAATTTCTTACTA
>NM_007415.3
GAGCTTGGGGGGGCGGTCCCGCCGCTAGGCATCAGTAATCTATCCTGAGCGGAGGCGGCTCTGCACGCTTGCGGGGGAAACCGACACGTTAGCGGAGCGCACCAGCGGCGGCGTCGGGCTGCCGCTGCAGCACGAGAAGGAGGATGGCGGAGGCCTCGGAGAGGCTTTATCGAGTGGAGTACGCGAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGTATTCCCAAGGACTCCCTCCGCATGGCCATCATGGTGCAGTCACCCATGTTCGATGGGAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCAGCCTGATGTTGAGGTGGATGGCTTCTCTGAGCTGCGCTGGGATGATCAGCAGAAGGTCAAGAAGACGGCCGAGGCTGGAGGCGTGGCAGGCAAAGGCCAGGATGGAAGTGGCGGCAAGGCGGAGAAGACATTGGGTGACTTTTTAGCGGAGTACGCCAAGTCCAACAGGAGCATGTGCAAGGGCTGCCTGGAGAAGATAGAGAAGGGCCAGATGCGCCTGTCCAAGAAGATGGTGGATCCAGAGAAGCCACAGCTGGGTATGATTGACCGCTGGTACCATCCAACTTGCTTTGTCAAGAAGCGGGACGAGCTGGGCTTCCGGCCTGAGTACAGTGCCAGTCAGCTCAAGGGCTTTAGCCTCCTCTCTGCAGAAGACAAAGAAGCTCTGAAGAAGCAGCTCCCGGCCATCAAGAATGAAGGaaagagaaaaggtgacGAGGTGGATGGAACAGATGAAGTGGccaaaaagaaatctaagaaagGGAAGGACAAGGATAGTAGTAAGCTGGAGAAGGCCCTCAAGGCTCAGAATGAGCTGATCTGGAATATCAAAGACGAGCTGAAGAAAGCGTGTTCCACCAACGACCTGAAGGAGCTGCTCATCTTCAACCAGCAGCAGGTGCCGTCAGGAGAGTCAGCGATCTTGGACAGAGTTGCTGACGGCATGGCGTTTGGGGCCCTTCTGCCCTGCAAGGAGTGTTCAGGCCAGCTGGTCTTTAAGAGCGACGCTTATTACTGTACTGGGGATGTCACTGCCTGGACCAAGTGCATGGTCAAGACACAGAATCCTAGCCGAAAGGAATGGGTAACTCCAAAGGAATTCCGAGAAATATCCTACCTCAAGAAGTTAAAGGTCAAAAAACAGGACCGAATATTCCCTCCAGAAAGCAGCGCCCCAGCACCACTGGCACTGCCCCTCTCTGTCACCTCAGCACCCACAGCTGTGAACTCCTCTGCTCCAGCAGACAAGCCCCTGTCTAACATGAAGATCCTGACTCTTGGGAAGCTCTCCCAGAACAAGGACGAAGCAAAAGCTGTGATTGAGAAACTCGGAGGCAAGTTGACAGGATCTGCCAACAAGGCCTCCTTGTGTATCAGCACTAAAAAGGAGGTGGAGAAGATGAGTAAGAAGATGGAGGAAGTGAAAGCGGCCAACGTTCGAGTTGTGTGTGAGGACTTCCTCCAGGACGTGTCTGCCTCCACTAAAAGCCTCCAAGAGCTGCTCTCGGCCCACAGCTTGTCCTCGTGGGGGGCTGAGGTGAAGGCAGAGCCTGGTGAAGTGGTGGCCCCCAAGGGGAAGTCAGCTGCACCCTCCAAGAAGAGCAAGGGTGCTGTCAAGGAGGAAGGTGTCAACAAATCTGAAAAGAGGATGAAATTAACTCTGAAGGGAGGAGCAGCCGTTGATCCTGACTCTGGTCTGGAACACTCTGCACACGTCCTGGAGAAAGGTGGGAAGGTGTTCAGCGCCACACTTGGCCTGGTGGACATTGTGAAAGGGACGAACTCCTATTACAAACTGCAGCTTCTGGAGGACGACAAGGAGAGCAGGTACTGGATCTTCCGGTCCTGGGGCCGGGTGGGCACAGTTATCGGCAGTAACAAACTTGAGCAGATGCCCTCCAAAGAGGACGCTGTTGAGCACTTCATGAAGCTGTATGAAGAGAAGACTGGGAATGCCTGGCACTCGAAAAACTTCACAAAGTATCCCAAGAAGTTCTACCCTCTGGAGATTGACTATGGCCAGGACGAAGAGGCAGTAAAGAAGCTGACGGTGAAGCCTGGCACCAAGTCGAAGCTGCCGAAGCCAGTGCAGGAGCTCGTGGGGATGATCTTCGACGTGGAGAGCATGAAAAAGGCCTTGGTGGAGTACGAGATTGACCTCCAGAAGATGCCCTTGGGGAAGCTGAGCAGAAGGCAGATCCAGGCCGCCTACTCTATCCTCAGCGAGGTCCAGCAGGCAGTGTCTCAAGGCAGCAGTGAATCCCAGATCCTAGATCTCTCCAATCGCTTCTACACTCTGATCCCCCATGACTTTGGAATGAAGAAGCCCCCACTCCTGAACAACGCAGACAGCGTGCAGGCCAAGGTGGAGATGCTAGACAACCTCCTGGACATCGAGGTGGCCTATAGTCTTCTCAGGGGTGGCTCTGACGACAGCAGCAAGGATCCCATCGACGTCAACTACGAGAAACTCAAAACTGACATTAAGGTGGTTGACAGAGATTCTGAAGAGGCCGAGGTCATCAGGAAGTACGTGAAGAACACTCATGCTACCACGCACAACGCCTATGACCTGGAAGTGATCGATATCTTCAAGATAGAGCGCGAGGGGGAGAGCCAGCGCTACAAGCCCTTCAGGCAGCTTCACAACCGGAGGCTGCTGTGGCACGGCTCCAGGACCACCAACTTTGCTGGCATCCTGTCGCAGGGTCTGCGGATAGCCCCACCTGAAGCGCCTGTGACAGGCTACATGTTTGGGAAAGGGATCTACTTTGCCGACATGGTGTCCAAAAGTGCAAACTACTGCCACACATCTCAGGGAGACCCGATTGGCTTAATACTGCTGGGAGAGGTTGCCCTTGGAAACATGTATGAACTCAAGCATGCTTCACATATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGTTTGGGAAAAACCACCCCTGACCCTTCGGCCAGCATCACCCTGGAGGGTGTAGAGGTTCCACTGGGAACAGGGATCCCATCTGGTGTCAACGACACCTGCCTGCTGTATAATGAGTACATTGTCTACGACATTGCTCAGGTGAATCTCAAATACCTGCTGAAACTCAAGTTCAATTTTAAGACATCCCTGTGGTAAAGTGCGAGGGGTGGGCTGTGCCCAGCACCCAGGGCCTAGGGGGCAATTCTCCCTAGTGCCTCTGCACCAGACACCACAAAACCTCAGCCATGCTGCCGCCGAAGGGTGGCCCCCTCACCGAATCTCCTTAGGAAGGGTTTTATACAGACAGGTTAAAGGGCTCTGGTTTCAAGTCCCTTGTCCATGCTGCACTGGGGCAGGCCGGTTGTTTGTGGTTTGTCCTACCAGCCACAGCTCCATAGACAGCAGCTGGCAGTAGAGCAAAAGTTGGGGAGAGGATTTTGTTGTTTGCCTAGACTAGTCCTGAGGGAAGAAACACCACGTCACAGTCACGATGTCTGCCTTACTGGCTTCCCCAGGGAAGGAAAAATGTGCTTCCTCCCTTTTTTCAAGGGTTCATCTTTGCTTTAATTTTGGCAAAATGTTAAGCATTTATTTTGagctaaaaataaaagttaatttcATACt

Publications

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