Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ChukP1
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr16:55702398-55704793  UCSC
Strand -
Parental Sequence NM_001162410.1
Parental seq. overlap 2019 bp
Parental seq. overlap (%) 57.6%
Genomic Region Intragenic (Nxpe3)
Retrocopy Summary ChukP1, located on chr16:55702398-55704793, is a retrocopy of the parental gene Chuk. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Chuk
Full Name conserved helix-loop-helix ubiquitous kinase
Also known as Chuk1|Fbx24|Fbxo24|IKBKA|IKK alpha|IKK1|Ikka|NFKBIKA
Coordinate chr19:44061773-44095938
Strand -
Gene summary Enables protein kinase activity. Involved in positive regulation of interferon-alpha production; protein phosphorylation; and response to virus. Acts upstream of or within several processes, including mammary gland development; osteoclast differentiation; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb. Used to study fetal encasement syndrome. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ChukP1
CTGTACCAGCACGGGAACTTGCTCTCAAAAAAGCAATTAAGTCTTGTCACTTAGAGCTAAGTACCAAAACCAGAGAGCGATGGTGCCATGAAATCCAGATCCTGAAAAAGTTGAGCCATGTGAATGTTGTAAAGGCCTGTGATGTTCCCGAGGGATTGAACTTTTTAATTAACGATGTGCCTCTTctagcaatggaggactgttctgGAGGGGACCTCCCGGAAGCGACTCAACAAATCAGAACATTGTTGTGGGCTTAAAGAAAGCCAGATACTTTCTTTACTGAGTGACATAGCATCTGGGATTTGATATTTGcatgaaaacaaaattatacaTCAGACCTAAAACCTGGAAATATAATTCTTCAGGATGTTGGTGGGAAggtaatacataaaataattgatTTGGGTTATGCCAAAGATGTTGATCAAGGAAGTCTCTGTACATCTTTTGTGGGAACATTGCAGTATTTGGCCCCAGGGCTCTTTGAAGATAATCCATACACAGCCACTGTGGATTATTGGAACTTTGAGACCATTGTGTCTGAATGTACTGCTGGATATAGGCCCTTTATGCAGCACCTGCAGCCATTTACCTGGCATAAGAAGATTAAGAAGAAAGATCCAAAGTGTATATTTGCATGTGAAGAGATGACCGGAGAAGTTCGGTTTAGTAGCCATTTACCTCAGCCAAATGGCCTTTGTAGTTTAACGGTAGAGCCAGTGGAAAGCTGGCTACAATTGATGTTGAATGGGGACCCACAGCAGAGAGGGGGACCCATTGATCTTACTTTGAAGTAGCCAAGATGTTTTGCATCAATGGATCACATTTTCAATGTAAAGATAGTGCACATCCTAACTATGACTTCTGcaaaaatcatttcttttctgttaccATGGATGAATGTCTTCATTCACAACAGTCTCGAACTGAGCGTCAAACAGGAATAAATACAGGTTCTCGAGAAGTTTTGTCAGAGGCAGGAATTTCTCTGGATCCACCGAAACCGGCCCCTCAGTGTGTGCTAGATGGAGTGAGAGGCCGTGATAGCTACATGGTTCATTTGTTTGGTAAAAGTAAGACTGTATATGAAGGACCATTTGCCTCCAGAAGTTTATTTGATTGTGTAAATTATATTGTACAAGACAGCAAAATACAGCTGCCAACTATACAGCTGTGGAAAGTATGGGCTGAAGCAGTGCACTATGTATGTATCTGGGCTAAAAGAAGACTACAGCAGGCTCTTTCAGGGACAAAGAGCAGCAGTGTTAAGTCTTCTTAGATATAATGCTAACTTGAGAAAAATGAAGAATACTTTGATCTCAGCATCACAGCAACTCTGCTaaattggagttttttttttttgtgaagccAATGAGGACCAGAAGAGTAGGATGATGGGTCTTGATTGGAGTCGGTCAGCAGAGTGACTCCACACTCGTTCACTGTCCTCGAGCCTACGAAGCTGTTCCTGCACCTACTCCAACGTCATCTTTACTTGCTGAAGCCAATCTTCGCATACCAGTCTGTGGAGGAGATGGCTGTGATCAGAAACTACGAGTGGCTTTCCAAGCACAGTAGCTTGgtgttttgcatttttttttaataattgtgATTTCTGAACAGATAGGATTTTATAATACATTAGTAAAATTAACTATTCTTTTTGACACTGCAACTAATTAGGGAGATCATTAGTGACCTGCTTATCttataaaattggaaaaatacTACCAGTTTAACTGATGAAGAAGATAATCTTCTAAAGGACTAAAATTTAGGCATAAGGCCCAACATGGTATTAGTATACAGAGATGAAAAATTCACCCAGTGTTCACTGTAAGTAGAGTTTATCTATGGAGTTTCTGTGGAAGAGAGCACTCACAAGTAAAATTGCACTTCCTGAAGTCTAAGCCCCACCCCCTTGTATTGttctcagcaagtgctcttcttGGCATCACTTGGAGTAGATGAATcccagccagatgaaTCCCATCTTTAATTGCACATTTAATAGAGTCCTTTTCTTATGTAAGGAATTGGACATATGTGCCTTTGATATCAGCTGACCATAATGAATTGTGTTGTgtgctatatgtatatgtatttaaggTGTACATTTAATAATGTCAAAGAGAAGATGCCTGTTAATTTATAGTGTATTTGAAGGTTGTATTATTTTTGCATTTGTAAAAATGGGttagttgt
>NM_001162410.1
GAGACGGAGGACTCCGCAAGCCTCGGCGGCCCGGAACCGGCCTTAGACCGGCGGCGTTGCCTGAGGCGGCTGGCGCTCCCGCCCCATGGAGCGGCCCCCGGGGCTGCGGCCGGGCGCGGGCGGCCCCTGGGAGATGCGGGAACGGCTTGGCACCGGCGGTTTCGGGAACGTCAGTCTGTACCAGCACCGGGAACTTGATCTCAAAATAGCAATTAAGTCTTGTCGTTTAGAGCTAAGTTCCAAAAACAGAGAGCGATGGTGCCATGAAATCCAGATCATGAAAAAGTTGGACCATGCGAATGTTGTAAAGGCCTGTGATGTCCCTGAGGAATTGAACTTTTTAATTAACGATGTGCCTCTTCTGGCAATGGAGTACTGTTCTGGAGGGGACCTCCGGAAGcTACTCAACAAACCAGAAAATTGTTGTGGACTTAAAGAAAGCCAGATACTTTCTTTACTGAGTGACATAGGATCTGGGATCCGATATCTGcatgaaaacaaaattatacaTCGAGATCTAAAACCTGAAAATATAGTTCTTCAAGATGTTGGTGGGAAGacaatacataaaataattgatTTGGGTTATGCCAAAGATGTTGATCAAGGAAGTCTCTGTACATCTTTTGTGGGAACATTGCAGTATTTGGCCCCAGAGCTCTTTGAAAATAAGCCGTACACAGCCACTGTGGATTATTGGAGCTTTGGGACCATGGTGTTTGAATGTATTGCTGGATATAGGCCTTTTTTGCATCATCTGCAGCCATTTACCTGGCATGAGAAGATTAAGAAGAAAGATCCAAAGTGTATATTTGCATGTGAAGAGATGACTGGAGAAGTTCGGTTTAGTAGCCATTTACCTCAGCCAAACAGCCTTTGTAGtttaATAGTAGAGCCAATGGAAAGCTGGCTCCAATTGATGCTGAATTGGGACCCACAGCAGAGAGGGGGACCTATTGATCTTACTTTGAAGCAGCCAAGATGTTTTGCATTAATGGATCACATTCTCAATTTAAAGATAGTGCACATCCTAAATATGACTTCTGcaaaaatcatttcttttctgttaccATGTGATGAAAGTCTTCATTCACTACAGTCTCGAATTGAGCGTGAAACAGGAATAAATACAGGTTCTCAGGAGCTTCTGTCAGAGACAGGGATTTCTCTGGATCCTCGGAAACCAGCCTCTCAGTGTGTTCTAGATGGAGTTagaGGCTGTGATAGCTACatggtttatttgtttgataaAAGTAAGACTGTATATGAAGGACCATTTGCATCCAGAAGTTTATCTGATTGTGTAAATTATATTGTACAAGACAGCAAAATACAACTGCCAATTATACAGCTGCGGAAAGTATGGGCTGAAGCAGTGCACTACGTATCTGGGCTAAAGGAAGACTACAGCAGGCTCTTCCAGGGACAAAGAGCAGCAATGTTAAGTCTTCTTAGATATAATGCTAACTTGACAAAAATGAAGAATACTTTGATCTCAGCATCACAGCAACTCAAAGCTAAATTGGAGTTTTTTCGAAAAAGCATTCAGCTTGACTTGGAGAGATATAGTGAGCAGATGACTTATGGGATATcttcagaaaaaatgttaaaagcatggaaagaaatggaagaaaaggcCATTCACTATTCTGAGGTTGGTGTCATTGGTTATCTTGAGGATCAAATTATGTCTTTGCACACTGAAATCATGGAGCTGCAGAAGAGCCCCTATGGACGACGCCAGGGAGACTTGATGGAGTCTCTggAGCAGCGTGCCATTGATCTCTATAAGCAGCTAAAGCACAGACCTCCTGATCACTTGTACAGCGACAGCACAGAGATGGTGAAGATCATCGTGCACACCGTGCAGAGTCAGGACCGTGTTCTCAAGGAGCTGTTTGGTCACCTGAGCAAGTTGTTGGGCTGCAAGCAGAAGATTATTGATCTACTCCCCAAGGTGGAAGTGGCCCTCAGTAACATCAAAGAAGCTGACAATACTGTCATGTTTATGCAgggaaagaggcagaaagaaattTGGCACCTCCTTAAAATTGCCTGTACACAGAGTTCTGCCCGCTCTCTTGTAGGATACAGTCTAGAAGGCACAGTAACCCCTCCAGTATCAGCATGGCTGCCCCCTACATTAGCAGACCGTGAACATCCTCTGACATGTGTGAGAGACGTTAGCacaaatgatagaagaaaatctGAACTGTCTTGGCCATTTAAGTACTATTATTCGTGAAGCAAATGAGGACCAGAGCAGTAGTTTGATGAGTCTTGATTGGAGTTGGTTAGCAGAATGACTCGACACTCGTTTACTGTCCTGGAGCCTACGAAGCTGTTTTGTCATTTACTCCAAAGTCATCTTTACTTGCTGAAGCCATTCCTCACTTACCAGTCCGTGAGGAGATGGCTGTGATCGGAAACTACGAGTGACTTTACAAGCACAgtagcttggtgttttgtttgtttctaataaTTATGATCTCTGAACAGATAGAATTTTATAGCAAATTAGTGAaattaattattctttttaacacCGCAACTAATGAGGGAGATCATTAGTGACCTGCTTATCttataaaattggaaaaatacTACTACTAGTTTAGCTGATGAAAAAGATAATCTTCTAAAGGCCTAAATTTTCGGCATAAGGCCCAACATGGTATTAGTATACAGGAATGAAAAATTCACCCAGTGTTCATTTGAAGTAAAGTTTTATCTATGGGTTTTCTGTGGAAGAGACTGCTGACAAGTAAAATTGCTCTTCCTGAAGACTAAGCCCAGCCTCCTTGTGTTGCTCTCAGCAAGTGTTCTTCATGGCATCACATGGAGTCAGATGAATCCCATCTTTAATCACACATTTAATAGAGTCCTTTTCCTGTGTAAGGGGTTGGACTTTTGTGCCTTTGATATCAGCTGACCATAATGAATTGTGTTGTgtgctatatgtatatgtatttaaggTGTACATTTAATAATATCAAAGAGAAGATGCCTGTTAATTTATAATGTATTTGAAGGTTGTATTGTTTTTGCATTTGTAAAAATGGGTTACTTGTTTAAACAATCTTTTATGTCTTGTCATACAAATTCCAAAGGGTCTGCATTCCTTTATCTGTAATTACAGTCTCAGAATCCAAGTTCTGAAAACAAGGTATCTATTCTGATCTGACACTGGATCTGCTTATCCCATTTAGTGTGAATATTCATTGATTTATGTGTTTGATTATTGGGATGTGCTGCCACAGGCTCTCTTGAAGGTTGATGTAGTGTGGCGTATGCACTGAATTACCTTTCTAAAATCTGAACAGTTCTCATTCTGAAACATCTAGACTTAAGGGTTTCAGATAAAAGACTGCGGTTCTCTGCCTTATGTTAAATAACTTAGAAGATGttattttgtttgaaaaaatGTGAAATGCTTTTATATTCTAGTTTTTCACTTTGCatattaaatgattttaaaattat

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