RCPedia: Rtcs

Summary

Retrocopy Name	RbpjP2	Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species	Mus musculus
Coordinates	chr6:46503867-46507818 UCSC
Strand	-
Parental Sequence	NM_001080928.1
Parental seq. overlap	3801 bp
Parental seq. overlap (%)	70.5%
Genomic Region	Intragenic (Cntnap2)
Retrocopy Summary	RbpjP2, located on chr6:46503867-46507818, is a retrocopy of the parental gene Rbpj. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	Rbpj
Full Name	recombination signal binding protein for immunoglobulin kappa J region
Also known as	CBF1\|Igkjrb\|Igkrsbp\|RBP-J\|RBP-J kappa\|RBP-Jkappa\|RBPjk\|Rbpsuh
Coordinate	chr5:53713121-53814787
Strand	+
Gene summary	Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including circulatory system development; positive regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; neural ectoderm; paraxial mesenchyme; and retina. Used to study aortic valve disease. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Human	Homo sapiens	Without Homology
Chimpanzee	Pan troglodytes	Without Homology
Bonobo	Pan paniscus	Without Homology
Gorilla	Gorilla gorilla	Without Homology
Orangutan	Pongo abelii	Without Homology
Gibbon	Nomascus leucogenys	Without Homology
Green monkey	Chlorocebus sabaeus	Without Homology
Crab-eating macaque	Macaca fascicularis	Without Homology
Rhesus	Macaca mulatta	Without Homology
Baboon	Papio anubis	Without Homology
Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>RbpjP2
GCCTATAGGAAGTTTGGTGAGCGGCCTCCACCCAAACGACTCACTAGGGAAGCTATGCGAAATTATTTAAAAGAACGAGGGGATCAAACAGTGCTCATTCTTCATGCAAAAGTTGCACAGAAGTCTTACGGAAATGAAAAACGATTTTTTTGCCCTCCTCCTTGTGTGTATCTTATGGGCAGtggttggaagaaaaaaaaagagcaaatggAACGAGATGGATGTTCTGAACAAGAGTCTCAACCCTGTGCGTTTATTGGAATAGGAAACAGTGACCAAGAAATGCAGCAGCTGAACTTGGAAGGGAAGAACTACTGCACAGCCAAAACATTGTACATATCTGATTCAGACAAGAGAAAACATTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGCGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAGGTCATCTCCAAACCCTCCAAAAAGAAGCAGTCACTGAAGAATGCTGACTTGTGCATTGCTTCAGGAACGAAGGTGGCACTGTTCAATCGCCTTCGGTCCCAGACAGTTAGTACCAGGTACCTGCATGTAGAAGGAGGGAATTTCCACGCCAGTTCACAACAGTGGGGAGCATTTTACATCCATCTCTTGGACGACGACGAGTCGGAAGGAGAGGAGTTCACAGTTAGAGATGGCTACATCCATTACGGGCAGACTGTCAAGCTTGTGTGCTCAGTGACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGACGGCATTACTGGATGCAGACGACCCTGTATCACAACTCCACAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTACTTGTGCCTTTCTCAAGAAAGAATAATCCAATTTCAGGCCACTCCATGtccaaaagaacaaaataaggAAATGATAAACGATGGAGCTTCCTGGACAATCATTAGCACAGACAAGGCAGAATACACGTTCTATGAGGGAATGGGCCCCGTCCTTGCCCCAGTCACCCCTGTGCCTGTCGTAGAAAGTCTTCAGTTGAATGGCGGCGGGGACGTAGCAATGCTTGAACTTACAGGACAAAACTTTACTCCAAATTTACGAGTGTGGTTTGGGGATGTAGAAGCCGAAACAATGTACAGATGTGGAGAGAGCATGCTCTGTGTGGTCCCAGACATTTCTGCATTCCGGGAAGGTTGGAGATGGGTCCGCCAGCCAGTCCAGGTTCCAGTGACTTTGGTCCGAAATGACGGGGTCATTTACTCCACCAGCCTTACCTTCACCTACACACCAGAGCCAGGGCCGAGGCCACACTGCAGCGCTGCAGGAGCGATTCTCAGAGCCAACTCCAGCCAAGTGCCCTCCAATGAGTCAAACACAAACAGCGAGGGGAattacacaaatgccagcacaaaTTCTACCAGTGTCACATCGTCCACAGCAACCGTGGTGTCCTAACTACCGTCTTTTTGCTGGGACTGAAACTGACTTGAATGCAGCAAAAAGTTGACAGAGAAAGGCAAGGATAAAGTGAACAATCTTTTGTGGTTTCTTGGGGAAACGTTTCGTACCAGGTGATCTATTCAAAACTGCCAGTGCAGGTGTGACATGCAGAGGCCACAGTACAATGAACAACATCAGAATGCACAGGCTGATGGAAATCCAGGTTTTCAGCTgtccctctcacacacacccctttaatGGCCAGGAAACAGatatgtggctggagcacaggctAAGCTAGAAGACACAAACCTAACATAGACTTATGGACCAAGGGACTCGCATAAGCTTTAGTGAAAGGTACATTTTCACCATGCCTTTTTTATATCACAGTGTGTACTACACCTTGTTACCAAACAGGTTGCGCTCCCCACCCTTTGAGGGTTGGCTCTAAAGTACATTCAGGTTCGAGCCTCACCATGTTTGTTCAGTCTGAACACTGAACACTTCCAGGTTCTTGTGGTCTAAGGCTGGAACTTTTTTAAGCTGAAGTCTTATGACTTTTTCATAAGTTGGAATTATTTTGATTTCAGCAAGTCAAATTTTGTAAAGGCCtgcatattttttttaagattatatgaAGTCTGCAAAAGCTTTAAAAATGCCTCTGCCTTGCCTGCAATACATGCAATGTGTGTTAACTGAGTCTGTTCTCAGAATCTGTTGGTAGTTATTTCtgtgttttccctttttttaaagaaatgtatttatagTGGTAATCTAAGAGATGCTAACAGCTCCGTGTGGCCATTTAGCCCTTTCTGAGTTCATGGCAGTGAGCACCGCCGTTCGAAGGCTGTGCGCCTCTGCCTGTTCATCAGTTCATCTGTGTTCCAGGATTTGTTCAGGTTTCCCCTTCCCCCAAATCTTGTACATAACTTGTATTAtgtgtaagttaaacattttaTCTTTACTTGGAATGTTCCCAGTGATTACATTTCACAGGGTGTTTCCCACCTTGTTGGCAAATGACAAAAAATATCATGCGAATTATTTGCTACCAAGATGGTGCCCGTAGGGTAAAATGAGGAACATCTCTGCAGGATGATTTattgtatgtttttctttttttttagcctAGCCAGAACATCATTATAATTTTAAAGACCATAAGATGGCTTTTATTAGATGATAACTAAATAAACTGAACTAAGTAGCCAGAAGACAGTACCTTAGAGACTGATAGTTGTAagtttataaaaatacaaatgtaacttatatttccattttcctcTTTGCCCCTTTGTTTATTTTCCCCAGTAGAAATGTTCTgtccagattttttttcccctttttagtTAAGCCTTGCTTGCATTCAGGCTTGTGTGTCAGCCCTGTGTGCCAATATGCCAGATTCATTTTGTTTCCATCCCTGCACTTTGGTTATTCCTCGTTCAGTTTCTTGGGAATTGAAGCAGACTCATTGGGCTACATTTAGTACAAGAACCACATGTGTGATGTTAAAGGACACAGTCTAGTGATGCCATCATCCTTGAGTAAAAACTACCTCTAGATTGTGGTAAGCTTTTACTGTCCCTTAAAACAGGAGCCACTAGTACCTTACGAATGCAGACTGTAACTTCTATGGCATTTTCTGGTGTCTTtctggctctctgggcttctgAAAGTTTTCACGTAGACCCTTAGACTCCTCTGTCAGGACCATTGCTTTCCAGCGTTGCTGCTTTCACTCGCTGTCTCGCAGACTGTACCACTGTAAGTGCCACTGCAAACATCTTTAAACGGCCTCCTCCTTGGCTTGTCAAGGGGAAGGCCACCTGTAAGATGTGGTGGTGACAGCCTTCCTGTCCACCCCAGGCTGCTCCTTACCAGCTGTTCTAGCCGATTCTCTTCAGATCAGCTACAGCCCACCTCCTCCCCGCCCCGCCTCACCCCTCCAGGCTGTCTCAGTGGTCCAGGGCAGAGCTCACTGTGGCCTTACTGATCTATCTCTGCAGTAACTGTTCTCCCTCAGTTGCGATGGAAGCAGGCCCCTGCGATCTGTTCAGAGCCTGAGCAGTTTGCAGTTCCGTTGTGCTTTCTGAGGTCCTAGATTCAGGATGTAGTTAAGTCGATAACTGAGAACAGATGAGATGCTTTTAAAGAACAAACTCTTCCTTACCCAGCTTTGTAGCTTAAAGTAAGTTTTCAAGTTCATGGCTTTATTAAAATGaactttgactttttaaaatgcttataTCTCATTTcggttcttttgtttattttagtaaGAATTGAAACAGACTATAAGtagttttccttttacaaagtTCAAGAATGTAACAATAAAGGCATTTTGCTATGGTtctatgtcagaa

>NM_001080928.1
CCTTCAAGATATCCAGCAAGTTGAGACTGGGTCCCACTCTGTAGCTCCGGCTGCTGTGGAATTTACAGCATAGCCCAGAACTCGAGGCGTCTGCTTAACCCGGCTTCTCAAATGTTGGCCTATAGGAAGTTTGGTGAGCGGCCTCCACCCAAACGACTCACTAGGGAAGCTATGCGAAATTATTTAAAAGAACGAGGGGATCAAACAGTGCTCATTCTTCATGCAAAAGTTGCACAGAAGTCTTACGGAAATGAAAAACGattTTTTTGCCCTCCTCCTTGTGTGTATCTTATGGGCAGtggttggaagaaaaaaaaagagcaaatggAACGAGATGGATGTTCTGAACAAGAGTCTCAACCCTGTGCGTTTATTGGAATAGGAAACAGTGACCAAGAAATGCAGCAGCTGAACTTGGAAGGGAAGAACTACTGTACAGCCAAAACATTGTACATATCTGATTCAGACAAGAGAAAACATTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGCGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAGGTCATCTCCAAACCCTCCAAAAAGAAGCAGTCACTGAAGAATGCTGACTTGTGCATTGCTTCAGGAACGAAGGTGGCACTGTTCAATCGCCTTCGGTCCCAGACAGTTAGTACCAGGTACCTGCATGTAGAAGGAGGGAATTTCCACGCCAGTTCACAACAGTGGGGAGCATTTTACATCCATCTCTTGGACGACGACGAGTCGGAAGGAGAGGAGTTCACAGTTAGAGATGGCTACATCCATTACGGGCAGACTGTCAAGCTTGTGTGCTCAGTGACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGACGGCATTACTGGATGCAGACGACCCTGTATCACAACTCCACAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTACTTGTGCCTTTCTCAAGAAAGAATAATCCAATTTCAGGCCACTCCATGtccaaaagaacaaaataaggAAATGATAAACGATGGAGCTTCCTGGACAATCATTAGCACAGACAAGGCCGAGTACACGTTCTATGAGGGAATGGGCCCCGTCCTTGCCCCAGTCACCCCTGTGCCTGTCGTAGAAAGTCTTCAGTTGAATGGCGGCGGGGACGTAGCAATGCTTGAACTTACAGGACAAAACTTTACTCCAAATTTAAGAGTGTGGTTTGGGGATGTAGAAGCCGAAACAATGTACAGatgtggagagaGCATGCTCTGTGTGGTCCCAGACATTTCTGCATTCCGGGAAGGTTGGAGATGGGTCCGCCAGCCAGTCCAGGTTCCAGTGACTTTGGTCCGAAATGACGGGGTCATTTACTCCACCAGCCTTACCTTCACCTACACACCAGAGCCAGGGCCGAGGCCACACTGCAGCGCTGCAGGAGCGATTCTCAGAGCCAACTCCAGCCAAGTGCCCTCCAATGAGTCAAACACAAACAGCGAGGGGAattacacaaatgccagcacaaaTTCTACCAGTGTCACATCGTCCACAGCAACCGTGGTGTCCTAACTACCGTCTTTTTGCTGGGACTGAAACTGACTTGAATGCAGCAAAAAGTTGACAGAGAAAGGCAAGGATAAAGTGAACAATCTTTTGTGGTTTCTTGGGGAAACGTTTCGTACCAGGTGATCTATTCAAAACTGCCAGTGCAGGTGTGACATGCAGAGGCCACAGTACAATGAACAACATCAGAATGCACAGGCTGATGGAAATCCAGGTTTTCAGCTGTCCCTCTCACACGCACccctttttggttgttttggtttggttttgatttaatGGCCAGGAAACAGatatgtggctggagcacaggctAAGCTAGAAGACACAAACCTAACATAGACTTATGGACCAAGGGACTCGCATAAGCTTTAGTGAAAGGTACATTTTCACCATGCCTTTTTTATATCACAGTGTGTACTACACCTTGTTACCAAACAGGTTGCGCTCCCCACCCTTTGAGGGTTGGCTCTAAAGTACATTCATTCAGGTTCGAGCCTCACCATGTTTGTTCAGTCTGAACACTGAACACTTCCAGGTTCTTGTGGTCTAAGGCTGGAACTTTTTTAAGCTGAAGTCTTATGACTTTTTCATAAGTTGGAATTATTTTGATTTCAGCAAGTCAAATTTTGTAAAGGCCtgcatattttttttaagattatatgaAGTCTGCAAAAGCTTTAAAAATGCCTCTGCCTTGCCTGCAATACATGCAATGTGTGTTAACTGAGTCTGTTCTCAGAATCTGTTGGTAGTTATTTCtgtgttttccctttttttaaagaaatgtatttatagTGGTAATCTAAGAGATGCTAACAGCTCCGTGTGGCCATTTAGCCCTTTCTGAGTTCATGGCAGTGAGCACTGCCGTTCGAAGGCTGTGCGCCTCTGCCTGTTCATCAGTTCATCTGTGTTCCAGGATTTGTTCAGGTTTCCCCTTCCCCCAAATCTTGTACATAACTTGTATTAtgtgtaagttaaacattttaTCTTTACTTGGAATGTTCCCAGTGATTACATTTCACAGGGTGTTTCCCACCTTGTTGGCAAATGACAAAAAATATCATGCGAATTATTTGCTACCAAGATGGTGCCCGTAGGGTAAAATGAGGAACATCTCTGCAGGATGATTTAttgtatgttttcctttttttttagccTAGCCAGAACATCATTATAATTTTAAAGACCATAAGATGGCTTTTATTAGATGATAACTAAATAAACTGAACTAAGTAGCCAGAAGACAGTACCTTAGAGACTGATAGTTGTAagtttataaaaatacaaatgtaacttatatttccattttcctcTTTGCCCCTTTGTTTATTTTCCCCAGTAGAAATGTTCtgtccagatttttttccccctttttagtTAAGCCTTGCTTGCATTCAGGCTTGTGTGTCAGCCCTGTGTGCCAATATGCCAGATTCATTTTGTTTCCATCCCTGCACTTTGGTTATTCCTTGTTCAGTTTCTTGGGAATTGAAGCAGACTCATTGGGCTACATTTAGTACAAGAACCACATGTGTGATGTTAAAGGACACAGTCTAGTGATGCCATCATCCTTGAGTAAAAACTACCTCTAGATTGTGGTAAGCTTTTACTGTCCCTTAAAACAGGAGCCACTAGTACCTTATGAATGCAGACTGTAACTTCTATGGCATTTTCTGGTGTCTTtctggctctctgggcttctgAAAGTTTTCACGTAGACCCTTAGACTCCTCTGTCAGGACCATTGCTTTCCAGCGTTGCTGCTTTCACTCGCTGTCTCGAAGACTGTACCACTGTAAGTGCCACTGCGAACATCTTTAAACGGCTCCTCCTTGGCTTGTCAAGGGGAAGGCCACCTGTAAGATGTGGTGGTGACAGCCTTCCTGTCCACCCCAGGCTGCTCCTTACCAGCTGTTCTAGCCGATTCTCTTCAGATCAGCTACAGCCCACCTCCTCCCCGCCCCGCCTCACCCCTCCAGGCTGTCTCAGTGGTCCAGGGCAGAGCTCACTGTGGCCTTACTGATCTATCTCTGCAGTAACTGTTCTCCCTCAGTTGCGATGGAAGCAGGCCCCTGCGATCTGTTCAGAGCCTGAGCAGTTTGCAGTTCCGTTGTGCTTTCTGAGGTCCTAGATTCAGGATGTAGTTAAGTCGATAACTGAGAACAGATGAGATGCTTTTAAAGAACAAACTCTTCCTTACCCAGCTTTGTAGCTTAAAGTAAGTTTTCAAGTTCATGGCTTTATTAAAATGaactttgactttttaaaatgcttataTCTCATTTcggttcttttgtttattttagtaaGAATTGAAACAGACTATAAGtagttttcctgtttgtttgtttgtttgtttgttttttacaaagtTCAAGAATGTAACAATAAAGGCATTTTGCTATGGTTCTATGTCAGACTCCTACCACAGAATAGTGTGAACAGATATGTCTGTCTGCTTTACCATGTTATTGATAGTTCTTTTGTCAGCTGCTTTTATTAAAAGTCCTCTTTTGTGAATTTGTAAATCAATTTCAATATATGATGTACAGGAGTCTTGTCCCCCGTTACTGTGGAATGTTCCCCCCTGTTGATGCTGGTCCCTTTATCCTCTTATCTTCTTAGAACCGGGAATTCTTCAGTTGTGGTGTGTGGCTGTATTTTTCTATTCTGTTTACAGTGCGTCTACACAGCTTCTTAAAACATGTCGAAATGCAGAATCCAAGATCCACCATGAATTTGTCAAGAGATTGGAAGGCAGGCCAAAACCTGAAAATGTGGGGTGCCCTTTGTACAATTGCAGAGTCAAGCACTAGTGGGAGTTTGAACTGGCTACTGACCGCTCTTAAACTGTGGCAGTGTCCTTGGGTACAGTTAACTAGCAGAACCTGCTGTCACTCTTCCTGCCACCATCTTAACCTTgacagttttgtttcttttctgtgtggTGCTGGGGTCAAATCCAGAGCCTTAGGCTTGCtaaggctttttgtttgtttgatttttccttGAGACAAGTGTCTCACCCATGGAGCCCCTCAGCATTCTTGAAAGTCTCTGCCTTAGCCTCCAGGTCCTGTGGTACCAGGTGTGGCAGGATGCTTTTGTCATTAGAGAAACTGGTCTGTGTCCAACCACAGAAAAATTCCAATGCAGTTTTTAATAATTAATCCACTAGTTATTTAATCAAAATCTTTTTGTAGGGAGAGattcctgtttgaaagaaaatgCTATTTGATTATTAACCAAGGTAACAGACACTGCTTTCCAAAGCAGCTGTGTTTCTGGTGAGTACTGAAcaaatgtgtggttttctgtgCCACCTTTGATTCATTTTTCAAGCACTGTTACTCGGGATGGATGGTTAGAAACATGATATTTTAGTGTTTCTACTTAACCCTTTCAGGACCGAGCTGTATTGCCTTTCTATTAATTTCCCCCTGTGTTGTGATAAATGTTTGCTCGTGTTCAGTCCTGTGTCAGTCCAGACGTAGGTTTGTGTAAAAGCTCAGTTGTAGCTTATTTCTTGTACCTTGCAGCATGTTCTACGCATCCAGTCCTTAAGGGGTTTACTCTACAAACTGTGCACCTGCGTGTAAGGGTCATTAGCAATAAGATAGAAAATTGAGCAAGTTTATACCATAATTTTGTAGAAAAAGGAATCTGCTCAATTCCATATTTCATCCATGAAAACTCTGCAATACGGGCAGTTTCtaggaataaataaaaaggagatgCAAACCATTGTAGATGTCTTCTGTGGGATGTGCCCGATGCGTGCATCATCGTCTTTGATTCCAGGTACTtcataaagataaaattaaattc

>NM_001080928.1 

CCTTCAAGATATCCAGCAAGTTGAGACTGGGTCCCACTCTGTAGCTCCGGCTGCTGTGGAATTTACAGCATAGCCCAGAACTCGAGGCGTCTGCTTAACCCGGCTTCTCAAATGTTGGCCTATAGGAAGTTTGGTGAGCGGCCTCCACCCAAACGACTCACTAGGGAAGCTATGCGAAATTATTTAAAAGAACGAGGGGATCAAACAGTGCTCATTCTTCATGCAAAAGTTGCACAGAAGTCTTACGGAAATGAAAAACGattTTTTTGCCCTCCTCCTTGTGTGTATCTTATGGGCAGtggttggaagaaaaaaaaagagcaaatggAACGAGATGGATGTTCTGAACAAGAGTCTCAACCCTGTGCGTTTATTGGAATAGGAAACAGTGACCAAGAAATGCAGCAGCTGAACTTGGAAGGGAAGAACTACTGTACAGCCAAAACATTGTACATATCTGATTCAGACAAGAGAAAACATTTCATGTTGTCTGTAAAGATGTTCTATGGCAACAGCGATGACATTGGTGTGTTCCTCAGCAAGCGGATAAAGGTCATCTCCAAACCCTCCAAAAAGAAGCAGTCACTGAAGAATGCTGACTTGTGCATTGCTTCAGGAACGAAGGTGGCACTGTTCAATCGCCTTCGGTCCCAGACAGTTAGTACCAGGTACCTGCATGTAGAAGGAGGGAATTTCCACGCCAGTTCACAACAGTGGGGAGCATTTTACATCCATCTCTTGGACGACGACGAGTCGGAAGGAGAGGAGTTCACAGTTAGAGATGGCTACATCCATTACGGGCAGACTGTCAAGCTTGTGTGCTCAGTGACTGGCATGGCACTCCCAAGATTGATAATTAGGAAAGTTGATAAGCAGACGGCATTACTGGATGCAGACGACCCTGTATCACAACTCCACAAATGTGCATTTTACCTTAAGGATACAGAAAGAATGTACTTGTGCCTTTCTCAAGAAAGAATAATCCAATTTCAGGCCACTCCATGtccaaaagaacaaaataaggAAATGATAAACGATGGAGCTTCCTGGACAATCATTAGCACAGACAAGGCCGAGTACACGTTCTATGAGGGAATGGGCCCCGTCCTTGCCCCAGTCACCCCTGTGCCTGTCGTAGAAAGTCTTCAGTTGAATGGCGGCGGGGACGTAGCAATGCTTGAACTTACAGGACAAAACTTTACTCCAAATTTAAGAGTGTGGTTTGGGGATGTAGAAGCCGAAACAATGTACAGatgtggagagaGCATGCTCTGTGTGGTCCCAGACATTTCTGCATTCCGGGAAGGTTGGAGATGGGTCCGCCAGCCAGTCCAGGTTCCAGTGACTTTGGTCCGAAATGACGGGGTCATTTACTCCACCAGCCTTACCTTCACCTACACACCAGAGCCAGGGCCGAGGCCACACTGCAGCGCTGCAGGAGCGATTCTCAGAGCCAACTCCAGCCAAGTGCCCTCCAATGAGTCAAACACAAACAGCGAGGGGAattacacaaatgccagcacaaaTTCTACCAGTGTCACATCGTCCACAGCAACCGTGGTGTCCTAACTACCGTCTTTTTGCTGGGACTGAAACTGACTTGAATGCAGCAAAAAGTTGACAGAGAAAGGCAAGGATAAAGTGAACAATCTTTTGTGGTTTCTTGGGGAAACGTTTCGTACCAGGTGATCTATTCAAAACTGCCAGTGCAGGTGTGACATGCAGAGGCCACAGTACAATGAACAACATCAGAATGCACAGGCTGATGGAAATCCAGGTTTTCAGCTGTCCCTCTCACACGCACccctttttggttgttttggtttggttttgatttaatGGCCAGGAAACAGatatgtggctggagcacaggctAAGCTAGAAGACACAAACCTAACATAGACTTATGGACCAAGGGACTCGCATAAGCTTTAGTGAAAGGTACATTTTCACCATGCCTTTTTTATATCACAGTGTGTACTACACCTTGTTACCAAACAGGTTGCGCTCCCCACCCTTTGAGGGTTGGCTCTAAAGTACATTCATTCAGGTTCGAGCCTCACCATGTTTGTTCAGTCTGAACACTGAACACTTCCAGGTTCTTGTGGTCTAAGGCTGGAACTTTTTTAAGCTGAAGTCTTATGACTTTTTCATAAGTTGGAATTATTTTGATTTCAGCAAGTCAAATTTTGTAAAGGCCtgcatattttttttaagattatatgaAGTCTGCAAAAGCTTTAAAAATGCCTCTGCCTTGCCTGCAATACATGCAATGTGTGTTAACTGAGTCTGTTCTCAGAATCTGTTGGTAGTTATTTCtgtgttttccctttttttaaagaaatgtatttatagTGGTAATCTAAGAGATGCTAACAGCTCCGTGTGGCCATTTAGCCCTTTCTGAGTTCATGGCAGTGAGCACTGCCGTTCGAAGGCTGTGCGCCTCTGCCTGTTCATCAGTTCATCTGTGTTCCAGGATTTGTTCAGGTTTCCCCTTCCCCCAAATCTTGTACATAACTTGTATTAtgtgtaagttaaacattttaTCTTTACTTGGAATGTTCCCAGTGATTACATTTCACAGGGTGTTTCCCACCTTGTTGGCAAATGACAAAAAATATCATGCGAATTATTTGCTACCAAGATGGTGCCCGTAGGGTAAAATGAGGAACATCTCTGCAGGATGATTTAttgtatgttttcctttttttttagccTAGCCAGAACATCATTATAATTTTAAAGACCATAAGATGGCTTTTATTAGATGATAACTAAATAAACTGAACTAAGTAGCCAGAAGACAGTACCTTAGAGACTGATAGTTGTAagtttataaaaatacaaatgtaacttatatttccattttcctcTTTGCCCCTTTGTTTATTTTCCCCAGTAGAAATGTTCtgtccagatttttttccccctttttagtTAAGCCTTGCTTGCATTCAGGCTTGTGTGTCAGCCCTGTGTGCCAATATGCCAGATTCATTTTGTTTCCATCCCTGCACTTTGGTTATTCCTTGTTCAGTTTCTTGGGAATTGAAGCAGACTCATTGGGCTACATTTAGTACAAGAACCACATGTGTGATGTTAAAGGACACAGTCTAGTGATGCCATCATCCTTGAGTAAAAACTACCTCTAGATTGTGGTAAGCTTTTACTGTCCCTTAAAACAGGAGCCACTAGTACCTTATGAATGCAGACTGTAACTTCTATGGCATTTTCTGGTGTCTTtctggctctctgggcttctgAAAGTTTTCACGTAGACCCTTAGACTCCTCTGTCAGGACCATTGCTTTCCAGCGTTGCTGCTTTCACTCGCTGTCTCGAAGACTGTACCACTGTAAGTGCCACTGCGAACATCTTTAAACGGCTCCTCCTTGGCTTGTCAAGGGGAAGGCCACCTGTAAGATGTGGTGGTGACAGCCTTCCTGTCCACCCCAGGCTGCTCCTTACCAGCTGTTCTAGCCGATTCTCTTCAGATCAGCTACAGCCCACCTCCTCCCCGCCCCGCCTCACCCCTCCAGGCTGTCTCAGTGGTCCAGGGCAGAGCTCACTGTGGCCTTACTGATCTATCTCTGCAGTAACTGTTCTCCCTCAGTTGCGATGGAAGCAGGCCCCTGCGATCTGTTCAGAGCCTGAGCAGTTTGCAGTTCCGTTGTGCTTTCTGAGGTCCTAGATTCAGGATGTAGTTAAGTCGATAACTGAGAACAGATGAGATGCTTTTAAAGAACAAACTCTTCCTTACCCAGCTTTGTAGCTTAAAGTAAGTTTTCAAGTTCATGGCTTTATTAAAATGaactttgactttttaaaatgcttataTCTCATTTcggttcttttgtttattttagtaaGAATTGAAACAGACTATAAGtagttttcctgtttgtttgtttgtttgtttgttttttacaaagtTCAAGAATGTAACAATAAAGGCATTTTGCTATGGTTCTATGTCAGACTCCTACCACAGAATAGTGTGAACAGATATGTCTGTCTGCTTTACCATGTTATTGATAGTTCTTTTGTCAGCTGCTTTTATTAAAAGTCCTCTTTTGTGAATTTGTAAATCAATTTCAATATATGATGTACAGGAGTCTTGTCCCCCGTTACTGTGGAATGTTCCCCCCTGTTGATGCTGGTCCCTTTATCCTCTTATCTTCTTAGAACCGGGAATTCTTCAGTTGTGGTGTGTGGCTGTATTTTTCTATTCTGTTTACAGTGCGTCTACACAGCTTCTTAAAACATGTCGAAATGCAGAATCCAAGATCCACCATGAATTTGTCAAGAGATTGGAAGGCAGGCCAAAACCTGAAAATGTGGGGTGCCCTTTGTACAATTGCAGAGTCAAGCACTAGTGGGAGTTTGAACTGGCTACTGACCGCTCTTAAACTGTGGCAGTGTCCTTGGGTACAGTTAACTAGCAGAACCTGCTGTCACTCTTCCTGCCACCATCTTAACCTTgacagttttgtttcttttctgtgtggTGCTGGGGTCAAATCCAGAGCCTTAGGCTTGCtaaggctttttgtttgtttgatttttccttGAGACAAGTGTCTCACCCATGGAGCCCCTCAGCATTCTTGAAAGTCTCTGCCTTAGCCTCCAGGTCCTGTGGTACCAGGTGTGGCAGGATGCTTTTGTCATTAGAGAAACTGGTCTGTGTCCAACCACAGAAAAATTCCAATGCAGTTTTTAATAATTAATCCACTAGTTATTTAATCAAAATCTTTTTGTAGGGAGAGattcctgtttgaaagaaaatgCTATTTGATTATTAACCAAGGTAACAGACACTGCTTTCCAAAGCAGCTGTGTTTCTGGTGAGTACTGAAcaaatgtgtggttttctgtgCCACCTTTGATTCATTTTTCAAGCACTGTTACTCGGGATGGATGGTTAGAAACATGATATTTTAGTGTTTCTACTTAACCCTTTCAGGACCGAGCTGTATTGCCTTTCTATTAATTTCCCCCTGTGTTGTGATAAATGTTTGCTCGTGTTCAGTCCTGTGTCAGTCCAGACGTAGGTTTGTGTAAAAGCTCAGTTGTAGCTTATTTCTTGTACCTTGCAGCATGTTCTACGCATCCAGTCCTTAAGGGGTTTACTCTACAAACTGTGCACCTGCGTGTAAGGGTCATTAGCAATAAGATAGAAAATTGAGCAAGTTTATACCATAATTTTGTAGAAAAAGGAATCTGCTCAATTCCATATTTCATCCATGAAAACTCTGCAATACGGGCAGTTTCtaggaataaataaaaaggagatgCAAACCATTGTAGATGTCTTCTGTGGGATGTGCCCGATGCGTGCATCATCGTCTTTGATTCCAGGTACTtcataaagataaaattaaattc

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