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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Fabp5P2
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr8:34774223-34774873  UCSC
Strand -
Parental Sequence NM_010634.3
Parental seq. overlap 620 bp
Parental seq. overlap (%) 65.1%
Genomic Region Intergenic
Retrocopy Summary Fabp5P2, located on chr8:34774223-34774873, is a retrocopy of the parental gene Fabp5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Fabp5
Full Name fatty acid binding protein 5, epidermal
Also known as E-FABP|Fabpe|Klbp|PA-FABP|mal1
Coordinate chr3:10077645-10081670
Strand +
Gene summary The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Fabp5P2
GTCTCTGCTGCTTTTGTGCTCTCCCGCCCGCCATGGCCAGCCTTAAGGATCTCGAAGGGAAGTGGCGCCTGATGGAAAGCCACGGCTTTGAGGAGTACGCGAAAGAGCTAGGAGTAGGACTGGCTCTTAGGAAGATGGCTGCCATGGCCAAGCCAGACTCTATCATTACTTGTGATGGCAACAACATCACCATCAAAACCGAGAGCACAGTGAAGACGACCGTGTTCTCTTGTACCCTGGGAGAGAAGTTTGATGAAACTATGGCTGATGGCAGAAAAACTGAGATGGTCTGTACCTTCCAAGATGGTGCCCTGGTCCAGCACCAGCAATGGGAAGGGGAGCACGATAACAGGAAAACTGAAGGATGGGAAGTTGATTGTGGAGCGTGTCATGAACAATGCCACCTGCACTCGGGTCTACGAGAAGGTGCAATGAGAGCTTCCTCGTCATCCTGGACAGGAGTTAGCTGCCAGAGTGAATATGCTCAATTCAGTGAGCGGACATAAACAACAAACAGCTTCacttctttggttttatttttcatgacTGTTGAGTTCTCTTTATCACAAACACTTTACATGGAACTTCATGTCAAACTTGGTTTACCCAGGATCATTCCTTTGGCTAGTAAATAAACGTGTTAGTgctaaa
>NM_010634.3
CGGAACAGCGCCCTCGCCACCGCGTCTCTGCTGCTTTTGTGCTCTCCCTCCCACCATGGCCAGTCTTAAGGATCTCGAAGGGAAGTGGCGCCTGATGGAAAGCCACGGCTTTGAGGAGTACATGAAAGAGCTAGGAGTAGGACTGGCTCTTAGGAAGATGGCTGCCATGGCCAAGCCAGACTGTATCATTACGTGTGATGGCAACAACATCACGGTCAAAACCGAGAGCACAGTGAAGACGACTGTGTTCTCTTGTAACCTGGGAGAGAAGTTTGATGAAACGACAGCTGATGGCAGAAAAACTGAGACGGTCTGCACCTTCCAAGACGGTGCCCTGGTCCAGCACCAGCAATGGGACGGGAAGGAGAGCACGATAACAAGAAAACTGAAGGATGGGAAGATGATCGTGGAGTGTGTCATGAACAATGCCACCTGCACTCGGGTCTATGAGAAGGTGCAATGAGGGCTTCCTCGTCATCCTGGACAGGAGTTAGCTGCCAGAGTGAATATGCTCAATTCAGTGAGCGGTCAAATGCAACAAACAGCTTCacttctttggttttatttttcatgacTGTTGAGTTCTCTTTATCACAAACACTTTACATGGACCTTCATGTCAAACTTGGTTTACCCAGGATCATTCCTTTGGTTAGTAAATAAACGTGTTAGTGCTAATTtatgatatgtgtgtgggttcttcAAGGAATTGAAAATTGGTGATACATTATAACACTTAGAAATTGAAAAGCTCTCTGGTATTCTTCAGGATCCCTTATGACTGATATATCCTAGCAACTTGTAGACGTGGCCAGCTTCTTTTGCAGTGAATACATGCCCCGTCATTTAAGCTTGCCTTAAATCGTTTGAACTTTGTCAACTCAATAATTGAGACTATTCCTATCGAATGAtagctacataaattttatagAATAAAGGGAGATCCAAGCTTA

Publications

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