Retrocopy Name | AlplP1 |
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Species | Mus musculus | |
Coordinates | chrX:65807365-65807679 UCSC | |
Strand | + | |
Parental Sequence | NM_001287172.1 | |
Parental seq. overlap | 267 bp | |
Parental seq. overlap (%) | 10.5% | |
Genomic Region |
Intergenic |
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Retrocopy Summary | AlplP1, located on chrX:65807365-65807679, is a retrocopy of the parental gene Alpl. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
Gene Name | Alpl |
Full Name | alkaline phosphatase, liver/bone/kidney |
Also known as | ALP|APTNAP|Akp-2|Akp2|TNAP|TNSALP |
Coordinate | chr4:137469042-137523695 |
Strand | - |
Gene summary | This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
Species | Scientific Name | Retrocopy | |
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Human | Homo sapiens | Without Homology |
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Chimpanzee | Pan troglodytes | Without Homology |
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Bonobo | Pan paniscus | Without Homology |
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Gorilla | Gorilla gorilla | Without Homology |
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Orangutan | Pongo abelii | Without Homology |
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Gibbon | Nomascus leucogenys | Without Homology |
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Green monkey | Chlorocebus sabaeus | Without Homology |
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Crab-eating macaque | Macaca fascicularis | Without Homology |
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Rhesus | Macaca mulatta | Without Homology |
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Baboon | Papio anubis | Without Homology |
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Golden snub-nosed monkey | Rhinopithecus roxellana | Without Homology |
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Marmoset | Callithrix jacchus | Without Homology |
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Mouse lemur | Microcebus murinus | Without Homology |
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Rat | Rattus norvegicus | Without Homology |
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Chinese hamster | Cricetulus griseus | Without Homology |
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Rabbit | Oryctolagus cuniculus | Without Homology |
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Pig | Sus scrofa | Without Homology |
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Cow | Bos taurus | Without Homology |
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Sheep | Ovis aries | Without Homology |
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Dolphin | Tursiops truncatus | Without Homology |
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Horse | Equus caballus | Without Homology |
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Dog | Canis familiaris | Without Homology |
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Panda | Ailuropoda melanoleuca | Without Homology |
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Cat | Felis catus | Without Homology |
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Pale spear-nosed bat | Phyllostomus discolor | Without Homology |
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Velvety free-tailed bat | Molossus molossus | Without Homology |
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Greater mouse-eared bat | Myotis myotis | Without Homology |
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Kuhl's pipistrelle | Pipistrellus kuhlii | Without Homology |
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Greater horseshoe bat | Rhinolophus ferrumequinum | Without Homology |
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Egyptian rousette | Rousettus aegyptiacus | Without Homology |
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Sloth | Choloepus didactylus | Without Homology |
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Tasmanian Devil | Sarcophilus harrisii | Without Homology |
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Opossum | Monodelphis domestica | Without Homology |
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Platypus | Ornithorhynchus anatinus | Without Homology |
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Chicken | Gallus gallus | Without Homology |
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Turkey | Meleagris gallopavo | Without Homology |
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Zebra Finch | Taeniopygia guttata | Without Homology |
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Budgerigar | Melopsittacus undulatus | Without Homology |
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Painted Turtle | Chrysemys picta | Without Homology |
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Lizard | Anolis Carolinensis | Without Homology |
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Frog | Xenopus tropicalis | Without Homology |
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Zebrafish | Danio rerio | Without Homology |
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Drosophila | Drosophila melanogaster | Without Homology |
>AlplP1 |
CCTCATCAGCGTTTGAAAGAACTTCAAACCCAGACATAAATACTCCCCACTATGTCTGGAACCGCACTGAACTGCAGGCCTTTGACCCCTCCAGGGTGGACTACCTCACAGGTCTCTTTGAGCCCAGGGACATACAATATGATTTGAACCAGAACTAACTGACTCTTCACTCTGAAATGGTGGTAGTAGCCCTCTGGATCCTGATAATTCCAAAGGCTTCTTCTTTCTGGTGGAAGAAGGCAGGATGGACCATGGGTACCTTGAGGGCAAAGCCAAGCAGGCACTGAATCAGGCAGTGGAGATGTACCAGGCCAT |
>NM_001287172.1 |
CTAGTGGGTTTGTGTGACAATCACATCTGAAGGCTCTCTTCACTCCAAGATGGCCCTCCTGTCGCCCACTCTGGACTTGGTGGTCACAGCAGTTGGTAGCTTCCTTCTGTTCGTGCTGGCCCTGGGCCTGCTCTGTTTCTTCACCTGTCGCCTGGCCAGGCCACTCAGGATCGGAACGTCAATTAACGTCAATTAACATCTgacgctgcccccccccccctcttcccACCATCTGGGCTCCAGCGAGGGACGAATCTCAGGGTACACCATGATCTCACCATTTTTAGTACTGGCCATCGGCACCTGCCTTACCAACTCTTTTGTGCCAGagaaagagagagaccccAGTTACTGGCGACAGCAAGCCCAAGAGACCTTGAAAAATGCCCTGAAACTCCAAAAGCTCAACACCAATGTAGCCAAGAATGTCATCATGTTCCTGGGAGATGGTATGGGCGTCTCCACAGTAACCGCTGCCCGAATCCTTAAGGGCCAGCTACACCACAACACGGGCGAGGAGACCCGGCTGGAGATGGACAAATTCCCCTTTGTGGCCCTCTCCAAGACATATAACACCAACGCTCAGGTCCCTGACAGCGCGGGCACTGCCACTGCCTACTTGTGTGGCGTGAAGGCCAACGAGGGCACAGTGGGAGTGAGCGCAGCCACAGAGCGCACGCGATGCAACACCACTCAGGGCAATGAGGTCACATCCATCCTGCGCTGGGCCAAGGATGCTGGGAAGTCCGTGGGCATTGTGACTACCACTCGGGTGAACCACGCCACACCCAGTGCAGCCTACGCACACTCGGCCGATCGGGACTGGTACTCGGATAACGAGATGCCACCAGAGGCTCTGAGCCAGGGCTGCAAGGACATCGCATATCAGCTAATGCACAATATCAAGGATATCGACGTGATCATGGGTGGCGGCCGGAAATACATGTACCCGAAGAACAGAACTGATGTGGAATACGAACTGGATGAGAAGGCCAGGGGTACAAGGCTAGATGGCCTGGATCTCATCAGTATTTGGAAGAGCTTTAAACCCAGACACAAGCATTCCCACTATGTCTGGAACCGCACTGAACTGCTGGCCCTTGACCCCTCCAGGGTGGACTACCTCTTAGGTCTCTTTGAGCCCGGGGACATGCAGTATGAATTGAATCGGAACAACCTGACTGACCCTTCGCTCTCCGAGATGGTGGAGGTGGCCCTCCGGATCCTGACCAAAAACCTCAAAGGCTTCTTCTTGCTGGTGGAAGGAGGCAGGATTGACCACGGACATCATGAGGGTAAGGCCAAGCAGGCTCTGCATGAAGCAGTGGAGATGGACCAGGCCATTGGCAAGGCAGGCGCCATGACATCCCAGAAAGACACCTTGACTGTGGTTACTGCTGATCATTCCCACGTTTTCACATTCGGTGGATACACCCCCCGGGGCAACTCCATCTTTGGTCTGGCTCCCATGGTGAGCGACACGGACAAGAAGCCCTTCACGGCCATCCTATATGGTAACGGGCCTGGCTACAAGGTGGTGGACGGTGAACGGGAAAATGTCTCCATGGTAGATTACGCTCACAACAACTACCAGGCCCAGTCCGCTGTTCCCCTGCGCCATGAGACCCACGGTGGAGAAGACGTGGCGGTCTTTGCCAAGGGCCCGATGGCACACCTGCTTCACGGCGTCCATGAGCAGAACTACATTCCCCATGTGATGGCGTATGCCTCCTGCATTGGGGCCAACCTTGACCACTGTGCCTGGGCCGGCTCTGGGAGCGCACCCTCCCCAGGGGCCCTGCTGCTTCCACTGGCTGTGCTCTCCCTACGCACCCTGTTCTGAGGGTGCAGGTCCCACAAGCCCGCAATGGACAGCCAGCTCCCCTCCTTTTGTGGCCCACCACCGGGCAGCCCACACTCAAGGGAGAGGTCCAGGCAACTTCCAGCAGGAACAGAAGTTCGCTATCTGCCTTGCCTGTATCTGGAATCCTCCATGGGCCAGATTCCTGGCTCTGCCTTTATTCCCTAGTTATTGCCCTTTGGCCAGCAGGTTTCTCTCTTGGGCAGGCAAGACACAGACTGCACAGATTCCCAAAGCACCTtatttttctaccaaatatattCTCCAGACCCTGCAACCTCCATGGAACATTCCAGATCTGACCTTctctcctccatcccttcccttccctctggaACACTGGGCCCCATAGTCACGGCCAGTCCTCAAGCCCAACCCTCCCTGGGGGGAAGACCAGGTCTGCTCAGGATGAGACTCCCAGGAAGCCACCTCCGGGGTTGGCTGTCTACCCAGGGTTGCCAAGCTGGGAAGAACACTCCAGCcggacaggacacacacacacactccccacccaATTGCAGAGACTCGCCAACCCTTCACTGAAGTGGCTCTCCTGTTTGGAatagcggggtggggtgggggagaagaaagaaagaaagaaaaaaaatttttaatttctctttttggTGTTGGTTAAAAGGGAACACAAGACATTTAAATAAAACATCCCAAATATTTCTGAGGCCAG |
PMID - Link | Title |
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