Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name VcpP1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Mus musculus
Coordinates chrX:103388873-103392111  UCSC
Strand -
Parental Sequence NM_009503.4
Parental seq. overlap 3185 bp
Parental seq. overlap (%) 96%
Genomic Region Intragenic (Abcb7)
Retrocopy Summary VcpP1, located on chrX:103388873-103392111, is a retrocopy of the parental gene Vcp. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Vcp
Full Name valosin containing protein
Also known as 3110001E05|CDC48|p97|p97/VCP
Coordinate chr4:42979964-43000507
Strand -
Gene summary Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process; aggresome assembly; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and synapse. Part of ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>VcpP1
ggcTTTTCTCGGTTCAGTCTCCGTGAAGCGTTTGCAGCCGTCGTTTGATTAGTCGCTGCCCCCCTCGCGGATTAGGAGCTAGCGTctCCGGTGCCCCTGGGAGGAAGCGAGAGGGAGGCTGCCAGAGGGTTTGTCACTGCTGTTGCTCCTCCGCCTCAGCGAGTCCAGCCCGGGCCTAGTCGGTCGCCTGCCTTTCTCATAGCCGTTACCCTCAGGCCGCCACAGCCGCCGACCGGGAGAGGCGCGCGCCATGGCCTCTGGAGCCGATTCAAAAGGTGATGATTTATCAACAGCCATTCTCAAACAGAAGAACCGACCCAATCGGTTAATTGTTGATGAAGCCATCAATGAAGATAACAGCGTGGTGTCCTTGTCCCAGCCCAAGATGGATGAACTGCAGTTGTTCCGAGGTGACACGGTGTtgctaaaaggaaagaaaagacggGAAGCTGTATGCATTGTTCTTTCTGATGACACGTGTTCTGATGAGAAGATTCGAATGAATAGAGTTGTTCGGAATAACCTCCGAGTTCGCCTAGGAGATGTCATCAGCATCCAGCCATGCCCTGATGTAAAGTATGGCAAACGTATCCACGTTCTACCCATCGATGACACAGTGGAAGGCATCACTGGCAATCTCTTTGAGGTATACCTTAAGCCGTACTTCCTGGAAGCTTATCGGCCCATCCGTAAAGGAGATATTTTTCTTGTCCGGGGTGGGATGCGTGCTGTGGAGTTCAAAGTTGTAGAGACAGATCCCAGCCCTTACTGTATTGTTGCTCCAGACACAGTGATCCACTGTGAGGGGGAGCCAATCAAacgagaggatgaggaggaatcCTTGAATGAAGTAGGCTATGATGACATCGGTGGTTGCAGGAAGCAGCTAGCTCAGATAAAGGAGATGGTGGAGCTGCCACTGAGACATCCTGCGCTCTTCAAGGCGATTGGTGTAAAGCCTCCTCGGGGAATCTTGTTGTATGGGCCTCCTGGGACAGGGAAGACCCTGATTGCTCGAGCTGTGGCAAATGAAACTGGAGCCTTCTTCTTTCTGATCAATGGTCCTGAAATCATGAGCAAATTGGCTGGTGAGTCTGAGAGCAACCTTCGTAAAGCCTTTGAGGAAGCTGAAAAGAATGCTCCTGCTATCATCTTCATCGATGAGCTTGATGCCATTGCACCCAAAAGAGAGAAAACTCATGGGGAAGTGGAGCGTCGCATCGTGTCTCAGTTGTTGACCCTCATGGATGGCCTAAAGCAGAGAGCACATGTGATAGTTATGGCAGCAACCAATAGACCCAACAGCATTGACCCAGCCCTACGGCGATTTGGTCGCTTTGACAGAGAGGTAGATATTGGAATACCTGATGCTACAGGACGTTTGGAGATTCTTCAGATCCATACCAAGAACATGAAACTGGCAGATGATGTGGACTTGGAACAGGTAGCCAATGAGACTCATGGTCATGTTGGTGCTGATTTGGCAGCCCTATGTTCAGAGGCTGCTCTGCAGGCCATCCGGAAAAAAATGGACCTCATTGACCTAGAAGATGAGACCATTGATGCTGAGGTCATGAATTCCCTGGCAGTTACTATGGATGACTTCCGGTGGGCTTTGAGTCAAAGCAACCCATCAGCACTTCGGGAAACTGTGGTAGAGGTGCCACAAGTAACCTGGGAAGATATTGGAGGCCTGGAGGATGTCAAACGTGAGCTTCAGGAGTTGGTTCAGTACCCCGTGGAACATCCAGACAAATTCCTCAAATTTGGCATGACTCCCTCCAAAGGTGTTCTTTTCTATGGACCTCCTGGCTGTGGGAAAACCTTACTGGCTAAAGCCATTGCTAATGAATGCCAGGCCAACTTCATCTCCATCAAGGGTCCTGAGCTGCTTACCATGTGGTTTGGGGAATCTGAGGCCAATGTCCGGGAAATTTTTGACAAGGCACGTGTACTCTTCTTTGATGAGTTAGATTCAATTGCCAAGGCTCGTGGTGGTAATATTGGAGATGGTGGTGGAGCTGCTGACCGAGTCATCAATCAGATCTTGACAGAAATGGATGGCATGTCTACAAAAAAGAATGTGTTTATCATTGGAGCTACCAACAGGCCTGACATCATTGATCCTGCTATCCTAAGACCTGGCCGTCTAGATCAGCTCATTTATATCCCACTTCCTGATGAGAAGTCCCGTGTTGCCATCCTAAAAGCCAATCTGCGAAAGTCCCCAGTTGCCAAGGATGTGGATTTGGAGTTCCTGGCTAAGATGACTAATGGCTTTTCTGGAGCTGATTTGACAGAAATTTGCCAACGGGCTTGTAAACTGGCCATTCGTGAATCTATTGAGAGTGAGATTAGGCGAGAACGAGAGAGGCAGACAAATCCATCGGCCATGGAGGTAGAAGAGGACGATCCAGTGCCTGAGATCCGCAGAGATCACTTTGAGGAAGCCATGCGTTTTGCCCGACGTTCTGTCAGCGATAATGACATTCGGAAGTATGAAATGTTCGCCCAGACACTGCAGCAGAGTCGAGGTTTTGGCAGCTTCAGATTCCCTTCAGGGAACCAGGGTGGAGCTGGTCCCAGCCAGGGCAGTGGAGGTGGCACAGGTGGCAGTGTGTACACAGAAGACAATGACGATGACCTGTATGGCTAAGTGATGTGCCAGCATGCAGCGAGCTGGCCTGGCTGGACCTTGTTCCCTGGGGGAGGGGGCGCTTGCCCAAGAGGGCCCAGGGGTGTGCCCATGGCCTGCTCCATTCCTCAGTCTGAACAGTTCAGCCCAGTCAGACTCTGGACAGGGGTTtcctgttgcaaaaaaaaaaattacaaaagcgataaaataaaagtgattttCATTTGGGAGGTGAAGAGTGAATTACCAGCAAGGAATTGGGTCTTGGGCCCACACGGTTTCTGTCGTAGTTTGGGGTGGTGCAGGTAACCTGTGTGGTGTGAACCAAGGCAttgccaccaccatcaccacagtaAAGCATCTATACTCAATGCTGTCCAAGTCCTCTCTTACCCTAGCCAACCTGGGTAGGTGGATGAGGGGCCTCAGTTTGCTGGGTGTTTATATAGAAAGtaggttgatttttattttacatgcttTTGAGTTACTGTTGGAAGACTAATCATAAGCAGTTtctaaaccagacatgttgtAAAAGGACAATAAATGTTGggtcaaaatgga
>NM_009503.4
GAGTCCCAAGGCCGGCGCTGATTGGTTGGGGTTAGAGCAGCTTTCCTTCCGATGATTCGGCTTTTCTCGGTTCAGTCTCCGTGAAGCGTTTGCAGCCGTCGTTTGATTAGTCGCTGCCCCCCTCGCGGATTAGGAGCTAGCGTctcccgcccgcccgcctgccGCCCCGGTGCCCCTGGGAGGAAGCGAGAGGGAGGCTGCCAGAGGGTTTGTCACTGCTGTTGCTCCTCCGCCTCAGCGAGTCCAGCCCCGGCCTAGTCGGTCGCCTGCCTTTCTCATAGCCGTTACCCTCAGGCCGCCACAGCCGCCGACCGGGAGAGGCGCGCGCCATGGCCTCTGGAGCCGATTCAAAAGGTGATGATTTATCAACAGCCATTCTCAAACAGAAGAACCGACCCAATCGGTTAATTGTTGATGAAGCCATCAATGAAGATAACAGCGTGGTGTCCTTGTCCCAGcCCAAGATGGATGAACTGCAGTTGTTCCGAGGTGACACGGTGTtgctaaaaggaaagaaaagacggGAAGCTGTATGCATTGTTCTTTCTGATGACACGTGTTCTGATGAGAAGATTCGAATGAATAGAGTTGTTCGGAATAACCTCCGAGTTCGCCTAGGAGATGTCATCAGCATCCAGCCATGCCCTGATGTAAAGTATGGCAAACGTATCCACGTTCTACCCATCGATGACACAGTGGAAGGCATCACTGGCAATCTCTTTGAGGTATACCTTAAGCCGTACTTCCTGGAAGCTTATCGGCCCATCCGTAAAGGAGATATTTTTCTTGTCCGGGGTGGGATGCGTGCTGTGGAGTTCAAAGTTGTAGAGACAGATCCCAGCCCTTACTGTATTGTTGCTCCAGACACAGTGATCCACTGTGAGGGGGAGCCAATCAAGCGAGAGGATGAGGAGGAATCCTTGAATGAAGTAGGCTATGATGACATCGGTGGTTGCAGGAAGCAGCTAGCTCAGATAAAGGAGATGGTGGAGCTGCCACTGAGACATCCTGCGCTCTTTAAGGCGATTGGTGTAAAGCCTCCTCGGGGAATCTTGTTGTATGGGCCTCCTGGGACAGGGAAGACCCTGATTGCTCGAGCTGTGGCAAATGAAACTGGAGCCTTCTTCTTTCTGATCAATGGTCCTGAAATCATGAGCAAATTGGCTGGTGAGTCTGAGAGCAACCTTCGTAAAGCCTTTGAGGAAGCTGAAAAGAATGCTCCTGCTATCATCTTCATCGATGAGCTTGATGCCATTGCACCCAAAAGAGAGAAAACTCATGGGGAAGTGGAGCGTCGCATCGTGTCTCAGTTGTTGACCCTCATGGATGGCCTAAAGCAGAGAGCACATGTGATAGTTATGGCAGCAACCAATAGACCCAACAGCATTGACCCAGCCCTACGGCGATTTGGTCGCTTTGACAGAGAGGTAGATATTGGAATACCTGATGCTACAGGACGTTTGGAGATTCTTCAGATCCATACCAAGAACATGAAACTGGCAGATGATGTGGACTTGGAACAGGTAGCCAATGAGACTCATGGTCATGTTGGTGCTGATTTGGCAGCCCTATGTTCAGAGGCTGCTCTGCAGGCCATCCGGAAAAAAATGGACCTCATTGACCTAGAAGATGAGACCATTGATGCTGAGGTCATGAATTCCCTGGCAGTTACTATGGATGACTTCCGGTGGGCTTTGAGTCAAAGCAACCCATCAGCACTTCGGGAAACTGTGGTAGAGGTGCCACAAGTAACCTGGGAAGATATTGGAGGCCTGGAGGATGTCAAACGTGAGCTTCAGGAGTTGGTTCAGTATCCTGTGGAACATCCAGACAAATTCCTCAAATTTGGCATGACTCCCTCCAAAGGCGTTCTTTTCTATGGACCTCCTGGCTGTGGGAAAACCTTACTGGCTAAAGCCATTGCTAATGAATGCCAGGCCAACTTCATCTCCATCAAGGGTCCTGAGCTGCTTACCATGTGGTTTGGGGAATCTGAGGCCAATGTCCGGGAAATTTTTGACAAGgcACGGCAAGCTGCCCCCTGTGTACTCTTCTTTGATGAGTTAGATTCAATTGCCAAGGCTCGAGGTGGTAATATTGGAGATGGTGGTGGAGCTGCTGACCGAGTCATCAATCAGATCCTGACAGAAATGGATGGCATGTCTACAAAAAAGAATGTGTTTATCATTGGAGCTACCAACAGGCCTGACATCATTGATCCTGCTATCCTAAGACCTGGCCGTCTAGATCAGCTCATTTATATCCCACTTCCTGATGAGAAGTCCCGTGTTGCCATCCTAAAAGCCAATCTGCGAAAGTCCCCAGTTGCCAAGGATGTGGATTTGGAGTTCCTGGCTAAGATGACTAATGGCTTTTCTGGAGCTGATTTGACAGAAATTTGCCAACGGGCTTGTAAACTGGCCATTCGTGAATCTATTGAGAGTGAGATTAGGCGAGAACGAGAGAGGCAGACAAATCCATCGGCTATGGAGGTAGAAGAGGACGATCCAGTGCCTGAGATCCGCAGAGATCACTTTGAGGAAGCCATGCGTTTTGCCCGACGTTCTGTCAGCGATAATGACATTCGGAAGTATGAAATGTTCGCCCAGACACTGCAGCAGAGTCGAGGTTTTGGCAGCTTCAGATTCCCTTCAGGGAACCAGGGTGGAGCTGGTCCCAGCCAGGGCAGTGGAGGTGGCACAGGTGGCAGTGTGTACACAGAAGACAATGACGATGACCTGTATGGCTAAGTGATGTGCCAGCATGCAGCGAGCTGGCCTGGCTGGACCTTGTTCCCTGGGGGAGGGGGCGCTTGCCCAAGAGGGACCAGGGGTGTGCCCATGGCCTGTTCCATTCCTCAGTCTGAACAGTTCAGCCCCAGTCAGACTCTGGACAGGGGTTtcctgttgcaaaaaaaaaaaattacaaaagcgataaaataaaagtgattttCATTTGGGAGGTGAAGAGTGAATTACCAGCAAGGAATTGGGTCTTGGGCCCACACGGTTTCTGTCGTAGTTTGGGGTGGTGCAGGTAACCTGTGTGGTGTGAACCAAGGCAttgccaccaccatcaccacagtaAAGCATCTATACTCAATGCTGTCCAAGTCCTCCCTTACCCTAGCCAACCTGGGTAGGTGGATGAGGGGCCTCAGTTTGCTGGGTGTTTATATAGAAAGtaggttgatttttattttacatgcttTTGAGTTACTGTTGGAAGATTAATCATAAGCAGTTtctaaaccaaaaaaaagaagaaaaaaaaaagacatgttgtAAAAGGACAATAAATGTTGGGTCAAAATGG

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