Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Prps1P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr12:35034881-35035827  UCSC
Strand +
Parental Sequence NM_021463.4
Parental seq. overlap 826 bp
Parental seq. overlap (%) 41.8%
Genomic Region Intergenic
Retrocopy Summary Prps1P1, located on chr12:35034881-35035827, is a retrocopy of the parental gene Prps1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Prps1
Full Name phosphoribosyl pyrophosphate synthetase 1
Also known as 2310010D17Rik|PRS-I|Prps-1
Coordinate chrX:139357352-139376889
Strand +
Gene summary Predicted to enable ATP binding activity; protein homodimerization activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in several processes, including 5-phosphoribose 1-diphosphate biosynthetic process; purine-containing compound biosynthetic process; and urate biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process and phosphorylation. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; inner ear; and retina. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens PRPS1L1
Chimpanzee Pan troglodytes PRPS1P1
Bonobo Pan paniscus PRPS1P1
Gorilla Gorilla gorilla PRPS1P1
Orangutan Pongo abelii PRPS1P1
Gibbon Nomascus leucogenys PRPS1P2
Green monkey Chlorocebus sabaeus PRPS1P2
Crab-eating macaque Macaca fascicularis PRPS1P1
Rhesus Macaca mulatta PRPS1P1
Baboon Papio anubis PRPS1P1
Golden snub-nosed monkey Rhinopithecus roxellana PRPS1P1
Marmoset Callithrix jacchus PRPS1P2
Mouse lemur Microcebus murinus PRPS1P3
Rat Rattus norvegicus Prps1P1
Chinese hamster Cricetulus griseus Prps1_1P2
Horse Equus caballus PRPS1P1
Cat Felis catus PRPS1P1
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Prps1P1
GCCAAGATGCCAAACATCAAACTCTTCAGCGGAAGCTCCCACCAGGACTTATCCCAGAAGATTACTGAGCGCCTGGGCCTCGAGCTCAGCAAGGTGGTCACTAAGAAGTTCAGCAACCAGGAGACCTGCGTGGAAATTGGTGAGAGTGTGCGTGGAGAAGATGTCTACATCGTTCAGAGCGGTTGTGGTGAGATCAACGACAGTCTAATGGAACTTTTGATCATGATCAATGCCTGCAAGATCGCTTCAGCCAGCAGGGTGACTGCAGTCATCCCGTGCTTCCCTTATGCCCGGCAGGATAAAAAGGATAAGAGCCGGGCTCCCATCTCTGCGAAGCTCGTAGCAAATATGCTGTCTATAGCAGGTGCAGATCACATTATCACCATGGACCTACATGCTTCTCAGATCCAGGGGTTTTTTGACATCCCGGTAGACAATTTGTATGCAGAGCCAGCTGTGCTGAAGTGGATAAAGGAGAATATTTCTGACTGGAGGAACTGCACGATTGTCTCTCCTGATGCTGGCGGAGCCAAGAGGGTCACTTCCATCGCGGACCATTTGAATGTGGATTTTGCCTTGATTCACAAAGAACGGAAGAAAGCCAATGAAGTGGACCGCATGGTGCTTGTGGGTGATGTGAAGGATCGGGTGGCTATTCTTGTAGATGACATGGCTGATACTTGTGGTACAATCTGTTACGCGGCGGACAAACTTCTCTCAGAGGGAGCTACCAGAGTTTATGCCATCTTGACTCATGGCATCTTTTCTGGCCCAGCTATTGCTCGCATCAATGGCGCATGCTTTGAAGCAGTAGTAGTCACAAACACCATACCTCAAGAAGACAAGATGAAACAGTGTAGCAAAATCCAGGTGATTGACATCGCCATGATCCTTGCTGAAGCCATCCGGAGAACCCATAACGGAGAATCTGTTTCCTACCTGTTCAG
>NM_021463.4
GCCGCGCGCTGGGCGGGAATGTAAGATGGCGGAGTAGCAACGCGGTACTGTTGGTGTTCAGACTGCCTGCTGACTTCCGTTCCCGTGttggcagcggcggcggcggcgaccaCTGAGCACGTTGAGGTAGTTACCCAAGATGCCGAATATCAAAATCTTCAGCGGGAGCTCCCACCAGGACTTATCCCAGAAAATCGCTGACCGCCTGGGCCTTGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACCTGtgtGGAAATTGGCGAAAGCGTTCGTGGAGAAGATGTCTACATTGTTCAAAGTGGGTGTGGTGAGATAAATGACAATCTAATGGAGCTTTTGATCATGATTAATGCTTGTAAGATCGCTTCAGCCAGCCGGGTTACTGCAGTCATCCCATGCTTCCCTTACGCCCGCCAAGATAAGAAGGATAAGAGCCGGGCTCCAATCTCAGCTAAGCTTGTTGCAAATATGCTATCTGTAGCAGGTGCAGATCATATTATCACCATGGATCTACATGCATCTCAAATTCAGGGTTTCTTTGATATCCCGGTGGACAATTTATATGCAGAGCCAGCTGTCCTAAAGTGGATACGGGAGAATATATCTGAGTGGAGAAACTGTACTATTGTCTCACCTGATGCTGGTGGAGCCAAAAGAGTGACCTCCATTGCAGACCGGCTGAATGTGGATTTTGCTTTGATTCACAAGGAACGGAAGAAGGCCAATGAAGTGGACCGCATGGTACTTGTGGGAGATGTGAAGGACCGTGTGGCTATACTTGTGGATGACATGGCTGACACTTGCGGTACAATCTGTCACGCCGCTGACAAACTTCTCTCAGCTGGCGCTACCAGAGTTTATGCTATCTTGACGCATGGAATCTTTTCTGGCCCTGCCATTTCTCGAATCAACAATGCATGCTTTGAAGCAGTAGTAGTTACCAATACCATACCTCAGGAGGACAAGATGAAACACTGCTCCAAGATACAGgTGATTGACATCTCTATGATCCTTGCAGAAGCCATCAGGAGAACCCACAATGGAGAATCTGTCTCCTACTTGTTCAGCCATGTTCCTTTATAACATAACTTCTGAAGCATTTTGAAAATAAACCAACCCCACCCCTTGTTTTTCTTGGTATTGGTGAGTTGAGCAGAAGACCCAGCTTGCTTCAGTATAGCTTTTTCCATCTCACATTAGCTATATTACCATTTGTCCTAAATGGGAGAAAGACAGATTGCTATTAGCTGCTAGGATGTTCAACCTGCATTGTTGTATCctggctttcttgtttattttgtgaACCTTGCAGCTTTAAGTTGAGCTCAGCTCTTGAAAGGTGTATAGACTGTTAAGAGAGTATTCCACAAGGTCCTTAGGACGTGATTGGCAAAGCTCATACTCCATTGCATGTGAACGCTTTGGGGTTTTCGTCATTCAGAATAACTAGCAACAAAGCCAGCCCATGTGTAATACATTTTCAGAGGTCTGCAGCAAGAACCCTGAGCATCcttaaacatagttgagcatccTGTAAGGCAGGGGCAGGTAGCTCAATGCAGTAATTAGGTTTTGGGAGGAAGAAGCCTGATCCATTGCTATTTAACTCTTCTCTATCTCGCTTGGATTCTCTACACCTATTCCTTTCCAGTTGGCTTTACCTTTAGCTATTGTGACCCTTTCCTGGCCAAATATCTTGGACTCAGTGATCATTGTAACAATATCTTCGGTAATACAGACTTGCTTCTTGCTATGTAACTGCTAACATTCACATTAGGTAACTTGCTGTAGCACGACCTTCCTTAGCCTACTACCTCTGAGGTGGTGGGTTTAGGTGGTGTCGCAGTGCCTTTTGATTAATTtaagtatttaatttttatcttcctTGGATCCGTTTGGCCTCTCAATTGAACTTACTGTATTGTGTAGAAGAAACTTAATAAAATGTCTGTCATGTGTGCA

Publications

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