| Retrocopy Name | PRPS1L1 |
|
| Species | Homo sapiens | |
| Coordinates (hg38) | chr7:18026812-18027796 UCSC | |
| Coordinates (T2T) | chr7:18156499-18157483 UCSC | |
| Coordinates (hg19) | chr7:18066435-18067419 UCSC | |
| Strand | - | |
| Parental Sequence | NM_002764.4 | |
| Parental seq. overlap | 907 bp | |
| Parental seq. overlap (%) | 43.8% | |
| Genomic Region |
Intergenic |
|
| Retrocopy Summary | PRPS1L1, located on chr7:18026812-18027796, is a retrocopy of the parental gene PRPS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
| Gene Name | PRPS1 |
| Full Name | phosphoribosyl pyrophosphate synthetase 1 |
| Also known as | ARTS|CMTX5|DFN2|DFNX1|PPRibP|PRS-I|PRSI |
| Coordinate | chrX:107628510-107651026 |
| Strand | + |
| Gene summary | This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
| >PRPS1L1 |
| GGTAGTTGGCCAAGACGCCGAATATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCCCAGAAAATTGCTGACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACCTGCGTGGAAATTGATGAGAGTGTGCGTGGAGAGGATGTCTACATCGTTCAGAGTGGTTGTGGCGAAATCAACGACAGTCTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCTTCAGCTAGCCGAGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGACAGGATAAGAAGGATAAGAGCCGGTCCCCAATCTCTGCCAAGCTTGTTGCAAATATGCTCTCTATAGCAGGTGCGGATCATATCATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATCCCAGTAGACAACTTGTATGCAGAGCCAACTGTCCTGAAGTGGATAAGGGAGAATATCCCTGAGTGGAAGAACTGCATTATTGTCTCGCCAGATGCTGGTGGAGCTAAAAGAGTGACCTCCATTGCAGACCAGTTGAATGTGGACTTTGCTTTGATTCATAAAGAACGGAAGAAGGCCAATGAAGTGGACTGCATAGTGCTAGTGGGAGATGTGAATGATCGTGTGGCTATCCTTGTAGATGACATGGCAGACACTTGTGTTACAATCTGCCTCGCAGCTGACAAACTTCTCTCAGCTGGAGCAACCAGAGTTTATGCTATCTTGACTCATGGAATCTTTTCTGGCCCAGCCATTTCTCGCATCAACACTGCATGCTTTGAAGCAGTGGTAGTCACCAATACCATACCTCAAGATGAGAAGATGAAGCATTGCTCCAAAATACGAGTAATTGACATCTCCATGATCCTTGCAGAAGCCATAAGGAGAACTCATAATGGGGAATCTGTTTCCTACCTGTTCAGCCATGTTCCTTTATAACAGAATAACTTCTA |
| >NM_002764.4 |
| AATGTAAGATGGCGGAGTAGCAACGCAAAGCGCTTGGTATTGAGTCTGTGGCCGACTTCGGTTCCGGTCTCTGCAGCAGCCGTGATCGCTTAGTGGAGTGCTTAGGGTAGTTGGCCAGGATGCCGAATATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCTCAGAAAATTGCTGACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACCTGTGTGGAAATTGGTGAAAGTGTACGTGGAGAGGATGTCTACATTGTTCAGAGTGGTTGTGGCGAAATCAATGACAATTTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCTTCAGCCAGCCGGGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGGCAGGATAAGAAAGATAAGAGCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGCTATCTGTAGCAGGTGCAGATCATATTATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATCCCAGTAGACAATTTGTATGCAGAGCCGGCTGTCCTAAAGTGGATAAGGGAGAATATCTCTGAGTGGAGGAACTGCACTATTGTCTCACCTGATGCTGGTGGAGCTAAGAGAGTGACCTCCATTGCAGACAGGCTGAATGTGGACTTTGCCTTGATTCACAAAGAACGGAAGAAGGCCAATGAAGTGGACCGCATGGTGCTTGTGGGAGATGTGAAGGATCGGGTGGCCATCCTTGTGGATGACATGGCTGACACTTGTGGCACAATCTGCCATGCAGCTGACAAACTTCTCTCAGCTGGCGCCACCAGAGTTTATGCCATCTTGACTCATGGAATCTTCTCCGGTCCTGCTATTTCTCGCATCAACAACGCATGCTTTGAGGCAGTAGTAGTCACCAATACCATACCTCAGGAGGACAAGATGAAGCATTGCTCCAAAATACAGGTGATTGACATCTCTATGATCCTTGCAGAAGCCATCAGGAGAACTCACAATGGAGAATCCGTTTCTTACCTATTCAGCCATGTCCCTTTATAATAGAGTAACTTCTGAGGCTTTTTGAGAATAAAATCCACCCCACCCTTGTTTCCCCTTGGTATTTGATGACAAATTCAGCAGAAGACCCGGCTTGCTCCAGTGTAGCTTTCTACATCCCACATCAGGTATATTAGAGCTTATCCGAACTGGGGAAAGACGGATTGAGATTAACTGCTGGGACCTCCTACCTGCATTATCTCATTCTGGCTTCCTTGATAATTCTGTGGGCCTTGCAGCTTTAACTATAGCTCAGCTGCTGCAAGATTTCAGACTTTTGAGGATGTTGTGTGAGGGTGTTTGACTGTGACTGGGGAAGCTCAGACTACTTTGTATGTGAATGCTTCAGGGTTTTCTTTGTTGAGAACAACTAGCAACAAAGGCAACCCATGTGTGACCAGTTCTCCCCAAGGTCTATGCTAAATTATAGCAAGAGCCCTGGGCAACCCCAAACCTAGTCCTGGTAGCTGAGCACCCTGTAAGGCAGGAGCAGGCAGCTCAGCTTGAGCAGACATTGGGTGGGGGGTGGGGGGTGGTTGAGGGGGGAGGCAGCACAGTGCAGCAAATGTTTCTTGGGAGGAAGAAGCCTGATCCATCACCATCTGCTTGACTATGTAGCTTGGATTCTCCTTTGTACCTATCCCTTTCGATTTGGCTTTACCTTCATCTATCTTGATCCTTTCCTGGCCAAATATCCTCTTGGGCCCAAATGAACATTGTACCATAGTCTTCTGGAAAGCAAACATGCTTCCTGCTATGTAATTGCTAACATTCATATTAGATGATGTGCTGTAGCTTGATCTTCCTTAGCCTACTGCCACTGAGGCAGTAGGTTTTAGGTGGTATCGTAGTGCCTTTTGATTAATTTAAGTATTTAATTTTCATCTTCCTTCTTTGGATCTATTTGGCCTCTCAAATGAACTGAGATTCCTGTTAAAAAAGATTGATGTTATTGTCTCTTGTAGAGGAAACTAATAAAGTGTGTGTACCTGTGTGA |
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