Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Calm3P2
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr13:3853826-3854011  UCSC
Strand -
Parental Sequence NM_007590.3
Parental seq. overlap 157 bp
Parental seq. overlap (%) 7.1%
Genomic Region Intergenic
Retrocopy Summary Calm3P2, located on chr13:3853826-3854011, is a retrocopy of the parental gene Calm3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Calm3
Full Name calmodulin 3
Also known as CaMA|Cam3|Camc
Coordinate chr7:16649304-16657957
Strand -
Gene summary Predicted to enable several functions, including N-terminal myristoylation domain binding activity; enzyme activator activity; and enzyme binding activity. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in myelin sheath. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; and long QT syndrome 15. Orthologous to human CALM1 (calmodulin 1); CALM2 (calmodulin 2); and CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Green monkey Chlorocebus sabaeus CALM3P1
Rat Rattus norvegicus Calm3P1
Chinese hamster Cricetulus griseus Calm3_1P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Calm3P2
GACTTCCCCGAGTTCCTGACAATGATGTCCAGGAAGATGAAAGACACTGACAGCGAGGAGGAGATCCGAGAGGCCTTCCGAGTGTTCGACAAGGATGGCAATGGCTTCGTCAGTGCAGCCGAGCTGAGGCACGTGATGACCAAGCTGGGGGAGAAGCTGAGCGATGAGGAAGTGGACGAAATGATA
>NM_007590.3
CGGGGCCGGGCGAGGCGGGGCGCGCGCGGCGGCCGTTGAGGGACCGTTGgggcgggcggcggcggcggtggcgcgCGCTGCGGGCAAAGAGTGTGGAGGCGCGGACGCGCGGCGGAGCTcgagctgctgcagctgctgccgcCGCCAGAGTAACCTCGATCCCCGAGCTCCGGATACCGGTGCCTCGCCATGgCTGACCAGCTGACTGAGGAACAGATTGCAGAGTTCAAGGAAGCCTTCTCCCTCTTCGACAAGGATGGAGATGGCACCATTACCACCAAGGAGCTGGGGACTGTGATGAGATCGCTGGGACAGAACCCCACTGAGGCGGAGCTGCAGGACATGATTAATGAGGTGGATGCTGATGGCAATGGGACCATTGACTTCCCAGAGTTCTTGACCATGATGGCCAGAAAGATGAAGGATACAGACAGCGAGGAGGAGATACGAGAGGCCTTCCGTGTCTTTGACAAGGATGGGAATGGCTATATTAGCGCTGCCGAGCTGCGTCACGTCATGACGAACCTGGGGGAGAAGCTGACAGATGAGGAAGTGGATGAGATGATCCGAGAGGCCGACATTGATGGAGATGGCCAGGTCAATTATGAAGAGTTTGTACAGATGATGACTGCGAAGTGAAGGCCCGGGCAGCTGGCCATGCCCGTTCTCCTGATCTCTTCTCGCGCTCTCCTCTCTTCAACACTCCCCTGCGTACCCGGTTCTAGCAAACAGCAATTGATTGACTGAGAATCTGATAAAGCACCAAAAGATTTGTCCCAAGCTGCATGactgctctctctccttcctcctgacTGTCCCTCCACGCCCTCACCGCTTCCTTTGGCCTTCCCCTTCCATTCCCAGTCTCCAGGCCTGATGCATTCACAAGGTGAACCCCATTGCCCTGCCCTGGGGAgcctctgccctcctcctccaGCCCGGATGGCTCTCCTCCggttttggtttgtttccttttgtttgccCTTCTTTTGGGTGCCGGGGTGGCCACCATTCCTGTCCCTGCTcagtggggaggggagcaagGCCTTCTGCCAGGTGGAGGAGCATGTCCCCTGCCACTGTCGCATGCACCCCAGCCCTGTGACTCTGTGTGCAAGCCCAGCAGCCTGTGGGGCGGGGTGCCAAGAGGGGATGACGGGACGTTCCAGGACCGAGGGAGTTGAGGATGTGACCCAggacggggggcgggggggggggttgtgtgtgtggaAGGGTGGGAAGAGGCAGGAAGGCCTTGGAAGCTAACATGCTTTCGCTACTGGAGGGGGACTGCATAGAGTGGACGGCACTCGGGTCTCGCTGCCGCTGTTCTGAAACCATCTGGCTGGCTTTCTGAGGTCAGGCTGGGTGGGGGGCTGTCATCGGCCATGCTGCCGATCATACTCGCCCTCCTCATCCCTCCAGCCATGTCCCGCTGTTCTGTAAATACCTGGTGCTAACATCCCATGCCGCTCCCCCGTGGCACCCCCAGCCACCTGCCCAGTTCAGGGCTGGTCCAGGAATGGATGTGGGGGATGGTCGCTGTGTAATGTGCCGGtgatctttttttccccttcccctttatGCCCCTTAAAACTTTGATTTTTGTCCTAAACATGCCGGGCCAACTaaagggtggggagaggagagatgcGCCCCACCATGCTCACAAGAACCAACCTGCAATAAACACTTCTATGGGCCGCCGCGCAGAGCACGCAGCGGGCACCTCCTGCCCCTCCGTGGTGACTTGGCATCGCTTTCTGCCCTCGCCCTGCCTGCCCCACTCCCCAGCGGAGAGCATGATCCGCACCCTTGCTTCTGACTCTAGCCTCTGGGACACGTCAGTCAACGCGGGCAGTTCGGTCTgggttcctttcctttctctgttctcATCTGGCCCCCCAGGGTGATCTTGTTGCTTTTTGCTGGGACCTGCCAGCTTTGAGACTCTCCACCCCTTGGCACCAGccttaagggagggagggacagagcaaATCAGGAGACCCAGCCTAGAGTTGAGGGCAAGGGCAGGTAGGCGTGAGGCTGTGGACTTTGCGGAATGTTTCggggttttattttggttttttgtttttccttttttttttttttttttaaacaaacaaacaaaccgggCAATATTGTGTTCAGTTCAAGCtgtgaagaaaaatatatatcaatgtTTTCCAATAAAATACAGTGACTACC

Publications

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