Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Fth1P3
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr18:52465036-52465200  UCSC
Strand +
Parental Sequence NM_010239.2
Parental seq. overlap 132 bp
Parental seq. overlap (%) 14%
Genomic Region Intragenic (Kctd1)
Retrocopy Summary Fth1P3, located on chr18:52465036-52465200, is a retrocopy of the parental gene Fth1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Fth1
Full Name ferritin heavy polypeptide 1
Also known as FHC|Fth|HFt|MFH
Coordinate chr19:9960010-9962475
Strand +
Gene summary Enables iron ion binding activity. Acts upstream of or within iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to human FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Gibbon Nomascus leucogenys FTH1P3
Baboon Papio anubis FTH1P4
Golden snub-nosed monkey Rhinopithecus roxellana FTH1P6
Marmoset Callithrix jacchus FTH1P6
Rat Rattus norvegicus Fth1P6
Chinese hamster Cricetulus griseus Fth1_1P1
Dolphin Tursiops truncatus FTH1P6
Cat Felis catus FTH1P1
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Mouse lemur Microcebus murinus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Fth1P3
AGAGAGGGAACATGCAGAGAAGCTAATGAAACTGCAGAACCAGCGAGGAGGCCGGATCTGCCTCCAGGACATCAAGAAGCCAGATAAAGATGACTGGGAATGCGGACTGCGGGCCATGGAATGTGCCCTGCTCCTGGAAAAGAATGTAAACCAGTCGCTGCTGGA
>NM_010239.2
AGCGCTCGCCTGACGCAGGATCCCGCTATAAGTGCGGCCCGCTGTCCCCTCCTGCGCCAGACGTTCTCGCCCAGAGTCGCCGCGGTTTCCTGCTTCAACAGTGCTTGAACGGAACCCGGTGCTCGACCCCTCCGACCCCCGCCGGCCGCTTCGAGCCTGAGCCCTTTGCAACTTCGTCGTTCCGCCGCTCCAGCGTCGCCACCGCGCCTCGCCCCGCCGCCACCATGACCACCGCGTCTCCCTCGCAAGTGCGCCAGAACTACCACCAGGACGCGGAGGCTGCCATCAACCGCCAGATCAACCTGGAGTTGTATGCCTCCTACGTCTATCTGTCTATGTCTTGTTATTTTGACCGAGATGATGTGGCTCTGAAGAACTTTGCCAAATACTTTCTCCACcaatctcatgaggagagggaGCATGCCGAGAAACTGATGAAGCTGCAGAACCAGCGAGGTGGCCGAATCTTCCTGCAGGATATAAAGAAACCAGACCGTGATGACTGGGAGAGCGGGCTGAATGCAATGGAGTGTGCACTGCACTTGGAAAAGAGTGTGAATCAGTCACTACTGGAACTGCACAAACTGGCTACTGACAAGAATGATCCCCACTTATGTGACTTCATTGAGACGTATTATCTGAGTGAACAGGTGAAATCCATTAAAGAACTGGGTGACCACGTGACCAACTTACGCAAGATGGGTGCCCCTGAAGCTGGCATGGCAGAATATCTCTTTGACAAGCACACCCTGGGACACGGTGATGAGAGCTAAGCTGACTTCCCCAAAGCCACGTGACTTTACTGGTCACTGAGGCAGTGCATGCATGTCAGGCTGCCTTCATCTTTTCTATAAGTTGCACCAAAACATCTGCttaagttctttaatttgtaccATTTCTTCAAATAAAGAATTTTGGTACCCAGCTTCTTTTCTTTGTGAT

Publications

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