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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name H2az1P8
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr14:108909820-108910359  UCSC
Strand +
Parental Sequence NM_016750.3
Parental seq. overlap 451 bp
Parental seq. overlap (%) 42%
Genomic Region Intragenic (Arhgap26)
Retrocopy Summary H2az1P8, located on chr14:108909820-108910359, is a retrocopy of the parental gene H2az1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name H2az1
Full Name H2A.Z variant histone 1
Also known as H2A.Z|H2A.Z1|H2a.z-1|H2afz
Coordinate chr3:137570248-137572683
Strand +
Gene summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>H2az1P8
GAATGCATCAAAAGATGTAAAGGTAAATTGTATTTCCACTGGTCACTTGCAACCTGCTATTCATGGAGATAAAGAATTGGACTATCTGATCAAGGCTAATTGCTGGTGGTGGTGTCATTCCTCACACCATAAATCTGATTGGGAAGAAGGGACAGGAGGAGATTTTGGATGACTGGATTCCTTGTTATCTCAGGACTctaagtattcttaaccactgtgcaGTGTTAGTAATGCCCGTGGACCATTTCTCTGTGAAAAATATAGTGTGGTCTTTTTGTGATTCTATCCAGCAAGTTGGAGGCTTAATTAGCGTTCCAACCAACCAAATTTCTGCATTCAAGCCTTGGCCATATTTAAGTATTATTGTGGCATCAAATAAGCTATTCTTTCTAAAGGAGTGTGTTTGGTTGAGTTGACTGTGTTTTTCAAAACTGGGCAAATTTTAATTGTGATGCAGGAATTATAGTAAAAAACATTTGGTTCGGTATAAACATTATGTGCATTCTGATGTATAAGCTCAGTAAGGTCATAGTCCAAact
>NM_016750.3
GTCCCGAGGGCGGGAGGCAACCATTGGTGGGCCGAACCGGCCGAGTTCCCGGATGAGGGAACATTCTGCAGTATAAAGGGCGCGAGGAAGGCGGGAGACGGCGCAGTTTGAATCGCGGTCCGACGGAGGAGTGGGCGCTGGGATCTCGCTGAGCGTCCGCCTGGCCTCGTCTCTTCCTCGCTCGTCGGAGCTTCAGCACGGTCCGAGATGGCTGGCGGTAAGGCTGGAAAGGACTCCGGAAAGGCCAAGACAAAGGCGGTTTCCCGCTCGCAGCGAGCCGGCTTGCAGTTCCCTGTGGGCCGTATTCATCGACACCTGAAATCTAGGACAACCAGCCACGGACGTGTGGGCGCGACCGCCGCTGTGTACAGCGCAGCCATCCTGGAGTACCTCACCGCAGAGGTACTTGAGTTGGCAGGAAATGCGTCAAAAGACTTAAAGGTAAAGCGTATCACCCCTCGTCACTTGCAGCTTGCTATACGTGGAGATGAAGAATTGGATTCTCTGATCAAAGCTACCATTGCTGGTGGTGGTGTCATCCCACACATCCACAAATCGCTGATCGGGAAGAAAGGACAACAGAAGACTGTTTAAGGATGCCTGGATTCCTTATTATCTCAGGACTCTAAATATTCCTAACAGCTGTCCAGTGTTGGTGATTCCAGTGGACTGTATCTCTGTGAAAAACACAATTTTGCCTTTTTGTAATTCTATTTGAGCAAGTTGGAGGCTTAATTAGCCTTCCAACCAACCAAATTTCTGCATTCGAGTCTTAACCATATTTAAGTGTTACTGTGGCTTCAAAGAAGCTATTGATTCTGAAGTAGTGGGTTTTGATTGAGTTgactgtttttaaaaaactgtttggATTTTAATTGTGATGCAGAAGTTATAGTAACAAGCATTTGGTTTTGTACAGACATTGTTTCCACTCTGGTGGATAAGCTCAATAAAGGTCATATCCCAAACTAGCTTTAAACTTGCTTAATAATCGGGACTTACCTTAGATCTCACTCAGCAACAAGTACATTCTCTGCTTACTAATTAAACAGTGCATCTGTAGTCATAA

Publications

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