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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Rps6P6
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr2:128007231-128007489  UCSC
Strand +
Parental Sequence NM_009096.3
Parental seq. overlap 211 bp
Parental seq. overlap (%) 15.1%
Genomic Region Intragenic (Ank2)
Retrocopy Summary Rps6P6, located on chr2:128007231-128007489, is a retrocopy of the parental gene Rps6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Rps6
Full Name ribosomal protein S6
Also known as S6R
Coordinate chr4:86772336-86775604
Strand -
Gene summary Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of ribosome. Involved in glucose homeostasis. Acts upstream of or within several processes, including T cell activation; activation-induced cell death of T cells; and ribosome biogenesis. Located in dendrite; perinuclear region of cytoplasm; and ribosome. Part of cytosolic small ribosomal subunit and polysome. Is expressed in several structures, including early conceptus; forelimb; gonad; intestine epithelium; and salivary gland. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus LOC100911372P11
Chinese hamster Cricetulus griseus LOC113837022P18
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Rps6P6
TTTCTATGAGAAGCCCATGGCCACAGAAGTATCTGCTGGCCGATGCTCTGGGTGGAGAGTGGAAGGGTAATGTGGTTGGGATCTGTGATGGGAGCAACAAACAAGGTTTCCCCAGGATGCAGGGTGTCCTAACCCGGGCAGAGTGTGCCTGCTGTTGGGTAAAGGGCATTCTTGTTCTAGACCAAGGGAAACTGGAGATAGGAAACACAAGTCTGTTCTGGGATGCACTGTGAATGCCAATCAGTGTGCTCAGCTtggt
>NM_009096.3
CTCTTTTTCGTGACGCCTCCCAGGCGCTCGGCTGTGTCAAGATGAAGCTGAACATCTCCTTCCCCGCCACCGGCTGTCAGAAGCTCATCGAGGTGGATGACGAGCGCAAGCTCCGCACCTTCTATGAGAAGCGCATGGCCACGGAAGTAGCCGCTGATGCTCTTGGTGAAGAGTGGAAGGGTTATGTGGTCCGGATCAGCGGTGGGAATGACAAGCAAGGTTTTCCCATGAAGCAAGGTGTTCTGACCCATGGCAGAGTGCGCCTGCTGTTGAGTAAGGGGCATTCCTGTTACAGGCCAAGGAGAACTGGAGAGAGGAAGCGCAAGTCTGTTCGTGGATGCATTGTGGACGCTAATCTCAGTGTTCTCAACTTGGTCATTGTAAAGAAAGGAGAGAAGGATATTCCTGGACTGACAGACACTACTGTGCCTCGTCGGTTGGGACCTAAAAGGGCTAGTAGAATCCGCAAGCTTTTTAATCTCTCCAAAGAAGATGATGTCCGCCAGTATGTTGTCAGGAAGCCCTTAAACAAAGAAGgtaagaagcccaggaccaaagcacccaagaTTCAGCGACTTGTTACTCCTCGTGTCCTGCAACACAAACGCCGACGTATTGCTCTGAAGAAGCAACGCACTaagaagaacaaggaggaggCTGCAGAATACGCTAAACTTTtggccaagagaatgaaggaagccaaagaaaagcGCCAGGAACAGATTGCCAAGAGACGTAGGCTGTCCTCACTGAGAGCTTCTACTTCTAAGTCTGAGTCCAGTCAAAAATGAGTCTTTAAGagcaacaaataaataatgacCTTGAATCTTTCATTGGCTTTCATTAATAGTGTAACTAGATAAATGATGGGAAAGATGAGACAGAAGAAGGAATACATCTATAGGACTGCTAGAATATGGGGAGAGTgattattttcaaattaatatGTATCGAGCTTCTACCCCaaggtaaataaataacatttggaGACCATTAAAATGTAGGATGGCATAGAAGAGGCCTTTACTAAGATTAATAATTAAAGAAACACAGCCTTTAAAGTAAAAAACACACTGTGCCTTTGAAACTTGCTAAAAAGATTAACTTCTGTCCCAAAAGGTATCAGCCATGCGCTACCAGCCTCCCTGCCCCTACAGTGGCAGTGGCTGCATTCTTGGTGAATGGTAGTGGAAGGGATTAAACCTAGGCCTCAGTCATGCTTCCCAGTCACTGGTACTGATTTGTATGCACCCGCTTAGGTGTGAAGGTAGTTTTGGTGTGTATCACAAGTTAGCCTGTGTAGCgaagacaggttttctccacCGTGTTTTTTGTTACACATGACTATTCACAAATGTGCTGCAGACAGTAAAATGAGAAATACCCTTCCAAGG

Publications

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