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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LDHBP2
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Bos taurus
Coordinates chr3:33600345-33601125  UCSC
Strand +
Parental Sequence NM_001316338.1
Parental seq. overlap 412 bp
Parental seq. overlap (%) 29.9%
Genomic Region Intergenic
Retrocopy Summary LDHBP2, located on chr3:33600345-33601125, is a retrocopy of the parental gene LDHB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LDHB
Full Name lactate dehydrogenase B
Also known as -
Coordinate chr5:88544523-88562770
Strand +
Gene summary This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Pseudogenes have been identified on chromosomes 1 and 11. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Pig Sus scrofa LDHBP2
Sheep Ovis aries LDHBP1
Dolphin Tursiops truncatus LDHBP1
Horse Equus caballus LDHBP1
Dog Canis familiaris LDHBP6
Panda Ailuropoda melanoleuca LDHBP2
Cat Felis catus LDHBP5
Greater horseshoe bat Rhinolophus ferrumequinum LDHBP3
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LDHBP2
TTTATGGCTGAAAACTTGGCATTCATTCCAGCAGCTGTCATGGATCATGGATGGATTTGGGGAGAACACGGTGACTCAAGTGTAGCTGTTTGGAGTAGAATATATGTGGCCAGCATTTCTGTTTGGGAACTGAGCCCAGAAATGGGAAAGAACAATAACAGTGAAAATTGGAAGGAAGAATGTAAGGTGGTCTAGCATGTAAGGTGGTAGTGGAAAGTGCCTGTGAAATCACCAAGCTAAAAGGGTAACCAACTGGTCTGTTGGATGACATGTGACTGATCTCATTGAATCCATGATGAAAAATCTATCCAGGATTCATCTGGTGTCACAATGGTGAAGGAGATGCGTGGCATTTAGAATTAAGTCTTCCTCAATCATCCGTGTGTCCTTAATGCTCAGGGGTTAACCAGTGTAATCAACCAAAAGCTGAAGGCTGATAAGGTTGCTCAACTCAAGAAAAGTGCAGATACACTGAGGGACATCCAGAAGGACCTGCAAGGCCTGTGGCTTC
>NM_001316338.1
GAAGCTCGGAGGCGGCCAAGGGGCGGGTCCCGCCTGCTCTTCCTCCCTCCTTGCGGATCCTGCGCCGGAGGAGACGCACGCTGCTGACTTTGTCTTCGTGCAGCCCTTATCACTCTCTGGAGAACTTTCTCTCCCCTGGGCACAATGGCAACTCTTAAGGAAAAATTGATTGCACCAGTTGCAGAAGAAGAGACAAGGATCCCAAACAATAAGATCACTGTAGTGGGTGTTGGACAAGTTGGTATGGCATGTGCCATCAGCATTCTGGGAAAGTCTCTGACTGACGAGCTTGCTCTTGTGGATGTTTTGGAAGATAAACTCAAAGGAGAAATGATGGACCTGCAGCACGGGAGCTTATTCCTTCAGACACCAAAAATTGTGGCAGACAAAGATTACTCTGTCACTGCCAATTCCAAGATTGTGGTGGTAACTGCAGGAGTTCGCCAGCAAGAAGGGGAGAGTCGCCTGAATTTGGTGCAAAGGAACGTTAACGTCTTCAAGTTCATCATTCCTCAGATCGTCAAGTACAGTCCTGACTGCATCATCATTGTGGTTTCCAACCCAGTGGATATTCTCACATATGTTACCTGGAAACTAAGTGGATTACCCAAGCACCGTGTGATTGGGAGTGGATGTAACCTGGATTCTGCTAGATTTCGCTACCTTATGGCTGAAAAACTTGGCATTCATCCCAGCAGCTGCCACGGATGGATTTTGGGGGAACATGGCGACTCAAGCGTGGCTGTGTGGAGTGGAGTGAATGTGGCAGGCGTTTCTCTCCAGGAACTGAATCCAGAAATGGGAACAGACAATGATAGTGAAAATTGGAAGGAAGTGCATAAGATGGTGGTTGAGAGTGCCTATGAAGTCATCAAGCTAAAAGGATATACCAACTGGGCTATTGGATTAAGTGTGGCTGATCTTATTGAATCCATGTTGAAAAATCTATCGAGGATTCACCCAGTGTCAACAATGGTGAAGGGCATGTATGGCATTGAGAATGAAGTCTTCCTGAGCCTTCCGTGTATCCTGAATGCTCGAGGGTTAACCAGTGTTATCAACCAGAAGCTGAAGGATGAAGAGGTTGCTCAACTCAAGAAAAGTGCAGACACCCTCTGGGGCATCCAAAAGGACCTGAAGGACCTGTGACTTCCGGCTGCAAGGCTGTAGACACTTAGAACTACAGTGTGATTAACCACAAGCCTTTAGTTTGCATCCATGTACATGGAGCACAGTTCGCTTTTGTCTTCCTAAGTCTGTGAATCTGGGCTCCCAGAATCAAAGCCCATGCTTGCTTTAATGCTTGCAAGATGAGTCCTTGAACAAATCAAATAAACCACCTAGTGTAGTGTG

Publications

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