Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MRPL50P4
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:59550893-59551893  UCSC
Coordinates (T2T) chr10:60405227-60406220  UCSC
Coordinates (hg19) chr10:61310651-61311651  UCSC
Strand -
Parental Sequence NM_019051.3
Parental seq. overlap 877 bp
Parental seq. overlap (%) 26.1%
Genomic Region Intergenic
Retrocopy Summary MRPL50P4, located on chr10:59550893-59551893, is a retrocopy of the parental gene MRPL50. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MRPL50
Full Name mitochondrial ribosomal protein L50
Also known as MRP-L50
Coordinate chr9:101387633-101398618
Strand -
Gene summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MRPL50P3
Bonobo Pan paniscus MRPL50P3
Gorilla Gorilla gorilla MRPL50P3
Orangutan Pongo abelii MRPL50P4
Gibbon Nomascus leucogenys MRPL50P2
Green monkey Chlorocebus sabaeus MRPL50P2
Crab-eating macaque Macaca fascicularis MRPL50P3
Rhesus Macaca mulatta MRPL50P2
Baboon Papio anubis MRPL50P3
Golden snub-nosed monkey Rhinopithecus roxellana MRPL50P1
Marmoset Callithrix jacchus MRPL50P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MRPL50P4
GGATCTCATTGAAGATGGTGGTGCAATCTGTGTCCAGCATTATCAGAAGAGTCTTTATGTGGACAGTCTCAGGGGCACCTGAAGAGAATTTTGGTCTCAATCCAGAAAAGAGAAAGAGCCAGTGGTTGCTGAGACAGTAAAAGAGGTGAAAAAAGAACCTATCCCAGTGCGTCCACCCTTACGAAGCCAAACATATACACCACCTGAAGGTCTCCAGAGTCGTTTGGAATCTTTATGTTAAATAAGTTTTTGGCTCATGTTTTCCTAGTAATTGGCAAGACATTTCCCTGGAAGATGGTTGTCTACAGTTCAATCTTTTGGCACATTTAGCTTATGACTTGGGTCATGTAGTCCCTAATTCCAGACTCCACCAGTTGTGCAGGATTAGAGATGTTCTTGGTTTCTATAATGTCCCTATTCAAGATAGATCTAAATTTTATGAACTCAATGCCAGTAATCTGCCCCCCAATTTGAAAATCACTTGGAGTTACTAAGCAATTCAGAAGAGAAATACATTGAAATCATTTTATCCCCCTGAGCAAGGGGGCTGCTTTTTAGGCTTTTTGATACTTTGCCATGTGAAATATTATCAGAACTGTTCTCTAAACCCACTTTTTCTATAGAGGAATGTATCATCTCTTTTTTTCTCATATTATGAATGGATAAAGAATAATAGGATTTTCTATTTTCATATTTGCTGAAATCATTTTTTAAATGAAATTAGGTCATTAATAATTTATGAAAAACTTTGAGAGGACACTGTCATTAACTTGGGTGTGAGACAGGAGGATATTACAAGCTCAGACCCTTCATAGGCATAAAGTAGTAGTAGTAGTTGCAAGAAAATATGTTCATCCTTTTAGGGCTCATATCTAAGATAGGTTATTATATATTACAAATATACAAATAAACTTGTATTACATAGATACCTATGAAAGAAACATAAAACGATGTTGTATATTACTGACCATTCTAGATTAATTTCTTTTGAAATTAAAGG
>NM_019051.3
GCTCAGGCCCGTGGATCTCATCGAAGATGGCGGCGCGATCTGTGTCGGGCATTACCAGAAGAGTCTTCATGTGGACAGTCTCAGGGACACCATGTAGAGAATTTTGGTCTCGATTCAGAAAAGAGAAAGAGCCAGTGGTTGTTGAGACAGTAGAAGAGAAAAAGGAACCTATCCTAGTGTGTCCACCTTTACGAAGCCGAGCATACACACCACCTGAAGATCTCCAGAGTCGTTTGGAATCTTACGTTAAAGAAGTTTTTGGTTCATCTCTTCCTAGTAATTGGCAAGACATCTCCCTGGAAGATAGTCGTCTAAAGTTCAATCTTCTGGCTCATTTAGCTGATGACTTGGGTCATGTAGTCCCTAACTCCAGACTCCACCAGATGTGCAGGGTTAGAGATGTTCTTGATTTCTATAATGTCCCTATTCAAGATAGATCTAAATTTGATGAACTCAGTGCCAGTAATCTGCCCCCCAATTTGAAAATCACTTGGAGTTACTAAGCAATTCGGAAGAGAAACACATTGAAATCACTGTCTTTCCCTGAGCAAGGGGGCTGCTCATTAGATCTTTTGATACTTTACCATGTGAAATACTACCAGAACTGTTCTCTAAACCCACTTTTTCTGTAGAGGAATGTATCATCTTTTTTTTTCTCATATTACAAATGGACAAATAACGGACTTTCTATTTTCATATTTGCTGAAACCATTTTTTAAATGAAATTAGGTCATTATTTATGAAAAGTTTTGAGAGGGCACTGTCAACTTGGGTTTAAGACAGGAGGACATTGCAAGTTCACACCTTTCATAAGCATAAAGTAGTTGCAAGAAAGTATTTTCATCCTGTTAGGATTCATATCTAAGATAGAGTTATGCATTGCACATACACAAATAAACTTTTATTAGATAGATACCTATAAAAGAAACATAAAAGTATGTTGTGTATTACTGACAGTTCTAGATTAATTTCTTTTAGAATTAAAGTAGATTTGTTAAAGTGTATTGTGTGTTGTAAATTTTTTAAGTGAAATTTGCTTGCGCTCTGCCTTGCCATTTCTTTCCAGTAAGTATAATTTTGAAAAAATTAGAATATATGCCAAATATTGAGTGCTGTGACTCTTCCTCATAAGAGATGTGCCAGATTCTATGTCTAATTGCATATTCTCTTCAGAGGAGATGATGCTTATTTTAAACCTTTTTCTCTATAACTTTTAAAAAGTGGTGCtgagtattcactagagtggcaagtctttgtgctttaatgcactcaatttgtggaaattacttaaatagcaggttatcagatggttctgaatgacaaaggtgttaaatttgggatttttttttcaagctttagatatggctggagagtaatgagacagaaggaatgtcttatattgttctgactgctgacaattcctaaagaaaagtgatagaagggtttttaacaaaataagttgcatttattctctttcccagggttactcctttgaagagggcaaaattcagttgggaatataaattctggaatcttcatgaagaaaattagtTAACAGTATAGACATGCCCTACAAATATCATCCACAGGCACTTCATTCAAGAACTTCAGGTGTCAGAGTGCCTGGAGCTCTGGAGCTTAGACATTAGAGTTGattccttggggattggttccaggacacctacttggataccaaagtccacagatgcccaagccccttttataaaatgatgtagtatttgcatattatgtatgcacatcctcccatatactttaaatcatctttagattacttatactgaatagaatgtaaatagtatttacaattgtgaatacaatgtattTAGTtatgtaaatatgtaaattttaaagttatgtaaatatgtagctatgtaaataGCTATAAAATAATATTTACAATTGTGAATAGTATGTAAATAGTTGTGAACATAACTATTGTGAATAATATGTTATATGTTATAGTTGTGAATGTAAATAGTATTCACAATTGTGAATACAATGTAAATAGCTTTCACAATTGTGAATACAATGTAAGTAGCTATGTAAATAGTGaatacaatgtaaatagctatgtaaatagttgttatgctgattagggaataatgagaaggaaaaaaagtatacatattcagtacagatgcagtcatctttttttcccctcgaacatttttgatccacaattggttgaatccacagatggggaacacacagTCTTGGTAAATTTAACCAACAAGGAGGGTAAACGCATCCCAACAGGGAAGGTAAActgcacatccatcagtacctctagagggcatcactggtttatagctcaatacagtgactatatcagaataatggcctttagttttcctgaaagattaaattaGGCTTGCTGTTGTTGAATGAGATAATCAAACATATGATGTAATTTTAAAGGGTTTACATACAGAAGGCCTGCTGTATGTCCTGCTTCTGCTGTGTAAAAGATTCAGCATGGAATCATTGGAATTTTATGTACAGGATTTCATTATCTCATTTTCTATACAATTTTTCCTTCTGATCCAGAGACACGGAAAAACAAAGGGCAAGATGGAAATAAGGGATGAGAAGGTCTATGTGGAAAAACAGTTACAACTGGAGTGGTAACTGCAAAAACCAAGCAGCTTCATGTGATCGTTAGGACAGAAGAAATTTCTCCTTTGTAGCCTAGAGCAATAttctcaaaatttaatgcgcatgttaatcatttggggatcttTTATTCATTTTTtcatgtggggatcttttaaaaatgcaaattctgatttggtaagtctggagtaggtcctgagcttctgcatgcttcaaaagctGATTATGTTTTGAGAACATGGATCTAGATGCTGGTATTGAGGTGGGAGACAAGTACTGCCACCTGAAACAACAGTCTTGGTAAATTTAGCCGACGAGGGTAAACACATCCTAACAGGGAAGGTAAACTGTACGTCCAtcagtaccactagagggcatcactggtttatagttcaatacagtgaatatatcagaataatggcctttagttttcctgaaagattaaattaggcttgctaacttgtttaaTGAGATAATCAGACATATGATGTAATTTTAAAGGGTTTACATTTTTAAAAATTTAATGATTGCTACATAAAAAGGGTATCAGTTAACTAATTTTACTTAGATGGAACTTCTGTAAGCTTAGTAGGTATGCTTAAATAAAGCCTGCTAATAAAATAGAGATTCAGACTCAATAGAATGGTTTTACATATGTAATATATGTTTTAAACTGCATAAAATAAACTCCTCCCTCCTTTC

Publications

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