Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZFRP2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:89139059-89140761  UCSC
Coordinates (T2T) chr10:90022962-90024665  UCSC
Coordinates (hg19) chr10:90898816-90900518  UCSC
Strand +
Parental Sequence NM_016107.5
Parental seq. overlap 1596 bp
Parental seq. overlap (%) 33.7%
Genomic Region Intergenic
Retrocopy Summary ZFRP2, located on chr10:89139059-89140761, is a retrocopy of the parental gene ZFR. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZFR
Full Name zinc finger RNA binding protein
Also known as SPG71|ZFR1
Coordinate chr5:32354350-32444740
Strand -
Gene summary This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZFRP1
Bonobo Pan paniscus ZFRP1
Gorilla Gorilla gorilla ZFRP1
Orangutan Pongo abelii ZFRP1
Gibbon Nomascus leucogenys ZFRP1
Green monkey Chlorocebus sabaeus ZFRP1
Crab-eating macaque Macaca fascicularis ZFRP1
Rhesus Macaca mulatta ZFRP1
Baboon Papio anubis ZFRP1
Golden snub-nosed monkey Rhinopithecus roxellana ZFRP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZFRP2
ACTATGGAGTTATTAGTAGAGAAAGCAATCAGCAGTGCTTCTAGCCCTCAGGGCCCTGGGGATGCACTGAGAAGAGTTTTTGAGTGCATTTCTTCAGGGATTATTTTTAAAGGTAGTCCTGGGCTTCTGGATCTTTGTGAAAAGGATCCCTTTGATACCTTGGCAACAATGACTGACCAGCAGTGTGAAGACTTCACATCCAGTACACAGTTTGCATTCAGACTCCTTGCATTCCACCAGATATACAAAGTTATAGGCATGGATCCATTACCACAAATGAGCCAACATTTTAACATCCATGACAACAGGAAATGAAGAAGGGATAGTGATGGAGTTGATGGATTTGAAGCTGAGGAGAAAAAAAGACAAAAAAAGATTATGATAACTTTTAAAAGGTGTCTGCAAATCTTCAGTGTTAAAAAAACAAAAAGTGCCCATTTGTTGGCTGTTTTTCATTCATAATAATGTCTACATTGAAACATTTATCAAGAATTTAAAGGATTTCATGGAAGAACCAAGTTTTTCTATGACATTAAAAAATGTACAGTGTTATGTATTATTTGAATGGAAAGACACCAAAAAAAAAAAATATGCTCCGACTAGGGGGAAAACAGTGGTTCCAATTTTTTCCCATTATTTTGATTTTATTTTCTGGTTGCCTTAGCTTCCCCACCCTATTTTTGTGTCTTCCATTAAGCAGTGCATTGTCATATTAAATCTTTACTGTATTTAATGCAGGATTTGTGCTTCAGTTGTTCTGTGTATTTTGATATTTTTATTTATAGATTTTGTTTGCTTTTTGACACGAGTTGTTAGTTTATGTTATAGATGATATCCTTTACCCCTTCTTAATATTGTACAGTACTTTTTTTGTAACGTGAGACTGAAGATTTTTTTTTTTGTTTTTCTATATGTGAAAGATTACAACTCAAAAAGTTATCCTGTCATTCGAGTGCTCAGAACGGAATGTTTCTGCAGATCTTGTGGCATTTGTCTCTAGTGTGATATAGAAAGGTGTAATTAAGACAGATTTCTGTTAATCTAATCAAGTTTGCTGTTAGTTGTGCATTAGCAGTATAAAAGCTAATATATACTATATGGTCTTGCAACAGTTTTAAAGCCTCTGCATAATTGATAGTAAAAAATGCATGACATTTTGGTCTTTAATAGACTTTTAAAATTATAATTTTAGGTTTAACATGTAGATCTTTGTACAGTTGACTTTTTGACATAGCAAGGCCAAAAGTAGCTTTCTGAATATTTTTTTCTTGTGTATAAGTGGAAACGGCATTTTTCACATATAAGTGGGCTAACCAATATTTTCAAAAGAACTTTATCATTGTGCAACTAACAACAGTAATTAGCCCTTAATTATGGTGACAGTTCCTTATTGGGGAGTGTGTGAGATTATCTAGCAACTATTACAGTATAACACAGTTAATCTTCTCCACACACCCTATTGCCCAGATAATTTACAATTCTGTTAATAGTGAGGTTGATAAAGTATTACTGATAAAAAAAAAGATTAAGAAAAAAACAGAAAATTATTTGGTGTGGCCATCTTACATGCTTATGTGTCTTCTACACAAAGCTAAATATTCTAGCAGTGATGTAATGAAAAATTACACCTTACTGTTGATGTATGTATGTTCTGGTACACAGATGTCATTTTGTTGTCACAGGACTACAGTGAAATACACAAA
>NM_016107.5
CTGTTCTCCGCTGAGGAGGAGCGGGGCAGAGGAGGGAGGCAGCGGGTGAGAGTTCAGAGTTCAGCAGCAGCAGCCCGAGCCCATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGGCAACTACTTTGGATTCACCCACAgcggggcggcggcggcggcggctgcggcCCAATATAGCCAGCAGCCAGCTTCGGGTGTAGCCTATTCTCATCCAACTACAGTTGCTAGCTACACTGTCCATCAGGCTCCAGTAGCTGCTCACACAGTTACTGCTGCCTATGCACCAGCAGCCGCCACAGTTGCAGTTGCCAGGCctgctccagtagctgttgcagctgctgcaacagctgctgctTATGGAGGCTACCCCACTGCACACACAGCAACTGACTATGGTTATACTCAGAGGCAACAAGAAGcaccaccaccaccacccccagctactacacaaaactaccaGGATTCATACTCATATGTAAGGTCCACAGCTCCTGCTGTAGCTTATGATAGTAAGCAATACTACCAACAACCAACAGCAActgctgctgctgtagctgccgctgcCCAACCTCAGCCTTCTGTTGCTGAAACTTACTATCAGACAGCCCCCAAAGCAGGTTACAGCCAAGGTGCAACTCAGTATACTCAAGCCCAGCAAACTCGACAAGTGACAGCCATAAAACCAGCCACACCAAGTCCAGCTACCACTACTTTCTCCATCTATCCTGTATCCTCCACCGTACAGCCAGTAGCAGCTGCGGCTACTGTGGTGCCATCCTATACTCAGAGTGCTACTTACAGTACCACAGCAGTTACATATTCTGGTACGTCTTATTCAGGTTATGAAGCAGCAGTGTATTCAGCTGCATCTTCCTACTATcaacagcagcagcagcaacagaagcaggcagcagcagcagctgctgctgctgctgcaacagctgcCTGGACAGGGACCACCTTTACTAAAAAAGCACCATTCCAAAATAAACAACTGAAACCAAAACAGCCTCCCAAACCACCACAGATTCACTATTGTGATGTTTGTAAGATCAGCTGTGCTGGACCACAGACTTATAAAGAACATTTAGAAGGACAGAAACATAAAAAAAAAGAAGCTGCATTGAAAGCCTCACAAAATACCAGCAGCAGCAACAGTTCTACTCGTGGGACTCAAAATCAGCTACGTTGTGAGCTCTGCGATGTGTCTTGTACAGGAGCAGATGCGTATGCTGCCCACATTCGTGGTGCTAAGCATCAGAAAGTGGTTAAGTTACACACAAAACTTGGTAAACCCATTCCATCAACAGAACCAAATGTTGTTAGCCAAGCTACTTCTTCAACAGCTGTATCTGCTTCAAAGCCGACTGCCTCTCCTTCAAGCATTGCAGCAAACAATTGTACTGTGAATACGTCATCAGTTGCAACGTCTTCAATGAAGGGTCTTACGACTACAGGAAACTCGTCTCTTAATAGCACATCTAACACTAAAGTATCAGCAGTGCCTACAAATATGGCTGCCAAGAAAACATCTACCCCCAAAATAAATTTTGTTGGTGGTAATAAGCTGCAGTCAACAGGAAATAAAGCAGAAGACATAAAAGGAACCGAATGTGTTAAAAGTACTCCTGTCACTTCTGCTGTGCAGATTCCTGAAGTAAAGCAAGACACAGTGTCAGAACCAGTCACACCTGCATCTCTTGCTGCTTTACAGAGTGATGTGCAGCCAGTGGGCCATGATTATGTGGAAGAGGTACGAAATGATGAAGGAAAAGTAATTCGGTTCCATTGTAAATTATGCGAGTGCAGCTTTAATGATCCCAATGCTAAGGAGATGCACTTAAAAGGGCGAAGACACAGACTTCAATATAAAAAAAAAGTAAATCCAGATTTGCAAGTAGAAGTAAAGCCTAGTATTCGAGCAAGAAAGATTCaagaagagaaaatgaggaagcaaatgcagaaggaggagtactggcgaagacgagaagaagaggaGCGTTGGAGAATGGAAATGAGACGTTATGAAGAGGACATGTACTGGAGGAGAATGGAGGAAGAACAACATCATTGGGATGATCGCCGCCGAATGCCAGATGGAGGTTATCCTCATGGTCCTCCAGGCCCATTAGGCCTTCTGGGAGTCCGACCAGGCATGCCTCCTCAGCCTCAGGGGCCTGCACCCTTACGTCGTCCTGACTCATCTGATGACCGTTATGTAATGACAAAACATGCCACCATTTATCCAACTGAAGAGGAGTTACAGGCAGTTCAGAAAATTGTTTCTATTACTGAACGTGCTTTAAAACTCGTTTCAGACAGTTTGTCTGAACATGAGAAGAACAAGAACAAAGAGGGAGATGATAAGAAAGAGGGAGGTAAAGACAGAGCTTTGAAAGGAGTTTTGCGAGTGGGAGTATTGGCAAAAGGATTACTTCTCCGAGGAGATAGAAATGTCAACCTTGTTTTGCTGTGCTCAGAGAAACCTTCAAAGACATTATTAAGCCGTATTGCAGAAAACCTACCCAAACAGCTTGCTGTTATAAGCCCTGAGAAGTATGACATAAAATGTGCTGTATCTGAAGCGGCAATAATTTTGAATTCATGTGTGGAACCCAAAATGCAAGTCACTATCACACTGACATCTCCAATTATTCGAGAAGAGAACATGAGGGAAGGAGATGTAACCTCGGGTATGGTGAAAGACCCACCGGACGTCTTGGACAGGCAAAAATGCCTTGACGCTCTGGCTGCTCTACGCCACGCTAAGTGGTTCCAGGCTAGAGCTAATGGTCTGCAGTCCTGTGTGATTATCATACGCATTCTTCGAGACCTCTGTCAGCGAGTTCCAACTTGGTCTGATTTTCCAAGCTGGGCTATGGAGTTACTAGTAGAGAAAGCAATCAGCAGTGCTTCTAGCCCTCAGAGCCCTGGGGATGCACTGAGAAGAGTTTTTGAATGCATTTCTTCAGGGATTATTCTTAAAGGTAGTCCTGGACTTCTGGATCCTTGTGAAAAGGATCCCTTTGATACCTTGGCAACAATGACTGACCAGCAGCGTGAAGACATCACATCCAGTGCACAGTTTGCATTGAGACTCCTTGCATTCCGCCAGATACACAAAGTTCTAGGCATGGATCCATTACCGCAAATGAGCCAACGTTTTAACATCCACAACAACAGGAAACGAAGAAGAGATAGTGATGGAGTTGATGGATTTGAAGCTGAGGGGAAAAAAGACAAAAAAGATTATGATAACTTTTAAAAAGTGTCTGTAAATCTTCAGTGTTAAAAAAACAGATGCCCATTTGTTGGCTGTTTTTCATTCATAATAATGTCTACATTGAAAAATTTATCAAGAATTTAAAGGATTTCATGGAAGAACCAAGTTTTTCTATGATATTAAAAAATGTACAGTGTTAGGTATTATTTGAATGGAAAGACACCCAAAAAAAAAAATGTGCTCCGACTAGGGGGAAAACAGTAGTTCCGATTTTTTCCCATTATTTTTATTTTATTTTCTGGTTGCCCTAGCTTCCCCCCCTATTTTTGTGTCTTTTATTAACTAGTGCATTGTCTTATTAAATCTTCACTGTATTTAATGCAGGATGTGTGCTTCAGTTGCTCTGTGTATTTTGATATTTTAATTTAGAGGTTTTGTTTGCTTTTTGACACTAGTTGTAAGTTACTTTGTTATAGATGGTATCCTTTACCCCTTCTTAATATTTTACAGCAGTACGTTTTTTTGTAACGTGAGACTGCAGAGTTTGTTTTTCTATATGTGAAGGATTACAACACAAAAAGTTATCCTGCCATTCGAGTGCTCAGAACTGAATGTTTCTGCAGATCTTGTGGCATTTGTCTCTAGTGTGATATATAAAGGTGTAATTAAGACAGAGTTCTGTTAATCTAATCAAGTTTGCTGTTAGTTGTGCATTAGCAGTATAAAAGCTAATATATACTATATGGTCTTGCAACAGTTTTAAAGCCTCTGCATAATTGATAATAAAAATGCATGACATTCTTGTTTTTAATAGACTTTTAAAATCATAATTTTAGGTTTAACACGTAGATCTTTGTACAGTTGACTTTTTGACATAGCAAGGCCAAAAATAACTTTCTGAATATTTTTTTCTTGTGTATAAGTGGAAAGGGCATTTTTCACATATAAGTGGGCTAACCAATATTTTCAAAAGAACTTCATCATTGTACAACTAACAACAGTAACTAGCCCTTAATTATGGTGACAGTTCCTTATTGGTGTGTGTGAGATTACTCTAGCAACTATTACAGTATAACACAGATGATCTTCTCCACACACCCCATCACCCAGATAATTTACAGTTCTGTTAACAGTGAGGTTGATAAAGTATTACTGATAAAAAATTATCTAAGGAAAAAAACAGAAAATTATTTGGTGTGGCCATCTTACCTGCTTATGTCTCCTACACAAAGCTAAATATTCTAGCAGTGATGTAATGAAAAATTACATCTTACTGTTGATATATGTATGCTCTGGTACACAGATGTCATTTTGTTGTCACAGCACTACAGTGAAATACACAAAAAATGAAATTCATATAATGACTTAAATGTATTATATGTTAGAATTGACAACATAAACTACTTTTGCTTTGAAATGATGTATGCTTCAGTAAAATCATATTCAAATTTA

Publications

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