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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name COX7A2LP2
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:113769599-113770004  UCSC
Coordinates (T2T) chr11:113779927-113780332  UCSC
Coordinates (hg19) chr11:113640321-113640726  UCSC
Strand +
Parental Sequence NM_001319036.1
Parental seq. overlap 357 bp
Parental seq. overlap (%) 19.3%
Genomic Region Intragenic (ZW10)
Retrocopy Summary COX7A2LP2, located on chr11:113769599-113770004, is a retrocopy of the parental gene COX7A2L. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COX7A2L
Full Name cytochrome c oxidase subunit 7A2 like
Also known as COX7AR|COX7RP|EB1|SCAF1|SCAFI|SIG81
Coordinate chr2:42335559-42368957
Strand -
Gene summary Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COX7A2LP2
Bonobo Pan paniscus LOC100968761P2
Gorilla Gorilla gorilla LOC101144032P1
Orangutan Pongo abelii COX7A2LP1
Gibbon Nomascus leucogenys LOC100596162P1
Crab-eating macaque Macaca fascicularis LOC102118608P2
Rhesus Macaca mulatta LOC106992283P3
Baboon Papio anubis LOC101002878P2
Golden snub-nosed monkey Rhinopithecus roxellana LOC104677541P3
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>COX7A2LP2
TGGGTCCTTCTCTGGGGTGGTCGTGCAGGCAGTAGATGCGGGAAGCCGGACTCCAGGCATCATGTACTACAAATTTAGTGGCTTCACGTTTGAGTTGGTGGGAGCATGGACTTCAGAGGCCTATAGCCCATAAGGATTAATGCCTGTGGTTTCCACAGAAGCACCACCTATCATATTTGCCATACCAACTAAGCTGACTTCTGATTCCACTGCATATAATTTTGCTAGGAAAAACAAAGTTCCAGAGCTGCAGAAGTTTCTCCAGAAAGCTGATGATGTGCCCATCCACCTGAAATGAGGCTTCCCTGACCAAATGCTATACTGGACCACCATGGTGCTGACTGTGGGTGGGATACTGCCTGATCACCCTCTACATGGCTTCACAGCCCCAAAACAAATGAGTTAG
>NM_001319036.1
GGGGAAAGCAGCCAGGGAGGTCGGGAGATGGACGGAAACTGCTGGGGATGTGAGAAGCCTGGGGCACTAACTGGAGTTGTTATTGACTTGGTTGCCAGGGGAAGCTTGGCCGACAAGTCTATACTCCTGGGCAGACTGAGCAACAGCAGGTGGTGGCTTCTGGATAAGAGGTGCTCTAGGTCGGAAGGAAATAAATGAGACTACGATCAGTTAAAGTTCGGTAAAGCAAGAGACGCCTTCAACCCGACGACCAGACGGTGGCTCCGCAGCACAGACTCTCTCGGATGGTGGAATTCCCAACCGGCTTCGATGTAGCCCCGCCCCTACCCAGACCACGCCCACCAATCACCGCCCTCTCCCCCCCAGGCCCCGCCTGGAGCCCGCCCCTCCTAAAGCATGCTCCACCTGACTCCGACACTGCCGGGCTTAGTCCGCCGGGCTTAGTCCGTGGAGCGCTTGCGCATTTCTTGAGTTGTCGTGGCACTGCCCAAATCTGAATGGGGGAAAGAGGGAACTTCATATTTCCTACAGACTCCGCCACAGCGACTTTGCGTGCTCTCTTAGAGCTGGTTTTGCCTTTCGTGGTCCTGAGAACCCTGGCTTTTGGTTCCCCAATGCGGCTTAAGTGTGCAGGTTTTAAGTTAGGCGATCTTCGGGCAGCCCTAGTCCCAGCACCGGGTCCTTGCGCTGAGTCTCGGGACCACAGCCGGGGAGGCGGGGTCCTTCTCTGGGGCGGTCGCGTTGGCAGCGGATGCGGGAAGCCGGACTCTGGGCGTCATGTACTACAAGTTTAGTGGCTTCACGCAGAAGTTGGCAGGAGCATGGGCTTCGGAGGCCTATAGCCCGCAGGGATTAAAGCCTGTGGTTTCCACAGAAGCACCACCTATCATATTTGCCACACCAACTAAACTGACCTCCGATTCCACAGTGTATGATTATGCTGGGAAAAACAAAGTTCCAGAGCTACAAAAGTTTTTCCAGAAAGCTGATGGTGTGCCCGTCTACCTGAAACGAGGCCTGCCTGACCAAATGCTTTACCGGACCACCATGGCGCTGACTGTGGGAGGGACCATCTACTGCCTGATCGCCCTCTACATGGCTTCGCAGCCCAAAAACAAATGAGTTAGGCTGCAGAGGACTGGTTTGTTTTTTGGCATAAACCCTTTGAAGTTCCTTTTTCATTGTTAAATTAAAATTTTTTTTTTTACTTGGATGGCTTAACATTTTTGCAAGAAAAATAGGAAGATATGAAGATGATGTTTTGGTTTGTTTATGAAATGCATATGGCTTGTCAGAGCTCATTCGACAGTTAAAGCCATTGTTTAAAGAAATGGTGCTTTGCTCTGTGTTTGTGCTCCTGATTTCCCTGGAGGTTCTGGATGAAGGCTGAACACAGGCTTGTTAATGTCAGTCTGTGCTGAGGACCTCAGGGACTTGAGGTTGCATTTTTGAGCATGGGGTGCAGGAGCCTTTCTGGATTTGGATGTGGCTATGGAAAGAACACAGAAGCCAAGGTCATGTGCATGAAATGAGGAGTTTGAGTTAGTCACCTCGGGGATTTTTTCCATTTTGCAGTAAAATGTTAAATTAATGTAGCCTGCCTCTATTTGTTGGGCAGGTAATTTCAAAGGGTTATTTGCCTCATCTCCTATCTTTAGTGAAATCTTATGTGTAATTATTCCACCGTGGGAACAGAGAATACCTGTTTAGTGTTGCACTTTAGACTGGTGTCTGTTTTGTTAATGCAGCTGTGCCACAAATTCTCCTTTATCTTTTAAAAATGTTATAGCTTTAAATTTTGATTTATTTTGACTGTGGAATAAATACATGAATGAAAAATTTTAA

Publications

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