Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BANF1P4
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:174756477-174757203  UCSC
Coordinates (T2T) chr1:174114437-174115163  UCSC
Coordinates (hg19) chr1:174725615-174726341  UCSC
Strand -
Parental Sequence NM_003860.4
Parental seq. overlap 663 bp
Parental seq. overlap (%) 90.7%
Genomic Region Intragenic (RABGAP1L)
Retrocopy Summary BANF1P4, located on chr1:174756477-174757203, is a retrocopy of the parental gene BANF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BANF1
Full Name BAF nuclear assembly factor 1
Also known as BAF|BCRP1|D14S1460|NGPS
Coordinate chr11:66002079-66004149
Strand +
Gene summary The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BANF1P1
Bonobo Pan paniscus BANF1P1
Gorilla Gorilla gorilla BANF1P1
Orangutan Pongo abelii BANF1P1
Gibbon Nomascus leucogenys BANF1P3
Green monkey Chlorocebus sabaeus BANF1P3
Crab-eating macaque Macaca fascicularis BANF1P1
Rhesus Macaca mulatta BANF1P1
Baboon Papio anubis BANF1P1
Golden snub-nosed monkey Rhinopithecus roxellana BANF1P4
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BANF1P4
AGTGGCTTGAGGTATAGGCAGGAGCAGCCAGGTGGCAGGAGGAACCATTATGGGAACTGAAGCTGACAATTAAACCTGAACAAGATTACAACCTCCCAAAAGCACCGAGACTTTGTGGCAGAGTCCGTGGGGGAAAAGCCAGTAGGGAGCCTGGCCGGGATTGGTGAAGTTATGGACAAGAAGCTGGAGGAAGGGTGCTTTGACAAGGCCTATGTTGTCCTTGGCCAGTTTCTGGTGCTAAAGAAAGATGAAGACCTCTTCTGAGAATGGCTGAGGGACACTGGTGGTGCCAATGCCAAGCAGTCCCAGGACTGCTTCAGATGCCTTCGAGAGTGGTGTGACACCTTCTTGTGATGCTTTCTGGGAAGCCCTCAATCCCCAGCCCTCATCCGGAGTTTGCAACCGAGTAGGGACTCCTCCCCTGTCCTCAACAAAGGAAAAGACTGCTATTGTCCTACTCACCTCCAATGTACTCCAGGGTCTTTTGGGAGTTTTCTCTCCTAATCATTTTAACTTTTTTGGATTCTCACTCTTGCATGCCTCCGCCTTCCTTTTTCCCCTGCTACTTCCCTGGGGACAGTCACCAGCTTTCCTGAATGGATTCCTGGCCCCATCCCTCACCCCCACCCTCAATTTCAGTCCGTTTGATACCATTTGGCTCCTTTTTTGGCAGAAAAGTCACTGTCCTTGTAAAGTTTTTTAGATCAATAAAGTCAGTGGCTTTCAA
>NM_003860.4
AGTGGCTTGAGGTATCCGCAGGAGCGGCCGGGTGGCGGGAGGAACCGTTACGGGAACTGAAGTTGCGGATTAAGCCTGATCAAGATGACAACCTCCCAAAAGCACCGAGACTTCGTGGCAGAGCCCATGGGGGAGAAGCCAGTGGGGAGCCTGGCTGGGATTGGTGAAGTCCTGGGCAAGAAGCTGGAGGAAAGGGGTTTTGACAAGGCCTATGTTGTCCTTGGCCAGTTTCTGGTGCTAAAGAAAGATGAAGACCTCTTCCGGGAATGGCTGAAAGACACTTGTGGCGCCAACGCCAAGCAGTCCCGGGACTGCTTCGGATGCCTTCGAGAGTGGTGCGACGCCTTCTTGTGATGCTCTCTGGGAAGCTCTCAATCCCCAGCCCTCATCCAGAGTTTGCAGCCGAGTAGGGACTCCTCCCCTGTCCTCTACGAAGGAAAAGATTGCTATTGTCGTACTCACCTCCGACGTACTCCGGGGTCTTTTGGGAGTTTTCTCCCCTAACCATTTCAACTTTTTTTTGGATTCTCGCTCTTGCATGCCTCCCCCGTCCTTTTTCCCTTGCCAGTTCCCTGGTGACAGTTACCAGCTTTCCTGAATGGATTCCCGGCCCCATCCCTCACCCCCACCCTCACTTTCAATCCGTTTGATACCATTTGGCTCCTTTTTTGGCAGAACAGTCACTGTCCTTGTAAAGTTTTTTAGATCAATAAAGTCAGTGGCTTTCATGA

Publications

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