Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LSM6P3
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:197238850-197239061  UCSC
Coordinates (T2T) chr1:196500695-196500906  UCSC
Coordinates (hg19) chr1:197207980-197208191  UCSC
Strand -
Parental Sequence NM_007080.3
Parental seq. overlap 171 bp
Parental seq. overlap (%) 7.7%
Genomic Region Intragenic (CRB1)
Retrocopy Summary LSM6P3, located on chr1:197238850-197239061, is a retrocopy of the parental gene LSM6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LSM6
Full Name LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Also known as YDR378C
Coordinate chr4:146175714-146191535
Strand +
Gene summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LSM6P1
Bonobo Pan paniscus LSM6P1
Gorilla Gorilla gorilla LSM6P1
Gibbon Nomascus leucogenys LSM6P3
Green monkey Chlorocebus sabaeus LSM6P5
Crab-eating macaque Macaca fascicularis LSM6P1
Rhesus Macaca mulatta LSM6P1
Baboon Papio anubis LSM6P1
Golden snub-nosed monkey Rhinopithecus roxellana LSM6P1
Orangutan Pongo abelii Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LSM6P3
AGAATATGCAAATGGACAACTGAAGAGTAAGTAAGAGATGCATCTATCCAAGGCAATACTGTTCCATACATAAATACGCAGAAGACTAGGATGTGAAGACACCAAAAGAAAGACACTTTTCACAGGTCGATATATTTCTTATGATTTCTTTCTATGTTTTTGTTCTTTTGTGATATAATTTGTCTTGTTTTTATAATAGCTGGTGAt
>NM_007080.3
CCCTGCCTCGGCGCTTTCGGTTTTGGCTGGGATCATCCGCGGCGGCCGGGCTCGTGGGGCGCCTGGAGTGAGGGTTCTGGTTCCCGCCGGCGAGGATTGTTAAAATGAGTCTTCGGAAGCAAACCCCTAGTGACTTCTTAAAGCAAATCATCGGACGACCAGTTGTGGTAAAATTAAATTCTGGAGTGGATTATCGAGGGGTCCTGGCTTGCCTGGATGGCTACATGAATATAGCCCTGGAGCAGACAGAAGAATATGTAAATGGACAACTGAAGAATAAGTATGGGGATGCATTTATCCGAGGAAACAATGTGTTGTACATCAGTACACAGAAGAGACGGATGTGAAGACACCAAGAGAGCAACGCTTTTCATAGTTGGATATATTTTTTTATGAATTTTTTCTAATTTTTGCTTCTTTTGTGATACAATTTGTCCTCTTTTTATAATAGTTGGTGATTTTTCACTGACATGTGAGTAAGATAAATGTATACAATTGTGGATTTAATTGTGAAATGTTCTTTCACTTGTAAGTTTCAGTCATTTTCTTTTACCTCGTTGTCAGTGTACAGAATGCTAAAATAATTAAAAAAAGACAAAATATACCTCTTCCTACAAGATTATTTAACTTAAGTTTCGAGAAGTGTCATTTCATTTGACTTGCTTTTCTTATCCAGCTAAAATGATGCATATATTTTATATATTGTATGGACATATAATTAAAACATTTTGGAGGAATCCTCCTTTATTGCATCCTTTTCTGTTCATACAGAATCCTTGCGTGAATATGTTCTACAAAGGCATCCAGTTTCAGTCTGAAGCTACAAAAAGGGGCCACAGGATCAGAAGTTCAGCCACTGATTGAGTCACCTAAATAAAAAACAGAATTGGAAAGCCAAGAGTGCCACTTGCACATAAGGAGTGGGAATTCGAACTGAGGTGCTGGAGAAATCCTAAAGATGAACAAGATTTCAGTGAGGAGAAAGCCCTCCTGTCAGTGGTCCCCCTGCATCTCCTTATGCAATTAGACTTTTTAGGTTTCCCTGCTCCCTTTCAGGAGCATTGGCATCAACGTTATTCTCTCAGTTTATGAACACAGTAGGGGAGGGGCCATTCCTGTACATCTCTCACAGTCAGATTAAAGCAAAGCCTAGAGTTTGTAAACATAATTCAGGTTCTAATTGCCGAGCTGAGATTGGGAAAGAATTTTTCCTAACTCTGGTCTAGCAAGTGGCTGTAGGGAGGCCTTTCTCAAAAATCAGCTGTATTTGCCTTTGACATTGTCCAGGAGCAGAGCACCAGGCTTTATGTTGCTTGGCACAAGGCAGCTCCTCTGGTTATGTGACTCCTGCTGAGAGGATTTTCACAATTTATTAATGAGCTTTCCACAACCCTGCTTTATTCTCCAAACAGTTTTACGCTGTCTCTAGGAACAACAAATATATCTGGGCACTGTGGTTGAATGAATACCAGACAATTGTGTGAATGTTGTATTGGACTTCCTCTTCCCTCCCTTCCCAATCTAAATAGCATTCCTATTTCAGGAGCCGATGGTGTGATTCGAAACAACTGCTTGGTTGAAGGATGGGGGGCAGGATCGAGAAGGAGAGAGGGAAGGGGCAGTGCTGATTCTGGAGAGGTGTATGTAGTGTTTTGTCTTGGTTTATTTTAAAGATCAGAGAGTAATTGGAAACAATTATTTTTTAATTAATAACTTGGGAAAGGTGAACAGAAGCATTTCACAGGGTTTTACCGTGTGCACACTGAAAATAAAACACTTTATGCTATGCTTCAATAATTTATCACTTCTTGACAGGGGCTTGGAAAAGGTCCAGTATGTAAGTACAAATCACCAATTTGCTCTTTTATAAATGAGTTCTTTTAAGGAGAAAATGGATGGCTCTCCAAGTGGAGCATACATGTTCTCATTTGTTTTGTAGAATATGTGGGGCTGCAGGTTATTGTGTCCCTTCATTCACTTATATCAGCCACCTCTAAAAGCAATTCCATTGTAGTCTCCCACTAATCTGTAGCGTCCTGTTTTTTCTAACTTCTTCCCTGACCTCGCCTTTGATATATAAGTCTTTATTTTCCCCTTGCCATCTCTCTAGTTTAATAGCTCTACAGTGGAGTACTGTTTTCAACCATGGAACTACTTTTAATCAAGATCAACTTTGGGAAGTGCTGCCATTTTTATGGTAATAAAGGACTGTATTATGCACTTGAA

Publications

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