Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CHMP5P2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:203805431-203806269  UCSC
Coordinates (T2T) chr1:203068617-203069455  UCSC
Coordinates (hg19) chr1:203774559-203775397  UCSC
Strand -
Parental Sequence NM_016410.6
Parental seq. overlap 762 bp
Parental seq. overlap (%) 40.1%
Genomic Region Intragenic (ZC3H11A)
Retrocopy Summary CHMP5P2, located on chr1:203805431-203806269, is a retrocopy of the parental gene CHMP5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CHMP5
Full Name charged multivesicular body protein 5
Also known as C9orf83|CGI-34|HSPC177|PNAS-2|SNF7DC2|Vps60
Coordinate chr9:33265049-33282070
Strand +
Gene summary CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CHMP5P1
Bonobo Pan paniscus CHMP5P1
Gorilla Gorilla gorilla CHMP5P1
Orangutan Pongo abelii CHMP5P1
Gibbon Nomascus leucogenys CHMP5P1
Green monkey Chlorocebus sabaeus CHMP5P1
Crab-eating macaque Macaca fascicularis CHMP5P1
Rhesus Macaca mulatta CHMP5P1
Baboon Papio anubis CHMP5P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CHMP5P2
CTCAAGATAAACTGATTCTTCAGGAAAGTGAAATTAAGGCTCCGCTGCCCAGCCTGAATGACTGCATTGGCATGGTGGACAGCAGGGCAGAATCCACTGACAAGATTTCTAGATTGGATGCTGAGCTAGTGAAGTATAAGGACCAGATCAAGATGAGAGGGGGTCCTACAAAGAATATGATTACGCAGAAAGCCTTGCGAGTTTTAAAACAAAAGCGGATGTATGAGCAGCAGCAGGACAATCGCACCCAAGAGTCATTCAACATGAAACAAGTTAATTACACCATCCAGTCATTGAAGGATACCAAGACCACGGTTGATGCTATGAAACTGGGAGCAAAGGAAATGAAGGTAGACAAGCAAGTGAAAACTGACCAGATTGAGAATTTACAAGACCAGCTAGTGGACATGATGGAAGATGCAAATGAAATCCAAGAAGCACTGAGTCGCAGTTATGGCGGCCCAGAATTAGATGAAGACAACCTAGAAGCAGAGTTGGATACACTGGGTGATGAGCTTGTGGCTGACCAAGAGTTCTATTTAGATGAGCCAGCATCTGCACCTGCAATTCCAGAAGGTGTTCCCACTGTCACAAAAACAAGGATGGAGTTCTGGTGGATGAATTTGGATTGCCACAGATCCCTGCTTCATACATTTGCATTTAAGTACATCATGTAAAACATATTATGGGACTATGAAATACTGATCTTTCCAAATTTACCGTAACAGATACGTTTCTGTCCTTTCTTTGAAGGAAAGTTTAATTACATTGCTCTTCTATTTTTTTCCTTTGAGACTCATTGCTTGGGAAATGCTTTCTTTGTACTAAAACTTGATTCT
>NM_016410.6
AGTGTTTGGGTTTCTTCGCGGCTGCTCAAGATGAACCGACTCTTCGGGAAAGCGAAACCCAAGGCTCCGCCGCCCAGCCTGACTGACTGCATTGGCACGGTGGACAGTAGAGCAGAATCCATTGACAAGAAGATTTCTCGATTGGATGCTGAGCTAGTGAAGTATAAGGATCAGATCAAGAAGATGAGAGAGGGTCCTGCAAAGAATATGGTCAAGCAGAAAGCCTTGCGAGTTTTAAAGCAAAAGAGGATGTATGAGCAGCAGCGGGACAATCTTGCCCAACAGTCATTCAACATGGAACAAGCCAATTATACCATCCAGTCTTTGAAGGACACCAAGACCACGGTTGATGCTATGAAACTGGGAGTAAAGGAAATGAAGAAGGCATACAAGCAAGTGAAGATCGACCAGATTGAGGATTTACAAGACCAGCTAGAGGATATGATGGAAGATGCAAATGAAATCCAAGAAGCACTGAGTCGCAGTTATGGCACCCCAGAACTGGATGAAGATGATTTAGAAGCAGAGTTGGATGCACTAGGTGATGAGCTTCTGGCTGATGAAGACAGTTCTTATTTGGATGAGGCAGCATCTGCACCTGCAATTCCAGAAGGTGTTCCCACTGATACAAAAAACAAGGATGGAGTTCTGGTGGATGAATTTGGATTGCCACAGATCCCTGCTTCATAGATTTGCATCATTCAAGCATATCTTGTAAAACAAACACATATTATGGGACTAGGAAATATTTATCTTTCCAAATTTGCCATAACAGATTTAGGTTTCTTTCCTTTCTTTGAAGGAAAGTTTAATTACATTGCTCTTTTATTTTTTCCATTAAGAGACTCATTGCTTGGGAAATGCTTTCTTCGTACTAAAATTTGATTCCTTTTTTTCTTATGAAAAACGAACTCAGTTTAAAAGTATTTTTAGCTCGTATGACTTGTTTTCATTCATTAATAATAATTTGAAATAAAACTAAGGAAATGGAATCTTAAAAGTCTATGACAGTGTAACTCTACAGTCTCAAAATGACCTGATAAATTGATAAGACAAAGATGAGATTATTGGGGCTGTTCATATTATGATTCAGAATCATTTTCTATTGTGGTATTATAGGTTGGTTAAAGTGATGGCCTTTTTGATGGGTTTTGTTGTGTCTTGTGAACAAGTCGTTACTGTGTCCATTATTGGAATGGAATTATCACTACTGTATCATGAGTGGGTATTTTGATTCTATGGTTCCCTCAGTATTACATCTTGACTTGTAATCAATTATGAATATTTCTTGATATTTAATGTATAGGACATTTATTTATACTCAATAAATATTTTTCAAAAGGATATAATTTTAATAATATCACTTCAGCTTAAAACCTCTACTGCGGAAACCAAATTTAATAGAATTTTAATGTCATTTCAGCCTATAACTCCACTACAGAAACCAAATTAACCAGTAGCATTGTGAGGAAAgagcaaggaacaatctgggcttgggccctgggtctaccatttactaactactgagtagtctattcaacctctctaaccttctgtttccttattagtaaaatcatgcttaactcacagagcttttgtgaggaataattgaggtaatggtcataagtaccttgttaactgcaaggggctattcttatatgagggattgttaACAATAAAAAAGAAACTGCTTCATTCTTTTCTTGGAAGGTGCCTGGAGTACTACAGCAAGTTCAAACTCCTGCCCAATTTCAGGGTCTTTAATGATCCTGTCCTCCCTTCCTCATTCAACTTGTTGCCAACAGCATGGCCCCTCCAGCCTAGCTGGGTGCCTCACAGTGCTATGTGCACCTGACTCTCATGTGTCTGCAGATCAAACCAATAAACATTTAGGAACACCA

Publications

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