Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DUSP5P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:228650486-228652296  UCSC
Coordinates (T2T) chr1:228028708-228030518  UCSC
Coordinates (hg19) chr1:228786233-228788043  UCSC
Strand +
Parental Sequence NM_004419.4
Parental seq. overlap 1525 bp
Parental seq. overlap (%) 60.5%
Genomic Region Intergenic
Retrocopy Summary DUSP5P1, located on chr1:228650486-228652296, is a retrocopy of the parental gene DUSP5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DUSP5
Full Name dual specificity phosphatase 5
Also known as DUSP|HVH3
Coordinate chr10:110497907-110511533
Strand +
Gene summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Marmoset Callithrix jacchus DUSP5P2
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DUSP5P1
TGGCCGTGATGGTGCTGAACTAGGGGAGCTGCCACGGGCAGAAGCTGTGCGAGGAGAGTGCCCGGCGGGTTGTCCTCACCTCACTGCTCGCCTGCCTGCCCTCCTGCTGGCGGGTCTACTTCCTCAAAGGGGGATATGAGACCTTCTTCCAGGGTTGCATGGATGTAAAACTCGTTTCACTCGTTTCAAAGTGAGAGAGCTCTCATCAGCCAGTGTGGAAAGCTAGTAGTGCTAAACATCAACTACAGGCCAGCTTATGATCAGGGTGGTCCAGTTGAAATCCTTTCCTCCCTCTACCTTGGAGGTGCCTACCATGCATCCAAGTGCAAGTTCCTCATCAAGCTATACATCACAGCCCAGCTGAATGTCCCCTTGTGGACCTGGCTGTGAGGCCTGCAAGACCCACCTACATACGAATGGATCCTTGTGGAAGAAGGCCACATGGCTGACATTAGCTCTCACTTTCAAGAAGCAATAGACTTCATTGACTGTGTCAGAGAAAAGAAAGGCAAGGTCCTGGTCCACTGTGAAGCTGGGTTCTCCTGTTCACCCACCATCTGCATGGCTTCCCTCATAAAGACCAAGCACTTCTGCCTGAAGGAGGCCTTCAATTATGTCAAGTGGAAGAGGAGCATGATCTCACCCAGCTTTGGCTTCATGGGCCAGCTCCTGCGGTAGGAATTTGAAATCCTCCCTTCCACACCCAATCCCTAGCTTCCCTCCTACCAGGGGGAGGCAGCAGGCTCTTCATTGATAAGCCATTTGCAGACATTTAGCCCTGACTTGAAGGGTGTCTACTGCACATTCCCTGCCTCAGTGCTGGCTCCAGTGCCCACCCACTGGACAGTCTCAGAGCTCAGCAGGAGCCCTGTGGCCACAGCCACATTCTGCTAAAACTGGGATAGAGGAACAAGCCCAGCCCCAAGAGCAGCTATGACTTTTGTTTTTAAGAATGGACATTTCACATCTGTGCAATACTGAAGACCTCACTTTGTCATGTTGCCCCAGTGACATAGTGAGAGGTCACCAGGCTTGCAAATGAACTTCACACAGACCTCAGGGTAGGTTCTCAGGATTGAAGGAAGGCCAAGCAATTACAGGAGCACAGCACGTGCTGACTACTGTACTTCCAGACCCCCTGCCCTCAAGGGACTGCCCAGTCCTTGCACCTCAAAGTTCGCCTTTTCATTTCAAGCATAAGGCAATAAATACCTGCAGCAACATGGGAGAAAGAAGTTGCTGGACCAACAGAAATGGCACTTATGAAGCCAATTCATTTTGAAGGAAGCACAATTTCCACCTTATTTTTCAAACTTTGGCAGTCTCAATGTCTGTCTCCGTaAGTAACCCTACAGGGTTTGTGGAGACATGATATATATGCCAATTTGAACCCTGAAATGTTTTTTACATACCCTCTTGGGTCCAATGGAGGCAGTTGGTTGAAGTAGCAAGATGTTGGCCTTTCTGGGTTTCTCTTTTGCTGTGGCTTCCTCACTGACCTTGGACTTTTATAAGTATGATACAAATCTACACTTGAATAAGTATGACTGTTACTCATACTTGAACTTATCTCATTGCACCTCTTCTCAGCAGCTCTTCATTTGAGAAAATATTTTTTCAGATCATAGACTAAAAAATCATACCATCAAGGTGGCGGCACCAGGTGCCAGGAGGAAAAGGGTACTTGCTGTGTATCCTGGGTCAGTAATATTGAAAACTGTCTTCTTCAGCTTCCTGTCCTTCTATGTGTTGTGTCTCTTGTGACAGTTGTTTT
>NM_004419.4
GGCTTCTAgggcggcgagcggccgggctggctatcgagcgagcggggcgggAACGCGGAGTTGCGCCGCCGCTCGGGCGCCGGGCTCCGTCGCGGCCGCAGCCCCGCGGGTCGCCCTCCCGTGCCTCGCCCGCGGACACCCTGGCCGTGGACACCCTGGCCGTGGGCACCcgcggggcgcgcggcgcggggccgctggccggcggcggcggcggcATGAAGGTCACGTCGCTCGACGGGCGCCAGCTGCGCAAGATGCTCCGCAAGGAGGCGGCGGCGCGCTGCGTGGTGCTCGACTGCCGGCCCTATCTGGCCTTCGCTGCCTCGAACGTGCGCGGCTCGCTCAACGTCAACCTCAACTCGGTGGTGCTGCGGCGGGCCCGGGGCGGCGCGGTGTCGGCGCGCTACGTGCTGCCCGACGAGGCGGCGCGCGCGCGGCTCCTGCAGGAGGGCGGCGGCGGCGTCGCGGCCGTGGTGGTGCTGGACCAGGGCAGCCGCCACTGGCAGAAGCTGCGAGAGGAGAGCGCCGCGCGTGTCGTCCTCACCTCGCTACTCGCTTGCCTACCCGCCGGCCCGCGGGTCTACTTCCTCAAAGGGGGATATGAGACTTTCTACTCGGAATATCCTGAGTGTTGCGTGGATGTAAAACCCATTTCACAAGAGAAGATTGAGAGTGAGAGAGCCCTCATCAGCCAGTGTGGAAAACCAGTGGTAAATGTCAGCTACAGGCCAGCTTATGACCAGGGTGGCCCAGTTGAAATCCTTCCCTTCCTCTACCTTGGAAGTGCCTACCATGCATCCAAGTGCGAGTTCCTCGCCAACCTGCACATCACAGCCCTGCTGAATGTCTCCCGACGGACCTCCGAGGCCTGCGCGACCCACCTACACTACAAATGGATCCCTGTGGAAGACAGCCACACGGCTGACATTAGCTCCCACTTTCAAGAAGCAATAGACTTCATTGACTGTGTCAGGGAAAAGGGAGGCAAGGTCCTGGTCCACTGTGAGGCTGGGATCTCCCGTTCACCCACCATCTGCATGGCTTACCTTATGAAGACCAAGCAGTTCCGCCTGAAGGAGGCCTTCGATTACATCAAGCAGAGGAGGAGCATGGTCTCGCCCAACTTTGGCTTCATGGGCCAGCTCCTGCAGTACGAATCTGAGATCCTGCCCTCCACGCCCAACCCCCAGCCTCCCTCCTGCCAAGGGGAGGCAGCAGGCTCTTCACTGATAGGCCATTTGCAGACACTGAGCCCTGACATGCAGGGTGCCTACTGCACATTCCCTGCCTCGGTGCTGGCACCGGTGCCTACCCACTCAACAGTCTCAGAGCTCAGCAGAAGCCCTGTGGCAACGGCCACATCCTGCTAAAACTGGGATGGAGGAATCGGCCCAGCCCCAAGAGCAACTGTGATTTTTGTTTTTAAGACTCATGGACATTTCATACCTGTGCAATACTGAAGACCTCATTCTGTCATGCTGCCCCAGTGAGATAGTGAGTGGTCACCAGGCTTGCAAATGAACTTCAGACGGACCTCAGGGTAGGTTCTCGGGACTGAAGGAAGGCCAAGCCATTACGGGAGCACAGCATGTGCTGACTACTGTACTTCCAGACCCCTGCCCTCTTGGGACTGCCCAGTCCTTGCACCTCAGAGTTCGCCTTTTCATTTCAAGCATAAGGCAATAAATACCTGCAGCAACGTGGGAGAAAGAAGTTGCTGGACCAGGAGAAAAGGCAGTTATGAAGCCAATTCATTTTGAAGGAAGCACAATTTCCACCTTATTTTTTGAACTTTGGCAGTTTCAATGTCTGTCTCTGTtgcttcggggcataagctgatcaccgtctagttgggaaAGTAACCCTACAGGGTTTGTAGGGACATGATCAGCATCCTGATTTGAACCCTGAAATGTTGTGTAGACACCCTCTTGGGTCCAATGAGGTAGTTGGTTGAAGTAGCAAGATGTTGGCTTTTCTGGATTTTTTTTGCCATGGGTTCTTCACTGACCTTGGACTTTGGCATGATTCTTAGTCATACTTGAACTTGTCTCATTCCACCTCTTCTCAGAGCAACTCTTCCTTTGGGAAAAGAGTTCTTCAGATCATAGACCAAAAAAGTCATACCTTCGAGGTGGTAGCAGTAGATTCCAGGAGGAGAAGGGTACTTGCTAGGTATCCTGGGTCAGTGGCGGTGCAAACTGGTTTCCTCAGCTGCCTGTCCTTCTGTGTGCTTATGTCTCTTGTGACAATTGTTTTCCTCCCTGCCCCTGGAGGTTGTCTTCAAGCTGTGGACTTCTGGGATTTGCAGATTTTGCAACGTGGTACTACTTTTTTTTTCTTTTTGTCTGTTAGTTATTTCTCCAGGGGAAAAGGCAATAATTTTCTAAGACCCGTGTGAATGTGAAGAAAAGCAGTATGTTACTGgttgttgttgttgttcttgtttttTATAGTGTAAAATAAAAATAGTAAAA

Publications

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