Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CFL1P4
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:241993205-241994508  UCSC
Coordinates (T2T) chr1:241405269-241406570  UCSC
Coordinates (hg19) chr1:242156507-242157810  UCSC
Strand +
Parental Sequence NM_005507.3
Parental seq. overlap 890 bp
Parental seq. overlap (%) 70.6%
Genomic Region Intergenic
Retrocopy Summary CFL1P4, located on chr1:241993205-241994508, is a retrocopy of the parental gene CFL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CFL1
Full Name cofilin 1
Also known as CFL|HEL-S-15|cofilin
Coordinate chr11:65854673-65858180
Strand -
Gene summary The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CFL1P2
Bonobo Pan paniscus CFL1P2
Gorilla Gorilla gorilla CFL1P2
Orangutan Pongo abelii CFL1P5
Gibbon Nomascus leucogenys CFL1P5
Rhesus Macaca mulatta CFL1P5
Baboon Papio anubis CFL1P1
Golden snub-nosed monkey Rhinopithecus roxellana CFL1P5
Marmoset Callithrix jacchus CFL1P12
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CFL1P4
ATCTCTGATGGTGTCATCAAGGTGTTCAACGACATGAAGGTGTGTAAGTCTTTGACGCCAGAGAAGGTGAAGAGGCACAGAAGACGGTGCTCTTCTGCCTGAGTGAGGACAAGAACATCATCCTGGGGGAAGGCAATGAGATCCTGGTGGGTGACGTGGGCCAGACCATCCATGACCCCTACACCGCCTTTGTCAAGATGCTGCCAGATAAGAACTGCCACTGTGCCCTCTACGACACAATCTATGAGACCAAGGAGAGCAAGAAGGAGGACCTGGTGTTTATCTTCTGGGCCACTGAATGGGCACCCCTTACGAGCAAAATGATCTATGCCAGCTCCAAAAATGCCATCAAGAAGAAGCTGACAGGGATCAAGCAAGAATTACAAGCAAACTGCTACGAGGAGGTCAAGGACCGCTGCACCCTGGCAGAGAAGGTGGGGGGCAGTGCCTTCATCCCCCTGGAGGGCAAGCCTTTGTGAGCCCTTTCTGGCTCCCTGCCTGGAGCATCTGGCAGCCCCACCTCTGCCCTCAGGGGTTGCAGGCTGCCCCCTTCCTACCAGACCGGAGGGGCTGGAGGGACCCCAGTAGGGGGAGGGCAATCCCTTCAGCCCAGTTGCCAAACAGACCTCCCACCGTGGATTTTCCTTCTCCCTCCATCCCTGACGGTTCTGGCCTTCCCAGACTGCTTTGGATCTTCTGATTCCTCTCGGGTTGAAGCAGATCAAGTTCCCCCCAGGCACCCGAGTTGTGAGGGAGACTGTATTTTTTTTAACAACACCCGCACTCCCCACCTGTTCCTTCCCCTTCCCATGCTGCCAACTACCATGCTGCCAACTTCTAACCACAATAGTGACTCTGTGCTTGTCTAGTTCTGTGTTTAAATGGAATGTTGTGAAGATGACCCCTCCCTGTGCCGACAGGTTCCTCTTCCTTTTCCCCTGGTCACAGCCACTCATGGAAGCAGGACCAGTAAGAAACCTACGATT
>NM_005507.3
GTTCAGTCGGGTCCCGGCAGCGGCTGCAGCGCTCTCGTCTTCTGCGGCTCTCGGTGCCCTCTCCTTTTCGTTTCCGGAAACATGGCCTCCGGTGTGGCTGTCTCTGATGGTGTCATCAAGGTGTTCAACGACATGAAGGTGCGTAAGTCTTCAACGCCAGAGGAGGTGAAGAAGCGCAAGAAGGCGGTGCTCTTCTGCCTGAGTGAGGACAAGAAGAACATCATCCTGGAGGAGGGCAAGGAGATCCTGGTGGGCGATGTGGGCCAGACTGTCGACGACCCCTACGCCACCTTTGTCAAGATGCTGCCAGATAAGGACTGCCGCTATGCCCTCTATGATGCAACCTATGAGACCAAGGAGAGCAAGAAGGAGGATCTGGTGTTTATCTTCTGGGCCCCCGAGTCTGCGCCCCTTAAGAGCAAAATGATTTATGCCAGCTCCAAGGACGCCATCAAGAAGAAGCTGACAGGGATCAAGCATGAATTGCAAGCAAACTGCTACGAGGAGGTCAAGGACCGCTGCACCCTGGCAGAGAAGCTGGGGGGCAGTGCCGTCATCTCCCTGGAGGGCAAGCCTTTGTGAGCCCCTTCTGGCCCCCTGCCTGGAGCATCTGGCAGCCCCACACCTGCCCTTGGGGGTTGCAGGCTGCCCCCTTCCTGCCAGACCGGAGGGGCTGGGGGGATCCCAGCAGGGGGAGGGCAATCCCTTCACCCCAGTTGCCAAACAGACCCCCCACCCCCTGGATTTTCCTTCTCCCTCCATCCCTTGACGGTTCTGGCCTTCCCAAACTGCTTTTGATCTTTTGATTCCTCTTGGGCTGAAGCAGACCAAGTTCCCCCCAGGCACCCCAGTTGTGGGGGAGCCTGTATTTTTTTTAACAACATCCCCATTCCCCACCTGGTCCTCCCCCTTCCCATGCTGCCAACTTCTAACCGCAATAGTGACTCTGTGCTTGTCTGTTTAGTTCTGTGTATAAATGGAATGTTGTGGAGATGACCCCTCCCTGTGCCGGCTGGTTCCTCTCCCTTTTCCCCTGGTCACGGCTACTCATGGAAGCAGGACCAGTAAGGGACCTTCGATTAAAAAAAAAAAAGACAATAATAAAAAGGCTCATTAATGGGATGTGTTTTTCAAGGTTGGGACACAGGAGACTTCAGGATTGGGGGTGCACTGGGATAATGGTGCTATCTCTCTCCTCTGTACTCCACACCCAACCAGCCCCTGCACACCCTTATCTGGCTCCAA

Publications

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