Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PHBP18
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:48168702-48169725  UCSC
Coordinates (T2T) chr12:48130058-48131081  UCSC
Coordinates (hg19) chr12:48562485-48563508  UCSC
Strand -
Parental Sequence NM_002634.4
Parental seq. overlap 939 bp
Parental seq. overlap (%) 51.1%
Genomic Region Intergenic
Retrocopy Summary PHBP18, located on chr12:48168702-48169725, is a retrocopy of the parental gene PHB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PHB1
Full Name prohibitin 1
Also known as HEL-215|HEL-S-54e|PHB
Coordinate chr17:49404052-49414882
Strand -
Gene summary This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PHBP13
Bonobo Pan paniscus PHBP12
Gorilla Gorilla gorilla PHBP13
Orangutan Pongo abelii PHBP13
Gibbon Nomascus leucogenys PHBP8
Green monkey Chlorocebus sabaeus PHBP8
Crab-eating macaque Macaca fascicularis PHBP9
Rhesus Macaca mulatta PHBP10
Baboon Papio anubis PHBP9
Golden snub-nosed monkey Rhinopithecus roxellana PHBP11
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PHBP18
GTGGCTGGGGAATTCATGTGTAGATCAGAGTGGAAGCAGGTGTGAGAGGGTCCAGCAGAAGAAAACATGGCAGCCAAAGTGTTTGAGTCCATCGGCAAGTTTGGCCCGGCCTTTGCTGTTGCAGGAGGCGTGGTGAACTCCGCCTTATATAATGTGTATGCTGGGCGGCAGAGCTGTCATCTTTGACCGATTCCGTGGAGTACAGGACATTGTGGTGGGGGAAGGGACTCACTTTCTCATCCCATGGGTACAGAAACCAATTATCTTTGACTGCCATTCTCCACCTCGTAATGTACCAGTCATCACTGGTAGCAAAGATTTACAGAATGTCAACATCACACTGCGCATCATCTTCCGGCCCATCGTTAGCCAGCTTCCTCGCATCTTCAGCATCGGAGACGACTATGATGAGCGTGTGCTGACGTCCACCACGACCAAGGTCCTCAAGTCAGTGGTGGCTAGCTTCGATGCTGGAGAAGTAATCACCCAGAGAGAGTTGGTCTCCAGGCAGGTGAACAACGACCTTACGGAGCGAGCAGCCACCTTAGGGCTCATCCTGGACGACGTGTCCTTGACACATCTGACCTTCGGGAAGGAATTCACAGAAGCGTTATAAGCCAAACAGGTGGCTCAGCAGGAAGCAGAGAGGGCCAGATCTGTGGTGGAAACGGCTGAGCAGCAGAAAAAGGCAGCCATCATCTCTGCTGAGGGCGACTCCAAAGCAGCCGAGCTGATTGCCAACTCACTGGCCACTGCAGGAGACGGCCTGAGTTGCCCAAGCTGGAAGCTGCGGAGGACATCGCGTAACAGCTCTCATGCTCTCGGAGCATGATCTACCTGCTGGCGGGGCAGACCGTGCTCCTCCGGCTGCTCCAGTGAGGGCCTGCCCACTCTGCCTGCACCTCCGCGGGCCAATTGAGCCACAGCCCCGATGATTCTTAACACCGCCGCCCACCCCCTCCACCCCAAAAATCACTGTGAAATTTCATGATTGGCTTAAAGTGAAGGAAATAAAGGTAAAATA
>NM_002634.4
GCAGTATGTGTGGTTGGGGAATTCATGTGGAGGTCAGAGTGGAAGCAGGTGTGAGAGGGTCCAGCAGAAGGAAACATGGCTGCCAAAGTGTTTGAGTCCATTGGCAAGTTTGGCCTGGCCTTAGCTGTTGCAGGAGGCGTGGTGAACTCTGCCTTATATAATGTGGATGCTGGGCACAGAGCTGTCATCTTTGACCGATTCCGTGGAGTGCAGGACATTGTGGTAGGGGAAGGGACTCATTTTCTCATCCCGTGGGTACAGAAACCAATTATCTTTGACTGCCGTTCTCGACCACGTAATGTGCCAGTCATCACTGGTAGCAAAGATTTACAGAATGTCAACATCACACTGCGCATCCTCTTCCGGCCTGTCGCCAGCCAGCTTCCTCGCATCTTCACCAGCATCGGAGAGGACTATGATGAGCGTGTGCTGCCGTCCATCACAACTGAGATCCTCAAGTCAGTGGTGGCTCGCTTTGATGCTGGAGAACTAATCACCCAGAGAGAGCTGGTCTCCAGGCAGGTGAGCGACGACCTTACAGAGCGAGCCGCCACCTTTGGGCTCATCCTGGATGACGTGTCCTTGACACATCTGACCTTCGGGAAGGAGTTCACAGAAGCGGTGGAAGCCAAACAGGTGGCTCAGCAGGAAGCAGAGAGGGCCAGATTTGTGGTGGAAAAGGCTGAGCAACAGAAAAAGGCGGCCATCATCTCTGCTGAGGGCGACTCCAAGGCAGCTGAGCTGATTGCCAACTCACTGGCCACTGCAGGGGATGGCCTGATCGAGCTGCGCAAGCTGGAAGCTGCAGAGGACATCGCGTACCAGCTCTCACGCTCTCGGAACATCACCTACCTGCCAGCGGGGCAGTCCGTGCTCCTCCAGCTGCCCCAGTGAGGGCCCACCCTGCCTGCACCTCCGCGGGCTGACTGGGCCACAGCCCCGATGATTCTTAACACAGCCTTCCTTCTGCTCCCACCCCAGAAATCACTGTGAAATTTCATGATTGGCTTAAAGTGAAGGAAATAAAGGTAAAATCACTTCAGATCTCTAATTAGTCTATCAAATGAAACTCTTTCATTCTTCTCACATCCATCTACTTTTTTATCCACCTCCCTACCAAAAATTGCCAAGTGCCTATGCAAACCAGCTTTAGGTCCCAATTCGGGGCCTGCTGGAGTTCCGGCCTGGGCACCAGCATTTGGCAGCACGCAGGCGGGGCAGTATGTGATGGACTGGGGAGCACAGGTGTCTGCCTAGATCCACGTGTGGCCTCCGTCCTGTCACTGATGGAAGGTTTGCGGATGAGGGCATGTGCGGCTGAACTGAGAAGGCAGGCCTCCGTCTTCCCAGCGGTTCCTGTGCAGATGCTGCTGAAGAGAGGTGCCGGGGAGGGGCAGAGAGGAAGTGGTCTGTCTGTTACCATAAGTCTGATTCTCTTTAACTGTGTGACCAGCGGAAACAGGTGTGTGTGAACTGGGCACAGATTGAAGAATCTGCCCCTGTTGAGGTGGGTGGGCCTGACTGTTGCCCCCCAGGGTCCTAAAACTTGGATGGACTTGTATAGTGAGAGAGGAGGCCTGGACCGAGATGTGAGTCCTGTTGAAGACTTCCTCTCTACCCCCCACCTTGGTCCCTCTCAGATACCCAGTGGAATTCCAACTTGAAGGATTGCATCCTGCTGGGGCTGAACATGCCTGCCAAAGACGTGTCCGACCTACGTTCCTGGCCCCCTCATTCAGAGACTGCCCTTCTCACGGGCTCTATGCCTGCACTGGGAAGGAAACAAATGTGTATAAACTGCTGTCAATAAATGACACCCAGACCTTCCGGCTCA

Publications

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