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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPS11P12
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:64396503-64397051  UCSC
Coordinates (T2T) chr12:64375136-64375684  UCSC
Coordinates (hg19) chr12:64790283-64790831  UCSC
Strand +
Parental Sequence NM_001015.5
Parental seq. overlap 464 bp
Parental seq. overlap (%) 80.7%
Genomic Region Intergenic
Retrocopy Summary RPS11P12, located on chr12:64396503-64397051, is a retrocopy of the parental gene RPS11. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPS11
Full Name ribosomal protein S11
Also known as S11
Coordinate chr19:49496434-49499708
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPS11P7
Bonobo Pan paniscus RPS11P6
Gorilla Gorilla gorilla RPS11P5
Orangutan Pongo abelii RPS11P5
Green monkey Chlorocebus sabaeus RPS11P4
Crab-eating macaque Macaca fascicularis RPS11P5
Rhesus Macaca mulatta RPS11P5
Baboon Papio anubis RPS11P3
Golden snub-nosed monkey Rhinopithecus roxellana RPS11P3
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPS11P12
TTTTTTCTCAGGCAGCCAAGAAGATGGTGGATTGAGACTGAGCATGCCTACCACAAGCAGCTGACCATCATTCAAAGCAAGAAGAGGGTACTGCTAAAGGAAACTGGCAAGAAGCAGCTCCTATGGTACTTACAAGAACATCGGTCTAGGCTTCAAGAGGTCCAAAGAGACTATTGAGGGCACCTACATTGACAAGGAATGCCTGTTCACTGGTAACGTCTCCATCTGAGGGCAGATCCTGTATGGCATGGTGACCAAGATGGAGATGCAGAGGACCACTGTCATCCAGAGAAACTATCTCCACTACATCCGCAAGTACAATTGCTTCGAGAAGTACCACAAGAACTTGTCCATGCACCTGTTCCTCTGCTTCAGGATGTCCAGATCAGCGACATTGTCACGTTGGATAAGTGCCAGTCCCTGAACAAGACGGTGTACTTCAATGTGCTCAAGGTCACCAAGGTCGCAGACATCAAGAAGCAATTCCAGAAGTTCTGAGGCTGAATGTCTGCCTGCTCCCCAAAATGAAATAAAGTTATTTTCTCATTC
>NM_001015.5
CTTTTTTTCAGGCGGCCGGGAAGATGGCGGACATTCAGACTGAGCGTGCCTACCAAAAGCAGCCGACCATCTTTCAAAACAAGAAGAGGGTCCTGCTGGGAGAAACTGGCAAGGAGAAGCTCCCGCGGTACTACAAGAACATCGGTCTGGGCTTCAAGACACCCAAGGAGGCTATTGAGGGCACCTACATTGACAAGAAATGCCCCTTCACTGGTAATGTGTCCATTCGAGGGCGGATCCTCTCTGGCGTGGTGACCAAGATGAAGATGCAGAGGACCATTGTCATCCGCCGAGACTATCTGCACTACATCCGCAAGTACAACCGCTTCGAGAAGCGCCACAAGAACATGTCTGTACACCTGTCCCCCTGCTTCAGGGACGTCCAGATCGGTGACATCGTCACAGTGGGCGAGTGCCGGCCTCTGAGCAAGACAGTGCGCTTCAACGTGCTCAAGGTCACCAAGGCTGCCGGCACCAAGAAGCAGTTCCAGAAGTTCTGAGGCTGGACATCGGCCCGCTCCCCACAATGAAATAAAGTTATTTTCTCATTCCCAGGCCAGACTTGGGATCTTC

Publications

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