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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NOP10P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:75964763-75965246  UCSC
Coordinates (T2T) chr12:75939848-75940331  UCSC
Coordinates (hg19) chr12:76358543-76359026  UCSC
Strand +
Parental Sequence NM_018648.4
Parental seq. overlap 441 bp
Parental seq. overlap (%) 86.8%
Genomic Region Intergenic
Retrocopy Summary NOP10P1, located on chr12:75964763-75965246, is a retrocopy of the parental gene NOP10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NOP10
Full Name NOP10 ribonucleoprotein
Also known as DKCB1|NOLA3|NOP10P
Coordinate chr15:34341719-34343136
Strand -
Gene summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NOP10P1
Bonobo Pan paniscus NOP10P1
Gorilla Gorilla gorilla NOP10P1
Orangutan Pongo abelii NOP10P1
Gibbon Nomascus leucogenys NOP10P1
Green monkey Chlorocebus sabaeus NOP10P1
Crab-eating macaque Macaca fascicularis NOP10P1
Rhesus Macaca mulatta NOP10P1
Baboon Papio anubis NOP10P1
Golden snub-nosed monkey Rhinopithecus roxellana NOP10P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NOP10P1
ACAGACGGAGCTGCGGACCAAATTGGAACCTCTGGCTTAAGAGTAATCATGTTTCTTCAGTATTAGTGAGCAGGGAGATCAGGTCTATACGCTGGAGAAATTTGACTCGATGGGACAACAGACCTGCTTAGCCCATCCTGCTCAGTTCTCCCCAGATGACAAATATTCCCGACACCGAATCACCATCAAGAAACGTTTAAAGGTGCTCATGACCCAGCAACCGCGCCCTGTCCTCTGAAGGTCCCTTAAACTGATGTCTCTTCTGCCACCTGTTACCCCCTAGAGACTCCGTAACCAAACTCTTCAATCTGTGAGCCCTGATGCCTTTTTGCCAGCCATGCTCTTTGGCATCCAGTCTCATCATGGTGATTGATCATGCTTGTGCGAGGCAATCATGGTGGCATCACCTGTAAAGGGAACACGTTTAACTTTTTTTCTCATATTTTAAATTACTGCAAGATTATTAAAGATAAAATGATTTGAA
>NM_018648.4
GTCGGGCGGACCACTGCAGACTGAGCGGTGGACCGAATTGGGACCGCTGGCTTATAAGCGATCATGTTTCTCCAGTATTACCTCAACGAGCAGGGAGATCGAGTCTATACGCTGAAGAAATTTGACCCGATGGGACAACAGACCTGCTCAGCCCATCCTGCTCGGTTCTCCCCAGATGACAAATACTCTCGACACCGAATCACCATCAAGAAACGCTTCAAGGTGCTCATGACCCAGCAACCGCGCCCTGTCCTCTGAGGGTCCCTTAAACTGATGTCTTTTCTGCCACCTGTTACCCCTCGGAGACTCCGTAACCAAACTCTTCGGACTGTGAGCCCTGATGCCTTTTTGCCAGCCATACTCTTTGGCATCCAGTCTCTCGTGGCGATTGATTATGCTTGTGTGAGGCAATCATGGTGGCATCACCCATAAAGGGAACACATTTGACTTTTTTTTCTCATATTTTAAATTACTACAAGATTATTAAAGATAAAATGATTTGAAAAA

Publications

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