Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DENRP2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:76057439-76059684  UCSC
Coordinates (hg19) chr12:76451219-76453464  UCSC
Strand +
Parental Sequence NM_003677.5
Parental seq. overlap 1540 bp
Parental seq. overlap (%) 56.5%
Genomic Region Intragenic (NAP1L1)
Retrocopy Summary DENRP2, located on chr12:76057439-76059684, is a retrocopy of the parental gene DENR. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DENR
Full Name density regulated re-initiation and release factor
Also known as DRP|DRP1|SMAP-3
Coordinate chr12:122752824-122771064
Strand +
Gene summary This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DENRP2
Bonobo Pan paniscus DENRP2
Gorilla Gorilla gorilla DENRP3
Orangutan Pongo abelii DENRP2
Gibbon Nomascus leucogenys DENRP2
Green monkey Chlorocebus sabaeus DENRP2
Crab-eating macaque Macaca fascicularis DENRP2
Rhesus Macaca mulatta DENRP2
Baboon Papio anubis DENRP2
Golden snub-nosed monkey Rhinopithecus roxellana DENRP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DENRP2
AGGCCCTGGCCGGGGAAACGAGTTGCATTTGTCGGCTCAGCTGGCAACAGTGGCGGGAGCAGAGCTGGCGGGGCCTGTGCAACTGCCTGGGTTTGTGAAATGGCTGCTGACGTTTCCGATTCCAATAGGGCTGACTGCAAAGGAGACCCAAGGAACAGAGCCAAGTTAGATGCTGATTACCTACTTTGAGTCCTTTATTGTGGAGTCTGTTCATTACCAATAGAGTACTGTGAATATATGCCTGATGTTGCTAAATGTAGACAATGATTAGAGAAGAATTTTCCAAATGAATATGCAAAACTTACTGTGGAAAATTCACCCAAACAAGAAGCTGGAATCTGTCAAGGTCAAGGAACAGCAGGGGAAGAAGAGGAGAAGAAAAAACAGAAGAGAGGTGGAAGGGGTCAAATAAAACAAAAAAACAAAGACGGTACCACAAAAGGTTACTATAGCCAAAATTCCCAGAGCAAAGAAATATGTGACAAGGGTTGTGGCCTTGTAACTTTTGAAATTGATCTTAAATCACACAAAGATTTTTTGCTCAAAAATTCTCCTGTGGTGCCTCAGTAACAGAGGAGGATGAAATTATCATTCAAGGAGACTTTACAGATGACATAATTGAGGTCATTCAGGAAAAACAGACAGAAGTAGATGATGACAGCATCGAAGATCTTGGAGAAGAAGTGAATTTGAAAATTTGTCTGTAGTTAATGGCCTGAACTGACAGTAGATATGGCCAAAGGGAGAGAGGCCTACGTATTCTACAGTAAAACTGTAGACTGCCTTCGTTCTTGGCATTTTCCCTGTTCTGTACAAGGCTGCTTATTTTTTTATTGCCAAAGTCAAATAAACAGGAGAGACTGTCATGCTCATACATGAACAGAATTTAGTCAAATAAAAAATTTTGGTTATTTGGTACTTTCTCTTTCTCTCTTTTTATTTTTTGAAAAACCCGGTAGACTTTGCGGTGACCATTTTTGTTGATTATTTTACTGATCTAAAGCTGAGTGATTTTTTAAAAGAATTTGAATTTGGCTTCCTCACCAATAATATGTCTCCTTGCTTCTCTGATGTGATAGTTTTGAGATGGGTGAGAATCTAATATATCTGTGGTTGAATTTGCTTTGCTGTTATCAAGTCCACCCTaCTGTGTGGTATGTTTATGTTTAAAGATGTGGTATGCATATGTTTAAAGAATCATATTTTCTAAGATTATTTGGAAACATGTTTGGTAATGTCAAGTGGGGGCACCCCAGATACATTTTAGACATTTAATCATCATCGTTCTGAGAGGAAGGCCATTCAGAGATGCTAGAGGTTCTTATTCTGGATATAAATTACATGAGTAAAATTCTACTAACCAATTAAAAATAATGTACAACCATGTTCAATATACAGTCCTGGAAATAGCAATTATGTCTTTTCACAAGAGAAAATGACAGTTTTAATGCTCCATCAGATGAATTCGAACTTTAAGTCAGGTGCTGCAAATTGGAAATAAGACTTGTGGTGTTTTAAACTGCTGTGGACACTTAAGAAACTTAGAACCCATGAAACCGCTGCTTATTGCCATGCAAATTACAATCTTGAATGACTGTTTTTTAAAAATAAAGTAATAGAAAAACGTGTAATAAAGACGTAAAATTAAAAAATG
>NM_003677.5
GTCTCGCGGGAGCGCTGCTGGCGGTCGGGCGCTCGGGCGGCCCTGGCCGGGGAGACGAGTTGCATGTGTTGGTTCAGCTGGCGATAGCGGCGGGAGCGGAGCCGGCGGGGCCTGTGCGACCGCCTGGGTTTGTGAAATGGCTGCTGACATTTCTGAATCCAGCGGGGCTGACTGCAAAGGAGACCCAAGGAACAGTGCCAAGTTAGATGCCGATTACCCACTTCGAGTCCTTTATTGTGGAGTCTGTTCATTACCAACAGAGTACTGTGAATATATGCCTGATGTTGCTAAATGTAGACAATGGTTAGAGAAGAATTTTCCAAATGAATTTGCAAAACTTACTGTAGAAAATTCACCCAAACAAGAAGCTGGAATTAGTGAGGGTCAAGGAACAGCAGGGGAAGAAGAGGAGAAGAAAAAACAGAAGAGAGGTGGAAGGGGTCAAATAAAACAAAAAAAGAAGACCGTACCACAAAAGGTTACTATAGCCAAAATTCCCAGAGCAAAGAAGAAATATGTGACAAGAGTATGTGGCCTTGCAACTTTTGAAATTGATCTTAAAGAAGCACAAAGATTTTTTGCTCAAAAATTCTCCTGTGGTGCCTCAGTAACAGGGGAGGATGAAATTATCATTCAGGGAGATTTTACAGATGACATAATTGATGTCATTCAGGAAAAATGGCCAGAGGTAGATGATGACAGCATCGAAGATCTTGGAGAAGTAAAGAAGTGAATTTGAAAATTTGTCTGTATTTAATGGCCTGAACTGAGAGTTGATATGGCCAAAGGGAGAGAGGCCTTTTAAAatatatatatatatacacatatatatgtatatatacacatatatgtatgtatacacatatacacatgtatatatacatgtgtgtatgtatacatgtatatatatatacatacacatatatgtatacatatatacacatatatgtatacatatatacacatatgtatacatatatatatatTCTACAGTAAAACTGTAGACTGTCCTCGTCCTTGGCATTTTCACTGTTCTGTACAAGGCTGCTTGTTTTTTTATTGCCAAAGTCAAATAAACGGGAGACTGTCATGCTCATGCATGAATAGAATTTAGTCAAATAAAAAATTTTGGTCATTTGGTACTGActttctctctctctctctctctcttttttttttttgacagagtctcgcactgttgcctgggctggaatgcagtggtgcgatctcggctcactgcaacctccgcctcccgggttcaagtgattctcctgcctcagcctcccaagtaggtgggattacaggcgcccgccaccacgcccagctaatttttgtatttttagtagagatggggtttcactatgttggccaggctggtctcgaactcctgacctcgtgattggcccacctcagcctcccaaagtgctggtattacagatgtgagccaccgcacccagcctgagtttctctttctctctTTTTAACTTTATTTTTTGAAAAACCCGGTAGACTTTTTGTGGGGAGCATTTTTGTTGATAATTTTACTGATCTAAAGCTGAGTGATTTTTTAAAAGAATTTGAATTTGGCTTCCTCACCAGTAATATGTCTCCTTGCTTCTTTGATGTGATAGTTTTGAGATGGGTGAGAATCTAATAGATCTGTGGTTGAATTTGCTGTGTTGTTATGAAGTCCACCCTGTGGGCACAATAAcataactgttggtaggagttgtttgagctattctggagattatttggtaaagtatactaaaagccttaaaaccatgtatgtgcgctgtttgaacccgtaagccacttctttgacattagaagacattagaagaaataatcagccttgcataaaacttatggatgaaagtattcatcacaatattatttataataaaaaattgcaaatgttataaatgaacaattgggaaatggttaaagaagtgatggtgcattgtgtggtagaatattatgcatatgtttaaagaatcatattttctaagattatttggaagcatgtttggtaatgtcaagtggaGTACCCCAGATACATTTTAGACATTTATCGTCATCATCTGCTCTGAGTGGAAGGCCGTTCAGAGAGGCTAGAGGTTCTTATTCTGGCTATAAATTATGTGAGTAAAATTGTGCTAACCAGTTAAAAGTACTGTACACCCATGCTCAATATATAGTCCTGGAAATAGCAATTGAAACATGTCTTCTCACAAGAGAAAATGACAGTTTTAATGATGTATTTGATGAATTTAAACTTTAAGTCAGGTGCTGCAAATTGGAAAGAAGACTTGTGGTGTTTTAAGTTGCTGTGGACACTTTTAAGAAACTTAGAACCCATGGAACCCTTGTTTATCGCCATGCAAATTACAATCTTGAATGAGTGTTTTTTAAAAATAAAGTATTAGAAAAATGTGTAGTAAAGATGTAAAATTAAAAAATGGAATTCTCCATTAACTGTGGATTTTACTAAATAGAATTACTGGTGAAGCAGATTTATCCATCGAGACTATCTGGTATGCGTTATGTATGTAGTCTGTTGCTGCTGAAAGATGTCTGTGTGCCTGTATCAACATGTGACTTCATGTAAAGTTTCTTTGTGTTCACAGTTCTTAGCAAATGCAGTTACAATCCATAGATAGCCAGCAGTGGATGTTACTCCAGGAAAATGCAGGATTAAAATTGTCCTTGTGTATAA

Publications

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