Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SUPT4H1P2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:8511305-8512789  UCSC
Coordinates (T2T) chr12:8494764-8496248  UCSC
Coordinates (hg19) chr12:8663901-8665385  UCSC
Strand -
Parental Sequence NM_003168.3
Parental seq. overlap 979 bp
Parental seq. overlap (%) 55.9%
Genomic Region Intergenic
Retrocopy Summary SUPT4H1P2, located on chr12:8511305-8512789, is a retrocopy of the parental gene SUPT4H1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SUPT4H1
Full Name SPT4 homolog, DSIF elongation factor subunit
Also known as SPT4|SPT4H|SUPT4H|Supt4a
Coordinate chr17:58345178-58352201
Strand -
Gene summary This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SUPT4H1P2
Bonobo Pan paniscus RNF43P1
Gorilla Gorilla gorilla SUPT4H1P2
Orangutan Pongo abelii SUPT4H1P2
Gibbon Nomascus leucogenys SUPT4H1P3
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SUPT4H1P2
AGGCCAGTCTCACACACTCACATTTTACATTTTCCTTACTGGAGACCCTTGGGCCTTGGCCGACTGCTGGGTCCTAGTCTGCCTTGTTTGTGCCCCTGTAGGAGGCAGGTCCTTTTCTCCGCCGGCCCAGTAGGGGACCTTGGGTAACATCCCATTTTTCGGCCAAAGTGAGTTATTTGTTTTAGGATAAAAAATTTACTACAAATTCTCATTTACTTAAATTTCCACAGAAATCCTGTTAGTGTCCCCATTTTTACTTCCTGCGGGTGCTCAGGCTGTGGCCATCTTCCTTGCTGTTGCTCTTCTCATTGGAGAAGATGGCCCTGGAGACGGTGCTGAAGGACCTGTGGCATCTGTGGGCCTGTTTGCTGTGTTCACTGGTCAAGGTACTATAGACCAGTTTGAATATGATGGTTGTGACTATTGAGATGCATATCTACAGATGAAGGGTAACTGAGAGATGCTATATGGCTGCACCAGCTCCTCCTTTGATGGAATCATTGCGATGATGAGTCCAGAGGACAGCTGGGTCTCCAACTGGCAGCGAGTCAATAACTTTAAGCCAGGTGTATATGCGGTGTCAACCACTGGTCGCTTGCCCTAAGGAATCGTGCGGGAGCTGAAAAGTTGAGGAGTGGCCTACAAATCCAAAGACACAGCTATAAAGACCAGACGCAGGGCTGCCAGCGTCTTTGCTCTCCACCTCCTGCCTCTGCTTATTTTTTGTTCTGGAACTAAATGGGCAGAGCTTCAAATGCTTCCTACCCTCCAATTCAGACTCAGCCAACTGTTGAGAGAACAGCACATCATTTTATCATTTTACCTTATTTGGACTTCAGGTGGGGGTGGGAGGGATTTGGGTTGGTGGATTAACAGATGGAATTGAGGAGAGAGTAGGATGCTGACTTTCCTACCTGTAGCCCAAGGCTGCGCCTTGCTCATGAAGAGGTCTAGGTCAAATGTCAATAAATAGAAACCTCTAGAAAGTTCTTAAGGCCATGACACCTGCCTCGCTTCCCTCTTCCTTTCTCTTAGGCACACAGTAAGAGCTTATTTGCCCTATAAGATACCTTCCCAGAGCAGCAGAGGCCCTTCCACTCCCTCTTGACTGTCTCAGCCTCCAGGATTGCAGCCTTTGTAGTGTGCTTCCTTGCTTCCTATCAGAAGGTGCTGTCCAGAGGCTCAGTAACCCCATCAGCTTGGTGGCCCTGGTGTCTTGTGCTTGTATCCTTCTGCCCTTGAGACCTGGCACAGCAGTATCCCTTGAAGAAATCCTGAGGCTTTGTCGTGCTCCTTGCTCCTTGACCATGTTTAATAAt
>NM_003168.3
ATTTACTTCCTGCGGGTGCACAGGCTGTGGTCGTCTATCTCCCTGTTGTTCTTCCCATCGGCGAAGATGGCCCTGGAGACGGTGCCGAAGGACCTGCGGCATCTGCGGGCCTGTTTGCTGTGTTCGCTGGTCAAGACTATAGACCAGTTTGAATATGATGGTTGTGACAATTGTGATGCATATCTACAAATGAAGGGTAACCGAGAGATGGTATATGACTGCACTAGCTCTTCCTTTGATGGAATCATTGCGATGATGAGTCCAGAGGACAGCTGGGTCTCCAAGTGGCAGCGAGTCAGTAACTTTAAGCCAGGTGTATATGCGGTGTCAGTCACTGGTCGCCTGCCCCAAGGAATCGTGCGGGAGCTGAAAAGTCGAGGAGTGGCCTACAAATCCAGAGACACAGCTATAAAGACCTAGCAAGATGCAAGGCTGCCAGCATCTTTGCTCTCCACCTCCTGCCTCTGCTTATTTCTTGTTCTGGAACTAAATGAACAGAACTTCAAATACTTCCTACCCTCCAATTCAGACTCAGCTGACTGTTGAGAGAGCAGCACATCATTTTATCATTTTATCTTCTTTGGACTACAGGTGGGGTGGGAGGGATTTGGGTTGGTGGATTAACAGATGGAATTGAGGAGAGAGTAGGATGCTGATTTTCCTACCCGTGGCCCAGGTCTGTGCCTTCCCCATGCCAAGGACTCTAGGTCAAATGTCAATAAATATGAACCTCGAGAAAGTTCTGAAGGCCATGACACCTGCCTTGCCTCCCTCTTCCATTCTCTTAGGCACAGTAATAGCTTATTTGCCCTATAAGAACCTTCCCAGAGCAGCAGAGGCCCTTCTACTCCCTCTTGACTGTCTCAGCCTCTGGGATTGCAGCCTTTGTAGTGTGCTTCCTTGCTTCCTATCGGAGGGTGCTGATCCAGAGGCTCAGTAACCCCATCAACTTGGTGGCCCTGGTGTCTCACACTTGTATCCTTCTGCCCTCGAGACCTGGCACAGCAGTATCCCTTGAAGAAATCCTGAGGCTTTGTAGAGTGCTCCTTGACCATGTTTAATAATTCTTCCCTCCCCTGCTTGTCTATTTTCTTCTCTTCACGGCTCTTCCTATACCTTAGGCCAGTCTCAAGCACTCACTGGAGACCCTTGGGCCTTGGGCGACCATTGAGTCCTAGTCTCCCTTGTTTGTGCCCCTGTAGGAGGTAGGTCCTTTTCTCCTCCGGCCTAGTAGGGGACCTTGGGTAACATCCCATTTTTCGGCCAAGGTGAGTTGTTTTAGGATAAAAAAATTTACCACAAATTCTCATTTAAATTTCCACAGAAATCCTGTTCGTATCCCCATTttgatttccctaagttccttgttctccctctaaaaagagaatgattgcaccctgcctgtttacctcaggattgttgtgattgtagaaacgaagctatgtgaaaattatataagtattataaagGTGAAATACTTTTGCTCTC

Publications

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