Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LAMTOR3P1
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:36922442-36923682  UCSC
Coordinates (T2T) chr13:36141643-36142889  UCSC
Coordinates (hg19) chr13:37496579-37497819  UCSC
Strand +
Parental Sequence NM_021970.4
Parental seq. overlap 1126 bp
Parental seq. overlap (%) 27%
Genomic Region Intergenic
Retrocopy Summary LAMTOR3P1, located on chr13:36922442-36923682, is a retrocopy of the parental gene LAMTOR3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LAMTOR3
Full Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Also known as MAP2K1IP1|MAPBP|MAPKSP1|MP1|PRO0633|Ragulator3
Coordinate chr4:99878336-99894546
Strand -
Gene summary This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla LAMTOR3P2
Orangutan Pongo abelii LAMTOR3P2
Gibbon Nomascus leucogenys LAMTOR3P3
Green monkey Chlorocebus sabaeus LAMTOR3P1
Crab-eating macaque Macaca fascicularis LAMTOR3P3
Rhesus Macaca mulatta LAMTOR3P3
Baboon Papio anubis LAMTOR3P3
Golden snub-nosed monkey Rhinopithecus roxellana LAMTOR3P2
Marmoset Callithrix jacchus LAMTOR3P2
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LAMTOR3P1
GGTCTTTGAAGCTGTTCCTGAAGTGACAGTGGAGAGAACCGGGCAGCCCAGAAACCCCAGGCAAGGAGATTGATCCTGCAAGAGAAGGGGGTTCATCATGGCGGATGACCTAAAGCGATTCATGTATCAAATGTTACAAAGTGTTGAAGGGCTCCATGCTATTGTTGTGTCAGAGTTGGAGTACCTGTTATTAAAGTGGCCATTGATAATGCTCCAGAGCATGCTTTGAGACCTGGTTTCTTACCTACTTTTGCCCTTGCAACAGACCACGGGAGCAAACTTGGACTTTCAAAAAATAAAAGTATCATCTGTTACTGTTACACCTACCTGGTGATTCAGTTAAATCATTTACCTTTGGTGGTGAGTTTCATAGCCAGCAGCAATGCCAATACAGAACTAATTGTCAGCCTAGAAAAGAAACTTACTCCATTATTTGAAGAATTGAGACAAGTTGTGGAAGTTTCTTAATCAGACAGTGGTTTCAATGTGTACCTTATCTTTATTATAACAACACAATATCGATCCAGCAATCTTTAGACCATAATACTTTTATCCATGTCCTCAAGAAAGGGCCTCTTTTTCCAACTTATACTGAAGAGCAAGCATATAGATAAAATTTATGGACGGATTGATTGTTATATTTTCTGGTGTAGGGTCTTTTCTTATTTAGTGAGATCTGGGGATACCACAAAAATAGTTCAGTCTGTCACAGCACCCATGGAGTTAGTCCAGCCACCAAATATGGATGAGATTCTATTCCGTGGATCAGAATCAAACTGGTACATTGATCCATTTGAGCCATTAAGTGCTCTCTATTGTACAATCTGCCCAGGCCTGCAGAATGAAGCAGATTTTTTATTGCGAATAATAATGAGATATTTTTCTTCAGATTATGTTTTATTTCTTCTCATTGAGTGTGAGGAACATAAAATGGCTTAGTAAAAGCAATAAAATCAGTACAGTCACTAGCTTTCCTTTGTACTTATTACTTTATGATATAGATGAATATTACTGATTGGTTTGATTCTTCTCAGAGGGTGCTGCTCTTTAATGAAAATAAAAATTATAGCTAATGGTTTTTCCTCAAACTCTGCTTTCTATAACTAATCAGTGTTTTAATGTTTGTGTGTTCTTTATAAAATTTAAATGTAATTGGTTACTGAATTCTGTTTCCAATATTAGTATTATGTAAACATGATAGTATAACCATTTTTTCATGTGAGTATACATAAAATAGTATT
>NM_021970.4
ATGAATCATGTGACGGTGGCTTGAGGAGGAACCTGTCTTTAAAGCTGTCCCTGAAGTGACAGCGGAGAGAACCAGGCAGCCCAGAAACCCCAGGCGTGGAGATTGATCCTGCGAGAGAAGGGGGTTCATCATGGCGGATGACCTAAAGCGATTCTTGTATAAAAAGTTACCAAGTGTTGAAGGGCTCCATGCCATTGTTGTGTCAGATAGAGATGGAGTACCTGTTATTAAAGTGGCAAATGACAATGCTCCAGAGCATGCTTTGCGACCTGGTTTCTTATCCACTTTTGCCCTTGCAACAGACCAAGGAAGCAAACTTGGACTTTCCAAAAATAAAAGTATCATCTGTTACTATAACACCTACCAGGTGGTTCAATTTAATCGTTTACCTTTGGTGGTGAGTTTCATAGCCAGCAGCAGTGCCAATACAGGACTAATTGTCAGCCTAGAAAAGGAACTTGCTCCATTGTTTGAAGAACTGAGACAAGTTGTGGAAGTTTCTTAATCTGACAGTGGTTTCAGTGTGTACCTTATCTTCATTATAACAACACAATATCAATCCAGCAATCTTTAGACTACAATAATACTTTTATCCATGTGCTCAAGAAAGGGCCCCTTTTTCCAACTTATACTAAAGAGCTAGCATATAGATGTAATTTATAGATAGATCAGTTGCTATATTTTCTGGTGTAGGGTCTTTCTTATTTAGTGAGATCTAGGGATACCACAGAAATGGTTCAGTCTATCACAGCTCCCATGGAGTTAGTCTGGTCACCAGATATGGATGAGAGATTCTATTCAGTGGATCAGAATCAAACTGGTACATTGATCCACTTGAGCCGTTAAGTGCTGCCAATTGTACAATATGCCCAGGCTTGCAGAATAAAGCCAACTTTTTATTGTGAATAATAATAAGGACATATTTTTCTTCAGATTATGTTTTATTTCTTTGCATTGAGTGAGGAACATAAAATGGCTTGGTAAAAGTAATAAAATCAGTACAATCACTAACTTTCCTTTGTACATATTATTTTGCAGTATAGATGAATATTACTAATCAGTTTGATTATTCTCAGAGGGTGCTGCTCTTTAATGAAAATGAAAATTATAGCTAATGTTTTTTCCTCAAACTCTGCTTTCTGTAACCAATCAGTGTTTTAATGTTTGTGTGTTCTTCATAAAATTTAAATACAATTCGTTATTCTGTTTCCAATGTTAGTATGTATGTAAACATGATAGTACAGCCATTTTTTTCATATGTGAGTAAAAATAAAATAGTATTTTTAAAAATATAGTTTGAGCACTGTATAGGTCCTTTTTTTGTTCAGACTTTTTCCAAAAATCTAAACATAATTAATATACTCTTTCAGCCACATGAATAAATAATGAGTGTTTCTTGTAGGTATTGGTTTGGAGATTGTTTTACGGTAGTATGAACTGTTAACTGGAAAAGAAACCTgagattgcagtcagccaagattgtgccactgcaccccagcctgggcaacagagactccgtctcaaaaacaaaaaagaaaagaaaCCAAGAAACCTCAGGCATGAACCTAATTTAATCTCCATGAAAGAGGTACTACAGTTCTAGAATATACCCTTTATGTTCAGGAATGCAGTCTATCATTCAGAGTTAATTTCTTTCTAGGCTCTTTGACAATCAGTTTTTCCCTGGATCAGTTCAGTACATATGCATTGAGCACCTGTGTGCCAGTCAGCCGAGCTATCAcattgcacaattctaagaagcaccattcatgtctcatcatatttctatgctctgggagttgcctttcacatagaatatgtgtgattgttatccctagaattgtgcagtgAGGCAATTGGCTAGGTGCTGTGCTGCtttttctttctttctttttttttttaagagacagagtcttgctgtgttgcccagtctggagtgcagtggtggcatgatcttgcctcactgtaacctctgcctcctgggttcaagctgttctcatgccccattctcccttgtagctgggattacaggcttacaccatcgcacttggcaaatttgtgtatttttagtagagacaggaattcaccatgttggccaggctggtcttgaactcctgacttaaagtgatccacctgctttggcctcccaaaatgctaggattataggtgtgagccactgcaccgggccATGTGCTACTTtttcttccttccatccttcctcccttcttcAGTGTAAATATGAGATTAATTTGTGATACCTTACTTTAAAGAACTTAGAGTTCAGTAAAGGAAGCAGGTATAGAaagtgctatgataaagctatacataggatggtatagaaccacagactaggggcacttaaaatgggcAAGAAAATAGCCTTTGTAAATAAAATAGAGGCAAGAGATATAATGCTTTACCTGCAAAGAGCTATAAATAcagccatgtaccatataatgatgtttcagttagtgaaggaccacatacgagggtggtcagaacagcaggctataccatatagcctaggtgtgtagtaggctataccatatagcctaggtgtgtagtagtaggctataccatatagcctaggtgtgtagtagtaggcgataccatatagcctaggtgtgtagtagtaggctataccatatagcctaggtgtatagtagtaggctataccatatagcctaggtgtgtagtaggctataccatatagcctaggtatgtagtagtaggctataccatatagcctaggtgtgtagtagtaggctataccatctggggttcctgtcagtacagtatgatgttcacataatgatgaaatcacctaacaaagcatgtctcgaaatgtatccacattgttacgtaacacatgactgTAGTTAATTGTTACAATTGAAATACTAGATGTACTCATTGAAATCCAGAATTCCCATTATCTGGATtatttaatatcgttcaggaaatttttgccagtgcaatggtgcatgaaacaatgtcttttagaaatgaggtggccagatttctatttgcagataataattgtatatctaaaaatccTAGAAAAAGAAATGATAACAAATGGAGCTACTTAACCTTTACATGTTGAATGCTGCCACTGTTAAAATTTCTGAGGGGGTATAATAGATAAACTATCCCATAGTTCATCTGGAAAAATAAGGTGGTGAAAATTGCTAAGAAATTTTTGAAAGGGTAATGTAAACCTAGATTAACTGTTTTTGAAAGGTAGTACAGAACTGAATGCACAACTAGATATCAATGGTATGTACTCACCCAGAAAAAAGACTTCAGTACATACATGTGAGGGCTTAAAACATTGTTATAAAGACGGGATCACAATGGGAAAAGGATTATTCAATAAgtagggcaggcattctctatgcctgctagggaagtgtgacttgttatactctttatgtacagcaattggcagtctgtgaaacttttaaattcatatacataaccttttgccctgcaattccacttctagaaatttatcctaccaaacaaagcacatagatgtgcaaaagtatgtatttacaagtatattctttgcaacttggtaatgtcaaagaattggaagcaacctaaatatctgccataggtaggataaccatatgctttggctttttgaacactaccagtttatacctgctgttcttggataattattaatagtgctttcattctcaatgtctcactttagataataaattacaGAGGATTGGTGAAACTAATTTGCCCAATGGaaaaaggaatgaagaagtgctttaggtactgagatgaaaagatctctaaggcataataatgtttattgagaaaagcatggtgtcaaactgtatggcatgctacaattgatgtataagaagaaaaaatgtgtatgtattcctatttgtttgtatatggtagactgtctctgaagacatatatggaagaacctgatcacattggtagtctccaaggagcagaactagatacctgggggataaggatcccaggagtgagccttttcattgtaaacttcattgtactttgagtttttaacTGTTCAAAAATAATAAAATTAGAAATAAAATATTTCAACAAACAATAAAATGGGATATTTGGGGAAGAAAGTTGTCtcagggctctccaaagaagcagaa

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