Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RBM8B
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Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:60397706-60400514  UCSC
Coordinates (T2T) chr14:54604011-54606819  UCSC
Coordinates (hg19) chr14:60864424-60867232  UCSC
Strand +
Parental Sequence NM_005105.5
Parental seq. overlap 2571 bp
Parental seq. overlap (%) 52.4%
Genomic Region Intergenic
Retrocopy Summary RBM8B, located on chr14:60397706-60400514, is a retrocopy of the parental gene RBM8A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RBM8A
Full Name RNA binding motif protein 8A
Also known as BOV-1A|BOV-1B|BOV-1C|C1DELq21.1|DEL1q21.1|MDS014|RBM8|RBM8B|TAR|Y14|ZNRP|ZRNP1
Coordinate chr1:145921556-145927484
Strand -
Gene summary This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>RBM8B
GGAGGTACCTAGTGTCTGAGCGGCACAGACGAGATCTCGATCGAAGGCGAGATGGCGGACGTGCTAGATCTTCACGAGGCTGGGGGCGAAGATTTCGCCATGGATGAGGATGGGGACGAGAGCATTCACAAACTGAAAGAAAAAGCGAAGAAACAGAAGGGTCGCGGCTTTGGCTCCGAAGAGGGGTCCCGAGCGCGGATGCGTGAGGATTATGACAGCGTGGAGCAGGATGGCGATGAACCCGGACCACAACGCTCTGTTGAAGGCTGGATTCTCTTTGTAGCTGGAGTCCATGAGGAAGCCACCTAAGAAGACATACACGACAAATTCGCAGAATATGGGGAAATTAAAAACATTCACCTCAACCTCAACAGGCGAACAGGATATCTGAAGGGGTATACTCTAGTTGAATATGAAACATACAAGGAAGCCCAGGCTGCTATGGAGGGACTCAATGGCCAGGATTTGATGGGACGGCCCATCAGCATTGACTGGTGTTTTGTTCGGGGTCCACCAAAAGGCAAGAGGAGAGGTGGCCGAAGACGCAGCAGAAGTCCAGACCGGAGACGTCGCTGACAGGTCCTCTGTTGTCCAGGTGTTCTCTTCAAGATTCCATTTGACCATGCAGCCTTGGACAAATAGGACTGGGGTGGAACTTGCTGTGTTTATATTTAATCTCTTACCCTATATGCGTAGTATTTGAGTTGCGAATAAATGTTCCATTTTTGTTTTCTACATTTAATGTTACTTTCCTGTCCTAAAATTGAAAGTTCTAAAGCATAGCAAGGCTGTATGGATCATTGTGAAGATACTTCTAGGGACTGAACTCTATGTAtTATGTGAGTTTCTATATTAGACATAGTCTCAAGTTTCAGGTAGGGTTTAAAGTAGAGACACTGGTCAGTATTTCTTTTTTGGGGGGAACTAGGAGAGCAGGAGTAGAAGTGAGATGTTAAGATCTTATGGCACTAAAGACTTACTATTCTGTTCCTACATACTCTGTTAGGATCAGATAGATGTTATAGAAATGCCTTTTGTTTCTCCTGCCCTTCTTGATGTCACAGTTTTTTGTACTTCCAGCTGTCTAAAGGCATGAATCTCCTCTTGGAGCATTCTCCCAGACCCTTCTTTAGAAGAGTCTATACTAAGTTCTTGGTGCCCTCTTCGGCAGCCAAGGGTGAAGGCCCCATAGAGGAGAGGATCCAAAGGAGCATTGAGGAGGCCCAAGAGGAAAAGGATGTGGCTCAGGCTGGGAGGGACTTCAGTTAGCATGGTGGGGGAGAACCAGTACCACATACCCAGTAGGTAATAAGGTGTCCAGCAGAGGATGAAGGTCAGCAAGATAAGCAGGGCCAGTCTCAGGGCCCGGAGACGAACACGGGGACAATTGTCAAAGGAGCGGGGGAGGGCAAATTCACCAGCAGGGGCTAGGAATTTAGAAAATATACTGTAATTCAGACACTCAGCTTCTGATCTGAGTATAGGGTGAATTGATGGAGGGGCATAGGTAGTGAGACAGAGCTCACCTCCTACAAGGAGGAGAATGTTGCAAACCGTTTTCCCCTTCCCAACCTGGGACTATATGATTTCTTACCCCCAGGGATTATGATAGAAATATGAAGCCACCAAGTCTAGACTTGATGGTGTTCAAGAATAAATAATACTCATTGCCTCCCTAGTCCTTGTCCAGCTAACTCAGCTGTTTATAATTGAAGGGATTCAACAAAATTATCTCTAGCATCAGGTGCTAGACATGGTTAGAATCTCACCATGGTTTAGTGACTGGTAGATAGCTATTAGGTAGGTAGATAAATAAATGATGCTAGAGGCAACAGGTCTAGGGTTAAGGATTAAGGCCTGGGAATTGGAGTCTCACCATGGCTCCCCTTCCTTGTCTGGGGGCTGGACACACTGAGGACAATGCGGCTATAGCAGATGACCATGGCAGTCAGTGGCAGCAGAAAGAGGCAGCAGAAGGTGAAGAGGTTATAGGTGGTCTCTTGCCATTGAGCCTTGAAGCTGCCTTTGGTGACACACTGAGTGAAAGGGACTGGGCCAGCTCAGTGGACGGTGTGGAACAGGAACAGCTGGAGTGGAGTTGAGGACTATTAGAACTGGTTCCCCTCACCACCCAACCTACCTACCTATGTCATACTATCTCCTCCCAATTCATCCTTAATTCCAAGTTAAGCAGCACAGTGCTGAGAAACAGTTCATCCATGGTGCCATGTTAAAGAAGTTGGAAATATATCTTGAAAATCCTATCTTCCTTTTAGGCTTGAATATGATGCTGAACAGTAAGTTTGTTAAATCTTGGAACTTAAAACAATCCTGCTTTCTCAAGTACTATTCTAACATTGTGCTTTATAAGGGATGATATTTCTACCACCTCACTCATATTTTTAGCTGAAATGATTTTCCTGGTATGTCTGTTATTTTGTGGAAAAAGAAATATTGTGTAAAATGGGTGCTGCCAAAATTCCAGGCCATTTTGCAGTGACTCTGAAGTGACCTTTAGTAGTAATAGTCTTATGTGCAGTAACTATAATGGTAAAGAATATTAAATAATAAAATTTAACATTTTCCAAATGC
>NM_005105.5
AGTTTCCCGAGGTACCTAGTGTCTGAGCGGCACAGACGAGATCTCGATCGAAGGCGAGATGGCGGACGTGCTAGATCTTCACGAGGCTGGGGGCGAAGATTTCGCCATGGATGAGGATGGGGACGAGAGCATTCACAAACTGAAAGAAAAAGCGAAGAAACGGAAGGGTCGCGGCTTTGGCTCCGAAGAGGGGTCCCGAGCGCGGATGCGTGAGGATTATGACAGCGTGGAGCAGGATGGCGATGAACCCGGACCACAACGCTCTGTTGAAGGCTGGATTCTCTTTGTAACTGGAGTCCATGAGGAAGCCACCGAAGAAGACATACACGACAAATTCGCAGAATATGGGGAAATTAAAAACATTCATCTCAACCTCGACAGGCGAACAGGATATCTGAAGGGGTATACTCTAGTTGAATATGAAACATACAAGGAAGCCCAGGCTGCTATGGAGGGACTCAATGGCCAGGATTTGATGGGACAGCCCATCAGCGTTGACTGGTGTTTTGTTCGGGGTCCACCAAAAGGCAAGAGGAGAGGTGGCCGAAGACGCAGCAGAAGTCCAGACCGGAGACGTCGCTGACAGGTCCTCTGTTGTCCAGGTGTTCTCTTCAAGATTCCATTTGACCATGCAGCCTTGGACAAATAGGACTGGGGTGGAACTTGCTGTGTTTATATTTAATCTCTTACCGTATATGCGTAGTATTTGAGTTGCGAATAAATGTTCCATTTTTGTTTTCTACATTTAATGTTACTTTCCTGTCCTAAAATTGAAAGTTCTAAAGCATAGCAAGGCTGTATGGATCATTGTGAAGATACTTCTAGGGACTGAACTCTATGTAtttcttttttttcttttttttgagatagagtcttgctgtgttacccagggtggattgcagctgatcatagctcactgcagcttcaaactcttgggctcaagccatccttctgcctcactgtccctagtagttgggattacaggcacatgccaccatgcccagctaaatttttaatatttttgtagagatggggtcttgctgtgttacctgggctagtTATGTGAGTTTCTATATTAGACATAGTCTCAAGTTTCAGGTAGGGTTTAAAGTAGAGACACTGGTCAGTATTTCTTTTTTGGGGGGAACTAGGAGAGCAGGAGTAGAAGTGAGATGTTAAGATCTTATGGCACTAAAGACTTACTATTCTGTTCCTACATACTCTGTTAGGATCAGATAGATGTTATAGAAATGCCTTTTGTTTCTCCTGCCCTTCTTGATGTCACAGTTTTTTGTACTTCCAGCTGTCTAAAGGCATGAATCTCCTCTTGGAGCATTCTCCCAGACCCTTCTTTAGAAGAGTCTATACTAAGTTCTTGGTGCCCTCTTCGGCAGCCAAGGGTGAAGGCCCCATAGAGGAGAGGATCCAAAGGAGCATTGAGGAGGCCCAAGAGGAAAAGGATGTGGCTCAGGCTGGGAGGGACTTCAGTTAGCATGGTGGGGGAGAACCAGTACCACATACCCAGTAGGTAATAAGGTGTCCAGCAGAGGATGAAGGTCAGCAAGATAAGCAGGGCCAGTCTCAGGGCCCGGAGACGAACACGGGGACAATTGTCAAAGGAGCGGGGGAGGGCAAATTCACCAGCAGGGGCTAGGAATTTAGAAAATATACTGTAATTCAGACACTCAGCTTCTGATCTGAGTATAGGGTGAATTGATGGAGGGGCATAGCTAGTGAGACAGAGCTCGCCTCCTACAAGGAGGAGAATGTTGCAAACCGTTTTCCCCTTCCCAACCTGGGACTATATGATTTCTTACCCCCAGGGATTATGATAGAAATATGAAGCCACCAAGTCTAGACTTGATGGTGTTCAAGAATAAATAATACTGATTGCCTCCCTAGTCCTTGTCCAGCTAACTCAGCTGTTTATAATTGAAGGGATTCAACAAAATTATCTCTAGCATCAGGTGCTAGACATGGTTAGAATCTCACCATGGTTTAGTGACTGGTAGATAGCTATTAGGTAGGTAGATAAATAAATGATGCTAGAGGCAACAGGTCTAGGGTTAAGGATTAAGGCCTGGGAATTGGAGTCTCACCATGGCTCCCCTTCCTTGTCTGGGGCCTGGACACACTGAGGACAATGCGGCTATAGCAGATGGCCATGGCAGTCAGTGGCAGCAGAAAGAGGCAGCAGAAGGTGAAGAGGTTATAGGTGGTCTCTTGCCATTGAGCCTTGAAGCTGCCTTTGGTGACACACTGAGTGAAAGGGACTGGGCCAGCTCAGTGGACCGTGTGGAACAGGAACAGCTGGAGTGGAGTTGAGGACTATTAGAACTGGTTCCCCTCACCACCCAACCTACCCACCTATGTCATACTGTCTCCTCCCAATTCATCCTTAATTCCAAGTGAAGCAGCACAGTGCTGAGAAACAGTTCATCCATGGTGCCATGTTAAAGAAGTTGGAAATATATCTTGAAAATCCTATCTTCCTTTTAGGCTTGAATATGATGCTGAACAGTAAGTTTGTTAAATCTTGGAACTTAAAACAATCCTGCTTTCTCAAGTACTATTCTAACATTGCGCTTTATAAGGGATGATATTTCTACCACCTCACTCATATTTTTAGCTGAAATGATTTTCCTGGTATGTCTGTTATTTTGTGGAAAAAGAAATATTGTGTAAAATGGGTGCTGCCAAAATTCCAGGCCATTTTGCAGGGACTCTGAAGTGACCTTTAGTAGTAATAGTCTTATGTGCAGTAACTATAATGGTAAAGAATGTTAAATAATAAAATTTAACATTTTCCAAATGCTATTGGGCTGCCCCTCCCCCTTTTTGTTAAATTGCTGGGTTTTCCAACTGAATCAGTAAAAACTATTTCTGTTTAGAGCTACAAGGTTAAAGTGCCTGCTTTCCAGTAATGGAGATTGAGTCACTATTAATTTGATAAAAGGTAAGCTCAGTAGGCATCAGATTCCTAGATACAAGGCATTTGGGAAAGTGATTTTAGCAGACATGAGGGACATTTAGGAAAGATGAATAGTTTCAGCCTAAGAGAATTTTGTGAACTGTTTGGAGTTACGATCAGGCTACTCTGAGCTAGTTGGGAAATGGTCTTTCCTCTTCCCATCTCTTGCATTCATATATTTCTAAGtttttttttttgtttttgtttttGTGCTCTGCCTAAGAAGTGCTTGAGAATTGTGAGGAGTATAAAAATAGTCAAAGCTggctgggcgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggcggatcacgaggttaggagatggagaccatcctggctaacacagtgaaaccctgtctgtactaaagatacaaaaaactagccgggcgtggtggtaggtgcctgtagtcccagctacttgggaactcgggaggctgaggcaggagaatgacctgaacccaggaggcggagcttgcagtgagcagagattgcgccattgcactccagcctgggcgacagagtaagactgtctccaaaaaaaaaaaaaaTAATAATCAAAGCTCTTGGATTTATAGTTTGGTCCACAGCCTTGTTTTGATCTTTCCTTTATCCTGTTTTATTGCCATTTACCACGTACTGTAGAAACATCCCTTTCAACTGCTGATAACTTGGAAACAAGCCTACAAAAATAAGTAATTTCTAACTACTCCTAATACTACCTATAACTACCCCTAAGCCCTTACCACTCTAACGTGACATTATTAAATTTTTTATTTTATTAACACTAATATTTTAACTACAATTACAGCATATGGGCAATACAGAATTTACCTAAAAGGATACTAATTTGGAACAAAAAAAATCACCTTTCGCACATGTATCATGTCACAACCAGTTTGCCATTGAAACAAATagaggttgcaaatattgtcagattgtcaggctgtaagaaaggatgaaattcatttcccattgcatcatcttgtggcccatggatttcaagtgccttagccaaaatcatatagctagttagcagtagagccgagactcagaaAAAAACAAAGTAAAACAGGCAGACTGAAACAAAAAGTCTTCTAATTCCCAGTCCACATGTAAAATTTGCTTCATATAAACAAACCTAATTGTAAATGGCACTGTAGCAACAGGCTTCTTTTTAACACTTGGATTGGTAAAGGTCTTGTTTGCAACATATTAGAAGTATTATTTTTCTCTTTCCCCCCCACCCCACCCCCAacagagtctggctctgccgcccacgccggagtgcagtggtgcagtcttggctcactgcagcctccacttcccaggttcaagcaattctcgtgcctcagcctcctgagtagttgggattacaggtgctcaccactatacccggctaatttttgtatttttagtagagatggggtttcgtcatgttggccaggttggtcttaaactcctgacctcaagtgatccacccaccttggccttccaaaatgctgggattacaggcttgagccaccaggccTTTCTTTGTTCTTAGGAGTATAGTCAGACTAACTTCTAGTAGTTATATTTCTAATAATTGAGGATGTAAGTAAGGATCAAATCTTAAATCAGTATAATGCATTGTCATTCCAGAGATAAATCCTAGACCCTTCTTGGCCTCCTTCTGACATAATTCTAATCCTACAGTCTCAGAGATGCTGTTGTATCCTGCCCCCCAACCCCATGATAGTGATAGTGGTTTTTGCCTTGAAGGAATTGCTTTGTATTTAGCTTTTCCCCCTCTAGATTTCTAGTTCCTTTTCAGTATTGGATTGGATTTGAGATTTGATTAACCTAGTACTCAGGTTCAGATGCTCGCCTCTTTGCAATTTTAACACTCATTCGACAATAAAGTCAGTAAAAAACACAAA

Publications

PMID - Link Title
No publications available for this retrocopy