Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GLRXP2
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:90107624-90108893  UCSC
Coordinates (T2T) chr14:84331809-84333078  UCSC
Coordinates (hg19) chr14:90573968-90575237  UCSC
Strand +
Parental Sequence NM_002064.3
Parental seq. overlap 994 bp
Parental seq. overlap (%) 65.4%
Genomic Region Intragenic (KCNK13)
Retrocopy Summary GLRXP2, located on chr14:90107624-90108893, is a retrocopy of the parental gene GLRX. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GLRX
Full Name glutaredoxin
Also known as GRX|GRX1
Coordinate chr5:95813849-95822726
Strand -
Gene summary This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GLRXP2
Bonobo Pan paniscus GLRXP2
Gorilla Gorilla gorilla GLRXP2
Orangutan Pongo abelii GLRXP2
Gibbon Nomascus leucogenys GLRXP4
Green monkey Chlorocebus sabaeus GLRXP2
Crab-eating macaque Macaca fascicularis GLRXP2
Rhesus Macaca mulatta GLRXP2
Baboon Papio anubis GLRXP2
Golden snub-nosed monkey Rhinopithecus roxellana GLRXP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GLRXP2
tGCAATACCTACAACTGAGGATTCTTCCCAGGGGGACCGCAGCCTGTCAGCATGGCTCAAGAGTGTGGGGACCCAAGAGATCCTCAGTCAACTGCCCATCAAACAAGGGCTTCTGGAATTTGTCGAGATCACAACCACCAACCACACTAACAAGATTCAAGATTATTTGGAACAGCTCACGGGAGCAAGAATGGGGCCTTGAGTCTTTATCAGTAAAGATTGTATAGGCAGATGCAGTGATCTAGTCACTATGCAATAGAGTGGGGAACTGCTGACGCGGCTAAAGCAGATTGGAGTTTTGCAGTAACCACAGAGCAGGCCACACGCTGACTTTCCTCCTCAAGAGCTGGATGGCATTGCATGTGATGACAGCACTTCCTGGTGGATGAATTTGGGGGGCACAAACAGCTTTTTTCTTCTTTTGCCTCAGTATTTAAAAGTGGATCAACTTGCTCTTGACCACGGGGCCAAGAAGGTTGATGGGCCATCTTGGTTTTCTTCTTGATGTGCTCTTTGGTTTTCAGAAGATTGTGACAAGTTCTGGCCTAGGATTCGCTCACTCACCCTCAATTGTTCTTTCTCTTTGGCACGCGTTTCTTACTGTTCTCCACGTGTCGGCATGCCTCTGCCTCTAAGCCAGTGTTTTTCAACTATGTTTCTACAGACTCCTTCTCCACAATGATGAATCCTTGGTTGGTTTTCTGCTACTGCCCATTAGCTGAAATCATTTTTCCTCTTGACTTTGTGGAGTTGGTGTTATGAAATCAGTGGGTATTTTGAATGTGTTCTTTCAAACGACTGCATCTCTCCGGAGACACAACCCCACCCCATCCCATCCCACCTTGAGAATCACTGCTCTGAACCAGTGTTGTCCACCTTGTCCTCTCACAGATCTCATAGGAAATGTTCAACAATTCTGTGAAAGCTCTCAGGACTCAACTGGAGAAATCATATGAAAAGTTAAGCATAGTTGGTCTTGCTGTCATATGGATCAGAGGCACAAGTGCAGAGGCTGTGGTCGTGTAGAACcTACCCTAAGAGTGTATCTCTGAAAGAGCCCCCAATGCTTTGAAAACTAAGAATCCCTT
>NM_002064.3
GCTCAATACCCCAAGCAATACCTGCAACTGAGGATTCTTCCCGGGGAGACCGCAGCCCATCGGCATGGCTCAAGAGTTTGTGAACTGCAAAATCCAGCCTGGGAAGGTGGTTGTGTTCATCAAGCCCACCTGCCCGTACTGCAGGAGGGCCCAAGAGATCCTCAGTCAATTGCCCATCAAACAAGGGCTTCTGGAATTTGTCGATATCACAGCCACCAACCACACTAACGAGATTCAAGATTATTTGCAACAGCTCACGGGAGCAAGAACGGTGCCTCGAGTCTTTATTGGTAAAGATTGTATAGGCGGATGCAGTGATCTAGTCTCTTTGCAACAGAGTGGGGAACTGCTGACGCGGCTAAAGCAGATTGGAGCTCTGCAGTAACCACAGAACAGGCCCCATGCTGACGTCCCTCCTCAAGAGCTGGATGGCATTGCAAATGATGACAGCACTTCTGGTGGATGAATTTGGGGGCACAAACAGCTTTTTTCCTCTTTTGGCTCAGTATTTAAAAGTGGACCAACTTGCTCTTAATCACAGGGCCAAGAAGGTTGACGGGCCATCTTGGTTTTCTTCTGGATGTGCTCTTTGGTTTTCAGAAGACTGTGACAAGTTCTGGCCCAGGATTCGCTCACTGACCCTCAATTGTCCTCTTTGGCATGCGTTTCTTACTGTTCTCCATGTGTCGGCATGTCTCTACCTCTAAGCCAGTGTTTTTCAACTATGTTTATCCAGACTCCTTCTCCACAATGATGAATCCACAGTTGGTTATCTGCTACTGCCCATTAGCTAAAATCATTTTGCTGCTTGACTTTATGGAGTTTGTATTATGAAATCAGTGGGTATTTTGAATGTGTTCTTTCTAACTACATGCATCTCTCCACTCAACTCCACCCCATCCCATCCCACCTTGAAAATCACTGCTCTGAACCAGTGTTCTCCACCTTGTCCTCCACAGATCTCATAGGAAATGTTCAACAATTCTGTGAAAGGTCACAGGACCCAATTGGAGAAATCATATGAAAAGCATAGTTGGTCTTGGTGTCATATGGATCAGAGGCACAAGTGCAGAGGCTGTGGtcatgcggaacactctgttatttaagatggctatccagataatcctgaacactgtgtatttattttatttagactaccagcaaagattaaagcatgaaatgtaaaacatctgataaaacttacagccccctacaccaagagtgtatctgtgaaAGAGCTCCTACACTTTGAAAACTTAAGAATCCCTTATCATGAAGTTTGCCTGTTCTAGAATTGTAAGATTGTTAATTTCCTTCAATCTCTAGTGACAACACTTAATTTCTTTTCTAATAAAAAAAACCTATAGATGATTCAGTGATTTTTGTCCAATTCATTTGCATGTTCTCAAGACATTAAGGAATGTTATGCGAAATACACTAACTTAAAACTGTGTTTATATTTGGCCCTGCCATTATAAATAAAGACACGTGCTGCTGTCA

Publications

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