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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPS8P12
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:21709594-21710295  UCSC
Coordinates (T2T) chr15:19057841-19058542  UCSC
Coordinates (hg19) chr15:22440168-22440869  UCSC
Strand -
Parental Sequence NM_001012.2
Parental seq. overlap 667 bp
Parental seq. overlap (%) 85.7%
Genomic Region Intergenic
Retrocopy Summary RPS8P12, located on chr15:21709594-21710295, is a retrocopy of the parental gene RPS8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPS8
Full Name ribosomal protein S8
Also known as S8
Coordinate chr1:44775540-44778779
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla RPS8P4
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPS8P12
CTCTTTCCAGCCAGTGCCGAGCGATGGACATCTCTTGGGACAACTGGCACAAGTGCCACAAAACCAGGGACAAGAGAAAGCCCTACCACAAGAAGCGGAAGTATGAGTTGGGGCACCCAGCTGCCAACACCAAGACTGGCCCCCGCCGCATCCACACAGTCCGTGTGTGGGGAGGTAACAAGAAATACTGTGCCCTGAGGCTGGACGTGAGGAATTTCTCCTGGGGCTCAGAATGTTGTGCTCATAAAACAACGATCATCGATGTTGTCTACAATGCATCTAATAACGAGCTGGTTCGTCCCAAGACCCTGGTGAAGAATTGCATTGTGCTCATTGACAGCACACTGTACCGACAGTGGTACGAGTCCCACTATGCGCCGCCCCTGGGCTGCAAGAAGGGAGCCAAGCTGACTCCTGAGGAAGAAGAGATTTTGAACAAAAAGCGATCTAAAAAAATTCAGAAGAAATATCATGAAAGGAAAAAGAATGCCAAAATCAGCAGTCTCCTGGGGGAGCAGTTCCAGCAGGGCAAGCTTCTTGCATGCATTGCTTCAAGGCCAGGACAGTGTGGCTGAGCAGATGGGTATGTGCTAGAGGGCAAAGAGTTGGAGTTCTATCTTAGGAAAATCAAGGCCCGGAAGGGCAAATAAATCCTTGTTTTGTCTTCACCCATGTAATAAAGGTGTTTATTGTTTTGTTCCA
>NM_001012.2
GTTTTACAAACCGAACCGTGAATCTTTGCGGTTTCTCTTTCCAGCCAGCGCCGAGCGATGGGCATCTCTCGGGACAACTGGCACAAGCGCCGCAAAACCGGGGGCAAGAGAAAGCCCTACCACAAGAAGCGGAAGTATGAGTTGGGGCGCCCAGCTGCCAACACCAAGATTGGCCCCCGCCGCATCCACACAGTCCGTGTGCGGGGAGGTAACAAGAAATACCGTGCCCTGAGGTTGGACGTGGGGAATTTCTCCTGGGGCTCAGAGTGTTGTACTCGTAAAACAAGGATCATCGATGTTGTCTACAATGCATCTAATAACGAGCTGGTTCGTACCAAGACCCTGGTGAAGAATTGCATCGTGCTCATCGACAGCACACCGTACCGACAGTGGTACGAGTCCCACTATGCGCTGCCCCTGGGCCGCAAGAAGGGAGCCAAGCTGACTCCTGAGGAAGAAGAGATTTTAAACAAAAAACGATCTAAAAAAATTCAGAAGAAATATGATGAAAGGAAAAAGAATGCCAAAATCAGCAGTCTCCTGGAGGAGCAGTTCCAGCAGGGCAAGCTTCTTGCGTGCATCGCTTCAAGGCCGGGACAGTGTGGCCGAGCAGATGGCTATGTGCTAGAGGGCAAAGAGTTGGAGTTCTATCTTAGGAAAATCAAGGCCCGCAAAGGCAAATAAATCCTTGTTTTGTCTTCACCCATGTAATAAAGGTGTTTATTGTTTTGTTCCCACATTTATGTTGCCTGAATATATGACTGTTTTCTCTGCTTTA

Publications

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