Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name N4BP2P1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:30288380-30288780  UCSC
Coordinates (T2T) chr15:28081642-28082042  UCSC
Coordinates (hg19) chr15:30580583-30580983  UCSC
Strand +
Parental Sequence XM_011513716.2
Parental seq. overlap 326 bp
Parental seq. overlap (%) 5.2%
Genomic Region Intergenic
Retrocopy Summary N4BP2P1, located on chr15:30288380-30288780, is a retrocopy of the parental gene N4BP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name N4BP2
Full Name NEDD4 binding protein 2
Also known as B3BP
Coordinate chr4:40056223-40187039
Strand +
Gene summary This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes N4BP2P1
Gorilla Gorilla gorilla N4BP2P1
Orangutan Pongo abelii N4BP2P1
Golden snub-nosed monkey Rhinopithecus roxellana N4BP2P1
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>N4BP2P1
GGCTAAAGTAAAAGACACTTCCTTAACTTAGAACTGTGAAGAATTTAATAGAGAAACAAGGCTGAACACATCTGAATTTTGAAGAGCTATTTATGACTTCATGTCGTATATGACAAATTTTATTATCGTTCTCTTTAAAATCGAGCAATTGATTCTCATCATCCAAAGGGTGAACCTGTTTTTAATAAATGAATTAACTATGAGACTGCTCATTAAAATGTAATATTGCAACTATCTATGGAAGAATAGATTATACAATTTTCAGCCAGCATAAGAAAAACAAAAAGATTTTATTTGAACTATTAAAAAAAGTAATTTTCCTGTCAACTCTGTACTTTTTTATATACATTTTTATAACTTTGCTTTAAAAATTTCTTGTGAAACGATTTGCAAATTACATA
>XM_011513716.2
TTGCAGCCTGGACCCCGCGCGCGTCAGGGCTCGTCCCAGCTCTGCTTTCCTTTCTCCCCTCACCTCGCGAGGCCGACCTTGTGTTTGTTTTGTTTTTTGGGGCTCGGGAGAGTGCCGAGGGCTAGAAACAGCTGTGGTTTACCGCGCCGCTTATTTTGGCAAAAATTCCGGGCCTGTTGCAATGTTCCCCAGCGCCAAACAGCTCCCGCCTTCCCCCCAAGCAGAACCCGACACTCGAAGAAGGGCTTGCTCCTCCAGGGACCCCCTGATAAGAAAAGTGGGGACCACGGCCCGCTCTCGGGCGAGACTTGGGGGGTGGGCGACCGGAAGCAGCCGAACCGGCCGGGCAGGGCTTGCTCTCCAACGGGAGAGCGGGAGCGGGAGAGGTGGGAGCGCCCGCGGGCTCAAGTCCCCCGGGCCGCCGCGCCGAGGCGGAGCTCGGGGACGAAGCAGAGGTCGTGGCGGACAGCCGGCGGGCTTGGGGGGGGGCGGTGGGCGGCGATCCACCTGGGCGACGTGGCAGCCATTGCCGGCGCCTCGAGACCCCTCcccacccggccgcccacccgccctctcgcGGCGGGCTTCTGCGCGGCTGCTCTTCCCCGGCCGGACGGAGAGCGGCAGTGTCTCCCCGCCGGGCGCGCTCGCCGTGTCTCCCCCGCGGCCGCAGCTGCTTGCTAGCCTTGCGCGGCGCGGGAGAGCGCAGTGGCGCCGGCGGGAAAGGGCTGCGGACCTGCGGCGCCGCGTTGTGCGTTCGACGACGCGGCACCGGCTTCGACGCCCTCTGCCCGCTCCAGAAGCAGTTGAAAATGCTATGGATTGTCTATTAGAATTATCTGCCACTGATACCAAGATAGAAGAATCATCTTCACAAAGTTTCGTTGCTTCTGAGAACCAAGTAGGTGCAGCAGAAAGTAAAATAATGGAAAAACGTCCTGAAGAAGAGAGTGAAGATTCAAAAATGGATTCATTTTTGGACATGCAGCTAACTGAAGACCTGGATTCCTTAATACAGAATGCTTTTGAGAAATTGAACTCTTCTCCTGATGACCAAGTATACTCATTTTTGCCTTCACAAGATGTTAATAGTTTTAATGACTCAAGTGAGTTTATAAATCCTGATTCAAGTAATATGACTCCCATTTTTTCTACACAAAATATGAATTTGAACGGTGAAAATTTAGAGAATTCTGGTTCTACTTTAAGTTTAAACCCATTACCTTCACATTCAGTTTTGAACGAGTCCAAGTGTTTTATAAAGGATAACACATTGGCTTTGGAAAGTAACTACCCGGAAGATTCTCTTCTCAGTAGTTCTTTAAATGTAGCAAGTGACTCCATCGCAGGTTGTAGCAGTCTCAATCAAAAACAGAAAGAACTTTTAGAATCTGAGTGCGTTGAGGCTCAATTCTCTGAAGCTCCTGTAGATTTGGATGCCAGTGAACCTCAGGCTTGTTTAAACCTTCCAGGGCTTGATTTACCAGGTACAGGTGGGGATCAGAAATCTACTCGGGTCTCTGATGTGTTTCTACCTTCCGAAGGGTTCAACTTCAAGCCACACAAACATCCTGAACTGCCAACTAAGGGGAAGGATGTGAGTTACTGCCCGGTACTTGCTCCTCTCCCATTGCTGTTGCCTCCTCCGCCACCTCCACCGATGTGGAATCCAATGATTCCTGCTTTTGACCTCTTCCAAGGAAACCATGGCTTTGTAGCTCCTGTTGTAACCACAGCTGCACACTGGAGATCTGTCAACTACACATTTCCACCCTCAGTTATTTCTCACACTTCCCCAACAAAAGTATGGAGAAATAAAGATGGAACAAGTGCTTATCAAGTACAAGAAACCCCAGTTTCTCAGGTTGTAAGAAAGAAGACATCTTACGTTGGACTAGTTCTTGTTCTTCTCAGAGGTCTTCCGGGATCTGGAAAATCTTTTTTGGCAAGGACTTTGCAAGAGGATAATCCAAGTGGAGTCATTCTTAGTACTGATGATTATTTTTATATAAATGGACAGTACCAGTTTGATGTAAAGTACTTAGGAGAAGCACATGAATGGAACCAGAATCGTGCAAAAGAAGCATTTGAGAAGAAGATATCTCCTATAATTATAGATAATACAAACCTACAGGCATGGGAAATGAAACCATATGTTGCTTTGTCTCAGAAACACAAATATAAAGTCCTTTTTCGGGAACCAGACACATGGTGGAAGTTTAAACCAAAGGAACTTGCAAGGCGTAACATTCATGGGGTAAGCAAAGAAAAAATAACAAGAATGTTGGAACATTATCAACGTTTTGTTTCAGTGCCAATAATTATGAGTTCTTCGGTTCCAGAGAAAATTGAACGTATTGAGTTGTGTGCATATTCTTGTGAGGATAGAAGCACTAGCCCAAGAGACGATGAAGATATTATCTCTGAAAAAGAAGAAAATATTTTATCTTTATCTTTGAAGCATCTAGAGTTCACTGAAGAGAAGAATCTTGATGTAACCAAAGAAACAATGTTACCTGAGAATGTTGCATATCTCTCTAATGCAGATTTAAACAAAAGAAGAAAAGAAATAAGTGATATGAATCCTAGCATTCAAAGTGCTTTAATTCTGGAAACTCCACACATGTATTTTTCTGACTCTGAAAGCAAACTACAGGCAACAGACAAAAGTGAAAACGAGCAAATAGAAATGGTGGCTGTAAAAGGGTATAGTAAAACTGACACAGATAGTTCTATGGAGAGAGTATCACCTAGTACTTGCTGTAGTGAAAATAATCAAGAAGACTGTGATCTTGCAAATAGTGGACCACTTCAAAATGAAAAATCCTCACCTGGTGAAATAGTGGAAGAAAGAGCAACAGTAACGAAAAAAGCCTTTGGGAAACAAAAAAGCAAATCGACTTTGGAAAAGTTCCCAAGACATGAGCTATCAAATTTTGTTGGTGACTGGCCAGTTGATAAGACTATTGGTCAGAGGACAAAAAGGAACAGAAAAACTGAAAAAACTTCATCCGTACAAAGCGACAAAAAGTATAATTACCCTCAGTCACACAAATTAGTTAACAGTGTATCTGTGAATACAGATTGTGTCCAGCAACGAGGATCTCCACATGAAAGTGTAGAGGATGGCAGAAAGTCACAGTGTGATGATGCTTCAGAGCCACTCAATAGCTATAAATATGATGCTTATAAAAATATTGACAAAAACTCATTCAACATTATGGGTGACTGGCCTTCATCTGATTCTTTAGCTCAGAGGGAACACAGATCAAGAATGCCAAAGACTGGTTTAAGTGAGCCCAACCTAGAAATTGGAACAAATGACAAAATGAATGAAATATCCTTATCTACAGCACATGAGGCCTGTTGGGGCACAAGCTCTCAAAAACTAAAGACATTGGGTAGCTCCAATCTAGGAAGTTCTGAAATGCTGCTCAGTGAAATGACCTGTGAGAGTCAGACTTGTCTAAGTAAAAAGAGTCATGGGCAACACACATCGTTGCCTCTTACTTTTACCAATAGTGCACCAACTGTTTCTGGAGTAGTAGAACCACAAACGTTAGCTGAATGTCAAGAGCAAATGCCTAAGAGAGACCCTGGAAAAGAAGTAGGCATGTGCACCCAGACTGAACCACAGGATTTTGCTCTTTTATGGAAAATAGAAAAGAATAAAATTAGCATTTCAGATTCTATCAAAGTATTAACAGGAAGATTAGATGGATTTAAGCCGAAAGTTTTCAATATTAACACAAAATCAGACGTTCAAGAAGCAATTCCATATAGAGTAATGTATGATAAAAGCACGTTTGTTGAAGAAAGTGAGCTTACCAGTGCAGATGAATCTGAAAATCTTAACATTCTTTGTAAACTGTTTGGATCCTTTTCATTAGAAGCCCTGAAAGACTTATATGAGAGGTGCAATAAAGATATTATTTGGGCCACAAGCCTTTTGTTGGATTCTGAAACTAAGTTATGTGAGGATACAGAGTTTGAGAATTTCCAAAAATCGTGTGATGGATCACAAATTGGGCCTTTTTCTCTGGGGTTGAATTTGAAAGAAATTATTAGCCAAAGAGGAACTTTAGAGAATTCTAATTCTCCTGTGCCAGAGTTTAGCCATGGGATTGGTATTAGTAACGCTGACTCACAGTCTACTTGTGATGCAGAAAGAGGAAACTCAGAGCAGGCGGAAATGAGAGCTGTCACTCCTGAAAACCATGAATCGATGACAAGTATATTTCCCAGTGCTGCTGTGGGTCTAAAGAATAATAATGACATACTTCCTAACAGCCAGGAAGAACTTTTATATAGCAGTAAGCAGTCCTTTCCAGGTATTCTAAAAGCTACTACTCCTAAAGATATGAGTGAAACAGAAAAAAACCTAGTAGTCACAGAGACTGGAGACAACATACATTCTCCTTCACATTTCTCTGATATTTTTAACTTTGTATCTAGTACTTCAAATCTTGAATTAAATGAAGAAATTTATTTTACTGATTCTCTTGAAATAAAGAGAAATGAAAATTTTCCAAAGGATTATGTGAAATTTTCAGATGAAGAAGAATTTATGAATGAAGATGAGAAGGAAATGAAGGAAATTCTAATGGCAGGAAGTAGTTTATCAGCTGGAGTTAGTGGGGAAGATAAAACCGAGATATTGAATCCCACTCCAGCGATGGCCAAATCTCTGACCATAGACTGTCTGGAATTGGCATTACCCCCTGAACTGGCTTTTCAACTTAATGAATTATTTGGTCCTGTTGGTATTGATTCAGGGTCTCTAACAGTTGAAGATTGTGTGGTTCATATAGATCTGAATCTGGCGAAAGTGATTCATGAGAAATGGAAAGAATCTGTAATGGAGCGACAAAGACAAGAAGAGGTGTCTTGTGGCAAGTTTATGCAAGATCCTTCCTTGGTTGGACATACTGGGCTTGATAATCCTGAACAAAAATCATCTCAGAGAACAGGCAAAAAATTACTGAAGACTTTAACAGCATCTGAAATGCTACCTTTATTGGATCATTGGAATACTCAAACTAAAAAAGTATCACTCAGAGAAATAATGTCAGAAGAAATTGCCTTACAGGAAAAACATAATTTGAAAAGGGAGACCCTTATGTTTGAAAAAGATTGTGCCACTAAACTAAAGGAGAAGCAGCTCTTTAAGATATTTCCAGCCATTAACCAAAATTTTCTGGTGGACATTTTCAAGGACCACAACTATTCATTAGAACACACAGTGCAATTTCTTAACTGTGTTCTTGAAGGGGACCCTGTAAAAACAGTTGTAGCCCAAGAGTTTGTTCACCAAAATGAGAATGTCACATCTCATACTGGCCAGAAGTCTAAAGAGAAAAAGCCAAAGAAATTAAAAGAGACTGAAGAAACACCAAGTGAACTGTCTTTCCAGGACTTTGAGTACCCAGACTATGATGACTACAGAGCAGAGGCTTTCCTTCACCAACAGAAGAGGATGGAGTGCTACAGCAAGGCCAAAGAAGCTTATCGGATAGGGAAAAAAAATGTCGCCACCTTTTATGCCCAGCAGGGTACTCTTCATGAGCAGAAGATGAAAGAAGCCAATCACCTTGCTGCCATAGAGATCTTTGAGAAAGTCAATGCTTCGCTGCTGCCACAGAATGTTTTAGACCTCCATGGGCTGCATGTGGATGAAGCTCTAGAACATTTGATGAGAGTTTTAGAGAAGAAGACTGAAGAATTTAAGCAGAACGGTGGGAAGCCCTATTTGTCTGTGATTACGGGGAGAGGAAACCACAGCCAGGGAGGAGTTGCTCGCATCAAACCAGCTGTCATTAAGTACCTCATAAGCCATAGCTTCAGGTTCTCTGAAATTAAACCAGGGTGCTTGAAAGTCATGCTAAAGTAAAATAAACATCCTTGAATTAGAAGTATGAAGAATTTAATAGAGAAACAAGGCTAGAACACATCTACATCCTGAAGAGCCGTTTATAACTTCATATTATATGATGACAAAGTTCATTATTTTCCTTAAAGTTGAGCAATTGACTTTTATGGTCCAATGATGAACTTATTATTAATAAATGATTGAGTTAACTGTGAGGCTTCTCATTAAAATACAATATTGCAGCTATCAGTTGGAGAATATATTATAAAATTTTCAGACAGTATATCAGAAAAATGTTTTTATTTGTACTGTATAGAAAATGTAATTTTGCTGTTAACTCTGTACTTTTTAAATTGAAAATGTTTTATAAATTTGCTTTTAAATTTTCTTATGAAGCCATTTGCAAATTACATACTTAATTTAATAAAATACTTTAGCCACA

Publications

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