Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ABCG2P1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:69022218-69024220  UCSC
Coordinates (T2T) chr15:66844752-66846754  UCSC
Coordinates (hg19) chr15:69314557-69316560  UCSC
Strand +
Parental Sequence NM_001348985.1
Parental seq. overlap 1634 bp
Parental seq. overlap (%) 34.2%
Genomic Region Intragenic (NOX5)
Retrocopy Summary ABCG2P1, located on chr15:69022218-69024220, is a retrocopy of the parental gene ABCG2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ABCG2
Full Name ATP binding cassette subfamily G member 2 (Junior blood group)
Also known as ABC15|ABCP|BCRP|BCRP1|BMDP|CD338|CDw338|CDw388|EST157481|GOUT1|MRX|MXR|MXR-1|MXR1|UAQTL1
Coordinate chr4:88090264-88231626
Strand -
Gene summary The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ABCG2P1
Bonobo Pan paniscus ABCG2P1
Gorilla Gorilla gorilla ABCG2P1
Orangutan Pongo abelii ABCG2P1
Gibbon Nomascus leucogenys ABCG2P1
Green monkey Chlorocebus sabaeus ABCG2P1
Crab-eating macaque Macaca fascicularis ABCG2P1
Rhesus Macaca mulatta ABCG2P1
Baboon Papio anubis ABCG2P1
Golden snub-nosed monkey Rhinopithecus roxellana ABCG2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ABCG2P1
GAAACTCTCCAGATGTCTTCCAATAATGTCGAAGTTTTTATCCCAATGTCACAAGGAAACACCAATGGCTTACCCAAGGTGACCTCAAAGACCTGAAAGCATTTACTGAAAGAGCTGTGCTTTCATAACATCTGTTATCAAGAAAAAGTGAAGAGCAGCTTTCTACATGGTCAAAAACCAGTTGAGAAAGAAATACAATTGAATATCAATGGGATCGTGAAACCTGGCCTCAATGCCATTCTGGGACCCGCAAGTGGAGGCATTATTAGATGTCTTAGTTTCAAGGAAAGACCCACATGTATTATCTGGAGATGTTCTGATAAACACAGCACCTCAACCTGCCAATTTCAAATGTAATTCAGGTTACATGGTACAGGATGATGTCATGATGAGTACCCCAACAGTGAGAGAACATTTACAGTTCTCAGAAGCTCTTCAGCTTCCAACAACTGTGATGAATTGTGAAAAAAAAATGAATAGATAAATATGGTCATTCAAGAGTTAGGTCTGGATAAAGCAGCAGATTTCAAGGTTAGAATTCAATTCATCTGCAGTGTGTCAGAAGGAAAAAGAAACAGGACTAATATAGGAATGGAGCCTATTACTGATCCTCTCATCTTGTTCCTGGATGAGCCCACAACTGGACTGGACTCAAGCACAGCAAATGCTGACCTTTTTGCTCCTGAAAAGGATGTCTAAGTAGGGACGAACAATCATCTTCTTCCCATTCACCAGCCTTGGTATTCCATCTTCAAGTTGTTTGATAGCCTCACCTTAATGGCCTCACAAAGAGGAATGTTCCATGGGCCTGCTTAAGAGGGCTTGGGGTACTTTGCATCAACTGGTTACCACTGTGAGTTCAATAATAACCCTGCAGACTTCTTCCTGGGTGTCATTAATGGAGATTCACTGCTGTGGTATTAAACAGAGAGGAAGAAGACTGAAGCCACGGAGACTGTAGAGACCGCTAAGAGAGATAAGTCACTCACAGAAAAATTAGCTGAGTTTTATGTCAACTCCTCCTTCAACAGAGAAACAAAAGCTGAATTAGATCAACTCTCAGAGGGTAAGAAAAAGAAGAGGATCTCAGCTTTCAAGATCACCTAATGCCACTTCATTCTCTCAGATGGGTTTCCATGCATTTATTCAAAAACCTGCTGGGTAAATCCCAGGCCTCTATAGCTCAGGTAATTGTCACAACCATACTGAGGCTGATTATAGGTGCCATTTACTTTGGGCTAAAAAATGATTCTACTGAAATCCCGAATAGAGCCAGGGTTGTCTTCTTGACCACCAGCTGGTGTTTCAGCAGTGTGTCGGTCATAGAGCTCTTTGTGCTAGAGAAGATCTTTATACACAAATATATTAGTGGATACTACAGAGTGTCATCTTATTTCTTTGGAAAACTGTTATCTAATTTACTACCAGGAAGATGTTACCAAGCATTATATTTACCTCTATAATAATACGTGCATTATAAAAATAATGCTGTATAATAATCCTAATCTTGTTAGGATTAAAGACAAAGGTGGACACCTTCATCATCATGATGTTTTCCCTCATGATGGTGACTTATTTAGCACTGGCCATAGCAGCAGGTCAGTGTGGTTTCCATAGCAATGCTTCTCCTGACCATCTCTTTTGTATTTATAATGGTTTTTTCAGGTCTATTAGTAAATCTCGCAACCATTGCATCTTGGCTGTaCTTCTGCCCAGGACTCCGTGAAATAGTAAACAATACTGTGGCTCCCCAATATGTACTGGCAAGGAATATTTGATAAACCAGCCATCAATGTCTTACCCTGGGGCTTGTGGAAGAATCATATAACCGTGGCTTGTATGGTTATCTTCCTGATTTGCCTACCTAAAATTGTTATTTCTTTTAAAATATTCTTACATTTCCCTTTAATTTACTATGATGTGTCCTCACATAAAAAA
>NM_001348985.1
TTACATCAGGGTTAAAAAAGCACAGGAAGTTTACGCACAGAGCAAAGCCATTTGCTAGAATTGGTTTTTATCCTTCCATTTCGAAAATAAAGTTGCTGTTTGTGTTGGAGATGCTGTCATCAGAATTCCGCGGCACAAAGAGAAAGATACAAAAATATCTCTCTGACATGTAACTTTCCCCCTTCTTCTAGCCCCTTGCTAGGAATGCCAGAAGAGGATCCCACGCTGACTGGAACCATTAGGTCTTTTGTTTGAATCCCAGTGATCGAGAAAGAAATGTGGTTCATAATCAGCTAGTAGTGGAGAAAAAAGGAACCCAAGGAGATAGGAGAGCTGTTAATTTCACTCGGGACATTTCCTCGAGGCTAGTTTACTCGGAAAGCCTCAATGTTCCCTGGTAGCTGCAGGATCTACTTTGGGGGCTGCCAAGTTTCCTCTCTCATTCTTTCTCCTGCCCCAAGAGCAGGCAGGAAGGAAAGTTCCTGGACTGATACTCGTCTGTTTAGTAGGCGTGGGTCCTGGTTGAAGTCTGTCTAGGAAAACTCCTAAGTGTAGAAATCTTCTTCGTATTACCACTGTCTCTGCACTGAGATTTGGGCTGCTTTGCTTCCAGCGTCACACATCATAACTGAGTGCAGTACCGGTTTGACTGTATCTTCAAGTTAAGAGAATTGCTGTATTCCCCAAAATATCTTGGTCATTTGAAAGTAAAGAGTTCTCggccgggcacagtggctcacgcctgtaatcccagcacttcagaaggcaaagAAAGATAAAAACTCTCCAGATGTCTTCCAGTAATGTCGAAGTTTTTATCCCAGTGTCACAAGGAAACACCAATGGCTTCCCCGCGACAGCTTCCAATGACCTGAAGGCATTTACTGAAGGAGCTGTGTTAAGTTTTCATAACATCTGCTATCGAGTAAAACTGAAGAGTGGCTTTCTACCTTGTCGAAAACCAGTTGAGAAAGAAATATTATCGAATATCAATGGGATCATGAAACCTGGTCTCAACGCCATCCTGGGACCCACAGGTGGAGGCAAATCTTCGTTATTAGATGTCTTAGCTGCAAGGAAAGATCCAAGTGGATTATCTGGAGATGTTCTGATAAATGGAGCACCGCGACCTGCCAATTTCAAATGTAATTCAGGTTACGTGGTACAAGATGATGTTGTGATGGGCACTCTGACGGTGAGAGAAAACTTACAGTTCTCAGCAGCTCTTCGGCTTGCAACAACTATGACGAATCATGAAAAAAACGAACGGATTAACAGGGTCATTCAAGAGTTAGGTCTGGATAAAGTGGCAGACTCCAAGGTTGGAACTCAGTTTATCCGTGGTGTGTCTGGAGGAGAAAGAAAAAGGACTAGTATAGGAATGGAGCTTATCACTGATCCTTCCATCTTGTTCTTGGATGAGCCTACAACTGGCTTAGACTCAAGCACAGCAAATGCTGTCCTTTTGCTCCTGAAAAGGATGTCTAAGCAGGGACGAACAATCATCTTCTCCATTCATCAGCCTCGATATTCCATCTTCAAGTTGTTTGATAGCCTCACCTTATTGGCCTCAGGAAGACTTATGTTCCACGGGCCTGCTCAGGAGGCCTTGGGATACTTTGAATCAGCTGGTTATCACTGTGAGGCCTATAATAACCCTGCAGACTTCTTCTTGGACATCATTAATGGAGATTCCACTGCTGTGGCATTAAACAGAGAAGAAGACTTTAAAGCCACAGAGATCATAGAGCCTTCCAAGCAGGATAAGCCACTCATAGAAAAATTAGCGGAGATTTATGTCAACTCCTCCTTCTACAAAGAGACAAAAGCTGAATTACATCAACTTTCCGGGGGTGAGAAGAAGAAGAAGATCACAGTCTTCAAGGAGATCAGCTACACCACCTCCTTCTGTCATCAACTCAGATGGGTTTCCAAGCGTTCATTCAAAAACTTGCTGGGTAATCCCCAGGCCTCTATAGCTCAGATCATTGTCACAGTCGTACTGGGACTGGTTATAGGTGCCATTTACTTTGGGCTAAAAAATGATTCTACTGGAATCCAGAACAGAGCTGGGGTTCTCTTCTTCCTGACGACCAACCAGTGTTTCAGCAGTGTTTCAGCCGTGGAACTCTTTGTGGTAGAGAAGAAGCTCTTCATACATGAATACATCAGCGGATACTACAGAGTGTCATCTTATTTCCTTGGAAAACTGTTATCTGATTTATTACCCATGAGGATGTTACCAAGTATTATATTTACCTGTATAGTGTACTTCATGTTAGGATTGAAGCCAAAGGCAGATGCCTTCTTCGTTATGATGTTTACCCTTATGATGGTGGCTTATTCAGCCAGTTCCATGGCACTGGCCATAGCAGCAGGTCAGAGTGTGGTTTCTGTAGCAACACTTCTCATGACCATCTGTTTTGTGTTTATGATGATTTTTTCAGGTCTGTTGGTCAATCTCACAACCATTGCATCTTGGCTGTCATGGCTTCAGTACTTCAGCATTCCACGATATGGATTTACGGCTTTGCAGCATAATGAATTTTTGGGACAAAACTTCTGCCCAGGACTCAATGCAACAGGAAACAATCCTTGTAACTATGCAACATGTACTGGCGAAGAATATTTGGTAAAGCAGGGCATCGATCTCTCACCCTGGGGCTTGTGGAAGAATCACGTGGCCTTGGCTTGTATGATTGTTATTTTCCTCACAATTGCCTACCTGAAATTGTTATTTCTTAAAAAATATTCTTAAATTTCCCCTTAATTCAGTATGATTTATCCTCACATAAAAAAGAAGCACTTTGATTGAAGTATTCAATCAAGTTTTTTTGTTGTTTTCTGTTCCCTTGCCATCACACTGTTGCACAGCAGCAATTGTTTTAAAGAGATACATTTTTAGAAATCACAACAAACTGAATTAAACATGAAAGAACCCAAGACATCATGTATCGCATATTAGTTAATCTCCTCAGACAGTAACCATGGGGAAGAAATCTGGTCTAATTTATTAATCTAAAAAAGGAGAATTGAATTCTGGAAACTCCTgacaagttattactgtctctggcatttgtttcctcatctttaaaatgaataggtaggttagtagcccttcagtcttaatactttatgatgctatggttTGCCATTATTTAATaaatgacaaatgtattaatgctatactggaaatgtaaaattgaaaatATGTTGGAAAAAAGATTCTGTCTTATAGGGTAAAAAAAGCCACCGTGATAGAAAAAAAATCTTTTTGATAAGCACATTAAAGTTAATAGAACTTACTGATATTCCTGTCTAGTGGTATAATATCTCAGGAATCTTGGCTGAGGGTTTGGAACTGTGGGTAGAGTAGAGGGCCAGGAGTCCAGTAATAGAATTCTTGCACCATTTCTGGAACATTCTAGCTCTGGGAGGTCACGTAACCTTCTTGGGGTAGTTCAGTGGTTTagtggtttataatccaggtgtgcgtcagaatcatctgaggaactttgctaaaatacaaaaatctggcctaagtagctccagatctacCTTCATAAAGGAATCTGACCACTCCTGGATTTGGTAATTTCCAAGTTCTGAAAATTTTACTTAGGATTTAATAACTATTAACATCTGTCCCTACATAGGTTTTCTTTCCTACTTATATACCTTATGTTCTCTTCATTCTAACCTTCATCAGTAATAGGGAAATGTTTTAATTTTATTTTTTTAGTTGAAGGGTAATGTACCAAAAAAtatagttcagtgaattaaaatgaacacacatgtgcaaccatcaattcaggtcaagaaatagaagattgtagcacacaaaagcctactcagccattctcccagtcactacttccttccTTACCCCTGGGTTATTTTTGAAATGACACTTGATGTATTTCCCTCTGTTGCTGTTATGAGAACATTGCTACAGCCAAGTGTTGTGTTTCTGTGTGCATAGGTTGATACTTAATTATCTCCCCACtttttaataaacttttaatttggaaataattttagattgacagaaaagttgcaaagatagtgaggaaagttcctgtctactctttgctcagcttcccttaatgttaacattttatatagcaagatgcatttgtcaaagctaacaagttaacattggtacaatcactgttaattaaactgcacacaatattcagatttcaccacttttccactaatattctttcattgttctaggattcaattcaggagaccacatttcatctagCCCTCTTTTTTAAAAGTAAATACTTTTCAGCACTTACAGGAGTTAACTGAGCTGGGGCATCATGGTGTATAGACGCCCTGACACTGGTCATCTTGGAATTCATTTAGTTTGTCAGTGGGTGCCCTGACATTCTGTCACAACATCAATTTGGGAACATGGCATTATATTTTTATCTTTGAACTTTTTTCTTTTTGGATGACATTTGATTAATGCGTCATCTTGGAACACATTATCTTTTTTCTTGGTTATGTGATCAGGAAGATTAATCAGTTTTTCCTGTTCTTGGTATAATTCCTGCTTTTCACATACCTGTCCCTTACAGTTCTCTATATATACCCTTCCCTTATTACACAGAGAGAAATATCTATCTATACTTTTTACACAAAATATACTTCAAAAGAAACAAAACAGCCACAATTATTAACTTTTTAAATAAATGAGAatttaattatatccta

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