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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZCRB1P2
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:78290606-78290797  UCSC
Coordinates (T2T) chr15:76153178-76153369  UCSC
Coordinates (hg19) chr15:78582948-78583139  UCSC
Strand -
Parental Sequence NM_033114.4
Parental seq. overlap 157 bp
Parental seq. overlap (%) 8.7%
Genomic Region Intragenic (SKIC8)
Retrocopy Summary ZCRB1P2, located on chr15:78290606-78290797, is a retrocopy of the parental gene ZCRB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZCRB1
Full Name zinc finger CCHC-type and RNA binding motif containing 1
Also known as MADP-1|MADP1|RBM36|SNRNP31|ZCCHC19
Coordinate chr12:42312086-42326107
Strand -
Gene summary Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZCRB1P1
Bonobo Pan paniscus ZCRB1P1
Gorilla Gorilla gorilla ZCRB1P1
Orangutan Pongo abelii ZCRB1P2
Gibbon Nomascus leucogenys ZCRB1P2
Horse Equus caballus ZCRB1P1
Sloth Choloepus didactylus ZCRB1P2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZCRB1P2
GTTGGATTTATTTTCTTTTTGGATAGGACTCTGCATAAAACTAGACCAGGCCATTAAACAGCCAACAGTTATTTGGTCCAGTAACAAAAGCAAGCATTGCTATTGACAGCTAAAGAGCAGCTAAATTCATCTGAAGGTAAAACTCCTTGGATGAATTTGGGTCTAATGAATGTAGGGAAAATAGACACTTAG
>NM_033114.4
AAACAGTCGGGAAGAAGCACCGTGGCTGCTATTATCTGCTCTCCGCGCCTGACCCCTCCCAGGACTCGTGATGCCAAGGCCGCTGCGAGCGGCTACGAAGAGTCGGGGTTGAGCCCCAGCTGAGCCGAGGGCTCGCACTCTTCTGGTCTCCCAGGCCCAACCCACCTGAAGAAATGAGTGGTGGATTGGCTCCAAGTAAGAGCACAGTGTATGTATCCAACTTGCCTTTTTCCCTGACAAACAATGACTTGTACCGGATATTTTCCAAGTATGGCAAAGTTGTAAAGGTTACCATCATGAAAGATAAAGATACCAGGAAGAGTAAAGGGGTTGCATTTATTTTATTTTTGGATAAAGACTCTGCACAAAACTGTACCAGGGCAATAAACAACAAACAGTTATTTGGTAGAGTGATAAAAGCAAGCATTGCTATTGACAATGGAAGAGCAGCTGAGTTCATCCGAAGGCGAAACTACTTTGATAAATCTAAGTGTTATGAATGTGGGGAAAGTGGACACTTAAGTTATGCCTGTCCGAAAAATATGCTCGGAGAACGTGAGCCTCCaaagaagaaagaaaaaaagaaaaaaaagaaagctcctgaaccagaagaagaaATTGAGGAAGTAGAAGAAAGTGAAGATGAAGGGGAGGATCCTGCTCTTGACAGCCTCAGTCAGGCCATAGCATTCCAGCAAGCCAAAATTGAAGAAGAACAAAAAAAATGGAAACCCAGTTCAGGAGTCCCCTCAACATCAGATGATTCAAGACGCCCAAGGATAAAGAAAAGCACATATTTCAGTGATGAGGAAGAACTTAGTGATTAAAATCTTGCCCCAGCACAGTAATAAAAATCAAGATTTGTTAGTAACAATCTTGAAGAGCTAATTTTAATAAAAATAAGAAAAATTAATACTATCATGTTAATACTATTATTGTCATCCCAAGAAAAAAGATATTTTAAAAATTTATTTGAAAAGTTCATTATAAGGGCTTTATTCATGCCTGATTTGTTTACATGAGGACTTCTGAAATTAATCCTTAAAACAAACTTCCTGAAGACCGAAAAGTTGAATGATTTATTGTTACTTATATTAATAAACTTTTCAAGAGAATTTTGTCTTTAAATATGGGTGTTTTGTCATCATATTTCTTGTAGCTTTATCCCAATCTGGataaattgtaaatacctataaaataaattataaatacctataaaatataaagtaACATAGCTCTAAAAGGCTTAAAATCAAACACAGGTGTTATTTGTCTGCCCTACCCATAGCACCAAATTCCATTCCCTAGAAGAAACTACTTACATGTGCACACATGTAGCTAAATAAAGTACATATATTTCAGTCACTTAATAAAAGAATAAAGGAGAATTATTCAATCTCTTATACTTCTCCTACCttcctcaatattcccaatgtggctgtattaaaaatttgggggaatccatatatatcttttttaataaccaagtaaatacttttcatttctgagccaaggaatatgctatgattacgttttttcctagagttaataattgtctattttttttccatgtattgtctttgtatttatgactaaatcttcccATTCTGTCTGCAGGTGGGTATATGGTAATGGGATTAGAGAGCCTTTAATTTTCTGCTTTGTATATTTCTATATTGTTTAACTTTGTAAGAATGCCCATTACTTTTTtaactagtaaaagcaatagaaataagttaatactatcatagtaatattattaTTGTCATCCCAAGAAAAAATATATTAAAAAGATATTTGAAATTTCA

Publications

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