Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ITM2BP1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:27612697-27612853  UCSC
Coordinates (T2T) chr17:28554171-28554327  UCSC
Coordinates (hg19) chr17:25939723-25939879  UCSC
Strand -
Parental Sequence NM_021999.5
Parental seq. overlap 133 bp
Parental seq. overlap (%) 1.3%
Genomic Region Intragenic (KSR1)
Retrocopy Summary ITM2BP1, located on chr17:27612697-27612853, is a retrocopy of the parental gene ITM2B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ITM2B
Full Name integral membrane protein 2B
Also known as ABRI|BRI|BRI2|BRICD2B|E25B|E3-16|FBD|RDGCA|imBRI2
Coordinate chr13:48233206-48270357
Strand +
Gene summary Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ITM2BP1
Bonobo Pan paniscus ITM2BP1
Gorilla Gorilla gorilla ITM2BP1
Orangutan Pongo abelii ITM2BP1
Gibbon Nomascus leucogenys ITM2BP1
Green monkey Chlorocebus sabaeus ITM2BP1
Crab-eating macaque Macaca fascicularis ITM2BP1
Rhesus Macaca mulatta ITM2BP1
Baboon Papio anubis ITM2BP1
Golden snub-nosed monkey Rhinopithecus roxellana ITM2BP1
Greater horseshoe bat Rhinolophus ferrumequinum ITM2BP2
Egyptian rousette Rousettus aegyptiacus ITM2BP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ITM2BP1
CAGACAGTGATCCTGCCAGCAATGTTCATGACCTTAACAAGAAGCTCACAGCCTGTTTGTATCTTAGCCTGGACAAGTGCTGGGTGGTCCCTCTGAAGACTTCAATTGTTATGCTGCCCAAATACTGACTGGAGTTGCTTATTAACATCAAGGCTGT
>NM_021999.5
AGTAGCCGCCTCTGCCGCCGCGGAGCTTCCCGAACCTCTTCAgccgcccggagccgctcccggagcccggccgtagaggctgcaatcgcagccgggagcccgcagcccgcgccccgagcccgccgccGCCCTTCGAGGGCGCCCCAGGCCGCGCCATGGTGAAGGTGACGTTCAACTCCGCTCTGGCCCAGAAGGAGGCCAAGAAGGACGAGCCCAAGAGCGGCGAGGAGGCGCTCATCATCCCCCCCGACGCCGTCGCGGTGGACTGCAAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAATACCTATGATTCATTTCACCTCAAGTTCCTAAGACAAAAAATTTCAATTCTGACTTTAGGAGGTCAGAGTTTTTAAAGCTTCCAACTCTTAAAGGATTTAGTCTAGAAACCAATTCTAATTCAAAAGGATATTATTTACTCATGGCTTTTCATTTCATTTCAGTAATATTGTCAGAACTTTAAGTCAGTGAGTTGGGTATTCAGGAATTAACAATTTTAGAAGACAATATGTTTCAATAAAATGAGAATTGGTTTTTCCTACTTTCCAGGCTCTAAAATTACATGAATTTTCAGGGAGCTGTGAACATTTAGGAGCACAttattcattcagcatcttttatatgcccaacatatgatattgtgttgaagatatatctgcaaagaagaaaaaaagccactgccgtcgtggagactcacaatctaggaaaagagagggacagcaaacaactcattacaatacattgggatcagtagtgtgagggagaaaaacaggtctaggttctttggaaaacatttaggagagtcaatgagactttcagaatgtgaagtgcatgggattaggtcatggaagaagACCATGTATGTCATCTTGAGGACTTCATTCTGTAGACCATGGGCCACTATTGAAGTTTTGCATTTTGGAAGGAGCTTATTAGTTTGTTTTCCTGTTGATTATAGTAGTAATGCAGTAtcagggtagctgaactgcaataataatcccaacatctcactggcttcatgcagtaggaatatgctttcatcacagtccagtatggCAGGCAACCTCCAGACTCCCAGGGACCCAAACTTACACTTTACTAAATGTAATTCTTTCATTTGAATTTTTAAAGGTTTTTGTATAATCATCTTAGTAAAACATTTGATAATTCTTCACAACATTTGCAATCATTGATTTGGCCAGATTGGTCTAACATGGTACCCATGATTTTACTTCATTTCCAGTACTATTCTGATAATTTCCTTTAGAGTCAATTGAGTAGAGAGTACCCCTCTCACCTAAGCTTAGTCATGTCCCAGGAATTTTGGAACTCCAACTGAGATTTCAGGCTCATTATTCATTCTAGGGCTGAATGAATAATGTGCCCTTTGAACCCTTGTGCCATGCTGGAAACTGTGGTCTTGGTGTGGCATGGAAAAACCAGAGGGTGAGGGATGTGGATGAGAAGATGACAGAGAATCAGACATGCAGAGAGGACTGCCAGGTCTCCCAGTGGGTTCCAGGGAGACTCAGCTATCCTTCCCTCTTCTTGAGTTCtgtcttagtccattcgggctactataacaaaataccatagactgagtggctttaaacaacagaagcttgtttctcacagttccagaagctggaaagttcaagatcaagtcacctgcagattcagtgtctgatgaggtcctccttcctcacagaaagctctcttctctctgtgaccttatatcacagatgactctgggttcctcttacaaggacactagttccattcatgggggttccactctcatgacctaacacctctcaaaggccccatttcctaatactgtcaccttgggggtaaggatttcaacatgaattctggggggacacaaacattcaaaccatagcaAGTTCCATAATGCACCCCATCATATGTGTGTGTGTGTGTATTTATTTATTTATCTAAGATAGCTCTAGTTTGCTGCTTTGCAACACATTCTGCCCCTATTGCATTGGTTTAAAAAAAAAGTACAGAAGTCAAGATGAGACTATATAAATCTTGACAAGTTGTTGGCCGTGATTGCTCTTTTGTGATGCAGGAGTGAGAATCTGGAGAATCTGGCTTAAGAGGTGGCTGAGAATTAAAATAATAGGCATGAAAATGCTTCATACAGCTCTGTACAGTTGTTGACAGTGCCTTTTTTGAAACCTATCACTGCTATATGTTAGCAAGCAAACACTGATCTTGTTTTGTAATGTGTAATTGTTCACTTCTGCTTTCCCTGTATCCCTTTTTAGATTCCACACCCATATTAGTGAGAAGCAAGAAAAAAAAATGTACACAGTGTCCTAAATGTTGTTTATCTCGAATAATAGAAGTAGGAGTGTAAAACTTAAAGGCTGATTAATAATGCAAATGAAAAGGCAAATGGATTATTGAATAGAAAAGGTCTAGATTCTATGTTTGAATGTGGTTATGAATTAATATGGGCAGAATCTCTAAGATTCTGCTAAGTGAACATTTAGTAGTTTACTAGACATCTTCTCTTCcacctagcaaagagtttgttgcccagagttatataaatcctactctattgcacactaatctttgcatgtttaactctttgggacttaggttcctagataaggacttcatgtgtatctatttagaaaaagaacatttcttcatttccacaaagctacacagccatcagttcgttcaatatcttgtccaaagttattgctagcgttcttctttctgagtctttgtggctaatgcttttttgaggaagaagcatgatttagtctcagctctctattgatcattttaggcttttatcttactgaaaaaattaagcacaatttaagattttttttgaaatatttactgaattttGAGGCCATAAATTATTTCCTGATAGCACACATGTATGGGTTGTAGATTCCACACTTTTAATCTTCCAGCCACCTATTGCAGATTGGTTCTGAGAAGCAGGATGAGTGGGAGTGGGCTTAGGGGTCAAAATTGAGACCTAAGTGGTATAAAACAAGATAATCCTAGCTTCCTCCCACTTAAAATAATTTGATGGGACTTCTGTATCTGATTTTTAAGCTTGCATTTGTGTTTATATTTTCATTGTAAAAATATCAAATAATACAGTTTTTGAAGGTAAAAAGTAAATGTTCCCGCCCTTCTACCATCCTCCTTCCTCAGTCCCATTCCCCAACAGTTTAACGTGCGATACAATAATGTGTGACACAAAATGACCTAGTTCTTGCCCTAGTGACTAAGCAGATGCAAACGCCTTCTTCTTTCCAAACAGTGTGGTCTTATCCCCGTCGCAAATGGAGGATATTTAAGAAACCCAAGCCAGAAACCCCACAGTCTTCACAGTCACTGTGTCCTCCAcctcctagcagcttcctgctgttctgctctagtggttctctctgcttccccacacccacccgtaagccacaacaatctttccaaaacacgaacttgatggtttcattgtcacaccccagcttaaaacactttcctggcttcccctggttcttaggataaagaccaaaatacttaatgctgcacagtccagtcccaacccactctccagcttcatcttaatcacacccctctttgctcctagtgtcctaccacattgcctgacttactgtttcttggtaaatgctattcttacttcctgaagattatttccatctcctcacccgacacccttcagttagcttccactcaaccttcagaatttagttcaggtgacccttcctcaagagaagattttcctgaaccattaggaaaggcttctcttgtttctcagtctcatagcatcatctgtctcttttttgtgacttgaatataattaatattttatattttgtccttgttgcttgtttggttaatagatttccaccactagactgctcaatacgttagtagggcacctgacacatagttgcagctcttatttattgaatgaatgaatGATTCCTTCCCGTACCACCCTAGTCTTGCCCACTGTCATTTTTATTCTGGGTATTATATTTCCCAACCAGTTGTCTGACTTTCTCCTCAGATCTCATCCCCATGGGTCTGAGTGAGTTGCCTTGAATATAAGATTCAGTGATGGTGTCCTGCTGCACTTAAGAGAAAATCCTTTTTTCAAGCCCTAAAATCCTGCCCTCACTAGACTTCTCTCACCATTTCTCTGTTTGCATCCTAGCCTTTTAGTTTTGGCCTCATATAAGCTTGCAGCCCTGCCTGAAACAGTTGTCTCTGTCCCCACTCTACCCCCTGCCCTCCACAAAGAAAAgttaactcttactcatctttcagatctcagactaaaagtttcctcAGAGATGCCACCATAGCTCTCTATTTCTCATACCTTTCATGATACTTCATCACCTGTCTTCATGAAGTCCTCCTCTAGACTATTAGCAAAATGCTCATACtgtgtcctcagtatttggcacataataggttttcTTGACACTGAAGGAAGGAATAAACATCTGGTAACTATAGCTAGAAAAAAAGGAAATACGGtatctacttcactaaaaccaaagggggtttttttgggcagacaatcttcattattcagatggaaattaatgtttgttgaatgaatgagctacatttcatggattaactccatgaaatggagttcagctagtaagggttatactttgaggctatttcatcttgatgggcttgttgttcaaagttagagcctcattttaagtaaaatgttctgtgggggccatattaagattttcatatgacagaagtgtatatatatccacaaatgtttcaagccaagattatgtcttcTTCCATAATGCCACCTTCTTCTAGGATAGTATTTTTGGGCCAGATGGTTTTCCACATTTAAAACATACCAACATTCTTTTAAGGCCcagtgattatcaaaagggattggcactacattttaaaatgtaggggggatttttgattgtcacaggactagaggatgccatttgtatttagtagatgaggccaggcaggatgctaaatgtcttaaaagtccgggagtcctgcacaaaaaattactgcccTTCTTGATTTGCCAATTATGCCCCTGCTGGGAAGCATGAAAGGAGAGAGAAGAGCTTTCAGAATGTCAGGGATAAATATATCCATTAAGCCTTCAGACTAAGATGCAggaatagttttccatttgggtatgaatacggcaagttcttagaacatttcttaaaacataattagccaaatactagtgtaacagctacaacttatctagttttaatcaactccagggaacattacactttatttaacccctaattatctgataacccaagttctgtcagaaacactgctgaggcatccaggaagatgagcctgtgaaatttgagaatccttcatgtctctggaatgagtccctagattctagccctgcagctagctgacactctaaaaaattatgagtgccttcctttagctccccatagaaatgtctttgtataaccatggcatgatattattctcttgacttttgttgaggattgatagaaataaaaatgagccagaaatgtttcttcagcttttgtaaagtgctgttaaaagcattatgtcatatctagtacttcttatctaagtattttaaaatttagtgttaggaaaatttttttcacataggatacatgttaatattaggtagtacatctaaagaattcatttgcttcccttttgccttggttgctgggaaactcagagccaaactcggtgcttaGATTAATTACTTTCAGCCTAGGTTTTTCTGTATATCACCCTTTCGGTAGGGCTTGAAGTAACCCTTCAGTTTGCTCATATTTTGTTGTGAGTTTTATAGatagtttacatgcaacgaaatgcatatatcttaagtgttcaactcagtgagttttgacacttttctttgtccatgttaacaatcatcaaaacattttcattgccccagaaaataccattgtgctcctttccggcaaatattccttccctctgctaaaactactttttcatttctatgaccatagttcagtttttggctattcttgaactttatttgaatggaatcgtacatatataatctttttgtttggcttttaaaactcagtataacgttttgacatttgtccatgttgttgcatgactcagcagttctttcttttcagttgctgtgtagtagtccatttcttttggttttgtgtgtgtgtgtgtgctttttaaatttattttttatttttttttttttgagacagagtctggctctgtcaactcaggctggagtgcagtggcatcatctcggctcactgcaatttctgtctcccaggctcaagccatcctctaacctcagcctcccgagtagctaagactctacaggcgtatgccaccatacctagtttgtttttgttattttttttagtacagatggggttttgccatgttgtccaggctggtctcgaactcctgggctcaaagcaatccaccctcctcggcctcccaaagtgctaggattacaagtgtgaggcactgtgccctgccagtattccattttttgtgtataccacaatttatcatttttttctgtgtaggtattttcattgtttccaagttgggaagtatgaataaagttgctatgaacatgcatgtacaagtctttgtagatagctcatgttttAAAAAGTGTTTGTTTAATGATTTCATTGCAAAATCATCTTTATTGTAAACATATCTTTTTGAGGGTAGATTGGTAAAATATACATAATAAATACATGACAATGCAGGAGTCCAAGTATTATTAGGTTTACAGTCATAACAAACACCAAGAACCATTTATAAATTTCAGTTTCTCATTGTTTTAGAATGGAAGGTCTAACCAAATATGTAATGTATCCCTTCAAGTAAACTAGTATAACTTGGGTACCTTCTCATATAAATTCCCCTTAAGGCATACGTTGctgtcttttccaaattcccattttgcttgtccaataggcattatcagatacaacatgttcaaaggcaaacttgattttcctcccatggtttcctcatctcagctcctttttttttccagttgcacaggctaaaaataggaagtcattctagattcctctctttttcataaacctcacatcaaatccatcagccaatctggtgtgctctaccttcaagatacggattatccagaattcagccgcttctcactgtctctactgctaacatagtagtcaaagctgctatcatctcttgcttggattggtgcaatggcctcacaactgatcttcctgcttccatacttgacccctagagcctcttctaaacagagtagctagagcgatcttttctaaatctaagccacatcatgtcactcccctgctcaaatcccaacattttattcagaataaaagtcgaacaatgccctacctgtaggtaatctaggcctccaaagctcttcttacatcacctcctgtaactctccccctttctcactcctctacagccacacagctgcctcactttcctttgaacgtaccaagggcaatcctgcttcagagcctttgcacttgctgtttctgggccaggaattccacaccctccttccctcacatgtatcccaaggctcactgccttccttcagttaagtctgctggaatgtcacttcattaggtattgcctgatcaccttttctaaagtgagtctcacctccaccctcaatgctGGCAATGTCTGTCTGTAGTGTATTCTTAACAATACAGATTAGCACAATGCAGGCCAGACCATGAAGACTGTTTCAAGTTCGAGGATGGGCAAAAATAATGACTAGGACTTGGCTCAAGATTCCTCAAACAGCCAATAAACAATGCAAAGAATAAATGAGAGAGTAATTGGAGACAAGCTTTCCCTTGGCTTCCCTTCTTTTCTCACAGAGGCTTTTCCAGAAGGTGGTCATTTCCATAGCCCATGTGGAATGAGATGTCCACTAGGGCAGAGAAGCACAGAACCGTGGGCACTGCTTCCCTTCCTTTAACCCTATCATATTGCTGCCCAGTGAGCAATATGGTCATTGGTCAAGAAGGCTTATGCCCAGGTATCCCTGTGGCTATGAGCATTGCTCCTTATCTATGCCTCTGCTCTTAGACTTTTCCATTCTGCCCTCTTAGGGGCCTTCCTGGCCATGACCacactaccttatttttctctatagtacttatcaccatctgacatgtatttatgtttgtatttgtttattgtctgtctctacaaataaaatgtaaattccctaaaaa

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