Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CBX3P2
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:2652815-2653262  UCSC
Coordinates (T2T) chr18:2808397-2808844  UCSC
Coordinates (hg19) chr18:2652814-2653261  UCSC
Strand -
Parental Sequence NM_007276.5
Parental seq. overlap 382 bp
Parental seq. overlap (%) 18.2%
Genomic Region Intergenic
Retrocopy Summary CBX3P2, located on chr18:2652815-2653262, is a retrocopy of the parental gene CBX3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CBX3
Full Name chromobox 3
Also known as HECH|HP1-GAMMA|HP1Hs-gamma
Coordinate chr7:26201443-26213607
Strand +
Gene summary At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CBX3P11
Bonobo Pan paniscus CBX3P11
Gorilla Gorilla gorilla CBX3P9
Orangutan Pongo abelii CBX3P10
Gibbon Nomascus leucogenys CBX3P4
Green monkey Chlorocebus sabaeus CBX3P10
Crab-eating macaque Macaca fascicularis CBX3P10
Rhesus Macaca mulatta CBX3P11
Baboon Papio anubis CBX3P11
Golden snub-nosed monkey Rhinopithecus roxellana CBX3P12
Mouse lemur Microcebus murinus CBX3P16
Pig Sus scrofa CBX3P3
Dolphin Tursiops truncatus CBX3P4
Dog Canis familiaris CBX3P8
Cat Felis catus CBX3P10
Greater horseshoe bat Rhinolophus ferrumequinum CBX3P5
Marmoset Callithrix jacchus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Horse Equus caballus Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CBX3P2
TACATTGCAAAAAAATGGGACAAAAGACTTAGTGGAAAGGGTATAAAAGCTGATGAAGCAGAGCCTGAGGATTTTGTGGTGGAAAAAGTACTACACCAAGGTGTGGTGAATGGGAAGGTGGAATATTCCCTGAAGCGGAAAGGATTTACACTTGCTGACAATAATTGAGAACCTGAAGAAAACTTAGATTTTCCTGAGTTCATTGAACTATTTCTTAATCCTCAAAAAAACTGGTAAAGGAAAAGATAGTACAAAAAGAAAATCTTTATCCGAGAGTGAATCTGATGACAGCAAATGAAAGGGATGCTGCTGAAAAACCAGGAGACTTTGCCAGAACTCTTGATCCTAAGCAAAGAATTGGTGCCACAGACTGCAGTGAAGAATTAATGTTTCTAATGGAATGCAAAGACTCAGACGAGGCTGACTTGGTGCTGGCAAAGAGGCAAAC
>NM_007276.5
GCGCCAGCCGCTGAGGCTGCCAAGCAGAAAAGCCACCGCTGAGGAGACTCCGGTCACTGTCCTCGCCCCGCCTCCCCCTTCCCTCCCCTTGGGGACCACCGGGCGCCACGCCGCGAACGTAATAGCTCTTCAAGTCTGCAATAAAAAATGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGAATGGAAAGAGTAAAAAAGTTGAAGAGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTAGTGAATGGGAAAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACTTGGGAACCTGAAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAGAAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGATGACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGTCTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATGAAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGTCCTCAAATTGTAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGATGAAGCTCAATAATTGTTCACATTGTTCTTTtatatatatttatatatatatataAAAATTGGGTCTTAGATTTTGATTTACTAGTGTGACAAAATAACTACATCCTAATGAAAATCAAGTTTGATATGTTTGTTTTGAAAGTAGCGTTGGAAGAGTTGTTGGGGGTTTTTTGCATCCATAGCACTGGTTACTTTGAACAAATAAATAAAAGCTTTCTGTAGTTGCTTCCTTTATCAGAAAAGAACATTTGATACCATGGTATATCATTTCCTCTTCATTAAAGAACAGCTTTTCTAAATGTTGGGGGAAATGTCCATAGTCATTACTCAGTCAAAACTTGTGTTCTCATGAGCCTAAGGACCATTCTAGATTTATTACGTGTTTTTtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtATCCATAAAATGCATATGTAAATTTTTTTTTGTTTTTAAGCATTCACCCAAACAAAAAAATCACAGGTAAACCCATGTTTCTGAGATGCCATTATTCCAAGCAAAATAAGAGATAATCCCTTCAAGTTAAATTGAAAATTTTCCTGAAACCATACATTTCAAGTGAAATAAGTAATTCTAGATAGGACAATTTAAATTGGATAATTTTAAAGTGTCTATAATTGCAGTGGTTTATTTGCAAAATTCCTAAAAGGAAAAATTTTATCACTGCCATCACAGCAGGTTTCCTCATCCAGATGAGGAAACTAGACAAATGCTAGTGTGTTTTAACTAGCTAAACAAAACTAAGTTAAATGAACATTTAAAAGTTTCCCTAGCGGGCCATTCCTTAGCAAAATGTTGGAATCCCTGTTGCTACATTGACTAAAAGGTCATGATGAATGGAATATGTAAGACTTGGCTCATAGAAACCTAATCAGATGGTTAGAGGTGTTGGCAGTTTAGGACCTGCTGTCATAAATGTGTGAACAACCTTTTGTAACCTAACCTATTGACCTGCATGTTTTTTCTTTACCCCAATTCATTACATGGAGGCTCAATCTTGAGTTTGCTTTACTGGTTCAGCAAAAGCCAGGAAGAACAACTTTGTAGTAATCAAAATGTTATCCAACTGTATATTGTTTACTTTATTGTAAATACTGGTGAACAGTGGTTAATAAATAGTTTTATATTCCTTTATGCAATTATTAGACTTTTTTCTTTATTTGATATGCCTTTACAGTAGAAATAGAAATGCCCACACTCATTGGATTATCTTTGTTTATAAGTTAGATGATACCAGTAAGGCATTACAGTACATATCCTAGATCTTTTGAGCTTACGAGTTTTAAACTTGAATATGTATTTCCACAGGAATGTTTCCACAGTTGGGAAATAAAAGTTTCATGTGATGCCTAGGGTCAATTGTCTCATTAAAATGAGGTTTTAAATTCTG

Publications

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