Summary

Retrocopy Name	MRPS17P10
Species	Homo sapiens
Coordinates (hg38)	chr18:57763719-57764242  UCSC
Coordinates (T2T)	chr18:57963992-57964515  UCSC
Coordinates (hg19)	chr18:55430951-55431474  UCSC
Strand	-
Parental Sequence	NM_015969.3
Parental seq. overlap	477 bp
Parental seq. overlap (%)	26.7%
Genomic Region	Intragenic (ATP8B1)
Retrocopy Summary	MRPS17P10, located on chr18:57763719-57764242, is a retrocopy of the parental gene MRPS17. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	MRPS17
Full Name	mitochondrial ribosomal protein S17
Also known as	HSPC011|MRP-S17|RPMS17|S17mt
Coordinate	chr7:55951877-55956500
Strand	+
Gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]

Homology

	Species	Scientific Name	Retrocopy
	Chimpanzee	Pan troglodytes	MRPS17P2
	Bonobo	Pan paniscus	MRPS17P2
	Gorilla	Gorilla gorilla	MRPS17P2
	Orangutan	Pongo abelii	MRPS17P2
	Gibbon	Nomascus leucogenys	MRPS17P1
	Marmoset	Callithrix jacchus	LOC100412910P2
	Green monkey	Chlorocebus sabaeus	Without Homology
	Crab-eating macaque	Macaca fascicularis	Without Homology
	Rhesus	Macaca mulatta	Without Homology
	Baboon	Papio anubis	Without Homology
	Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
	Mouse lemur	Microcebus murinus	Without Homology
	Mouse	Mus musculus	Without Homology
	Rat	Rattus norvegicus	Without Homology
	Chinese hamster	Cricetulus griseus	Without Homology
	Rabbit	Oryctolagus cuniculus	Without Homology
	Pig	Sus scrofa	Without Homology
	Cow	Bos taurus	Without Homology
	Sheep	Ovis aries	Without Homology
	Dolphin	Tursiops truncatus	Without Homology
	Horse	Equus caballus	Without Homology
	Dog	Canis familiaris	Without Homology
	Panda	Ailuropoda melanoleuca	Without Homology
	Cat	Felis catus	Without Homology
	Pale spear-nosed bat	Phyllostomus discolor	Without Homology
	Velvety free-tailed bat	Molossus molossus	Without Homology
	Greater mouse-eared bat	Myotis myotis	Without Homology
	Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
	Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
	Egyptian rousette	Rousettus aegyptiacus	Without Homology
	Sloth	Choloepus didactylus	Without Homology
	Tasmanian Devil	Sarcophilus harrisii	Without Homology
	Opossum	Monodelphis domestica	Without Homology
	Platypus	Ornithorhynchus anatinus	Without Homology
	Chicken	Gallus gallus	Without Homology
	Turkey	Meleagris gallopavo	Without Homology
	Zebra Finch	Taeniopygia guttata	Without Homology
	Budgerigar	Melopsittacus undulatus	Without Homology
	Painted Turtle	Chrysemys picta	Without Homology
	Lizard	Anolis Carolinensis	Without Homology
	Frog	Xenopus tropicalis	Without Homology
	Zebrafish	Danio rerio	Without Homology
	Drosophila	Drosophila melanogaster	Without Homology

Expression

This retrocopy transcript is not present in the ARCHS4 database for expression quantificationThis retrocopy transcript is not present in the GTEx database for expression quantification.

Related Sequence

>MRPS17P10

GCTCCCTGGGGCAGGTGGCTGCACAGTCATGGCGGAGGTGACCAAAGCCACATCATGTCCGTCGTTCGTTCATCTGTCCATGCCAGATGGATCGTGGGGAAGGTGATTGGGACAAAAATACAAAAGACTGCTAAAGCGAGAGTGACCGGGCTTGTTCTGGATCCCTATTTATTAAAGTATTATAATAAGTGGAAAACCTCCTTTGTTCACGATGGCCTTCGGCAGTGCACAGCTGGGGATATCGTGCTTCTCAGAGCTTTACCTGTCCCATGAACGAAGCATGTGAAACATGAACAGGCCAAGATCATTTTCAAAGTTGGAAAAGTCATAGATCCAGTGACAGGAAAGCCCCGTGCAGGAACTACCTACCTGGAGAGTCTGTTGAGTTTAGAAACTACCCAGCTAAGCAAAAATCTGGAAGAACTCAGTATCTCTTCGGCACACTGAAGGAGGAGTGGAAGGAGCTAAAGGGAAAGATTGACATGTTTATGTTATGCAAAAATAAATTTTTCAAAGCTTCATCC

>NM_015969.3

ATCCCGCTGCGACCGGCGCTCCCCGGGGCAGGTGGCTGCATAGTCTTGGCGGAGGTGACCAAAGCCACGTAATGTCCGTAGTTCGCTCATCCGTCCATGCCAGATGGATTGTGGGGAAGGTGATTGGGACAAAAATGCAAAAGACTGCTAAAGTGAGAGTGACCAGGCTTGTTCTGGATCCCTATTTATTAAAGTATTTTAATAAGCGGAAAACCTACTTTGCTCACGATGCCCTTCAGCAGTGCACAGTTGGGGATATTGTGCTTCTCAGAGCTTTACCTGTTCCACGAGCAAAGCATGTGAAACATGAACTGGCTGAGATCGTTTTCAAAGTTGGAAAAGTCATAGATCCAGTGACAGGAAAGCCCTGTGCTGGAACTACCTACCTGGAGAGTCCGTTGAGTTCGGAAACCACCCAGCTAAGCAAAAATCTGGAAGAACTCAATATCTCTTCAGCACAGTGAAGCGGGAGTGGAAGAAGGATCTAAAGGGAAAAACTGACATGTTTATGTTATGGAAAAAGAAATTTTTCTAAGTTTCATCACAAACTGTGTCCAGTTTCTCTGTGGTGTTTATGAAATAGCTAAAAGCAAATGAAGTAAAGGGCATACTATGGTTTTTCACAAAGGTTTATGGTCGTGTTTCAAATTTTCATCATTTCAGTGAACATACTTCCACGTTACATTAAGTGTGCCTAGCAGTCTGTTGCATTTTGTAAGCTCACAGttttttgttttgagatggaatctcactctgtcacccaggctggagtgcagtggtgcaatcttggctcactgcaagctccgcctcccgggttcacgccgttctcctgcctcagcctcccgagtagctgggactacaggcgcctgccaccatgcccagctaatttttttttttttttttttggtatttttagtagagacggggtttcaccgtgttagccaggatggtcttgatctcctgacctcgtgatctgcctgccttggcctctcagagtgctgggattacaggcgtgagccactgtgcTTAGCAAGCTCACTGTTTTAGAAGGttttatttttgtcttttgagacagggttttgctttgttgtgggggctggagtgcagtggtatgatcttggctcactgcagccttgacctccctggctctagcatctttccaccccagccttctgagtagctgggaacacaggagcgtaccactacacttggctgattttttgtaaattttgtagagacagggtctccctgtgttgcccaggttggtctcggactcctgggagcaatctgcccatcttggcctaacagtgctgggattacaggcctgagccactgtgcccagccGGTTTCCTTTATTTCATTCAAAGGAATTTTGAATTTATCTTAGAACCTTTATTTTGAAGGAAGAAAGTCttttttttttttgagctggagtttcactcttgttgcccaggctggagtgcaatggcatgatctcagcccaccacgacctccgcctcccaggttcaagtgattctgcttcagcctcctgagtagctaggattacaggcatgtgccaccacgcccagctaattttgtatttttagtagggatggggtttctccatgtttgtcaggctagtcttgaactccggacctcaggtgatccgcccgcctgggcctctcaaagtgcttggattacaggcatgagccactgcATGTAATGACCAGCCACTGGTCAGAATTCTTTCAATCAAGCTGTGTTAATAAGAATATTGATGTGTGGAAAATAAAATTTTACAATTCTG

Publications

PMID - Link	Title
No publications available for this retrocopy