Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name MRPS5P4
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Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:60519851-60524436  UCSC
Coordinates (T2T) chr18:60722817-60727402  UCSC
Coordinates (hg19) chr18:58187084-58191669  UCSC
Strand +
Parental Sequence NM_001321997.2
Parental seq. overlap 633 bp
Parental seq. overlap (%) 17.1%
Genomic Region Intergenic
Retrocopy Summary MRPS5P4, located on chr18:60519851-60524436, is a retrocopy of the parental gene MRPS5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MRPS5
Full Name mitochondrial ribosomal protein S5
Also known as MRP-S5|S5mt
Coordinate chr2:95085369-95122003
Strand -
Gene summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MRPS5P3
Bonobo Pan paniscus MRPS5P3
Gorilla Gorilla gorilla LOC101141821P3
Orangutan Pongo abelii MRPS5P3
Gibbon Nomascus leucogenys MRPS5P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.050.1
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth01234
log10(TPM+1)

Related Sequence

>MRPS5P4
AGCCATCATCACCATCTGCTGGCTCATTGGCATCAAAGACTTGTATGCCAAGGTCTTTGGGTCCGTCAGTATGCCCAACCTCACCTGGGGCCTCTTTCGTGGGCTCTCCAGCCGGGAAATCCATCAACAGCTGGCTGATAAAAAGGGCCTCTACATTGTGGCCCTCTGCCTGGAGTGGTTGCCTACCCCTGGGGGCCCTTGAGAAATGATCCAGAGCTGGATGATTAGGTTCCAGACATCAATCTGGACTAGGAAGAAGTGAAGGCTGTGCAGCGAATGAAGTGCTCTGTATGGTCCAGTTTAAAGAGAGTTGCCAGGTAACCTCTCTGACCTTGTGCAGCCAGTGCCTGGTGCTACCCAACACCTAGGAGAAATTCAGATCCCTCACATCTTGGGGTGTTACCTTGTTTTCTGTTTGTTCGAGGAAACTTTAACCTTTAAACTGTTTAGAAATACAAGACTACTTTAAATATTCATCCGAACTAGCAAAAGTAAATGAATTAGTGAGACGGTGCTAATAATCTGACCCAATTCATAATAATATGCACAATGATAATTGCTATAATTATAGTGAATATATATTAACTCAGTCTTCCAAAGTCAATACGATTAGTCTCATTTTACAGAGCAGGTAAAGAATTTGACTACCAAACAGGAGCTTGAAGGCTACAAATGGGAATGTTAAATCAGATACATGATTTACAAAATTTTTTTATTCATTCTATGGGATACATTTTTTTAAaAA
>NM_001321997.2
AGGCGCCCGCGGGGCTGTCCGCGGTCGCGCCGGGCTCCGCCTGCAGTGTGGCCCGTCCGGACAGTCCCTCACCCCGGCCTGCGCTGCTGCGTGGACTCGGGCCTCAGGAATTCCGCTGCGGCCCAAGGCTTGCCGTTTGACGAGGAGCAGTCGCGGTAGGCGGTGGGCAAGGCTGCCCTGGGCGGAGGCCGAGGCGCGGCTCGGACTCCAGCATGGCGACCGCGGTGCGCGCTGTGGGCTGCCTCCCCGTGCTGTGTAGCGGGACGGCAGGTGAGAGCTGGGACGCCGGGAGCAGGGGCTCTGAGCGGGCCGGGAGTGGGGGGCTCGCCTGGGGCCTGCAGAAGTCGGGGCGGAGGGAAGCGAGAAGCCGCGGCCCCCGGCTCTTCACGCCGTGCCCCCACCTTCCGCCGGAGCCgctgtgtgaccttgcgcgcgtcctctccctctctgggtcgcggagctcttgtctgtaaaatgagggggaactggacgtcgttcttcagggttcttcccagttcACGAAACCGCTTGAGCGTGCTTGGCGAAGAGGAGCGGAAACTGGTCATTTATTGGGGAGGCAGTGTTCCCTAAACACCTTACCAGCAGCTTCCATTTTGGCATGGAAGAGTGTTCTCGGCAATGGCCATTTGTCATCACTGGGAACCAGAGACACCCATCCCTACGCCAGCTTGAGCCGTGCACTGCAGACACAATGCTGTATTTCTTCTCCCAGTCACCTGATGAGCCAGCAGTATAGACCATATAGTTTCTTCACTAAATTGACTGCAGATGAGCTGTGGAAAGGCGCTTTAGCAGAGACTGGTGCTGGAGCAAAAAAAGGAAGAGGCAAAAGAACTAAAAAGAAGAAAAGAAAGGATCTGAACAGGGGTCAGATCATTGGTGAAGGGCGTTATGGTTTTCTATGGCCCGGACTGAATGTCCCTCTTATGAAAAATGGAGCAGTGCAGACCATTGCCCAAAGAAGCAAGGAAGAGCAGGAGAAGGTGGAGGCAGACATGATCCAGCAGAGAGAAGAGTGGGACCGAAAGAAGAAGATGAAGAAACATATGAGGATTTTGATACCAGGATACTTGAGGTAAGAAACGTTTTCACTATGACTGCGAAAGAGGGAAGAAAGAAATCGATCCGTGTCTTGGTGGCTGTGGGGAACGGAAAAGGAGCTGCAGGTTTTTCTATTGGGAAAGCTACTGATCGGATGGATGCTTTCAGGAAAGCAAAGAACAGAGCAGTTCACCATTTGCATTATATAGAACGATATGAAGACCATACAATATTCCATGATATTTCATTAAGATTTAAAAGGACGCATATCAAGATGAAGAAACAACCCAAAGGTTACGGCCTCCGCTGCCACAGGGCCATCATCACCATCTGCCGGCTCATTGGCATCAAAGACATGTATGCCAAGGTCTCTGGGTCCATTAATATGCTCAGCCTCACCCAGGGCCTCTTCCGTGGGCTCTCCAGACAGGAAACCCATCAACAGCTGGCTGATAAGAAGGGCCTCCATGTTGTGGAAATCCGGGAGGAATGTGGCCCTCTGCCCATTGTGGTTGCGTCCCCCCGGGGGCCCTTGAGGAAGGATCCAGAGCCAGAAGATGAGGTTCCAGACGTCAAACTGGACTGGGAAGATGTGAAGACTGCACAGGGAATGAAGCGCTCTGTGTGGTCTAATTTGAAGAGAGCCGCCACGTAACCTCTCTGGCCTTGTGCAGCCAGTTCCTGTGCTGCCCTGCACCTAGGAGAGACTCAGCCCCTCACAGCTTGGGATGTTACCTTGCCTTTTGTTTGTTTTGAGGGAAGTTTAATCTTTAAACTCTTTGGAAATAaataattatagctttcatttgttgagcacatgttatatgccaatgtgatagaacctttacatacatatctcagttCAAGACTACTTTAAATATTCATCCAAAGTAACAAAAGTAAATGAATTAGGGAGACGGGGTTAATAATTTGACCCAATCAGTAATAATGTACACAATGATAATTGCTGTAGTAATTATAGCTAATATATATGAACTCATTCATCCAAAGTGAATGTGATTAACTTCATTTTACAGAGCAGTTAAGTAACTTGACTACCGtgaggaacttccaaaccgttttccacagtggaaatggaagttgtaggctactattgggaatgttaaatggtatattaattgtataccattgcaattttgacttgtatttccctgatggctgatgatgttgaacatcttttcatgtgctgattggccatttgtatatgttttttggagaaatgtctattcagagcctttgcccatttaaaaagttattttttattattattgagttccttatagtttctagatataagcccccctatcatacatgctttacagaagtttttacccattctgtggaatatatatatttttatttctttgcatactctttctgccccacccacatcctctttctgggacactgatgaccaaaatgttgaatcttttactattgtcccgtgagtccctgaggcgctgtttattttttttccagtctgttttctctgtgttgctcagtttaggtaatttctattgttttatcttcagaataactggttatttactctttcctttccattctgctcttgaaccatccatgcagtactttaactttgactgtcattgtatatttcagttaaaatttccatttggtttattttttatgtcttctctttatttgctgaggctatttgctgagactttttttttctttaaatggcttcaagagtgtttataattgctcactgaagcatttttatggtggctgctttaaaatctttgtcatcaggtaggtgtggtggctcacgcctataaccccagcactttgtgaaggtgaggcaggaggattgcttcagcccaggagtttgagatcagcctaggcaacaaagtgagacctcatctctacaaaaagtaaaagtaaatttaaaagttagacacacatggtggtgtatgcctgtagtcccagctacataggaggctgaagtgggaggatcatttgattgcaggaggttgaggctgcagtgagccttgttcatgccactccagcctgggtggcagagtgagaccttgtctccaaaaaaaaaaaaaaaattgtcataaagtttcaacatctgtgtcatcttagtgttgacatcccttgaggttttttctcattcaagtttacaatgtcctagttcttgttatgatgagtgactttggctgtatcctggtcatcttcactgttatgaagctctgggagttatttaaatctctcagcatgcttcctctgacggtgctggtatgggatggggcactgcctcgttactgcctggtgaggatggagatccaggtttccTCCTGTCGCTGTCCTCGGGACCTCTGCTGAGGCCTTTCTGCTGGAAGTAGGAGGAGCACCCTAATGGCACCGTGGGATAGGGAGCAGGCCATGTTAGGCTGGATGGTGAAAGTTTTCAGCCTGTGACGTTGTCTGGTGTGGGTGGGTCCCCTTTTTTTGTGTGTGGTATTTTGCTAGAGTAAGGTAGTTATTTCCTAAAACTTATCTGTCCTGTTAGTTTTCCTTCTTAAGTACCTAACAAATATAaagacaatgaactttaagcaataaaagacaatgatcctttggagaggggaaacaaaa

Publications

PMID - Link Title
12706105Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.