Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CAPNS1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:89394042-89394782  UCSC
Coordinates (T2T) chr1:89237306-89238046  UCSC
Coordinates (hg19) chr1:89859601-89860341  UCSC
Strand +
Parental Sequence NM_001302632.2
Parental seq. overlap 619 bp
Parental seq. overlap (%) 40.2%
Genomic Region Intergenic
Retrocopy Summary CAPNS1P1, located on chr1:89394042-89394782, is a retrocopy of the parental gene CAPNS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CAPNS1
Full Name calpain small subunit 1
Also known as CALPAIN4|CANP|CANPS|CAPN4|CDPS|CSS1
Coordinate chr19:36140066-36150353
Strand +
Gene summary This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CAPNS1P1
Bonobo Pan paniscus CAPNS1P1
Gorilla Gorilla gorilla CAPNS1P1
Orangutan Pongo abelii CAPNS1P1
Gibbon Nomascus leucogenys CAPNS1P1
Crab-eating macaque Macaca fascicularis CAPNS1P1
Rhesus Macaca mulatta CAPNS1P1
Baboon Papio anubis LOC101020329P1
Marmoset Callithrix jacchus CAPNS1P1
Green monkey Chlorocebus sabaeus Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CAPNS1P1
TTCCTAGGTGGAATCATTAGCTCCATCATGGAGGTGGCTACACAGCACAACCTGGAGCCCCTGCCTCAACACACACATTGCTCCAACACTGAGGCCAACAAGAGTGAGGAGGTCCATCATTTCTGGAGGCTCTTTGCCCGGTTGGCTGGAGATGACATCGAGGTCAGCGGCACAGAACTCATGAATGTTGTCAACAAGGTTGTGATCAGTAGGACTGAACTGAAGACTCATGGTTTTGGCATTGATACATGTCAAAGCATGGTGGCCATGATGGATAGTGACACCATAGGCAAGCTGGATTTTGAGGAATTCAACTACCTGTGGAACAACATCAAAAAGTGACACAATATACAAGCAGTTTGATGTTGACCGATCCGGAACCATTTGCAGCAGTGAACTTGCAGAGGCCTTTGAGGCAGCAGGGTTCCATCTGAATGAACAACTCTACAACATAATATTCTGACACTACTTGCATGAAGGAGAGAACATGGATTTTGGCAACTTTATCAGCTGCTTGGTCAGGCCAGATGCTTCGTTTCATGCCTGGAAATCTCTTTACAAAGATGACACTAGACCATTCTAAGTGAATATCCAAGAGTGGCTGCAGCTGACAATGTATTTCTAAATGGGAAACCCAGGCCTGCCCCTTCACTGCCTTGCTATAGGAGTCACCTTGGAGCCTCAGCCTCTCCCAGTGCTGATCCCATTTGCAGTCACATCTTCATGGGTCCTGCTGACCCA
>NM_001302632.2
GAGTCACCGGCCCCGCCCTCCGGAGCCGGACGCTGCGGGAGGCCCGGGAGCGGCAGTGGAACCGACTCCCAGAACTCCGGACGTGTGCGGCGGTAAGCGCCCGGCCCGTACCCCCTCCGCACCCCGCAACTCCGACTTTGGCGGCCCCCAGACCCGGCGAAACCGTGAAGTCTCGGCCTCAGGAGCCCCCCAGATCCATGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGggcggcggcggcggcggcgggggaggcgggggcCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGggcggcggcggcggcggcggcggcggcggcggtggtggaggcggcggtggcggTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACACCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGGCTTTGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTGCAGTAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAGTGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCGTGCCTTCAAATCTCTTGACAAAGATGGCACTGGACAAATCCAGGTGAACATCCAGGAGTGGCTGCAGCTGACTATGTATTCCTGAACTGGAGCCCCAGACCCGCCCCCTCACTGCCTTGCTATAGGAGTCACCTGGAGCCTCGGTCTCTCCCAGGGCCGATCCTGTCTGCAGTCACATCTTTGTGGGGCCTGCTGACCCACAAGCTTTTGTTCTCTCAGTACTTGTTACCCAGCTTCTCAACATCCAGGGCCCAATTTGCCCTGCCTGGAGTTCCCCCTGGCTCTAGGACACTCTAACAAGCTCTGTCCACGGGTCTCCCCATTCCCACCAGGCCCTGCACACACCCACTCCGTAACCTCTCCCCTGTACCTGTGCCAAGCCTAGCACTTGTGATGCCTCCATGCCCCGAGGGCCCTCTCTCAGTTCTGGGAGGATGACTCCAGTCCCTGCACGCCCTGGCACACCCTTCACGGTTGCTACCCAGGCGGCCAAGCTCCAGACCGTGCCAGACCCAGGTGCCCCAGTGCCTTTGTCTATATTCTGCTCCCAGCCTGCCAGGCCCAGGAGGAAATAAACATGCCCCAGTTGCTGATCTCTA

Publications

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