Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL28P5
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:12260091-12260582  UCSC
Coordinates (T2T) chr19:12388367-12388858  UCSC
Coordinates (hg19) chr19:12370906-12371397  UCSC
Strand +
Parental Sequence NM_000991.5
Parental seq. overlap 455 bp
Parental seq. overlap (%) 10.8%
Genomic Region Intergenic
Retrocopy Summary RPL28P5, located on chr19:12260091-12260582, is a retrocopy of the parental gene RPL28. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL28
Full Name ribosomal protein L28
Also known as L28
Coordinate chr19:55385932-55403342
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL28P5
Bonobo Pan paniscus RPL28P6
Gorilla Gorilla gorilla RPL28P5
Orangutan Pongo abelii RPL28P5
Gibbon Nomascus leucogenys RPL28P4
Green monkey Chlorocebus sabaeus RPL28P1
Crab-eating macaque Macaca fascicularis RPL28P5
Rhesus Macaca mulatta RPL28P6
Baboon Papio anubis RPL28P5
Marmoset Callithrix jacchus RPL28P14
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL28P5
GGTCTCAGGCCGCCACTGCGAGAGGAGCCGCCACCATGTCCGCGCATCTGCAATGGATGGTCGTGCAGAACTGCTCCAGTTTCTGATCAAGAGGACTATGCCGACCTACAGCACCAAGCCCAGTAACTTGAAGGCCCCAGCTCCTTCCGCTACAACGGGCTGATTCACCACAAGACTGTGGGCGTGGAGCCGGCAGCCGAGGACAAAGGTGTGGTGGTGGTCACGAAGCAGAGATCCGGCCAGCCGAAGCCTGCCACCTCCTACGCGCGGACCACCATCAACAAGAATGCTGGCGTCACGCTCAGCAGCATCAGACACATGATCCTCAAGAACAAGTACCGCCCCGACCTGCGCATGGCAGCCATCCGCAGGGTCAGCGCCATCCTGTGCAGCCAGAAGCCTGTGATGGTGAAGCGGAAGCGGACCCGCGCCACCAAGAGCTCCTGAGCCCCCTGCCCCCAAAGCAATAAAGAGTCAGCTGGCTTTCTCACC
>NM_000991.5
CTCTTTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTCCTGATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGCAAGACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCCTATGTGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCAGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTGCGCATGGCAGCCATCCGCAGGGCCAGCGCCATCCTGCGCAGCCAGAAGCCTGTGATGGTGAAGAGGAAGCGGACCCGCCCCACCAAGAGCTCCTGAGCCCCCTGCCCCCAGAGCAATAAAGTCAGCTGGCTTTCTCACCTGCCTCGACTGGGCCTCCCTTTTTGAAACGCTCTGGGGAGCTCTGGCCCTGTGTGTTGTCATTCAGGCCATGTCATCAAAACTCTGCATGTCACCTTGTCCATCTGGAGGTGATGTCAATGGCTGGCCATGCAGGAGGGGTGGGGTAGCTGCCTTGTCCCTGGTGAGGGCAAGGGTCACTGTCTTCACAGAAAAAGTTTGCTGACTTGTGATTGAGACCTACTGTCCCATTGTGAGGTGGCCTGAAGAATCCCAGCTGGGGCAGTGGCTTCCATTCAGAAGAAGAAAGGCCTTTTCTAGCCCAGAAGGGTGCAGGCTGAGGGCTGGGCCCTGGGCCCTGGTGCTGTAGCACGGTTTGGGGACTTGGGGTGTTCCCAAGACCTGGGGGACGACAGACATCACGGGAGGAAGATGAGATGACTTTTGCATCCAGGGAGTGGGTGCAGCCACATTTGGAGGGGATGGGCTTTACTTGATGCAACCTCATCTCTGAGATGGGCAACTTGGTGGGTGGTGGCTTATAACTGTAAGGGAGATGGCAGCCCCAGGGTACAGCCAGCAGGCATTGAGCAGCCTTAGCATTGTCCCCCTACTCCCGTCCTCCAGGTGTCCCCATCCCTCCCCTGTCTCTTTGAGCTGGCTCTTGTCACTTAGGTCTCATCTCAGTGGCCGCTCCTGGGCCACCCTGTCACCCAAGCTTTCCTGATTGCCCAGCCCTCTTGTTTCCTTTGGCCTGTTTGCTCCCTAGTGTTTATTACAGCTTGtgaggccaggagtttgagaccatcctaggcaacataatgagacaccgtctctaaaataaaattagctgggtgtggtggtgcaccgcctgtggtcccagctcctcagaggttgagtagaggctgaggtgagcggagcacttgagccaagagtatgaggctgcagtgagcccatgagccccaccactacactccagcctggaagacaCCATGACACACAGTGAGGCCTGGATGGGGAAAGAGTCCTGCTGTTGATCCTcacatgtttcctgggcacctaactctgtcagccactgccagggaccaaggatccagcatccatggcacccctggttcctgccatcctggggtacccgattcaaagaaggaCTCTGCTCCCTGTCTGAGACCACCCCCGGCTCTGACTGAGAGTAAGGGGACTGTCAGGGCCTCGACTTGCCATTGGTTGGGGTCGTACGGGGCTGGGAGCCCTGCGTTTTGAGGCAGACCACTGCCCTTCCGACCTCAGTCCTGTCTGCTCCAGTCTTGCCCAGCTCGAAGGAGAGCAGATCTGACCACTTGCCAGCCCCTGTCTGCTGTGAATTACCATTTCCTTTGTCCTTCCCTTAGTTGGGTCTATTAGCTCAGATTGAGAGGTGTTGCCTTAAAACTGAGTTGGGTGACTTGGTACCTGCTCAGGACCCCCCGCACTGTCCCAATCCCACTCAGGCCCACCTCCAGCTGGCCTCACTCCGCTGGTGACTTCGTACCTGCTCAGGAGCCCCCACTGTCCCAGTCCCACTCAGGCCCATCTCTGGCTGGCCTCACTGCGCTGGGACTCCGCCTTCATAAGGAGAGCTCACTGCTCACGTTAGTAGATGGCCCCTTCTCGTGAGGCCTCTCCCCTGGCACCTGCTTCAGTTGTCCTCCACAGCACTGATTTGCAGCCCACAAGCTGGCAGGTTTATCTGTCTCATGTTTGTCTTGTGCTGGTGGGCAAGGGGTTTGTCTAGCACACCAGCATATAATGAGATGCTTGATGAATGGTGCATATTGAATGTATAAAGCCCACCGGTCCTGAGAGTTTGCTCACTGGAGACtttctggagatggagtctcgctctgttgcccaggctggcgagtgcaatggcgcgatcttggctcactgcagcctccacctcctgggttcaagcgattctcctgcctcagcctcccgagtagctgggattacaggtgggtgtcaccacacccagctcagtattgtatttttagcagagatggggtttcaccattttgcccaggctggtttggaactcctgacttcaaattacccacctgcctcagcctcccaaagtgctggcattacaggcgCTCGAGGCTTTCTGATGTGGCTGCTGCTGCTCAGAAGGCCTTGTCCTTAACCACCTCCTTGCCTGCCCTGGAGGCTTGTGCCTCTAGGCCCCACCCCCTGTGGAGTCCTGCTGGCTTTCTCCATCCCTATCTGAATCCTCCCTGCTGTGTGGCCTCCCCTGGTCTCATCCGTAACACAGCCCAGCTTAGTGGGCCTCTGTTCCTGCGGGTGGCCAGCCTGTCTGTGTGGCTGGGCTGGGGAGGCCACGTCTGGTATCTGAATGCTATCGGTGGGTTGGGGTGGAGGAACCAGGAGAGGGCTGGAGGGAGGGAGATGGTCTCAGCCCCACAGAGTTTGGAGTCCTCAGTGTGCTGAGCAAACGTGGAGACACCATTTCCCTCCTCTAGACCTCATCTTGGAGAGAGAGATGTTGGATGGGGCCATCTATTCCAGCTTTATTCACACAAATCATGTCTGTTGGCCTGGAAATTGGAAAACCAGTTAaaccaaaaacatgatattaagaaaacaggcaggctcaccatagtaaaaatgctgaaagccaaagacaaaattgggagaacaaaagaaaagcgtcttgtcacatacagaaggtccctgataaagttagtagctgccctcatcagaaaccaggcccaggcagtggggacacatccagagtgctgaaagaaCCTCCCCCAGGTCATCCTATCCCCAAGAGTGATGCCCGGCAGCATTCCCAGCTCAGGGCtaatggttcacggaagccaggaatcaaactgcctgggttccagtcccagctctgccagttatgcccagctgtggggacttgggcagctcgtttagtagcaccgtgcctcagtttcccatatgtaaaaGGCCATTTTGAGTGCCTTTCACAGCCCTGCATAAGGCAGGTGTCTCAGtgttcactgctgtctctccagctcttagtccagtagctgcatggtgagtgAGCGTAGGGCGCACCCTGGAAGGCTGCCAAGCCCAAAGTTGTGCAGAGCGCTGGGGACTCCAGACTCCCCACAGCAGCAGAGACTCGGGACTGAGGCATCCTCTGTTCAcaggacatgctggcatctactgggtcagggctctgctgctcggtggctgtgcaaccttgggcaagttcctcaacctctctgtgtcttcgtaccctcatctgtaacatgcgtgtcgatagaccctactactcagggttgatgagaagattaaatgTGCAAAACCTGCTTGACTGTGCCCACAAATCCTGATTGTAGGAATAAATTAATGACTTTTTATAAATATTTTGATCAGATGGACTCATGATCACAGATGTCTTCACATGCCTATGACTAATTTGTACACAAACTAATGCTCGTGTTTCCCAAGCACCTGGAAGACATGCCAGATCCATGTGCAGTAATGCCTGGTGGCTCCAGGTCTGCCCCGCCGTCCTGTGGGGCTGTGAGCTTTCCCAGCCTCCTGCCCGTGTTTGTGAATATCATTCTGTCCTCAGCTGCATTTCCAGCCCAGGCTGTTTGGCGCTGCCCAGGAATGGTATCAATTCCCCTGTTTCTCTTGTAGCCAGTTACTAGAATAAAATCATCTACTTTAAAA

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